Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Carcinogenesis

• Publication date

  2008-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/carcin/bgn013PMID 18204073PMCID PMC9939032
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PIAS3 Interacts with ATF1 and Regulates the Human Ferritin H Gene through an Antioxidant-responsive Element*

  2007cited by this paper
• Keap1 eye on the target: chemoprevention of liver cancer

  2007cited by this paper
• Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells.

  2007cited by this paper
• Translational Control of Nrf2 Protein in Activation of Antioxidant Response by Oxidants

  2007cited by this paper
• Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models

  2007cited by this paper
• The p65 Isoform of Nrf1 Is a Dominant Negative Inhibitor of ARE-mediated Transcription*

  2007cited by this paper
• Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

  2007cited by this paper
• 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.

  2006cited by this paper
• Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.

  2005cited by this paper
• Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide: contributions of glutathione, glutathione S-transferase, and MRP1.

  2005cited by this paper
• Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein.

  2005cited by this paper
• Sulforaphane-induced Cell Death in Human Prostate Cancer Cells Is Initiated by Reactive Oxygen Species*

  2005cited by this paper
• JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress

  2005cited by this paper
• PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress*

  2004cited by this paper
• A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway.

  2004cited by this paper
• Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.

  2004cited by this paper
• Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells.

  2004cited by this paper
• The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

  2004cited by this paper
• Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2).

  2004cited by this paper
• Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

  2004cited by this paper
• The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.

  2004cited by this paper
• Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts.

  2003cited by this paper
• Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells.

  2003cited by this paper
• Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

  2003cited by this paper
• Pivotal role of electrophilicity in glutathione S-transferase induction by tert-butylhydroquinone.

  2003cited by this paper
• Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.

  2003cited by this paper
• Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression*

  2003cited by this paper
• Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells.

  2003cited by this paper
• CHAPTER 20 – MRP2, THE APICAL EXPORT PUMP FOR ANIONIC CONJUGATES

  2003cited by this paper
• CHAPTER 19 – MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1)

  2003cited by this paper
• ABC proteins : from bacteria to man

  2003cited by this paper
• ABC proteins: from bacteria to man

  2003cited by this paper
• High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.

  2002cited by this paper
• Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.

  2002cited by this paper
• Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.

  2002cited by this paper
• Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

  2002cited by this paper
• Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription*

  2002cited by this paper
• Chemoprevention: Increased potential to bear fruit

  2001cited by this paper
• Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins.

  2001cited by this paper
• Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism.

  2001cited by this paper
• Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes.

  2001cited by this paper
• Role of Multidrug Resistance Protein 1 (MRP1) and GlutathioneS-Transferase A1-1 in Alkylating Agent Resistance: KINETICS OF GLUTATHIONE CONJUGATE FORMATION AND EFFLUX GOVERN DIFFERENTIAL CELLULAR SENSITIVITY TO CHLORAMBUCILVERSUSMELPHALAN TOXICITY

  2001cited by this paper
• Role of Multidrug Resistance Protein 1 (MRP1) and Glutathione S-Transferase A1-1 in Alkylating Agent Resistance

  2001cited by this paper
• Role of multidrug‐resistance protein 2 in glutathione S‐transferase P1‐1–mediated resistance to 4‐nitroquinoline 1‐oxide toxicities in HepG2 cells

  2000cited by this paper
• Detoxification of 1-chloro-2,4-dinitrobenzene in MCF7 breast cancer cells expressing glutathione S-transferase P1-1 and/or multidrug resistance protein 1.

  1999cited by this paper
• Concise review of the glutathione S-transferases and their significance to toxicology.

  1999cited by this paper
• Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

  1999influential reference
• Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity.

  1998cited by this paper
• Coordinated Action of Glutathione S-Transferases (GSTs) and Multidrug Resistance Protein 1 (MRP1) in Antineoplastic Drug Detoxification

  1998cited by this paper
• An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.

  1997cited by this paper
• Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.

  1997cited by this paper
• Functional antioxidant responsive elements.

  1997cited by this paper
• Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide, and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol.

  1996cited by this paper
• The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.

  1995cited by this paper
• Forward and reverse catalysis and product sequestration by human glutathione S-transferases in the reaction of GSH with dietary aralkyl isothiocyanates.

  1995cited by this paper
• Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.

  1995cited by this paper
• Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.

  1994cited by this paper
• New colorimetric cytotoxicity assay for anticancer-drug screening.

  1990cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper
• Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

  1969cited by this paper

• Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression.

  2021cites this paper
• Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs?

  2020cites this paper
• The A‐B‐C of small‐molecule ABC transport protein modulators: From inhibition to activation—a case study of multidrug resistance‐associated protein 1 (ABCC1)

  2019cites this paper
• Expression of multidrug-resistance associated proteins in human retinoblastoma treated by primary enucleation.

  2018cites this paper
• Enhanced B‐Raf‐mediated NRF2 gene transcription and HATs‐mediated NRF2 protein acetylation contributes to ABCC1‐mediated chemoresistance and glutathione‐mediated survival in acquired topoisomerase II poison‐resistant cancer cells

  2017cites this paper
• Nitro-fatty acid inhibition of triple-negative breast cancer cell viability, migration, invasion, and tumor growth

  2017cites this paper
• Metabolism of Glutathione S-Conjugates: Multiple Pathways

  2017cites this paper
• Individual expression features of GPX2, NQO1 and SQSTM1 transcript variants induced by hydrogen peroxide treatment in HeLa cells

  2017cites this paper
• Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1).

  2016influential citation
• A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity*

  2016cites this paper
• Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy

  2015cites this paper
• Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.

  2014cites this paper
• Suppression of pro-inflammatory signalling pathways by sulforaphane

  2014cites this paper
• Nuclear factor erythroid 2-related factor gene variants and susceptibility of arsenic-related skin lesions

  2014cites this paper
• Plant Polyphenols as Epigenetic Modulators of Glutathione S-Transferase P1 Activity

  2013cites this paper
• Summary and Perspective

  2013cites this paper
• Non-Specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense

  2013cites this paper
• Natural isothiocyanates: genotoxic potential versus chemoprevention.

  2012cites this paper
• Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth

  2012cites this paper
• The bioavailability of sulforaphane from broccoli products in men and its epigenetic activity

  2012cites this paper
• Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies.

  2011influential citation
• Cyclopentenone Prostaglandins with Dienone Structure Promote Cross-Linking of the Chemoresistance-Inducing Enzyme Glutathione Transferase P1-1

  2010cites this paper
• Cyclopentenone prostaglandins with dienone structure promote cross-linking of the chemoresistance-inducing enzyme Glutathione S-Transferase P1-1

  2010cites this paper
• Enzymes Involved in Processing Glutathione Conjugates

  2010cites this paper
• Sulforaphane induces glutathione S‐transferase isozymes which detoxify aflatoxin B1‐8,9‐epoxide in AML 12 cells

  2010cites this paper
• Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation.

  2009cites this paper
• Glutathione dysregulation and the etiology and progression of human diseases

  2009cites this paper
• Dietary chemoprevention strategies for induction of phase II xenobiotic-metabolizing enzymes in lung carcinogenesis: A review.

  2009cites this paper
• Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.

  2009cites this paper
• Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation.

  2009cites this paper
• Noncatalytic interactions between glutathione S-transferases and nitroalkene fatty acids modulate nitroalkene-mediated activation of peroxisomal proliferator-activated receptor gamma.

  2009cites this paper
• Chemopreventive effects of natural dietary compounds on cancer development.

  2008cites this paper
• Benzylglucosinolate, benzylisothiocyanate, and myrosinase activity in papaya fruit during development and ripening.

  2008cites this paper
• Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications.

  2008cites this paper
• Differential Potencies of Naturally Occurring Regioisomers of Nitrolinoleic Acid in PPAR γ Activation †

  2008cites this paper