Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Neuroscience Letters

• Publication date

  1999-04-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0304-3940(99)00107-XPMID 10319999
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondria and apoptosis.

  1998cited by this paper
• A model of O·2-generation in the complex III of the electron transport chain

  1998cited by this paper
• A model of O2.-generation in the complex III of the electron transport chain.

  1998cited by this paper
• Cooperative Interception of Neuronal Apoptosis by BCL‐2 and BAG‐1 Expression: Prevention of Caspase Activation and Reduced Production of Reactive Oxygen Species

  1997cited by this paper
• Role of oxidative stress in the manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced apoptosis in PC12 cells.

  1997cited by this paper
• Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones

  1996cited by this paper
• Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody*

  1996cited by this paper
• Aging, energy, and oxidative stress in neurodegenerative diseases

  1995cited by this paper
• Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells.

  1995cited by this paper
• Mitochondrial changes associated with glutathione deficiency.

  1995cited by this paper
• Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

  1994cited by this paper
• Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

  1994cited by this paper
• Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental lewy body disease

  1992cited by this paper
• Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples.

  1990cited by this paper
• Crucial role of sulfhydryl groups in the mitochondrial inner membrane structure.

  1985cited by this paper
• Isolation of mitochondria from ascites tumor cells permeabilized with digitonin.

  1984cited by this paper
• Glutathione.

  1983cited by this paper
• Status of the mitochondrial pool of glutathione in the isolated hepatocyte.

  1982cited by this paper
• Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.

  1979cited by this paper
• [1] Citrate synthase. [EC 4.1.3.7. Citrate oxaloacetate-lyase (CoA-acetylating)]

  1969cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Ethacrynic Acid Inhibits Root Gravitropism in Arabidopsis

  2024cites this paper
• Ethacrynic Acid: A Promising Candidate for Drug Repurposing as an Anticancer Agent

  2023cites this paper
• Degradation of Carbendazim by Molecular Hydrogen on Leaf Models

  2022cites this paper
• Protein Carbonyl, Lipid Peroxidation, Glutathione and Enzymatic Antioxidant Status in Male Wistar Brain Sub-regions After Dietary Copper Deficiency

  2022cites this paper
• Multidimensional bioresponses in nematodes contribute to the antagonistic toxic interaction between pentachlorophenol and TiO2 nanoparticles in soil.

  2021cites this paper
• Glutathione depletion: Starting point of brain metabolic stress, neuroinflammation and cognitive impairment in rats.

  2018cites this paper
• Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs.

  2015cites this paper
• Genotoxic effect of ethacrynic acid and impact of antioxidants.

  2015cites this paper
• Pilot study of intravenous melphalan combined with continuous infusion L‐S,R‐buthionine sulfoximine for children with recurrent neuroblastoma

  2015influential citation
• Effect of antioxidants on the genotoxicity of phenethyl isothiocyanate.

  2015cites this paper
• Electroanalytical Sensors and Methods for Assays and Studies of Neurological Biomarkers

  2014cites this paper
• Functional Module Connectivity Map (FMCM): A Framework for Searching Repurposed Drug Compounds for Systems Treatment of Cancer and an Application to Colorectal Adenocarcinoma

  2014cites this paper
• Bioenergetics and mitochondrial dysfunction in aging: recent insights for a therapeutical approach.

  2014cites this paper
• Role of the Ascorbate–Glutathione Cycle in Paraquat Tolerance of Rice

  2013cites this paper
• Glutathione and thioredoxin dependent systems in neurodegenerative disease: what can be learned from reverse genetics in mice.

  2013cites this paper
• Conversion of aristolochic acid I into aristolic acid by reaction with cysteine and glutathione: biological implications.

  2013cites this paper
• Epigallocatechin gallate attenuates L-DOPA-induced apoptosis in rat PC12 cells

  2013cites this paper
• sensitivein rat cerebellar granule cells is redox

  2013cites this paper
• Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione

  2013cites this paper
• Ethacrynic Acid Oxadiazole Analogs Induce Apoptosis in Malignant Hematologic Cells through Downregulation of Mcl-1 and c-FLIP, Which Was Attenuated by GSTP1-1

  2013cites this paper
• Relationship between Human Aging Muscle and Oxidative System Pathway

  2012cites this paper
• Bacopa monnieri modulates endogenous cytoplasmic and mitochondrial oxidative markers in prepubertal mice brain.

  2011cites this paper
• Measurement of extracellular (exofacial) versus intracellular protein thiols.

  2010cites this paper
• Rat brain endothelial cells are a target of manganese toxicity.

  2010cites this paper
• Reactive oxygen species in bovine oocyte maturation in vitro.

  2009cites this paper
• Pro-oxidative and pro-apoptotic action of defatted seeds of Oenothera paradoxa on human skin melanoma cells.

  2009cites this paper
• Investigations of Olfactory Stem Cells in Schizophrenia

  2009cites this paper
• The Gluttathion Role As Antioxidant in Inhibition of Neurode generative Disease and Brain Aging

  2009influential citation
• Structural and functional analysis of the neuronal mitochondrial fission factor GDAP1 and its homolog GDAP1L1

  2009cites this paper
• Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on 4-hydroxy-2-nonenal-induced apoptotic T cell death.

  2008cites this paper
• Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway.

  2007cites this paper
• Mitochondrial isocitrate dehydrogenase protects human neuroblastoma SH‐SY5Y cells against oxidative stress

  2007cites this paper
• The Development of a Bacterial Biosensor Designed to Detect Oxidative Chemicals in Water: Correlating Sensor Relevance to Mammalian Brain Cells and Assessing Bacterial Cell Immobilization Strategies

  2007cites this paper
• Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.

  2007cites this paper
• Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation

  2007cites this paper
• Mitochondrial glutathione

  2007cites this paper
• Ethacrynic acid butyl-ester induces apoptosis in leukemia cells through a hydrogen peroxide mediated pathway independent of glutathione S-transferase P1-1 inhibition.

  2007cites this paper
• Metabolism of glutathione in tumour cells as evidenced by 1H MRS

  2007cites this paper
• Mechanism of 4-Hydroxynonenal induced toxicity in Jurkat CD4+ T lymphocytes.

  2006cites this paper
• Na-K-ATPase in rat cerebellar granule cells is redox sensitive.

  2006cites this paper
• Gypenosides protect primary cultures of rat cortical cells against oxidative neurotoxicity.

  2006cites this paper
• Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes.

  2006cites this paper
• The bipyridyl herbicide paraquat-induced toxicity in human neuroblastoma SH-SY5Y cells: relevance to dopaminergic pathogenesis

  2006cites this paper
• Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons*

  2005cites this paper
• The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO)

  2005cites this paper
• Preventive mechanism of cellular glutathione in monomethylarsonic acid-induced cytolethality.

  2005cites this paper
• The Bipyridyl Herbicide Paraquat Produces Oxidative Stress-Mediated Toxicity in Human Neuroblastoma SH-SY5Y Cells: Relevance to the Dopaminergic Pathogenesis

  2005cites this paper
• Induction of mitochondrial fusion by cysteine‐alkylators ethacrynic acid and N‐ethylmaleimide

  2005influential citation
• Up-regulation of glutathione biosynthesis in NIH3T3 cells transformed with the ETV6-NTRK3 gene fusion.

  2005cites this paper
• Regulation of apoptosis by glutathione redox state in PC12 cells exposed simultaneously to iron and ascorbic acid.

  2005cites this paper
• Activation of plasma membrane reduced glutathione transport in death receptor apoptosis of HepG2 cells.

  2004cites this paper
• Reversible Modulation of Cell Cycle Kinetics in NIH/3T3 Mouse Fibroblasts by Inducible Overexpression of Mitochondrial Manganese Superoxide Dismutase

  2004cites this paper
• Effect of melatonin on temporal changes of reactive oxygen species and glutathione after MPP+ treatment in human astrocytoma U373MG cells

  2004cites this paper
• Developmental up‐regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury

  2004cites this paper
• Transcriptional regulation of glutathione synthetase in the fission yeast Schizosaccharomyces pombe.

  2004cites this paper
• Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus.

  2004cites this paper
• Inactivation of the cytotoxic activity of repin, a sesquiterpene lactone from Centaurea repens.

  2004cites this paper
• Effects of glutathione depletion on the viability of human NT2-derived neuronal and astroglial cultures.

  2004cites this paper
• Characterization of the role of glutathione in repin-induced mitochondrial dysfunction, oxidative stress and dopaminergic neurotoxicity in rat pheochromocytoma (PC12) cells.

  2004cites this paper
• Glutathione depletion-induced apoptosis of Ha-ras-transformed NIH3T3 cells can be prevented by melatonin

  2003cites this paper
• Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia.

  2003influential citation
• Adenosine A2A receptors regulate oxidative stress formation in rat pheochromocytoma PC12 cells during serum deprivation.

  2003cites this paper
• Gene dosage-dependent effects of bcl-2 expression on cellular survival and redox status.

  2003cites this paper
• Radiation Response of Cells during Altered Protein Thiol Redox

  2003cites this paper
• ROLE OF GLUTAMATE-CYSTEINE LIGASE IN MAINTAINING GLUTATHIONE HOMEOSTASIS AND PROTECTING AGAINST OXIDATIVE STRESS

  2003cites this paper
• Neurotrophic Factor Effects on Oxidative Stress–Induced Neuronal Death

  2003cites this paper
• Cytosolic and mitochondrial glutathione in microglial cells are differentially affected by oxidative/nitrosative stress.

  2003cites this paper
• Is glutathione an important neuroprotective effector molecule against amyloid beta toxicity?

  2003cites this paper
• Glutathione Might Exert an Important Function in Caerulein-Stimulated Amylase Release in Isolated Rat Pancreatic Acini

  2002cites this paper
• Tyrphostins Protect Neuronal Cells from Oxidative Stress*

  2002cites this paper
• Melatonin attenuates MPP+‐induced neurodegeneration and glutathione impairment in the nigrostriatal dopaminergic pathway

  2002cites this paper
• Oxidative stress in glial cultures: Detection by DAF‐2 fluorescence used as a tool to measure peroxynitrite rather than nitric oxide

  2002cites this paper
• Ethacrynic acid inhibits pancreatic exocrine secretion.

  2001cites this paper
• Physiological Properties of Resveratrol Isomers in Wine: Compositional Changes during Processing

  2001cites this paper
• Vergleich Haptischer Wahrnehmungsleistungen Zwischen Blinden und Sehenden Personen

  2001cites this paper
• Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes.

  2001cites this paper
• Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells.

  2000cites this paper
• Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells.

  2000cites this paper
• Metabolism and functions of glutathione in brain.

  2000cites this paper
• Glutathione, oxidative stress and neurodegeneration.

  2000cites this paper