Probing the Function of Bordetella bronchiseptica Adenylate Cyclase Toxin by Manipulating Host Immunity

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Infection and Immunity

• Publication date

  1999-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.67.3.1493-1500.1999PMID 10024599PMCID PMC96485
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
• Integration of multiple domains in a two‐component sensor protein: the Bordetella pertussis BvgAS phosphorelay.

  1996cited by this paper
• Intranasal Inoculation of Bordetella Bronchiseptica in Mice Induces Long‐Lasting Antibody and T‐Cell Mediated Immune Responses

  1996cited by this paper
• Central Role of the BvgS Receiver as a Phosphorylated Intermediate in a Complex Two-component Phosphorelay*

  1996cited by this paper
• Ectopic expression of the flagellar regulon alters development of the Bordetella-host interaction.

  1995cited by this paper
• Susceptibility of beige mice to Mycobacterium avium: role of neutrophils

  1995cited by this paper
• Cloning and sequence of the Bordetella bronchiseptica adenylate cyclase-hemolysin-encoding gene: comparison with the Bordetella pertussis gene.

  1995cited by this paper
• BvgAS-mediated signal transduction: analysis of phase-locked regulatory mutants of Bordetella bronchiseptica in a rabbit model

  1994cited by this paper
• Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.

  1994cited by this paper
• Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis.

  1994cited by this paper
• Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins

  1994cited by this paper
• Effective immunization against Bordetella pertussis respiratory infection in mice is dependent on induction of cell-mediated immunity

  1993cited by this paper
• Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model

  1993cited by this paper
• Protection of mice against respiratory Bordetella pertussis infection by intranasal immunization with P.69 and FHA.

  1993cited by this paper
• Virulence of a Bordetella pertussis strain expressing a mutant adenylyl cyclase with decreased calmodulin affinity.

  1993cited by this paper
• Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC.

  1993cited by this paper
• Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin

  1993influential reference
• Construction and analysis of Bordetella pertussis mutants defective in the production of fimbriae.

  1992cited by this paper
• Targeted mutations that ablate either the adenylate cyclase or hemolysin function of the bifunctional cyaA toxin of Bordetella pertussis abolish virulence.

  1992cited by this paper
• Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection.

  1992cited by this paper
• Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice

  1990cited by this paper
• Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence.

  1989cited by this paper
• Invasive adenylate cyclase toxin of Bordetella pertussis.

  1989cited by this paper
• Lethal infection by Bordetella pertussis mutants in the infant mouse model

  1989cited by this paper
• The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli.

  1988cited by this paper
• The calmodulin‐sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia col

  1988cited by this paper
• Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase.

  1988cited by this paper
• Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functions

  1987cited by this paper
• Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.

  1984cited by this paper
• Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.

  1984cited by this paper
• Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

  1982cited by this paper
• Phagocyte impotence caused by an invasive bacterial adenylate cyclase.

  1982cited by this paper
• Experimental infection of Bordetella bronchiseptica to rabbits.

  1982cited by this paper
• Calmodulin activates prokaryotic adenylate cyclase.

  1980cited by this paper
• Biology of Bordetella bronchiseptica

  1980cited by this paper
• The beige mutation in the mouse selectively impairs natural killer cell function

  1979cited by this paper
• Soluble adenylate cyclase from the culture medium of Bordetella pertussis: purification and characterization

  1976cited by this paper
• SECONDARY FAMILIAL ATTACK RATES FROM PERTUSSIS IN VACCINATED AND UNVACCINATED CHILDREN

  1940cited by this paper

• Pertussis resurgence: epidemiological trends, pathogenic mechanisms, and preventive strategies

  2025cites this paper
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  2025cites this paper
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  2024cites this paper
• Eosinophils as drivers of bacterial immunomodulation and persistence

  2024cites this paper
• Pathogenicity of Bordetella bronchiseptica isolated from apparently healthy rabbits in guinea pig, rat, and mouse

  2022influential citation
• Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis

  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
• Bordetellosis

  2019cites this paper
• Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Enhancement of immune response against Bordetella spp. by disrupting immunomodulation

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
• Bordetella protein toxins

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer

  2013cites this paper
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  2013cites this paper
• Analyse du contrôle allostérique et prédiction de structure pour une toxine de pathogène : l'apport des simulations de dynamique moléculaire

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• A Type VI Secretion System Encoding Locus Is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo

  2012cites this paper
• Identification of a CO2 Responsive Regulon in Bordetella

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• Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin*

  2012cites this paper
• Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice.

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• sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

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  2010cites this paper
• Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin.

  2010cites this paper
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• infection in a rodent model of bordetellosis parapertussis Bordetella Acellular pertussis vaccination facilitates

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• Immune-mediated evasion of the adaptive immune response by the Bordetellae

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• Role of Neutrophils in Response to Bordetella pertussis Infection in Mice

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• Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses.

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  2007cites this paper
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  2007cites this paper
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