Cimetidine protects against acetaminophen hepatotoxicity in rats.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Gastroenterology

• Publication date

  1981-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0016-5085(81)80011-XPMID 7286583
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An integrated approach to the study of chemically reactive metabolites of acetaminophen.

  1981cited by this paper
• Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice.

  1981cited by this paper
• Acetaminophen hepatotoxicity.

  1980cited by this paper
• Effect of cimetidine and other antihistaminics on the elimination of aminopyrine, phenacetin and caffeine.

  1980cited by this paper
• Additive effects of inducers and fasting on acetaminophen hepatotoxicity.

  1980cited by this paper
• Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.

  1980cited by this paper
• Cimetidine spares the glucuronidation of lorazepam and oxazepam.

  1980cited by this paper
• Cimetidine impairs elimination of chlordiazepoxide (Librium) in man.

  1980cited by this paper
• The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat.

  1980cited by this paper
• Effect of N-acetylcysteine on the pharmacokinetics of acetaminophen in rats.

  1979cited by this paper
• Metyrapone as a treatment for acetaminophen (paracetamol) toxicity in mice.

  1979cited by this paper
• Paracetamol metabolism following overdosage: application of high performance liquid chromatography

  1977cited by this paper
• Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.

  1977cited by this paper
• Reduction of acetaminophen toxicity by sodium sulfate in mice.

  1977cited by this paper
• Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine.

  1977cited by this paper
• Reversal of experimental paracetamol toxicosis with N-acetylcysteine.

  1976cited by this paper
• Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage.

  1976cited by this paper
• REVERSAL OF EXPERIMENTAL PARACETAMOL TOXICOSIS WITH N-ACETYLCYSTEINE

  1976cited by this paper
• The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning

  1974cited by this paper
• Acetaminophen‐induced hepatic injury: Protective role of glutathione in man and rationale for therapy

  1974cited by this paper
• N-hydroxyphenacetinn as a precursor of 3-substituted 4-hydroxyacetanilide metabolites of phenacetin.

  1974cited by this paper
• Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

  1973cited by this paper
• Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

  1973cited by this paper
• Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

  1973cited by this paper
• Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

  1973cited by this paper
• On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain.

  1971cited by this paper
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  1971cited by this paper
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  1970cited by this paper
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  1969cited by this paper
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  1957cited by this paper
• The estimation of acetanilide and its metabolic products, aniline, N-acetyl p-aminophenol and p-amino-phenol, free and total conjugated, in biological fluids and tissues.

  1948cited by this paper

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• Effects of Cimetidine and Phenobarbitone on Paracetamol Induced Hepatotoxic Rats

  2010cites this paper
• PENGARUH TEH JAMUR TERHADAP KERUSAKAN HATI TIKUS

  2009cites this paper
• Cimetidine as an alternative to N-acetylcysteine in patients with paracetamol poisoning

  2009cites this paper
• Cimetidine in the treatment of paracetamol ingestion in humans

  2009cites this paper
• Protective effect of diltiazem against acetaminophen hepatotoxicity in mice.

  2008cites this paper
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  2007cites this paper
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  2007cites this paper
• The Misuse of Cimetidine in Patients with Cirrhosis

  2007cites this paper
• What is your diagnosis? Paracetamol poisoning.

  2007cites this paper
• Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen‐induced acute liver injury

  2006cites this paper
• Acetaminophen hepatotoxicity: Is there a role for prostaglandin synthesis?

  2005cites this paper
• Pharmacokinetic consequences and toxicologic implications of metyrapone-induced alterations of acetaminophen elimination in man

  2004cites this paper
• Dose-dependent transitions in mechanisms of toxicity: case studies.

  2004cites this paper
• BRODIE ENZYME INDUCTION AND INHIBITION

  2002cites this paper
• Protective Effects of Cimetidine on Radiation-induced Micronuclei and Apoptosis in Human Peripheral Blood Lymphocytes

  2002cites this paper
• Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.

  2001cites this paper
• Effect of different doses of S-adenosyl-L-methionine on paracetamol hepatotoxicity in a mouse model.

  2000cites this paper
• Protective Effect of Chlormethiazole, a Sedative, against Acetaminophen-Induced Liver Injury in Mice

  1999cites this paper
• Treatment of acetaminophen overdose.

  1999cites this paper
• Paracetamol-induced hepatotoxicity: Lack of enhancement of the hepatoprotective effect of N-acetylcysteine by sodium sulphate

  1998cites this paper
• Role of cimetidine in the treatment of acetaminophen poisoning.

  1998cites this paper
• Gastrointestinal drugs.

  1998cites this paper
• Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.

  1997cites this paper
• Selective protein arylation and acetaminophen-induced hepatotoxicity.

  1997cites this paper
• Regulation of sulphation and glutathion conjugation of acetaminophen in isolated rat hepatocytes.

  1996cites this paper
• The enhanced effect of parenteral nutrition on hepatotoxicity.

  1996cites this paper
• Cimetidine as adjunctive treatment for acetaminophen overdose

  1995cites this paper
• [Plasma levels of alanine aminotransferase in experimental liver necrosis induced by overdosage of paracetamol in mice].

  1995cites this paper
• Prevention and treatment of drug-induced liver disease.

  1995cites this paper
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  1995cites this paper
• 4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat.

  1994cites this paper
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  1993cites this paper
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  1992cites this paper
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  1991cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1989cites this paper
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  1989cites this paper
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  1989cites this paper
• [Paracetamol. Present status of knowledge in 1989].

  1989cites this paper
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  1989cites this paper
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  1989cites this paper
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  1989cites this paper
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  1988cites this paper
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  1988cites this paper
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  1988cites this paper
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  1988cites this paper
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  1987cites this paper
• Potential Use of Cimetidine for Treatment of Acetaminophen Overdose

  1987cites this paper
• [Pharmacokinetic interaction of histamine H2 receptor antagonists: mechanism and clinical implications].

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  1987cites this paper
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  1986cites this paper
• Drug Overdose: Changing Concepts for Modern Drugs

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  1986cites this paper
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• Protective Agents for Acetaminophen Overdose

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  1985cites this paper
• Ranitidine‐acetaminophen interaction: Effects on acetaminophen‐induced hepatotoxicity in fischer 344 rats

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• Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat.

  1985cites this paper
• H2 receptor antagonists, cytochrome P450, and paracetamol-induced hepatotoxicity.

  1985cites this paper
• Drug interactions with cimetidine: an update.

  1985cites this paper
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  1984cites this paper
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  1984cites this paper
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  1984cites this paper
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  1984cites this paper