Selected signalling proteins recruited to the T‐cell receptor–CD3 complex

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Immunology

• Publication date

  2018-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/imm.12809PMID 28771705PMCID PMC5721247
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

  2017cited by this paper
• Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen

  2017cited by this paper
• TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3ζ chain.

  2017cited by this paper
• Sclerosing cholangitis and intracranial lymphoma in a child with classical Wiskott–Aldrich syndrome

  2017cited by this paper
• Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning

  2016cited by this paper
• A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

  2016cited by this paper
• CD3ε recruits Numb to promote TCR degradation.

  2016cited by this paper
• A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli

  2016cited by this paper
• A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation.

  2016cited by this paper
• Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain*

  2016cited by this paper
• First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases

  2016cited by this paper
• T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells

  2015cited by this paper
• Decreased miR‐146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1型糖尿病患者外周血单个核细胞miR‐146表达下调与胰岛持续免疫失衡相关

  2015cited by this paper
• T-cell receptor diversity is selectively skewed in T-cell populations of patients with Wiskott-Aldrich syndrome.

  2015cited by this paper
• T cell receptor dwell times control the kinase activity of Zap70

  2015cited by this paper
• Evidence for inducible recruitment of Wiskott-Aldrich syndrome protein to T cell receptor-CD3 complex in Jurkat T cells.

  2015cited by this paper
• Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation

  2014cited by this paper
• Insight into the therapeutic aspects of 'Zeta-Chain Associated Protein Kinase 70 kDa' inhibitors: a review.

  2014cited by this paper
• Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor

  2014cited by this paper
• The adapter proteins ADAP and Nck cooperate in T cell adhesion.

  2014cited by this paper
• Crammed signaling motifs in the T-cell receptor.

  2014cited by this paper
• X-Linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis

  2014cited by this paper
• The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192

  2014cited by this paper
• Distinct T cell receptor signaling pathways drive proliferation and cytokine production in T cells

  2013cited by this paper
• Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development

  2013cited by this paper
• Faculty Opinions recommendation of Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.

  2013cited by this paper
• Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

  2013cited by this paper
• Metabolic pathways in immune cell activation and quiescence.

  2013cited by this paper
• T cell receptor signalling networks: branched, diversified and bounded

  2013cited by this paper
• Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

  2013cited by this paper
• T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

  2013cited by this paper
• Conformational states of the kinase Lck regulate clustering in early T cell signaling

  2012cited by this paper
• How the TCR balances sensitivity and specificity for the recognition of self and pathogens

  2012cited by this paper
• Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement

  2012cited by this paper
• How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism

  2012cited by this paper
• Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers

  2011cited by this paper
• RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling

  2010cited by this paper
• Checkpoints in lymphocyte development and autoimmune disease

  2010cited by this paper
• Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

  2010cited by this paper
• ITAM-mediated signaling by the T-cell antigen receptor.

  2010cited by this paper
• The endocytic adaptor Numb regulates thymus size by modulating pre-TCR signaling during asymmetric division.

  2010cited by this paper
• The multiple functions of Numb.

  2010cited by this paper
• ZAP-70: an essential kinase in T-cell signaling.

  2010cited by this paper
• Characterization of ζ-associated protein, 70 kd (ZAP70)-deficient human lymphocytes.

  2010cited by this paper
• T cell activation.

  2009cited by this paper
• Nck adapter proteins: functional versatility in T cells

  2009cited by this paper
• Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

  2009cited by this paper
• Essential function for the GTPase TC21 in homeostatic antigen receptor signaling

  2009cited by this paper
• Tailoring T-cell receptor signals by proximal negative feedback mechanisms

  2008cited by this paper
• Kinase inhibitors for the treatment of inflammatory and autoimmune disorders

  2008cited by this paper
• The actin cytoskeleton in T cell activation.

  2008cited by this paper
• The Proline-Rich Sequence of CD3ε as an Amplifier of Low-Avidity TCR Signaling1

  2008cited by this paper
• Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

  2008cited by this paper
• The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.

  2008cited by this paper
• The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

  2008cited by this paper
• The Membrane-proximal Portion of CD3 ϵ Associates with the Serine/Threonine Kinase GRK2*

  2007cited by this paper
• Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

  2007cited by this paper
• Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence.

  2007cited by this paper
• Reciprocal Regulation of SH3 and SH2 Domain Binding via Tyrosine Phosphorylation of a Common Site in CD3ε1

  2007cited by this paper
• The membrane-proximal portion of CD3 epsilon associates with the serine/threonine kinase GRK2.

  2007cited by this paper
• Biological consequences of the phosphorylation of serine 59 on the tyrosine kinase Lck

  2007cited by this paper
• Development of N-4,6-pyrimidine-N-alkyl-N'-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase.

  2006cited by this paper
• Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.

  2006cited by this paper
• The Notch Regulator Numb Links the Notch and TCR Signaling Pathways1

  2005cited by this paper
• The role of the T cell in autoimmune inflammation

  2005cited by this paper
• Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases

  2005cited by this paper
• Structure and regulation of Src family kinases

  2004cited by this paper
• SLP-76 Coordinates Nck-Dependent Wiskott-Aldrich Syndrome Protein Recruitment with Vav-1/Cdc42-Dependent Wiskott-Aldrich Syndrome Protein Activation at the T Cell-APC Contact Site 1

  2003cited by this paper
• Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

  2003cited by this paper
• A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8

  2003cited by this paper
• TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

  2003cited by this paper
• Initiation of TCR signaling: regulation within CD3 dimers

  2003cited by this paper
• A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection.

  2002cited by this paper
• Recruitment of Nck by CD 3 Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

  2002cited by this paper
• Lck inhibitors as a therapeutic approach to autoimmune disease and transplant rejection.

  2001cited by this paper
• Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway*

  2001cited by this paper
• A Role for Wiskott-Aldrich Syndrome Protein in T-cell Receptor-mediated Transcriptional Activation Independent of Actin Polymerization*

  2001cited by this paper
• Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor

  2001cited by this paper
• WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement.

  2001cited by this paper
• Lymphocytes with a complex: adapter proteins in antigen receptor signaling.

  2000cited by this paper
• Conversion of p56lck to p60lck in human peripheral blood T lymphocytes is dependent on co‐ stimulation through accessory receptors: involvement of phospholipase C, protein kinase C and MAP‐kinases in vivo

  2000cited by this paper
• Signal transduction by the TCR for antigen.

  2000cited by this paper
• Tyrosine 319, a Newly Identified Phosphorylation Site of ZAP-70, Plays a Critical Role in T Cell Antigen Receptor Signaling*

  1999cited by this paper
• Phosphorylation of Tyr319 in ZAP‐70 is required for T‐cell antigen receptor‐dependent phospholipase C‐γ1 and Ras activation

  1999cited by this paper
• The CD3 epsilon subunit of the TCR contains endocytosis signals.

  1999cited by this paper
• The Vav Binding Site (Y315) in ZAP-70 Is Critical for Antigen Receptor–mediated Signal Transduction

  1997cited by this paper
• Tyrosine Phosphorylation of the CD3-ε Subunit of the T Cell Antigen Receptor Mediates Enhanced Association with Phosphatidylinositol 3-Kinase in Jurkat T Cells*

  1997cited by this paper
• Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?

  1997cited by this paper
• N‐WASP, a novel actin‐depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2‐dependent manner downstream of tyrosine kinases.

  1996cited by this paper
• Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity

  1996cited by this paper
• SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction (*)

  1996cited by this paper
• Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

  1996cited by this paper
• Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

  1995cited by this paper
• ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity

  1995cited by this paper
• Activation of ZAP‐70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

  1995cited by this paper
• Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase.

  1994cited by this paper
• Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.

  1994cited by this paper
• Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

  1994cited by this paper
• A kinase-independent function of Lck in potentiating antigen-specific T cell activation.

  1993cited by this paper
• T-cell activation.

  1992cited by this paper

• Mechanistic basis and therapeutic modulation of T cell fitness to enhance CAR-T cell efficacy in hematological malignancies.

  2026cites this paper
• Advances in cancer immunotherapy using small-molecular inhibitors targeting the PD-1/PD-L1 interaction.

  2025cites this paper
• Diagnostic Efficacy and Clinical Significance of Lymphocyte Subsets, Granzyme B and Perforin in the Peripheral Blood of Patients with Invasive Breast Cancer Following Neoadjuvant Chemotherapy

  2025cites this paper
• Two Are Better than One: The Bi-Specific Antibody Mosunetuzumab Reveals an Improved Immune Response of Vγ9Vδ2 T Cells Targeting CD20 in Malignant B Cells in Comparison to the Mono-Specific Antibody Obinutuzumab

  2025cites this paper
• A New PD-L1 Nanobody Enhances Cell Death in Lung Cancer In Vitro and In Vivo

  2025cites this paper
• Identification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells

  2025cites this paper
• Transitioning from native to synthetic receptors: broadening T-cell engineering and beyond

  2025cites this paper
• Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects

  2025cites this paper
• Challenges and strategies in clinical applications of CAR-T therapy for autoimmune diseases

  2025cites this paper
• TCR/BCR Secondary Rearrangement in Autoimmune Diseases: Molecular Mechanisms, Pathogenic Roles, and Therapeutic Frontiers

  2025cites this paper
• Immune analysis according to Lauren type for gastric cancer and its significance in individual treatment and prognostic prediction

  2025cites this paper
• Integrated bioinformatics and machine learning reveal key genes and immune mechanisms associated with uremia

  2025cites this paper
• The Immunomodulatory Function of Assembled Composite Nanopolypeptide Containing Bursal-Derived BP7 (CNPB7) in Promoting the Mucosal Immune Response within Poultry Immunization

  2024cites this paper
• Key links in the physiological regulation of the immune system and disease induction: T cell receptor -CD3 complex.

  2024cites this paper
• Investigating underlying molecular mechanisms, signaling pathways, emerging therapeutic approaches in pancreatic cancer

  2024cites this paper
• Identification of shared mechanisms and targets between immune checkpoint inhibitor-associated myocarditis and autoimmune myocarditis

  2024cites this paper
• Histomorphometric evaluation of melanomacrophage centers (MMCs) and CD3+ T cells of two morphs of brown trout (Salmo trutta) fed diets with immunostimulants.

  2023cites this paper
• T-Cell Immunity in COVID-19-Recovered Individuals and Individuals Vaccinated with the Combined Vector Vaccine Gam-COVID-Vac

  2023cites this paper
• Lymph-Node-Based CD3+ CD20+ Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection

  2023influential citation
• Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats.

  2023cites this paper
• Modulating T Cell Responses by Targeting CD3

  2023influential citation
• Tumor Infiltration Levels of CD3, Foxp3 (+) Lymphocytes and CD68 Macrophages at Diagnosis Predict 5-Year Disease-Specific Survival in Patients with Oropharynx Squamous Cell Carcinoma

  2022cites this paper
• Mutation of the Polyproline Sequence in CD3ε Evidences TCR Signaling Requirements for Differentiation and Function of Pro-Inflammatory Tγδ17 Cells

  2022cites this paper
• Single-cell RNA Sequencing Uncovered the Involvement of an Endothelial Subset in Neutrophil Recruitment in Chemically Induced Rat Pulmonary Inflammation

  2022cites this paper
• Back on the scene: advances and challenges in CD3-related drugs in tumor therapy.

  2022cites this paper
• Cyclin-Dependent Kinase Inhibitors Function as Potential Immune Regulators via Inducing Pyroptosis in Triple Negative Breast Cancer

  2022cites this paper
• Tumor‐associated macrophages regulate the function of cytotoxic T lymphocyte through PD‐1/PD‐L1 pathway in multiple myeloma

  2022cites this paper
• Tumor HPV Status, Level of Regulatory T Cells and Macrophage Infiltration Predict up to 20-Year Non-Disease-Specific Survival in Oropharynx Squamous Cell Carcinoma Patients

  2022cites this paper
• The modulatory role of dendritic cell-T cell cross-talk in breast cancer: Challenges and prospects.

  2022cites this paper
• BAP31 affects macrophage polarization through regulating helper T cells activation

  2022cites this paper
• Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells

  2022cites this paper
• Imbalanced T-Cell Subsets May Facilitate the Occurrence of Osteonecrosis of the Femoral Head

  2022cites this paper
• Expression and Clinical Significance of Th1/Th2/Th17 Cytokines and Lymphocyte Subsets in PCNSL

  2022cites this paper
• Attenuated T cell activation and rearrangement of T cell receptor β repertoire in silica nanoparticle-induced pulmonary fibrosis of mice.

  2022cites this paper
• Immune Cell Networks Uncover Candidate Biomarkers of Melanoma Immunotherapy Response

  2022cites this paper
• Investigation of the Effects of Glutens on Serum Interleukin-1 Beta and Tumor Necrosis Factor-Alpha Levels and the Immunohistochemical Distribution of CD3 and CD8 Receptors in the Small Intestine in Male Rats

  2021cites this paper
• Engineering Nanoscale Artificial Antigen-Presenting Cells by Metabolic Dendritic Cell Labeling to Potentiate Cancer Immunotherapy.

  2021cites this paper
• Identification of Hub Genes and Pathways of Triple Negative Breast Cancer by Expression Profiles Analysis

  2021cites this paper
• GFI1 cooperates with IKAROS/IKZF1 to activate gene expression in T-cell acute lymphoblastic leukemia

  2021cites this paper
• Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling

  2021cites this paper
• Immune cell networks uncover candidate biomarkers of cancer immunotherapy response

  2021cites this paper
• Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control

  2021cites this paper
• Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells

  2021cites this paper
• c‐Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR‐145‐5p/SPOP/PD‐L1 axis

  2021cites this paper
• Multimodular Optimization of Chemically Regulated T Cell Switches Demonstrates Flexible and Interchangeable Nature of Immune Cell Signaling Domains

  2021cites this paper
• T Cell Development and T Cell Receptor Structure

  2021cites this paper
• Early‐life thermal stress mediates long‐term alterations in hypothalamic microglia

  2021influential citation
• Identi cation of Potential Biomarkers in Synovial Tissue of Rheumatoid Arthritis via Integrated Microarray Analysis. Identi cation of Biomarkers of Rheumatoid Arthritis

  2021cites this paper
• CFP is a prognostic biomarker and correlated with immune infiltrates in Gastric Cancer and Lung Cancer

  2021cites this paper
• Assessing the Multivariate Relationship between the Human Infant Intestinal Exfoliated Cell Transcriptome (Exfoliome) and Microbiome in Response to Diet

  2020cites this paper
• Regulatory T-cell expansion in oral and maxillofacial Langerhans cell histiocytosis.

  2020cites this paper
• Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

  2020cites this paper
• CRISPR/Cas9-mediated PD-1 Knock-out in Human Primary T Cells Shows Enhanced Cytotoxicity Against Cancer Cells

  2020cites this paper
• Characterization of CD3γ/δ+ cells in grass carp (Ctenopharyngodon idella).

  2020cites this paper
• A Head Start: CAR-T Cell Therapy for Primary Malignant Brain Tumors

  2020cites this paper
• Regulation of T Helper Cell Fate by TCR Signal Strength

  2020cites this paper
• Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain

  2020cites this paper
• Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells

  2020cites this paper
• Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency

  2020cites this paper
• Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy.

  2020cites this paper
• Immunoproteasome Function in Lymphocyte Activation

  2019cites this paper
• NK cells specifically TCR-dressed to kill cancer cells

  2019cites this paper
• CD4 regulatory T cells: their requirement for CD80 and CD86 costimulation and their role in autoimmune hepatitis

  2019cites this paper
• Detection and phenotypic characterization of drug (metabolite)-specific t-cells from patients with drug-induced skin and liver injury and healthy donors

  2019cites this paper
• Teleost cytotoxic T cells.

  2019cites this paper
• A system level approach to identify novel cell size regulators

  2019cites this paper
• It’s all about the CD3+ T-cells: how circulating immune cell subset analyses can predict early relapse in Hodgkin lymphoma

  2019cites this paper
• Effects of Infliximab against Methotrexate Toxicity in Splenic Tissue via the Regulation of CD3, CD68, and C200R in Rats

  2019cites this paper
• Theassocation of CD247 Gene rs858554 and rs704848 Polymorphisms with Immune Trombocytopenia Disease

  2019cites this paper
• Ki‐67/CD3 ratio in the diagnosis of chronic inflammatory enteropathy in dogs

  2019cites this paper
• The regenerating skeletal muscle niche guides muscle stem cell self-renewal

  2019cites this paper
• On the activation and deactivation pathways of the Lck kinase domain: a computational study

  2019cites this paper
• Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

  2019cites this paper
• Peculiar Expression of CD3-Epsilon in Kidney of Ginbuna Crucian Carp

  2018cites this paper
• The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling

  2018cites this paper
• Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes.

  2018cites this paper
• Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

  2018cites this paper
• Simulation of Stimulation: Cytokine Dosage and Cell Cycle Crosstalk Driving Timing-Dependent T Cell Differentiation

  2018cites this paper
• Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen

  2017cites this paper