αKAP is an anchoring protein for a novel CaM kinase II isoform in skeletal muscle

No abstract is available for this paper.

• Publication year

  1998

• Venue

  EMBO Journal

• Publication date

  1998-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/17.19.5598PMID 9755160PMCID PMC1170888
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation at the Nuclear Localization Signal of Ca2+/Calmodulin-dependent Protein Kinase II Blocks Its Nuclear Targeting*

  1998influential reference
• Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations.

  1998cited by this paper
• Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.

  1998cited by this paper
• In Vivo and In Vitro Characterization of the Sequence Requirement for Oligomer Formation of Ca2+/Calmodulin‐Dependent Protein Kinase IIα

  1998cited by this paper
• Autophosphorylation-dependent Targeting of Calcium/ Calmodulin-dependent Protein Kinase II by the NR2B Subunit of theN-Methyl- d-aspartate Receptor*

  1998cited by this paper
• Sites of Interaction between Kinase-related Protein and Smooth Muscle Myosin*

  1997cited by this paper
• Signaling through scaffold, anchoring, and adaptor proteins.

  1997influential reference
• SH2/SH3 Adaptor Proteins Can Link Tyrosine Kinases to a Ste20-related Protein Kinase, HPK1*

  1997cited by this paper
• The Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Regulates Atrial Natriuretic Factor Gene Expression in Ventricular Myocytes*

  1997cited by this paper
• Translocation of Autophosphorylated Calcium/Calmodulin-dependent Protein Kinase II to the Postsynaptic Density*

  1997cited by this paper
• Phosphorylation-dependent Reversible Association of Ca2+/Calmodulin-dependent Protein Kinase II with the Postsynaptic Densities*

  1997cited by this paper
• A Protein Kinase C Translocation Inhibitor as an Isozyme-selective Antagonist of Cardiac Function*

  1996cited by this paper
• Molecular cloning of a novel protein containing the association domain of calmodulin-dependent protein kinase II.

  1996influential reference
• Common Principles of Protein Translocation Across Membranes

  1996cited by this paper
• Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor*

  1996cited by this paper
• Biochemical and functional characterization of the synaptic vesicle-associated form of CA2+/calmodulin-dependent protein kinase II.

  1996cited by this paper
• A novel pancreatic beta-cell isoform of calcium/calmodulin-dependent protein kinase II (beta 3 isoform) contains a proline-rich tandem repeat in the association domain.

  1995cited by this paper
• Localization of protein kinases by anchoring proteins: a theme in signal transduction.

  1995cited by this paper
• The multifunctional calcium/calmodulin-dependent protein kinase: from form to function.

  1995cited by this paper
• Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells

  1995influential reference
• A novel pancreatic β‐cell isoform of calcium/calmodulin‐dependent protein kinase II (β 3 isoform) contains a proline‐rich tandem repeat in the association domain

  1995cited by this paper
• Interaction of Autophosphorylated Ca2+/Calmodulin-dependent Protein Kinase II with Neuronal Cytoskeletal Proteins

  1995cited by this paper
• Developmental and regional expression of multifunctional Ca2+/calmodulin-dependent protein kinase isoforms in rat brain

  1995cited by this paper
• Phosphorylation Modulates the Function of the Calcium Release Channel of Sarcoplasmic Reticulum from Cardiac Muscle (*)

  1995influential reference
• Characterization of gamma- and delta-subunits of Ca2+/calmodulin-dependent protein kinase II in rat gastric mucosal cell populations.

  1994cited by this paper
• Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

  1994cited by this paper
• Regulation of Ca2+/calmodulin-dependent protein kinase II by inter- and intrasubunit-catalyzed autophosphorylations.

  1994cited by this paper
• Identification and characterization of delta B-CaM kinase and delta C-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms.

  1994cited by this paper
• Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus

  1994cited by this paper
• Identification and characterization of δB-CaM kinase and δC-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms

  1994cited by this paper
• Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals.

  1994cited by this paper
• On target with a new mechanism for the regulation of protein phosphorylation.

  1993cited by this paper
• A kinase-related protein stabilizes unphosphorylated smooth muscle myosin minifilaments in the presence of ATP.

  1993cited by this paper
• Phosphorylation and activation of the Ca(2+)-pumping ATPase of cardiac sarcoplasmic reticulum by Ca2+/calmodulin-dependent protein kinase.

  1993cited by this paper
• p34cdc2 protein is complexed with the c-mos protein in rat skeletal muscle.

  1993influential reference
• Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues.

  1993cited by this paper
• New isoforms of multifunctional calcium/calmodulin‐dependent protein kinase II

  1993cited by this paper
• Differential expression of mRNAs encoding gamma and delta subunits of Ca2+/calmodulin-dependent protein kinase type II (CaM kinase II) in the mature and postnatally developing rat brain.

  1993cited by this paper
• Inactivation of the sarcoplasmic reticulum calcium channel by protein kinase

  1992cited by this paper
• Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I

  1992influential reference
• Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant

  1992cited by this paper
• Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase

  1992cited by this paper
• Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene

  1992cited by this paper
• Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene.

  1991cited by this paper
• Structural features of Ca2+/calmodulin-dependent protein kinase II revealed by electron microscopy

  1991cited by this paper
• Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity.

  1991cited by this paper
• A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene

  1991cited by this paper
• In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain

  1990cited by this paper
• Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation.

  1989cited by this paper
• Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs.

  1989cited by this paper
• Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptide.

  1988cited by this paper
• A short amino‐terminal segment of microsomal cytochrome P‐450 functions both as an insertion signal and as a stop‐transfer sequence.

  1987cited by this paper
• Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

  1987cited by this paper
• Phosphorylation-dependent subcellular translocation of a Ca2+/calmodulin-dependent protein kinase produces an autonomous enzyme in Aplysia neurons

  1985cited by this paper
• Cytoskeletal calmodulin-dependent protein kinase. Characterization, solubilization, and purification from rat brain.

  1985cited by this paper
• Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

  1984cited by this paper
• Preparation and morphology of sarcoplasmic reticulum terminal cisternae from rabbit skeletal muscle

  1984influential reference
• A calmodulin-dependent protein kinase system from skeletal muscle sarcoplasmic reticulum.

  1984cited by this paper
• A calmodulin-dependent protein kinase system from skeletal muscle sarcoplasmic reticulum. Phosphorylation of a 60,000-dalton protein.

  1982cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Aβ impairs the LTP-related movement of endogenous CaMKII but not of exogenous GFP-CaMKII.

  2025cites this paper
• MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo

  2025cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)-Targeted Drug Discovery: Challenges and Strategies.

  2025cites this paper
• Immunofluorescent Localization of Ca2+ Sensor Proteins in Somatic Motor Muscles of the Earthworm Lumbricus terrestris

  2024cites this paper
• Maternal oxytocin treatment at birth increases epigenetic age in male offspring.

  2024cites this paper
• Immunofluorescent Localization of Ca²⁺-Sensor Proteins in The Somatic Motor Muscles of The Earthworm Lumbricus terrestris

  2024cites this paper
• CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: isoform specificity.

  2024cites this paper
• Calcium/Calmodulin-Stimulated Protein Kinase II (CaMKII): Different Functional Outcomes from Activation, Depending on the Cellular Microenvironment

  2023cites this paper
• Reduced O-GlcNAcylation diminishes cardiomyocyte Ca2+ dependent facilitation and frequency dependent acceleration of relaxation.

  2023cites this paper
• Enhanced capacity for CaMKII signaling mitigates calcium release related contractile fatigue with high intensity exercise.

  2023cites this paper
• AKAP18δ Puts CaMKII in the Right Place at the Right Time: Implications for Cardiac Ca2+ Handling.

  2022cites this paper
• Compartmentation of β2‐adrenoceptor stimulated cAMP responses by phosphodiesterase types 2 and 3 in cardiac ventricular myocytes

  2021influential citation
• A Modular Mathematical Model of Exercise-Induced Changes in Metabolism, Signaling, and Gene Expression in Human Skeletal Muscle

  2021cites this paper
• CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution

  2021cites this paper
• Regulation of Multifunctional Calcium/Calmodulin Stimulated Protein Kinases by Molecular Targeting.

  2020cites this paper
• Functional implications of CaMKII alternative splicing

  2020cites this paper
• Role of CaMKII and sarcolipin in muscle adaptations to strength training with different levels of fatigue in the set

  2020cites this paper
• Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation

  2020cites this paper
• Phosphorylation of α-dystrobrevin is essential for αkap accumulation and acetylcholine receptor stability

  2020cites this paper
• Assessing conservation of alternative splicing with evolutionary splicing graphs

  2020cites this paper
• CaM Kinase: Still Inspiring at 40.

  2019cites this paper
• Heterogeneity in human hippocampal CaMKII transcripts reveals an allosteric role for the hub domain in activity regulation

  2019cites this paper
• Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice

  2018cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II Activity and Expression in the Aged Mouse Hippocampus

  2018cites this paper
• Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets.

  2018cites this paper
• Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation

  2018cites this paper
• Early changes in costameric and mitochondrial protein expression with unloading are muscle specific

  2018influential citation
• Dissection of Protein Kinase Pathways in Live Cells Using Photoluminescent Probes: Surveillance or Interrogation?

  2018cites this paper
• The role of calcium calmodulin dependent protein kinase II in type 2 diabetic heart dysfunction

  2017cites this paper
• Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

  2017cites this paper
• CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression

  2017cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II in Vascular Smooth Muscle.

  2017cites this paper
• Vascular CaMKII: heart and brain in your arteries.

  2016cites this paper
• Relation entre CaMKII et les dynamiques calciques endothéliales : impact de l'hypertension arterielle

  2016cites this paper
• The Knockdown of αkap Alters the Postsynaptic Apparatus of Neuromuscular Junctions in Living Mice

  2015cites this paper
• adult mouse skeletal muscle fibers in fast-to-slow fiber type transformation of cultured Roles of the calcineurin and CaMK signaling pathways

  2015cites this paper
• CaMKII isoforms differ in their specific requirements for regulation by nitric oxide

  2014cites this paper
• Degeneration of Neuromuscular Junction in Age and Dystrophy

  2014cites this paper
• CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle

  2014cites this paper
• Muscle-Type Specific Autophosphorylation of CaMKII Isoforms after Paced Contractions

  2014cites this paper
• Potential Role of αKAP, a CaMKII Kinase Anchoring Protein in Myocardium

  2013cites this paper
• Calcium/Calmodulin dependent protein kinase II signaling and IGFR signaling are courter-balanced to regulate protein degradation in C. elegans muscle

  2013cites this paper
• The role of the LAMMER kinase Kns1 and the calcium/calmodulin-dependent kinase Cmk2 in the adaptation of Saccharomyces cerevisiae to alkaline pH stress

  2013cites this paper
• Sensory pathways of muscle phenotypic plasticity: Calcium signalling through CaMKII

  2013cites this paper
• The Role of CaMK-II in Skeletal Muscle Function and Swimming Behavior in Zebrafish

  2013cites this paper
• CaMKII activity is reduced in skeletal muscle during sepsis

  2013cites this paper
• Exploration of neuromuscular plasticity: an examination of acetylcholine receptor and skeletal muscle fiber adaptations

  2012cites this paper
• The role of molecular regulation and targeting in regulating calcium/calmodulin stimulated protein kinases.

  2012cites this paper
• A Role for the Calmodulin Kinase II-Related Anchoring Protein (αkap) in Maintaining the Stability of Nicotinic Acetylcholine Receptors

  2012influential citation
• A role for the CaM Kinase II related anchoring protein ( α kap ) in maintaining the stability of nicotinic Acetylcholine Receptors

  2012influential citation
• Ca 2+ /Calmodulin-Dependent Protein Kinase II (CaMKII)

  2012cites this paper
• The role of CaMKII in regulating GLUT4 expression in skeletal muscle.

  2012cites this paper
• CaMKII in cerebral ischemia

  2011cites this paper
• Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention-An in vivo perspective.

  2011cites this paper
• The role of in vivo Ca2+ signals acting on Ca2+–calmodulin‐dependent proteins for skeletal muscle plasticity

  2011cites this paper
• Calcium/Calmodulin Kinase II-Dependent Acetylcholine Receptor Cycling at the Mammalian Neuromuscular Junction In Vivo

  2010cites this paper
• The Role of the Ca2+-dependent protein kinase, CaMK-II, in Heart and Kidney Development in the Zebrafish, Danio rerio

  2010cites this paper
• Xenopus Mouse Emi2 as a distinctive regulatory hub in second meiotic

  2010cites this paper
• Mouse Emi2 as a distinctive regulatory hub in second meiotic metaphase

  2010cites this paper
• The activation of membrane targeted CaMK-II in the zebrafish Kupffer's vesicle is required for left-right asymmetry

  2010cites this paper
• Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function.

  2010cites this paper
• Regulation of CaMKII In vivo: The Importance of Targeting and the Intracellular Microenvironment

  2009cites this paper
• Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right.

  2009cites this paper
• Effects of Zofenopril on Cardiac Sarcoplasmic Reticulum Calcium Handling

  2009cites this paper
• α-Kinase Anchoring Protein αKAP Interacts with SERCA2A to Spatially Position Ca2+/Calmodulin-dependent Protein Kinase II and Modulate Phospholamban Phosphorylation*

  2009cites this paper
• Supramolecular assemblies and localized regulation of voltage-gated ion channels.

  2009cites this paper
• Upregulation of CaMKIIβ and Nogo-C mRNA in schizophrenia and the prevalence of CAA insert in the 3'UTR of the Nogo gene.

  2008influential citation
• Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle.

  2008cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II Signaling in Vascular Smooth Muscle

  2008cites this paper
• Multiple downstream proarrhythmic targets for calmodulin kinase II: moving beyond an ion channel-centric focus.

  2007cites this paper
• Differential expression of CaMK‐II genes during early zebrafish embryogenesis

  2007cites this paper
• Chronic Antidepressants Induce Redistribution and Differential Activation of αCaM Kinase II between Presynaptic Compartments

  2007cites this paper
• Activation of Ca(2+)-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca(2+) release.

  2007cites this paper
• Regulation and function of Ca2+–calmodulin‐dependent protein kinase II of fast‐twitch rat skeletal muscle

  2007cites this paper
• Roles of the calcineurin and CaMK signaling pathways in fast-to-slow fiber type transformation of cultured adult mouse skeletal muscle fibers.

  2007cites this paper
• Activation of Ca2+‐dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca2+ release

  2007cites this paper
• Effect of endurance exercise training on Ca2+–calmodulin‐dependent protein kinase II expression and signalling in skeletal muscle of humans

  2007influential citation
• CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy.

  2006cites this paper
• Ca2+–calmodulin‐dependent protein kinase expression and signalling in skeletal muscle during exercise

  2006influential citation
• Transition from Reversible to Persistent Binding of CaMKII to Postsynaptic Sites and NR2B

  2006cites this paper
• CaMKIIbeta association with the actin cytoskeleton is regulated by alternative splicing.

  2006cites this paper
• Increased expression of δCaMKII isoforms in skeletal muscle regeneration: Implications in dystrophic muscle disease

  2006influential citation
• Nuclear targeting of the CaMKII anchoring protein alphaKAP is regulated by alternative splicing and protein kinases.

  2006cites this paper
• Long Lasting Inhibition of Adenylyl Cyclase Selectively Mediated by Inositol 1,4,5-Trisphosphate-evoked Calcium Release*

  2005cites this paper
• Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity.

  2005cites this paper
• Alternative splicing generates a CaM kinase IIβ isoform in myocardium that targets the sarcoplasmic reticulum through a putative αKAP and regulates GAPDH

  2005influential citation
• Unresponsiveness Kinase II in T Cells : From Activation to Calcium / Calmodulin-Dependent Protein A Pivotal Role for the Multifunctional Gascoigne

  2005cites this paper
• A Pivotal Role for the Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II in T Cells: From Activation to Unresponsiveness1

  2005cites this paper
• CaMK-II oligomerization potential determined using CFP/YFP FRET.

  2005cites this paper
• Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias.

  2005cites this paper
• Modulation of the GABAA receptor by CaMK-II dependent phosphorylation

  2005cites this paper
• Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.

  2004cites this paper
• Activity-Dependent Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Localization

  2004cites this paper
• Glycogen- and PP1c-targeting Subunit GM Is Phosphorylated at Ser48 by Sarcoplasmic Reticulum-bound Ca2+-Calmodulin Protein Kinase in Rabbit Fast Twitch Skeletal Muscle*

  2004cites this paper
• Targeting of calcium/calmodulin-dependent protein kinase II.

  2004cites this paper
• The Muscle-specific Calmodulin-dependent Protein Kinase Assembles with the Glycolytic Enzyme Complex at the Sarcoplasmic Reticulum and Modulates the Activity of Glyceraldehyde-3-phosphate Dehydrogenase in a Ca2+/Calmodulin-dependent Manner*

  2004cites this paper
• Topology of Homer 1c and Homer 1a in C2C12 myotubes and transgenic skeletal muscle fibers.

  2004cites this paper
• The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis

  2004cites this paper
• Post-natal developmental expression of αKAP splice variants in rabbit fast-twitch and slow-twitch skeletal muscle

  2004cites this paper
• Targeting of alpha-kinase-anchoring protein (alpha KAP) to sarcoplasmic reticulum and nuclei of skeletal muscle.

  2003cites this paper