Identification of ROCK1 as an Upstream Activator of the JIP-3 to JNK Signaling Axis in Response to UVB Damage

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Science Signaling

• Publication date

  2008-11-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1126/scisignal.1161938PMID 19036714PMCID PMC2649725
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina.

  2009cited by this paper
• A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity

  2008cited by this paper
• Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells.

  2008cited by this paper
• Cytoskeleton and apoptosis.

  2008cited by this paper
• JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.

  2008cited by this paper
• PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

  2008influential reference
• Air Pollution Exposure Potentiates Hypertension Through Reactive Oxygen Species–Mediated Activation of Rho/ROCK

  2008cited by this paper
• Identification of ROCK1 as an Upstream Activator of the JIP-3 to JNK Signaling Axis in Response to UVB Damage

  2008cited by this paper
• Rho Kinase (ROCK) Inhibitors

  2007cited by this paper
• The functional contrariety of JNK

  2007cited by this paper
• A ROCK inhibitor permits survival of dissociated human embryonic stem cells

  2007cited by this paper
• The JNK signal transduction pathway.

  2007cited by this paper
• Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices

  2007cited by this paper
• TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.

  2007cited by this paper
• Oxygen Activates the Rho/Rho-Kinase Pathway and Induces RhoB and ROCK-1 Expression in Human and Rabbit Ductus Arteriosus by Increasing Mitochondria-Derived Reactive Oxygen Species: A Newly Recognized Mechanism for Sustaining Ductal Constriction

  2007cited by this paper
• Rho kinase in the regulation of cell death and survival

  2007cited by this paper
• Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

  2006cited by this paper
• Physiological role of ROCKs in the cardiovascular system.

  2006cited by this paper
• RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress.

  2006cited by this paper
• ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

  2005cited by this paper
• Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

  2005cited by this paper
• Role of JNK activation in apoptosis: A double-edged sword

  2005cited by this paper
• Regulation of PTEN by Rho small GTPases

  2005cited by this paper
• Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1+/− Haploinsufficient Mice

  2005cited by this paper
• The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.

  2004cited by this paper
• Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury.

  2004cited by this paper
• Mitogen-Activated Protein Kinase Activation in UV-Induced Signal Transduction

  2003influential reference
• Coordinated histone modifications mediated by a CtBP co-repressor complex

  2003cited by this paper
• Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)

  2003cited by this paper
• Targeting JNK for therapeutic benefit: from junk to gold?

  2003cited by this paper
• Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

  2003cited by this paper
• JNK‐interacting protein 3 associates with Toll‐like receptor 4 and is involved in LPS‐mediated JNK activation

  2003cited by this paper
• Regulation of MAP kinase signaling modules by scaffold proteins in mammals.

  2003influential reference
• ROCKs: multifunctional kinases in cell behaviour

  2003cited by this paper
• The JNK signal transduction pathway.

  2002cited by this paper
• RHO–GTPases and cancer

  2002cited by this paper
• Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway : a new mode of regulation of the MAP kinase cascade

  2002cited by this paper
• Phosphorylation-dependent Scaffolding Role of JSAP1/JIP3 in the ASK1-JNK Signaling Pathway

  2002cited by this paper
• Kinesin molecular motors: Transport pathways, receptors, and human disease

  2001cited by this paper
• LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505.

  2001cited by this paper
• Apoptosis: caspases orchestrate the ROCK `n' bleb

  2001cited by this paper
• Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules

  2001cited by this paper
• Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

  2000cited by this paper
• Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3

  2000cited by this paper
• Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.

  2000cited by this paper
• Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow

  2000cited by this paper
• JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway

  1999cited by this paper
• Photocarcinogenesis and susceptibility to UV radiation in the v-Ha-ras transgenic Tg.AC mouse.

  1998cited by this paper
• A Rho-associated Protein Kinase, ROKα, Binds Insulin Receptor Substrate-1 and Modulates Insulin Signaling*

  1998cited by this paper
• A mammalian scaffold complex that selectively mediates MAP kinase activation.

  1998cited by this paper
• Sunlight and skin cancer: Inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens

  1997cited by this paper
• The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

  1996cited by this paper
• Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

  1996cited by this paper
• p53 GENE MUTATIONS AND PHOTOCARCINOGENESIS

  1995cited by this paper
• ReportPin 1 Mediates Neural-Specific Activation of the Mitochondrial Apoptotic Machinery

  year unknowncited by this paper

• Rho/ROCK Pathway as a Therapeutic Target in Multiple Diseases

  2025cites this paper
• A toxic gain-of-function variant in MAPK8IP3 provides insights into JIP3 cellular roles

  2025cites this paper
• G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis

  2024cites this paper
• The Chronic Effects of a Single Low-Intensity Blast Exposure on Phosphoproteome Networks and Cognitive Function Influenced by Mutant Tau Overexpression

  2024cites this paper
• Role of miR-496 in prediction of type 2 diabetes mellitus in Iraqi patients

  2024cites this paper
• PARP15 Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy–Associated Systemic Capillary Leak Syndrome)

  2024cites this paper
• Proteomic and Phosphoproteomic Reprogramming in Epithelial Ovarian Cancer Metastasis

  2023influential citation
• Nephroprotective peptides of Laennec® in the context of pharmacotherapy for nephro-hepato-metabolic disorders

  2023cites this paper
• Role of stress granules in tumorigenesis and cancer therapy.

  2023cites this paper
• Rho-associated kinase1 promotes laryngeal squamous cell carcinoma tumorigenesis and progression via the FAK signaling pathway

  2022cites this paper
• Deficiency of Rho Kinase 1 (ROCK1) attenuates neutrophil NETosis and ameliorates UVB-induced skin inflammation

  2021cites this paper
• Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation

  2021cites this paper
• Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer.

  2020cites this paper
• ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis

  2020cites this paper
• Serum ROCK1 mRNA is of great diagnostic value for glioma patients

  2019cites this paper
• Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

  2019cites this paper
• Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

  2018cites this paper
• JIP3 deficiency attenuates cardiac hypertrophy by suppression of JNK pathway.

  2018cites this paper
• TGF-β1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a c-Jun NH2-terminal kinase-1-dependent manner.

  2018cites this paper
• Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair

  2018cites this paper
• RESEARCH ARTICLE Biomarkers in Lung Diseases: From Pathogenesis to Prediction to New Therapies TGF- (cid:2) 1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a c-Jun NH 2 -terminal kinase-1-dependent manner

  2018cites this paper
• The tumor suppressor DLC1 inhibits cancer progression and oncogenic autophagy in hepatocellular carcinoma

  2018cites this paper
• Molecular Characterization of Two Human Lens Epithelial Cell Lines: HLE-B3 And SRA01/O4

  2016cites this paper
• RhoA/Rho-Associated Kinase as Marker of Cardiovascular Health

  2016cites this paper
• Avaliação da participação de grânulos de estresse na resposta a agentes antineoplásicos em linhagens celulares de tumores cerebrais

  2015cites this paper
• Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach

  2015cites this paper
• Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.

  2015cites this paper
• Role of Rho kinases in abnormal and normal hematopoiesis

  2014cites this paper
• Rho-associated coiled-coil containing kinases (ROCK)

  2014cites this paper
• The scaffold protein JLP plays a key role in regulating ultraviolet B‐induced apoptosis in mice

  2014cites this paper
• Role of the scaffolding protein JLP in UVB-induced apoptosis

  2014cites this paper
• ETS-1-mediated Transcriptional Up-regulation of CD44 Is Required for Sphingosine-1-phosphate Receptor Subtype 3-stimulated Chemotaxis*

  2013cites this paper
• Stress granules and cell signaling: more than just a passing phase?

  2013cites this paper
• Rho-associated coiled-coil kinase (ROCK) signaling and disease

  2013cites this paper
• Identification of ROCK1 kinase as a critical regulator of Beclin1 mediated autophagy during metabolic stress

  2013cites this paper
• Rho Kinases in Cardiovascular Physiology and Pathophysiology: The Effect of Fasudil

  2013cites this paper
• Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder

  2012cites this paper
• A reagent to facilitate protein recovery from cells and tissues

  2012cites this paper
• Toxin-induced RhoA Activity Mediates CCL1-triggered Signal Transducers and Activators of Transcription Protein Signaling*

  2012influential citation
• Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells.

  2012cites this paper
• Rho-Kinase in Development and Heart Failure: Insights From Genetic Models

  2011cites this paper
• DDR1 Receptor Tyrosine Kinase Promotes Prosurvival Pathway through Notch1 Activation*

  2011cites this paper
• Long‐term diabetic complications may be ameliorated by targeting Rho kinase

  2011cites this paper
• Commonality and Stochasticity in Systems Toxicology

  2011cites this paper
• ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.

  2011cites this paper
• Rho kinase proteins--pleiotropic modulators of cell survival and apoptosis.

  2011cites this paper
• Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusion.

  2010cites this paper
• Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth.

  2010cites this paper
• RhoA/ROCK1 signaling regulates stress granule formation and apoptosis.

  2010cites this paper
• Non-muscle myosin II regulates survival threshold of pluripotent stem cells.

  2010cites this paper
• RhoA/Rho kinase: a novel therapeutic target in diabetic complications.

  2010cites this paper
• Focus Issue: Coping with Cellular Stress

  2009cites this paper
• C-Jun N-Terminal kinase mediates disassembly of apical junctions in model intestinal epithelia

  2009cites this paper
• Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

  2009cites this paper
• Parameters of protection against ultraviolet radiation‐induced skin cell damage

  2009cites this paper
• Science Signaling Podcast: 02 December 2008

  2008cites this paper
• Identification of ROCK1 as an Upstream Activator of the JIP-3 to JNK Signaling Axis in Response to UVB Damage

  2008cites this paper