Endothelin Receptor Inhibition with Bosentan Delays Onset of Liver Injury in Streptozotocin-Induced Diabetic Condition

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Drug Research

• Publication date

  2014-06-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1055/s-0034-1377024PMID 24918345
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Impaired cytokine production by peripheral blood mononuclear cells in type 1 diabetic patients.

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• Diabetic hepatosclerosis: diabetic microangiopathy of the liver.

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• Interactions of endothelin and insulin: expanding parameters of insulin resistance.

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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Mechanism of progression of renal disease: current hemodynamic concepts.

  1998cited by this paper
• Role of endothelin-1 in diabetes mellitus.

  1998cited by this paper
• [The role of endothelin-1 in diabetes mellitus].

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• A novel potent vasoconstrictor peptide produced by vascular endothelial cells

  1988cited by this paper
• Liver disease in patients with diabetes mellitus.

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