Wnt5a Skews Dendritic Cell Differentiation to an Unconventional Phenotype with Tolerogenic Features

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Immunology

• Publication date

  2011-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1101243PMID 21918189
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Wnt signaling in stem and cancer stem cells.

  2013cited by this paper
• The canonical BMP signaling pathway is involved in human monocyte‐derived dendritic cell maturation

  2011cited by this paper
• Lung Cancer-Derived Galectin-1 Mediates Dendritic Cell Anergy through Inhibitor of DNA Binding 3/IL-10 Signaling Pathway

  2011cited by this paper
• Modulation of Dendritic Cell Differentiation in the Bone Marrow Mediates Sustained Immunosuppression after Polymicrobial Sepsis

  2011cited by this paper
• Glycogen Synthase Kinase-3 Is an Early Determinant in the Differentiation of Pathogenic Th17 Cells

  2011cited by this paper
• PD‐L1 expression on tolerogenic APCs is controlled by STAT‐3

  2011cited by this paper
• Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

  2010cited by this paper
• Wnt5a Induces Endothelial Inflammation via β-Catenin–Independent Signaling

  2010influential reference
• GSK3: a multifaceted kinase in Wnt signaling.

  2010cited by this paper
• Differentiation and function of mouse monocyte‐derived dendritic cells in steady state and inflammation

  2010cited by this paper
• DC subsets in positive and negative regulation of immunity

  2010cited by this paper
• Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.

  2010cited by this paper
• Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

  2010cited by this paper
• WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways.

  2010cited by this paper
• Tolerogenic Dendritic Cells Generated with Different Immunosuppressive Cytokines Induce Antigen-Specific Anergy and Regulatory Properties in Memory CD4+ T Cells

  2010influential reference
• Wnt signaling in hematopoiesis: Crucial factors for self‐renewal, proliferation, and cell fate decisions

  2010cited by this paper
• Transient β‐catenin stabilization modifies lineage output from human thymic CD34+CD1a– progenitors

  2010cited by this paper
• Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis‐infected macrophages

  2010cited by this paper
• Harnessing human dendritic cell subsets for medicine

  2010cited by this paper
• Dishevelled: The hub of Wnt signaling.

  2010influential reference
• Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).

  2010cited by this paper
• An updated overview on Wnt signaling pathways: a prelude for more.

  2010influential reference
• TLR Triggering on Tolerogenic Dendritic Cells Results in TLR2 Up-Regulation and a Reduced Proinflammatory Immune Program1

  2009cited by this paper
• Towards an integrated view of Wnt signaling in development

  2009cited by this paper
• Wnt signaling as a therapeutic target for bone diseases

  2009cited by this paper
• Notch and wingless signaling cooperate in regulation of dendritic cell differentiation.

  2009cited by this paper
• Demystifying the development of dendritic cell subtypes, a little

  2008cited by this paper
• Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10

  2008influential reference
• CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.

  2008cited by this paper
• Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins

  2008influential reference
• Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II.

  2008cited by this paper
• Activation of a TGF-β-Specific Multistep Gene Expression Program in Mature Macrophages Requires Glucocorticoid-Mediated Surface Expression of TGF-β Receptor II1

  2008cited by this paper
• GSK-3 mediates differentiation and activation of proinflammatory dendritic cells.

  2007influential reference
• Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation

  2007cited by this paper
• Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging

  2007cited by this paper
• Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration.

  2007cited by this paper
• Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation.

  2007cited by this paper
• Signaling to NF-?B by Toll-like receptors

  2007cited by this paper
• Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis

  2007cited by this paper
• Signaling to NF-kappaB by Toll-like receptors.

  2007cited by this paper
• Dendritic Cells Transduced with SOCS-3 Exhibit a Tolerogenic/DC2 Phenotype That Directs Type 2 Th Cell Differentiation In Vitro and In Vivo1

  2006cited by this paper
• Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation.

  2006cited by this paper
• Wnt signaling regulates transendothelial migration of monocytes

  2006cited by this paper
• The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.

  2006cited by this paper
• Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro

  2006cited by this paper
• Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression.

  2005cited by this paper
• Wnt signalling in rheumatoid arthritis.

  2005cited by this paper
• Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

  2003cited by this paper
• TNF Skews Monocyte Differentiation from Macrophages to Dendritic Cells 1

  2003cited by this paper
• Regulation and possible function of beta-catenin in human monocytes.

  2001cited by this paper
• Regulation and Possible Function of β-Catenin in Human Monocytes1

  2001cited by this paper
• The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape.

  2000cited by this paper
• IL-6 switches the differentiation of monocytes from dendritic cells to macrophages

  2000influential reference

• Wnt signaling - using the bloodstream to send a message

  2025cites this paper
• Genetics and humoral responses of the immune system to Aspergillus fumigatus.

  2025cites this paper
• Comparison of characteristics and immune responses between paired human nasal and bronchial epithelial organoids

  2025cites this paper
• Activation of Wnt/β-catenin signal induces DCs to differentiate into immune tolerant regDCs in septic mice.

  2024cites this paper
• Characteristics of a CCL21-gene modified dendritic cell vaccine utilized for a clinical trial in non-small cell lung cancer.

  2024cites this paper
• Role of indoleamine 2, 3-dioxygenase 1 in immunosuppression of breast cancer

  2023cites this paper
• Wnt Signaling Pathways: From Inflammation to Non-Melanoma Skin Cancers

  2023cites this paper
• The Roles of Secreted Wnt Ligands in Cancer

  2023cites this paper
• Myeloid-derived suppressor cells and tolerogenic dendritic cells are distinctively induced by PI3K and Wnt signaling pathways

  2023cites this paper
• Concomitant inhibition of PPARγ and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells.

  2023cites this paper
• Frizzled-6 promotes hematopoietic stem/progenitor cell mobilization and survival during LPS-induced emergency myelopoiesis

  2022cites this paper
• Investigation on the Inhibitory Effect of Wnt-5a on Colonic Mucosal Inflammation in Patients with Ulcerative Colitis

  2022cites this paper
• Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition

  2022cites this paper
• The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment

  2022cites this paper
• The value of WNT5A as prognostic and immunological biomarker in pan-cancer

  2022cites this paper
• The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand–dependent Cancer Models

  2022cites this paper
• Wnt-β-Catenin Signaling in Human Dendritic Cells Mediates Regulatory T-Cell Responses to Fungi via the PD-L1 Pathway

  2021cites this paper
• Myeloid and Mesenchymal Stem Cell Therapies for Solid Organ Transplant Tolerance

  2021cites this paper
• Beta‐catenin non‐canonical pathway: A potential target for inflammatory and hyperproliferative state via expression of transglutaminase 2 in psoriatic skin keratinocyte

  2020cites this paper
• Immune cell engineering: opportunities in lung cancer therapeutics

  2020cites this paper
• Wnt Signaling Cascade in Dendritic Cells and Regulation of Anti-tumor Immunity

  2020cites this paper
• CellsNatural and Induced Tolerogenic Dendritic

  2020cites this paper
• Signaling pathways that regulate Trypanosoma cruzi infection and immune response.

  2020cites this paper
• Immunoparasitology: A Unique Interplay Between Host and Pathogen

  2020cites this paper
• Wnt Signaling In Lymphopoiesis And Hematopoiesis

  2020influential citation
• The pancancer landscape of Wnt family expression reveals potential biomarkers in urinary system tumors

  2020cites this paper
• Natural and Induced Tolerogenic Dendritic Cells

  2020cites this paper
• The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment

  2020influential citation
• Investigating the Wnt/β-catenin Pathway in Conventional Dendritic cells in Obesity-Induced Tissue Inflammation and Insulin Resistance

  2019cites this paper
• Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

  2019cites this paper
• The pathological role of Wnt5a in psoriasis and psoriatic arthritis

  2019cites this paper
• Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression

  2019cites this paper
• Wnt5a is a TLR2/4-ligand that induces tolerance in human myeloid cells

  2019cites this paper
• Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

  2019cites this paper
• Functions of the WNT Signaling Network in Shaping Host Responses to Infection

  2019cites this paper
• Cell-Intrinsic Wnt4 Influences Conventional Dendritic Cell Fate Determination to Suppress Type 2 Immunity

  2019cites this paper
• Cell-intrinsic Wnt4 controls early cDC1 commitment and suppresses development of pathogen-specific Type 2 immunity

  2018cites this paper
• Chemical Modulation of WNT Signaling in Cancer.

  2018cites this paper
• Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages

  2018cites this paper
• Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon

  2018cites this paper
• The non-canonical Wnt pathway leads to aged dendritic cell differentiation

  2018cites this paper
• Dendritic cells in sepsis: Potential immunoregulatory cells with therapeutic potential

  2018cites this paper
• The Canonical but Not the Noncanonical Wnt Pathway Inhibits the Development of Allergic Airway Disease

  2018influential citation
• Searching for the Transcriptomic Signature of Immune Tolerance Induction—Biomarkers of Safety and Functionality for Tolerogenic Dendritic Cells and Regulatory Macrophages

  2018cites this paper
• Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma.

  2018cites this paper
• Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications

  2017cites this paper
• WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice.

  2017cites this paper
• WNT Signaling and Colorectal Cancer

  2017cites this paper
• Relationship between uric acid and technique failure in patients on continuous ambulatory peritoneal dialysis: a long-term observational cohort study

  2017cites this paper
• The potential impact of Wnt5a on differentiation and phenotype of dendritic cells found in renal cell carcinoma

  2017cites this paper
• Human Regulatory T Cells Mediate Transcriptional Modulation of Dendritic Cell Function

  2017influential citation
• Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside

  2016cites this paper
• Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases

  2016cites this paper
• Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

  2016cites this paper
• Immune evasion pathways and the design of dendritic cell-based cancer vaccines.

  2016cites this paper
• Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer

  2016cites this paper
• Interactions between canonical Wnt signaling pathway and MAPK pathway regulate differentiation, maturation and function of dendritic cells.

  2016cites this paper
• β-Catenin Signaling in Dendritic Cells Reduces Atherosclerosis

  2015cites this paper
• Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis

  2015cites this paper
• Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy

  2015influential citation
• Effects of DKK-3, a Wnt signaling inhibitor, on dendritic cell phenotype and T cell polarization

  2015cites this paper
• Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis.

  2015cites this paper
• Wnt signaling in dendritic cells: its role in regulation of immunity and tolerance.

  2015influential citation
• Novel immune cell-based therapies for atherosclerosis

  2015cites this paper
• Melanoma-Derived Wnt 5 a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance : Opportunities for PharmacologicEnhancementof Immunotherapy

  2015influential citation
• Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation

  2015cites this paper
• Septic Shock in Advanced Age: Transcriptome Analysis Reveals Altered Molecular Signatures in Neutrophil Granulocytes

  2015cites this paper
• Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy

  2014cites this paper
• Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll‐like receptor 4

  2014cites this paper
• Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis

  2014cites this paper
• Development and optimization of a workflow to enable mass spectrometry-based quantitative membrane proteomics of mature and tolerogenic dendritic cells

  2014cites this paper
• Targeting Wnt signaling at the neuroimmune interfacefordopaminergicneuroprotection/repairin

  2014cites this paper
• Non-canonical wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction

  2014cites this paper
• Biomarkers in sepsis and other severe infections

  2014cites this paper
• Ad-REIC treatment inhibits cancer progression via the upregulation of systemic anticancer immunity. Under experimental conditions, autologous cancer vaccination via cancer-specific apoptosis and anticancer immune activation is a possible therapeutic mechanism. The robust anticancer effects observed

  2014cites this paper
• Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining

  2014cites this paper
• Homeobox Transcription Factor VentX Regulates Differentiation and Maturation of Human Dendritic Cells*

  2014cites this paper
• Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease.

  2014cites this paper
• Noncanonical Wnt Signaling Promotes Obesity-Induced Adipose Tissue Inflammation and Metabolic Dysfunction Independent of Adipose Tissue Expansion

  2014cites this paper
• Latency-associated protein Acr1 impairs dendritic cell maturation and functionality: a possible mechanism of immune evasion by Mycobacterium tuberculosis.

  2014cites this paper
• Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-γ production by CD4+ T cells.

  2014cites this paper
• Wnt5a Inhibits the Proliferation and Melanogenesis of Melanocytes

  2013cites this paper
• Canonical and Noncanonical Wnt Proteins Program Dendritic Cell Responses for Tolerance

  2013cites this paper
• Dendritic Cells and Cancer: Development, Dysfunction and Therapeutic Targets

  2013cites this paper
• Wnt your brain be inflamed? Yes, it Wnt!

  2013cites this paper
• Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?

  2013cites this paper
• This information is current as Tolerance Program Dendritic Cell Responses for Canonical and Noncanonical Wnt Proteins

  2013cites this paper
• The Dark Side of Dendritic Cells: Development and Exploitation of Tolerogenic Activity That Favor Tumor Outgrowth and Immune Escape

  2013cites this paper
• Regulatory Multitasking of Tolerogenic Dendritic Cells – Lessons Taken from Vitamin D3-Treated Tolerogenic Dendritic Cells

  2013cites this paper
• Adenovirus-mediated REIC/Dkk-3 gene therapy: Development of an autologous cancer vaccination therapy (Review)

  2013cites this paper
• Wnt5a Inhibits the Proliferation and Melanogenesis of

  2013cites this paper
• Activation of Wnt/β-Catenin Pathway in Monocytes Derived from Chronic Kidney Disease Patients

  2013cites this paper
• Inflammation, Aging and Cancer: Friend or Foe?

  2012cites this paper
• The Effects of TLR Activation on T-Cell Development and Differentiation

  2012cites this paper
• Wnt5a inhibits the CpG oligodeoxynucleotide‐triggered activation of human plasmacytoid dendritic cells

  2012cites this paper
• Concomitant inhibition of PPAR g and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells

  year unknowncites this paper
• Journal of Stem Cell Research

  year unknowninfluential citation