Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Cellular Physiology

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcp.20647PMID 16547974
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Blood-Brain Barrier/Neurovascular Unit in Health and Disease

  2005cited by this paper
• Gap junctions and connexin-interacting proteins.

  2004cited by this paper
• Junctional adhesion molecules (JAMs): more molecules with dual functions?

  2004cited by this paper
• Endothelial cell–cell junctions: happy together

  2004cited by this paper
• Barriers built on claudins

  2004cited by this paper
• Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP.

  2004cited by this paper
• Diversity in protein-protein interactions of connexins: emerging roles.

  2004cited by this paper
• Contribution of connexins to the function of the vascular wall.

  2004influential reference
• Incorporation of connexins into plasma membranes and gap junctions.

  2004cited by this paper
• Connexin 26-mediated gap junctional intercellular communication suppresses paracellular permeability of human intestinal epithelial cell monolayers.

  2004cited by this paper
• Gap junctions and the connexin protein family.

  2004cited by this paper
• Neuronal connexin36 association with zonula occludens‐1 protein (ZO‐1) in mouse brain and interaction with the first PDZ domain of ZO‐1

  2004cited by this paper
• Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

  2003cited by this paper
• The JAM family of junctional adhesion molecules.

  2003cited by this paper
• Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions.

  2003cited by this paper
• Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways.

  2003cited by this paper
• Gap junctions – from cell to molecule

  2003cited by this paper
• Plasma membrane channels formed by connexins: their regulation and functions.

  2003cited by this paper
• Tight junctions and human diseases

  2003cited by this paper
• Differential Expression of Connexin43 in Foetal, Adult and Tumour-associated Human Brain Endothelial Cells

  2002influential reference
• Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line.

  2002cited by this paper
• Tight junctions of the blood-brain barrier: development, composition and regulation.

  2002cited by this paper
• Hepatocyte Nuclear Factor (HNF)‐4α Induces Expression of Endothelial Fas Ligand (FasL) to Prevent Cancer Cell Transmigration: A Novel Defense Mechanism of Endothelium against Cancer Metastasis

  2002cited by this paper
• Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40.

  2002cited by this paper
• Endothelium‐specific replacement of the connexin43 coding region by a lacZ reporter gene

  2001cited by this paper
• Ultrastructure and Immunolabeling of the Tight Junction

  2001cited by this paper
• Gap junction channels formed by coexpressed connexin40 and connexin43.

  2001cited by this paper
• Expression of GFRα-1,receptor for GDNF,in rat brain capillary during postnatal development of the BBB

  2001cited by this paper
• Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice

  2001cited by this paper
• Cx32 but not Cx26 is associated with tight junctions in primary cultures of rat hepatocytes.

  2001cited by this paper
• Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions

  2001cited by this paper
• Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier

  2001cited by this paper
• Expression of GFRalpha-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB.

  2000cited by this paper
• Impaired conduction of vasodilation along arterioles in connexin40-deficient mice.

  2000cited by this paper
• Wnt-1 regulation of connexin43 in cardiac myocytes.

  2000cited by this paper
• The Coiled-coil Domain of Occludin Can Act to Organize Structural and Functional Elements of the Epithelial Tight Junction*

  2000cited by this paper
• Connexin mimetic peptides reversibly inhibit Ca(2+) signaling through gap junctions in airway cells.

  2000cited by this paper
• Peptide inhibitors of intercellular communication.

  2000cited by this paper
• Occludin modulates organization of perijunctional circumferential actin in rat endothelial cells

  1999cited by this paper
• Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells.

  1999cited by this paper
• The cell biology of the blood-brain barrier.

  1999cited by this paper
• Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier.

  1999cited by this paper
• Induction of tight junctions in human connexin 32 (hCx32)-transfected mouse hepatocytes: connexin 32 interacts with occludin.

  1999cited by this paper
• Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells.

  1999influential reference
• Endothelial Claudin

  1999cited by this paper
• Inhibition of gap junction communication in alveolar epithelial cells by 18α-glycyrrhetinic acid.

  1999cited by this paper
• Inhibition of gap junction communication in alveolar epithelial cells by 18alpha-glycyrrhetinic acid.

  1999cited by this paper
• Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

  1998cited by this paper
• Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block.

  1998cited by this paper
• Characterization of the gap junction protein connexin37 in murine endothelium, respiratory epithelium, and after transfection in human HeLa cells.

  1998cited by this paper
• The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein.

  1998cited by this paper
• Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed.

  1998cited by this paper
• Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors.

  1998cited by this paper
• Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes*

  1998cited by this paper
• Gap Junction Localization and Connexin Expression in Cytochemically Identified Endothelial Cells of Arterial Tissue

  1997cited by this paper
• Occludin as a possible determinant of tight junction permeability in endothelial cells.

  1997cited by this paper
• Female infertility in mice lacking connexin 37

  1997cited by this paper
• Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

  1997influential reference
• Linear gap and tight junctional assemblies between capillary endothelial cells in the eel rete mirabile

  1995cited by this paper
• Transcriptional activation by tetracyclines in mammalian cells.

  1995cited by this paper
• Introduction to the Blood-Brain Barrier

  1994cited by this paper
• Occludin: a novel integral membrane protein localizing at tight junctions

  1993cited by this paper
• Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins.

  1993cited by this paper
• Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2

  1993cited by this paper
• Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier.

  1992cited by this paper
• Gap junction messenger RNA expression by vascular wall cells.

  1990cited by this paper
• Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication.

  1987cited by this paper
• Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature

  1975cited by this paper
• JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

  1963cited by this paper

• Regulation of the Angiogenic Potential of Endothelial Cells In Vitro under Conditions of Acute Hypoxic Stress: The Role of Homotypic Communication via Gap Junctions.

  2026cites this paper
• Claudin Proteins: Their Potential Role in Obesity and Adipose Tissue Signaling, Physiology and Disease

  2025cites this paper
• Brain Remodeling in Stroke Patients: a Comprehensive Review of Mechanistic and Neuroimaging Studies.

  2025cites this paper
• Material considerations for delivering therapeutics across the blood–brain barrier

  2025cites this paper
• A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: lessons from human and animal studies

  2025cites this paper
• Heparan sulfate acts in synergy with tight junction through STAT3 signaling to maintain the endothelial barrier and prevent lung injury development.

  2025cites this paper
• Neuroglia and the blood-brain barrier.

  2025cites this paper
• Extracellular vesicular delivery of ceramides from pulmonary macrophages to endothelial cells facilitates chronic obstructive pulmonary disease

  2025cites this paper
• Direct connexin-26 interactions with membrane proteins functionally relevant to the cochlea

  2025cites this paper
• Effect of chronic heat stress on duodenal epithelial barrier integrity in low- and high-water-efficient broiler chickens

  2025cites this paper
• Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes

  2025cites this paper
• Deceiving the gatekeepers: virus modulation of gap junctions

  2025cites this paper
• CFTR as a therapeutic target for severe lung infection.

  2025cites this paper
• Understanding the Blood-Brain Barrier: From Physiology to Pathology.

  2025cites this paper
• ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis

  2024cites this paper
• Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae

  2024cites this paper
• The Basic Requirement of Tight Junction Proteins in Blood-Brain Barrier Function and Their Role in Pathologies

  2024cites this paper
• Insight into the pathophysiological advances and molecular mechanisms underlying cerebral stroke: current status

  2024cites this paper
• Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina

  2024cites this paper
• Transcriptomic and western blot characterisation of the human CLEFF4 clone, a new rapid cell line replacement for the Caco2 model.

  2024cites this paper
• Effects of xenobiotics on the blood-brain barrier and neural gene expression

  2024cites this paper
• Treatment with Glycyrrhiza glabra Extract Induces Anxiolytic Effects Associated with Reduced Salt Preference and Changes in Barrier Protein Gene Expression

  2024cites this paper
• Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome

  2024cites this paper
• Pathophysiology in Brain Arteriovenous Malformations: Focus on Endothelial Dysfunctions and Endothelial-to-Mesenchymal Transition

  2024cites this paper
• Combined effect of Cerium oxide nanoparticles loaded scaffold and photobiomodulation therapy on pain and neuronal regeneration following spinal cord injury: an experimental study

  2024cites this paper
• The roles of connexins and gap junctions in the progression of cancer

  2023cites this paper
• Relationship between neurological inflammation and debilitated blood brain barrier subsequent to General Anaesthesia

  2023cites this paper
• Postnatal Maturation of the Blood–Brain Barrier in Senescence-Accelerated OXYS Rats, Which Are Prone to an Alzheimer’s Disease-like Pathology

  2023cites this paper
• Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae

  2023cites this paper
• 20 kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3

  2023cites this paper
• Brain Metabolomics in Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS)

  2023cites this paper
• Adherens, tight, and gap junctions in ependymal cells: A systematic review of their contribution to CSF-brain barrier

  2023cites this paper
• Investigation of Endothelial Mechanics on Primary Cell Functions: Endothelium Permeability and Wound Healing

  2023cites this paper
• The Crosstalk between the Blood–Brain Barrier Dysfunction and Neuroinflammation after General Anaesthesia

  2022cites this paper
• Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage

  2022cites this paper
• Trans-Compartmental Regulation of Tight Junction Barrier Function

  2022cites this paper
• Connexin 43 across the Vasculature: Gap Junctions and Beyond

  2022cites this paper
• Optimal infusion rate of hypertonic saline to encephalic vessel vasodilatation using magnetic resonance imaging in normovolemic dogs

  2022influential citation
• Insights into the Steps of Breast Cancer–Brain Metastases Development: Tumor Cell Interactions with the Blood–Brain Barrier

  2022cites this paper
• BLOOD BRAIN BARRIER AS AN INTERFACE FOR ALCOHOL INDUCED NEUROTOXICITY DURING DEVELOPMENT.

  2022cites this paper
• Connexin and Pannexin Large-Pore Channels in Microcirculation and Neurovascular Coupling Function

  2022cites this paper
• Connexins in the Heart: Regulation, Function and Involvement in Cardiac Disease

  2021cites this paper
• Chronic Stress and Gonadectomy Affect the Expression of Cx37, Cx40 and Cx43 in the Spinal Cord

  2021cites this paper
• Blood-Brain Barrier Overview: Structural and Functional Correlation

  2021cites this paper
• Connexins

  2021cites this paper
• Syndecan-1 Shedding by Matrix Metalloproteinase-9 Signaling Regulates Alveolar Epithelial Tight Junction in Lipopolysaccharide-Induced Early Acute Lung Injury

  2021cites this paper
• Blood-Brain Barrier Dysfunction in the Detrimental Brain Function

  2021cites this paper
• AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43

  2021cites this paper
• The region‐selective regulation of endothelial claudin‐5 expression and signaling in brain health and disorders

  2021cites this paper
• The complexity of the blood-brain barrier and the concept of age-related brain targeting: challenges and potential of novel solid lipid-based formulations.

  2021cites this paper
• Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders.

  2021cites this paper
• Transcryptomic Analysis of Human Brain-Microvascular Endothelial Response to -Pericytes: Cell Orientation Defines Barrier Function

  2021cites this paper
• Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability

  2021cites this paper
• The Neurovascular Unit in Glaucomatous Neurodegeneration

  2020cites this paper
• Novel MRI Techniques Identifying Vascular Leak and Paravascular Flow Reduction in Early Alzheimer Disease

  2020cites this paper
• Structural and Functional Remodeling of the Brain Vasculature Following Stroke

  2020cites this paper
• Connexins: Key Players in the Control of Vascular Plasticity and Function.

  2020cites this paper
• Paracellular Permeability Changes Induced by Multi-walled Carbon Nanotubes in Brain Endothelial Cells and Associated Roles of Hemichannels.

  2020cites this paper
• ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction

  2020cites this paper
• Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress

  2020cites this paper
• Adenovirus targets transcriptional and posttranslational mechanisms to limit gap junction function

  2020cites this paper
• Physiology, Blood Brain Barrier

  2020cites this paper
• Liposomes: Novel Drug Delivery Approach for Targeting Parkinson's Disease.

  2020cites this paper
• Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

  2020cites this paper
• Connexins in oligodendrocytes and astrocytes: possible factors for demyelination in multiple sclerosis.

  2020cites this paper
• Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation

  2020cites this paper
• Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression

  2020cites this paper
• Brain Disorders and Chemical Pollutants: A Gap Junction Link? †

  2020influential citation
• The dynamic Nexus: gap junctions control protein localization and mobility in distinct and surprising ways

  2020cites this paper
• Tight Junction Proteins in the Weaned Piglet Intestine: Roles and Regulation.

  2019cites this paper
• Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium

  2019influential citation
• Ferroportin-mediated iron export from vascular endothelial cells in retina and brain.

  2019cites this paper
• Clinical and neuroimaging disparity between Chinese and German patients with cerebral small vessel disease: a comparative study

  2019cites this paper
• Blood-Brain Barrier: From Physiology to Disease and Back.

  2019cites this paper
• Domain‐specific distribution of gap junctions defines cellular coupling to establish a vascular relay in the retina

  2019influential citation
• Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway.

  2019cites this paper
• Implication des connexines gliales dans les atteintes de la Neuromyélite Optique : un rôle dans la démyélinisation et les altérations neuronales

  2019cites this paper
• Probing Endothelial Cell Mechanics through Connexin 43 Disruption

  2018cites this paper
• Knee Joint Tissues Effectively Separate Mixed Sized Molecules Delivered in a Single Bolus to the Heart

  2018cites this paper
• Blood‐brain barrier (BBB) and the complement landscape

  2018cites this paper
• Protein–Protein Interactions with Connexin 43: Regulation and Function

  2018cites this paper
• Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases

  2018cites this paper
• Connexins and Pannexins in cerebral ischemia.

  2018cites this paper
• The Pulmonary Vascular Barrier: Insights into Structure, Function, and Regulatory Mechanisms.

  2018cites this paper
• Inhibition of Cx43 gap junction uncoupling prevents high glucose‐induced apoptosis and reduces excess cell monolayer permeability in retinal vascular endothelial cells

  2018cites this paper
• The effect of mechanosensitive channel MscL expression in cancer cells on 3D confined migration

  2018cites this paper
• Relationship of Cx43 regulation of vascular permeability to osteopontin-tight junction protein pathway after sepsis in rats.

  2018cites this paper
• Molecular and Functional Insights Into the Pulmonary Vasculature

  2018cites this paper
• Connexins in the control of vasomotor function

  2018cites this paper
• Integration of Gap Junction Coupling in Adenosine Signalling of Endothelial Cells

  2018cites this paper
• Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation

  2018cites this paper
• Connexin channel and its role in diabetic retinopathy

  2017influential citation
• Blood-brain barrier-supported neurogenesis in healthy and diseased brain

  2017cites this paper
• Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain

  2017cites this paper
• Elevated expression of JAM‐A promotes neoplastic properties of lung adenocarcinoma

  2017cites this paper
• 10 Role of Connexin Hemichannels in Neurodegeneration

  2017cites this paper
• The role of connexin 43 gap junction formation in monocytes trans-endothelial migration

  2017cites this paper
• Gap junction-mediated regulation of endothelial cellular stiffness

  2017cites this paper
• Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development.

  2017cites this paper
• Inhibitors of connexin and pannexin channels as potential therapeutics

  2017cites this paper