The role of 5-HT₁A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: a possible antidepressant mechanism.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neuropharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neuropharm.2011.06.017PMID 21740919
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 5-HT1B receptor: behavioral implications.

  2025cited by this paper
• The neurobiology of depression.

  2012cited by this paper
• 5-HT(1A)-receptor over-expressing mice: genotype and sex dependent responses to antidepressants in the forced swim-test.

  2011cited by this paper
• Chronic ω-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol.

  2011cited by this paper
• The role of BDNF in depression on the basis of its location in the neural circuitry

  2011cited by this paper
• Lowered omega-3 PUFAs are related to major depression, but not to somatization syndrome.

  2010cited by this paper
• Modifying 5-HT1A Receptor Gene Expression as a New Target for Antidepressant Therapy

  2010cited by this paper
• A longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain.

  2010cited by this paper
• Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice.

  2010cited by this paper
• Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine.

  2010cited by this paper
• Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: pitfalls and solutions.

  2010influential reference
• Involvement of serotonin receptor subtypes in the antidepressant-like effect of TRIM in the rat forced swimming test.

  2010cited by this paper
• Higher dietary intake of long-chain omega-3 polyunsaturated fatty acids is inversely associated with depressive symptoms in women.

  2009cited by this paper
• 5-HT(1A) receptor function in major depressive disorder.

  2009cited by this paper
• Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects.

  2009cited by this paper
• The 5-HT1B receptor: a novel target for the pathophysiology of depression.

  2009cited by this paper
• PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus.

  2009cited by this paper
• Chronic stress during paradoxical sleep deprivation increases paradoxical sleep rebound: association with prolactin plasma levels and brain serotonin content.

  2008cited by this paper
• The role of polyunsaturated fatty acids (PUFAs) in development, aging and substance abuse disorders: review and propositions.

  2008influential reference
• Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.

  2008cited by this paper
• The antidepressant role of dietary long-chain polyunsaturated n-3 fatty acids in two phases in the developing brain.

  2008cited by this paper
• Interaction between BDNF and Serotonin: Role in Mood Disorders

  2008cited by this paper
• Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats.

  2008cited by this paper
• Depression in Parkinson's disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation.

  2008cited by this paper
• Important messages in the 'post': recent discoveries in 5-HT neurone feedback control.

  2007cited by this paper
• Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies.

  2007cited by this paper
• Augmentation of SSRI Effects on Serotonin by 5-HT2C Antagonists: Mechanistic Studies

  2007cited by this paper
• Dietary omega-3 fatty acids for women.

  2007cited by this paper
• Omega-3 fatty acid deficiency in major depressive disorder is caused by the interaction between diet and a genetically determined abnormality in phospholipid metabolism.

  2007cited by this paper
• Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats.

  2006cited by this paper
• Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology.

  2006influential reference
• Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States

  2006cited by this paper
• Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei.

  2005cited by this paper
• Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test

  2005cited by this paper
• Nutrition and depression: implications for improving mental health among childbearing-aged women.

  2005cited by this paper
• Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test.

  2005cited by this paper
• Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression‐like behaviour: effects of chronic paroxetine treatment

  2005cited by this paper
• The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels.

  2004cited by this paper
• Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.

  2004cited by this paper
• Effects of Fish Oil on the Central Nervous System: A New Potential Antidepressant?

  2004cited by this paper
• Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors.

  2003cited by this paper
• Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain.

  2003influential reference
• Effects of chronic paroxetine treatment on dialysate serotonin in 5‐HT1B receptor knockout mice

  2003cited by this paper
• Increased extracellular serotonin level in rat hippocampus induced by chronic citalopram is augmented by subchronic lithium: neurochemical and behavioural studies in the rat

  2003cited by this paper
• Neurobiology of depression.

  2002cited by this paper
• Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test.

  2002cited by this paper
• Dietary long chain PUFAs differentially affect hippocampal muscarinic 1 and serotonergic 1A receptors in experimental cerebral hypoperfusion.

  2002cited by this paper
• Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine.

  2000cited by this paper
• Role of uptake inhibition and autoreceptor activation in the control of 5‐HT release in the frontal cortex and dorsal hippocampus of the rat

  2000cited by this paper
• The Role of Dietary n–6 and n–3 Fatty Acids in the Developing Brain

  2000cited by this paper
• Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test

  1999influential reference
• Preferential Potentiation of the Effects of Serotonin Uptake Inhibitors by 5‐HT1A Receptor Antagonists in the Dorsal Raphe Pathway: Role of Somatodendritic Autoreceptors

  1997cited by this paper
• Autoreceptor antagonists enhance the effect of the reuptake inhibitor citalopram on extracellular 5-HT: this effect persists after repeated citalopram treatment.

  1997cited by this paper
• (+)‐WAY 100135, a partial agonist, at native and recombinant 5‐HT1B/1D receptors

  1997cited by this paper
• Age-related changes in phospholipid fatty acid composition and monoaminergic neurotransmission in the hippocampus of rats fed a balanced or an n-3 polyunsaturated fatty acid-deficient diet.

  1997cited by this paper
• The forced swimming test as a model for core and component behavioral effects of antidepressant drugs.

  1997cited by this paper
• Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

  1995cited by this paper
• Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo.

  1995cited by this paper
• International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

  1994cited by this paper
• GABAergic innervation of serotonergic neurons in the dorsal raphe nucleus of the rat studied by electron microscopy double immunostaining.

  1992cited by this paper
• Role of central serotonergic neurons in the effect of sertraline in rats in the forced swimming test.

  1991cited by this paper
• Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors.

  1985cited by this paper
• Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors.

  1985cited by this paper
• Depression: a new animal model sensitive to antidepressant treatments

  1977cited by this paper
• Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin.

  1976cited by this paper

• Sex-based differences in the prevention of stress-induced anxiety by Resolvin D5 and its precursor docosahexaenoic acid: A comparative study.

  2025cites this paper
• Omega‐3 Fatty Acids Supplementation and Neuroprotection, Inflammation, Fatigue, and Physical Activity in Multiple Sclerosis: A Randomized Controlled Trial

  2025cites this paper
• Omega-3 Fatty Acids in Alzheimer’s Disease Prevention Among Elderly Women: Mechanisms of Action, Clinical Evidence, and the Critical Role of Early Intervention

  2025cites this paper
• Maternal supplementation with Dipteryx alata Vog. modulates fecal microbiota diversity, accelerates reflex ontogeny, and improves non-associative and spatial memory in the offspring of rats.

  2024cites this paper
• Evaluation of Anxiolytic Effects of Justicia secunda Methanol Leaf Extract and Its Chemical Constituents in Mice

  2024cites this paper
• Dietary Intervention with Omega-3 Fatty Acids Mitigates Maternal High-Fat Diet-Induced Behavioral and Myelin-Related Alterations in Adult Offspring

  2024cites this paper
• Systemic Modulators: Potential Mechanism for the 5-HT System to Mediate Exercise Amelioration in Alzheimer's Disease

  2024cites this paper
• Deep brain stimulation mitigates memory deficits in a rodent model of traumatic brain injury.

  2024influential citation
• Impact of Nutrition on Depression: A Review of Some Dietary Components with Antidepressant Effects and Their Mechanism of Action

  2023cites this paper
• Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms

  2023cites this paper
• Synergistic antidepressant-like effect of n-3 polyunsaturated fatty acids and probiotics through the brain-gut axis in rats exposed to chronic mild stress.

  2023cites this paper
• Omega-3 supplementation improves depressive symptoms, cognitive function and niacin skin flushing response in adolescent depression: A randomized controlled clinical trial.

  2023cites this paper
• n-3 PUFA Improve Emotion and Cognition during Menopause: A Systematic Review

  2022cites this paper
• Preventive treatment with fish oil facilitates the antidepressant-like effect of antidepressant drugs in type-1 diabetes mellitus rats: implication of serotonergic system.

  2022cites this paper
• Plant-based dietary changes may improve symptoms in patients with systemic lupus erythematosus

  2022cites this paper
• BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

  2022cites this paper
• Behavioural disruption in diabetic mice: Neurobiological correlates and influences of dietary α-linolenic acid.

  2022cites this paper
• Mediterranean Diet on Sleep: A Health Alliance

  2022cites this paper
• Resolvin D5 disrupts anxious- and depressive-like behaviors in a type 1 diabetes mellitus animal model

  2022cites this paper
• Neuroprotection induced by omega-3 polyunsaturated fatty acids: focus on neuropsychiatric disorders

  2022cites this paper
• Interaction between dietary total antioxidant capacity and BDNF Val66Met polymorphism on lipid profiles and atherogenic indices among diabetic patients

  2021cites this paper
• Serum long chain omega-3 fatty acids and depression among adults in the United States: An analysis of NHANES 2011–2012

  2021cites this paper
• Omega‐3 fatty acid in ultra‐high‐risk psychosis: A systematic review based on functional outcome

  2021cites this paper
• Menhaden fish oil attenuates postpartum depression in rat model via inhibition of NLRP3-inflammasome driven inflammatory pathway

  2021cites this paper
• Participation of the nucleus accumbens dopaminergic system in the antidepressant-like actions of a diet rich in omega-3 polyunsaturated fatty acids

  2020influential citation
• Docosahexaenoic acid protects motor function and increases dopamine synthesis in a rat model of Parkinson's disease via mechanisms associated with increased protein kinase activity in the striatum.

  2020cites this paper
• Erythrocytes Polyunsaturated Fatty Acids Mediate Relationship between Dietary Patterns and Depression.

  2020cites this paper
• Antidepressant-Like Properties of Fish Oil on Postpartum Depression-Like Rats Model: Involvement of Serotonergic System

  2020cites this paper
• Investigating the potential of fish oil as a nutraceutical in an animal model of early life stress

  2020cites this paper
• N-3 PUFA improved pup separation-induced postpartum depression via serotonergic pathway regulated by miRNA.

  2020cites this paper
• Fish-oil supplementation decreases Indoleamine-2,3-Dioxygenase expression and increases hippocampal serotonin levels in the LPS depression model.

  2020cites this paper
• Twelve-Month Studies on Perilla Oil Intake in Japanese Adults—Possible Supplement for Mental Health

  2020cites this paper
• N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells

  2020cites this paper
• Preventing adolescent stress-induced cognitive and microbiome changes by diet

  2019cites this paper
• The association between diet and mood: A systematic review of current literature.

  2019cites this paper
• The effect of omega-3 supplementation and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus

  2019cites this paper
• Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level

  2019cites this paper
• Neuroprotective Effects of Melatonin and Omega-3 on the Central Nervous System Exposed to Electromagnetic Fields in the Pre- and Postnatal Periods

  2019cites this paper
• Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota–brain axis

  2019cites this paper
• Anxiolytic- and Antidepressant-Like Effects of Fish Oil-Enriched Diet in Brain-Derived Neurotrophic Factor Deficient Mice

  2018cites this paper
• The Role of Physical Exercise and Omega-3 Fatty Acids in Depressive 
Illness in the Elderly

  2018influential citation
• Particulate Matter Triggers Depressive-Like Response Associated With Modulation of Inflammatory Cytokine Homeostasis and Brain-Derived Neurotrophic Factor Signaling Pathway in Mice

  2018cites this paper
• Omega-3 fatty acids and anxiety: A systematic review of the possible mechanisms at play

  2018cites this paper
• Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning

  2018cites this paper
• The Role of Essential Fatty Acids Supplementation on the Treatment of Prenatal Depression

  2018cites this paper
• Ultrasonically tailored, chemically engineered and "QbD" enabled fabrication of agomelatine nanoemulsion; optimization, characterization, ex-vivo permeation and stability study.

  2018cites this paper
• The effect of omega-3 supplementation and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus

  2018cites this paper
• The effect of omega-3 supplementation and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus

  2018cites this paper
• Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depression and Mood Disorders

  2017cites this paper
• ATA DE SESSÃO PÚBLICA DE DEFESA DE DISSERTAÇÃO PARA A OBTENÇÃO DO GRAU DE MESTRE EM FARMACOLOGIA

  2017cites this paper
• The effects of omega‐3 fatty acids and vitamin E co‐supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double‐blind, placebo‐controlled trial

  2017cites this paper
• Ácidos grasos omega-3 y depresión: una revisión sistemática

  2017cites this paper
• Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide synthase

  2017cites this paper
• Maternal Omega-3 Supplement Improves Dopaminergic System in Pre- and Postnatal Inflammation-Induced Neurotoxicity in Parkinson’s Disease Model

  2017cites this paper
• Antidepressant-Like Effect of Lipid Extract of Channa striatus in Chronic Unpredictable Mild Stress Model of Depression in Rats

  2016cites this paper
• Sex-specific effects of dietary fatty acids on saliva cortisol and social behavior in guinea pigs under different social environmental conditions

  2016cites this paper
• N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology

  2016cites this paper
• Exercise and Nutritional Benefits in PD: Rodent Models and Clinical Settings.

  2016cites this paper
• Does fish oil or folic acid prevent vascular changes in female progeny caused by maternal exposure to fluoxetine?

  2016cites this paper
• Effects ofomega-3 fatty acid in the treatment of major depressive disorder: a review

  2016cites this paper
• Co-exposure to fish oil or folic acid does not reverse effects in the progeny induced by maternal exposure to fluoxetine.

  2016cites this paper
• Role of n-3 ( Omega - 3 ) Polyunsaturated Fatty Acids in Postpartum Depression: Mechanisms and Implications for Prevention and Treatment

  2016cites this paper
• Role of Omega-3 Fatty Acids in the Etiology, Treatment, and Prevention of Depression: Current Status and Future Directions.

  2016cites this paper
• The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically?

  2016cites this paper
• Effects of Omega-3 Fatty Acid Supplementation on Cognition in Children

  2016cites this paper
• Role of Dietary Fatty Acids in Mood Disorders

  2016cites this paper
• Effect of omega-3 polyunsaturated fatty acid treatment over mechanical allodynia and depressive-like behavior associated with experimental diabetes.

  2016cites this paper
• Neurobiological effects of long chain n-3 polyunsaturated fatty acids

  2016cites this paper
• INDUCTION OF DEPRESSION MODEL IN MICE: IMPLICATION OF DIFFERENT RESERPINE DOSES

  2016cites this paper
• Serum n-3 polyunsaturated fatty acids are inversely associated with longitudinal changes in depressive symptoms during pregnancy

  2016cites this paper
• Combination of resveratrol and fluoxetine in an acute model of depression in mice: Prevention of oxidative DNA fragmentation and monoamines degradation -

  2016influential citation
• N-3 polyunsaturated fatty acids and 17β-estradiol injection induce antidepressant-like effects through regulation of serotonergic neurotransmission in ovariectomized rats.

  2015cites this paper
• Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats

  2015cites this paper
• Serotonin 5-HT1A Receptors and Antipsychotics - An Update in Light of New Concepts and Drugs.

  2015cites this paper
• The Antidepressant-Like Effect of Fish Oil: Possible Role of Ventral Hippocampal 5-HT1A Post-synaptic Receptor

  2015cites this paper
• Diet, Nutrition, and Depression

  2015cites this paper
• An examination of the impact of dietary lipids on behaviour and neurochemistry

  2015cites this paper
• The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system

  2015cites this paper
• [The possibility of a novel pain control system through brain long chain fatty acid receptor GPR40/FFAR1].

  2015cites this paper
• Omega-3 fatty acids improve behavioral coping to stress in multiparous rats.

  2015cites this paper
• Combined Oral Supplementation of Fish Oil and Quercetin Enhances Neuroprotection in a Chronic Rotenone Rat Model: Relevance to Parkinson’s Disease

  2015cites this paper
• Toxicological aspects of trans fat consumption over two sequential generations of rats: Oxidative damage and preference for amphetamine.

  2015cites this paper
• Cross-Generational trans Fat Consumption Favors Self-Administration of Amphetamine and Changes Molecular Expressions of BDNF, DAT, and D1/D2 Receptors in the Cortex and Hippocampus of Rats

  2015cites this paper
• Brain membrane lipids in major depression and anxiety disorders.

  2015cites this paper
• Adult emotionality and neural plasticity as a function of adolescent nutrient supplementation in male rats.

  2015cites this paper
• Flaxseed mitigates brain mass loss, improving motor hyperactivity and spatial memory, in a rodent model of neonatal hypoxic-ischemic encephalopathy.

  2015cites this paper
• Antidepressant-like effect of n-3 PUFAs in CUMS rats: role of tPA/PAI-1 system.

  2015cites this paper
• Neuroprotective efficacy of a combination of fish oil and ferulic acid against 3-nitropropionic acid-induced oxidative stress and neurotoxicity in rats: behavioural and biochemical evidence.

  2014cites this paper
• Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms

  2014cites this paper
• Omega-3 deficiency and neurodegeneration in the substantia nigra: involvement of increased nitric oxide production and reduced BDNF expression.

  2014cites this paper
• Substantia Nigra Modulation by Essential Fatty Acids

  2014cites this paper
• Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression.

  2014cites this paper
• Fish oil improves anxiety‐like, depressive‐like and cognitive behaviors in olfactory bulbectomised rats

  2014influential citation
• Environmental enrichment induces changes in brain monoamine levels in gilthead seabream Sparus aurata.

  2014cites this paper
• n-3 LCPUFA improves cognition: the young, the old and the sick.

  2014cites this paper
• The effect of omega-3 supplementation and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus

  2014cites this paper
• Ethanol extracts from Hemerocallis citrina attenuate the upregulation of proinflammatory cytokines and indoleamine 2,3-dioxygenase in rats.

  2014cites this paper
• [Antinociceptive effect of docosahexaenoic acid (DHA) through long fatty acid receptor G protein-coupled receptor 40 (GPR40)].

  2014cites this paper
• Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

  2014cites this paper
• Fish oil has beneficial effects on behavior impairment and oxidative stress in rats subjected to a hepatic encephalopathy model.

  2013cites this paper