Direct observation of the influence of cardiolipin and antibiotics on lipid II binding to MurJ.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Nature Chemistry

• Publication date

  2018-01-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nchem.2919PMID 29461535PMCID PMC5912511
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Membranes by the Numbers

  2017cited by this paper
• Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

  2017cited by this paper
• The role of interfacial lipids in stabilizing membrane protein oligomers

  2017cited by this paper
• RodA as the missing glycosyltransferase in Bacillus subtilis and antibiotic discovery for the peptidoglycan polymerase pathway

  2017cited by this paper
• Crystal structure of the MOP flippase MurJ in an inward-facing conformation

  2016cited by this paper
• NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

  2016cited by this paper
• Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

  2016cited by this paper
• Lipid Flippases for Bacterial Peptidoglycan Biosynthesis

  2016cited by this paper
• SEDS proteins are a widespread family of bacterial cell wall polymerases

  2016cited by this paper
• Filling holes in peptidoglycan biogenesis of Escherichia coli.

  2016cited by this paper
• High-resolution mass spectrometry of small molecules bound to membrane proteins

  2016cited by this paper
• Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

  2015cited by this paper
• The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry.

  2015cited by this paper
• Impact of the β-Lactam Resistance Modifier (−)-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus

  2015cited by this paper
• Lantibiotic Resistance

  2015cited by this paper
• A subset of annular lipids is linked to the flippase activity of an ABC transporter.

  2015cited by this paper
• A new antibiotic kills pathogens without detectable resistance

  2015cited by this paper
• The role of the detergent micelle in preserving the structure of membrane proteins in the gas phase.

  2015cited by this paper
• Structural variations of the cell wall precursor lipid II in Gram-positive bacteria - Impact on binding and efficacy of antimicrobial peptides.

  2015cited by this paper
• MurJ and a novel lipid II flippase are required for cell wall biogenesis in Bacillus subtilis

  2015cited by this paper
• LipidII: Just Another Brick in the Wall?

  2015cited by this paper
• Faculty Opinions recommendation of Bacterial cell wall. MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis.

  2014cited by this paper
• Multidrug Transport Protein NorM from Vibrio cholerae Simultaneously Couples to Sodium- and Proton-Motive Force*

  2014cited by this paper
• Membrane proteins bind lipids selectively to modulate their structure and function

  2014cited by this paper
• Prospects for novel inhibitors of peptidoglycan transglycosylases

  2014cited by this paper
• Specificity of the Transport of Lipid II by FtsW in Escherichia coli*

  2014cited by this paper
• MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

  2014cited by this paper
• Determination of protein-ligand binding constants of a cooperatively regulated tetrameric enzyme using electrospray mass spectrometry.

  2014cited by this paper
• Structural insights into H+-coupled multidrug extrusion by a MATE transporter

  2013cited by this paper
• Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

  2013cited by this paper
• Mass spectrometry of intact membrane protein complexes

  2013cited by this paper
• Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

  2013cited by this paper
• Quantification of cardiolipin molecular species in Escherichia coli lipid extracts using liquid chromatography/electrospray ionization mass spectrometry.

  2012cited by this paper
• Lipidomics profiling by high-resolution LC-MS and high-energy collisional dissociation fragmentation: focus on characterization of mitochondrial cardiolipins and monolysocardiolipins.

  2011cited by this paper
• Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane

  2011cited by this paper
• An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway.

  2010cited by this paper
• Gamma-secretase activating protein, a therapeutic target for Alzheimer's disease

  2010cited by this paper
• Structure of a cation-bound multidrug and toxic compound extrusion transporter

  2010cited by this paper
• The bacterial cell envelope.

  2010cited by this paper
• Cardiolipin membrane domains in prokaryotes and eukaryotes.

  2009cited by this paper
• A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface

  2009cited by this paper
• Lipid II: a central component in bacterial cell wall synthesis and a target for antibiotics.

  2008cited by this paper
• Involvement of an Essential Gene, mviN, in Murein Synthesis in Escherichia coli

  2008cited by this paper
• Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase in Escherichia coli

  2008cited by this paper
• Lipid Intermediates in the Biosynthesis of Bacterial Peptidoglycan

  2007cited by this paper
• In vitro susceptibility of Staphylococcus aureus to thrombin-induced platelet microbicidal protein-1 (tPMP-1) is influenced by cell membrane phospholipid composition and asymmetry.

  2007cited by this paper
• Determining the stoichiometry and interactions of macromolecular assemblies from mass spectrometry

  2007cited by this paper
• Lipid Intermediates in the Biosynthesis of Bacterial Peptidoglycan

  2007cited by this paper
• Lipid II as a target for antibiotics

  2006cited by this paper
• Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity.

  2005cited by this paper
• Membrane intermediates in the peptidoglycan metabolism of Escherichia coli: possible roles of PBP 1b and PBP 3

  1992cited by this paper
• Escherichia coli intracellular pH, membrane potential, and cell growth

  1984cited by this paper
• A rapid method of total lipid extraction and purification.

  1959cited by this paper

• Convergent MurJ flippase inhibition by phage lysis proteins.

  2026cites this paper
• Bacillus subtilis MurJ and Amj Lipid II flippases are not essential for growth

  2025cites this paper
• Membrane Protein Complexity Revealed Through Native Mass Spectrometry.

  2025cites this paper
• Heterogenous Expression and Purification of Lipid II Flippase from Staphylococcus aureus

  2024cites this paper
• Assessment of the Conformation Stability and Glycosylation Heterogeneity of Lactoferrin by Native Mass Spectrometry.

  2024cites this paper
• Detergents with Scalable Properties Identify Noncanonical Lipopolysaccharide Binding to Bacterial Inner Membrane Proteins

  2024cites this paper
• Lipopeptide antibiotics disrupt interactions of undecaprenyl phosphate with UptA

  2024cites this paper
• Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions

  2024cites this paper
• The fall of the mycobacterial cell wall: interrogating peptidoglycan synthesis for novel anti-TB agents

  2024cites this paper
• Native MS-guided lipidomics to define endogenous lipid microenvironments of eukaryotic receptors and transporters

  2024cites this paper
• Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions

  2023cites this paper
• Chloride Ions Are Required for Thermosipho africanus MurJ Function

  2023cites this paper
• Native mass spectrometry of proteoliposomes containing integral and peripheral membrane proteins

  2023cites this paper
• Emerging native Orbitrap mass spectrometry for probing higher-order structures of proteins: Recent progress and applications

  2023cites this paper
• Combining native mass spectrometry and lipidomics to uncover specific membrane protein–lipid interactions from natural lipid sources

  2023cites this paper
• Recent advances in membrane mimetics for membrane protein research

  2023cites this paper
• Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria

  2023cites this paper
• Rationalizing the Optimization of Detergents for Membrane Protein Purification.

  2023cites this paper
• Native mass spectrometry-directed drug discovery: recent advances in investigating protein function and modulation.

  2023cites this paper
• Mass spectrometry of intact membrane proteins: shifting towards a more native-like context

  2023cites this paper
• Emergence of mass spectrometry detergents for membrane proteomics

  2023cites this paper
• Plasma Membrane-Cell Wall Feedback in Bacteria

  2023influential citation
• What have molecular simulations contributed to understanding of Gram-negative bacterial cell envelopes?

  2022cites this paper
• Ion currents through Kir potassium channels are gated by anionic lipids

  2022cites this paper
• Undecaprenyl phosphate translocases confer conditional microbial fitness

  2022cites this paper
• Genome-Wide Transposon Mutagenesis Screens Identify Group A Streptococcus Genes Affecting Susceptibility to β-Lactam Antibiotics

  2022cites this paper
• Probing the structures of G protein-coupled receptors with mass spectrometry-based techniques

  2022cites this paper
• Crystal structure of the lipid flippase MurJ in a "squeezed" form distinct from its inward- and outward-facing forms.

  2022cites this paper
• Non-ionic hybrid detergents for protein delipidation.

  2022cites this paper
• Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients

  2022cites this paper
• Structure and Mechanism of the Lipid Flippase MurJ.

  2022cites this paper
• The Bacterial Cell Wall: From Lipid II Flipping to Polymerization.

  2022cites this paper
• Insights into the Role of Membrane Lipids in the Structure, Function and Regulation of Integral Membrane Proteins

  2021cites this paper
• Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins

  2021cites this paper
• Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport

  2021cites this paper
• Integration of Mass Spectrometry Data for Structural Biology.

  2021cites this paper
• Ion currents through Kir potassium channels are gated by anionic lipids

  2021cites this paper
• Entropy in the Molecular Recognition of Membrane Protein-Lipid Interactions.

  2021cites this paper
• Elucidating the molecular mechanisms of perfluorooctanoic acid-serum protein interactions by structural mass spectrometry.

  2021cites this paper
• Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall

  2020cites this paper
• Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.

  2020cites this paper
• Discovery of potent charge-reducing molecules for native ion mobility mass spectrometry studies.

  2020cites this paper
• Assembly and regulation of the chlorhexidine-specific efflux pump AceI

  2020cites this paper
• Regulation of peptidoglycan synthesis and remodelling

  2020cites this paper
• Insight into the selectivity of Kir3.2 toward phosphatidylinositides.

  2020cites this paper
• Exploring the structure and dynamics of macromolecular complexes by native mass spectrometry.

  2020cites this paper
• Fluorescence anisotropy assays for high throughput screening of compounds binding to lipid II, PBP1b, FtsW and MurJ

  2020cites this paper
• Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide

  2020cites this paper
• Detection of transport intermediates in the peptidoglycan flippase MurJ identifies residues essential for conformational cycling.

  2020cites this paper
• Native Mass Spectrometry of Membrane Proteins.

  2020cites this paper
• The Cell Wall of Bacillus subtilis.

  2020cites this paper
• Impact of charge state on 193 nm ultraviolet photodissociation of protein complexes.

  2019cites this paper
• Visualizing conformation transitions of the Lipid II flippase MurJ

  2019cites this paper
• Membrane Protein-Lipid Interactions Probed Using Mass Spectrometry.

  2019cites this paper
• Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel

  2019cites this paper
• Mass spectrometry: From plasma proteins to mitochondrial membranes

  2019cites this paper
• The Different Effects of Substrates and Nucleotides on the Complex Formation of ABC Transporters

  2019cites this paper
• Peptidoglycan.

  2019cites this paper
• Characterization of Membrane Proteins and Ligand Interactions by Native Ion Mobility Mass Spectrometry

  2019cites this paper
• Illuminating protein interactions in the periplasm

  2019cites this paper
• A Mass‐Spectrometry‐Based Approach to Distinguish Annular and Specific Lipid Binding to Membrane Proteins

  2019cites this paper
• Structural and functional contributions of lipids to the stability and activity of the photosynthetic cytochrome b6f lipoprotein complex

  2019cites this paper
• Exploring the substrate specificity of the antimicrobial peptide transporter BceAB of Bacillus subtilis

  2019cites this paper
• Therapeutic compounds targeting Lipid II for antibacterial purposes

  2019influential citation
• Peptidoglycan Structure, Biosynthesis, and Dynamics During Bacterial Growth

  2019cites this paper
• Structural mass spectrometry comes of age: new insight into protein structure, function and interactions.

  2019cites this paper
• Lipid II flippase MurJ, inward closed conformation

  2019cites this paper
• Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles’ heel for the TB-causing pathogen

  2019cites this paper
• Phage single-gene lysis: Finding the weak spot in the bacterial cell wall

  2018cites this paper
• FtsW activity and lipid II synthesis are required for recruitment of MurJ to midcell during cell division in Escherichia coli

  2018influential citation
• Protein–Lipid Interfaces Can Drive the Functions of Membrane-Embedded Protein–Protein Complexes

  2018cites this paper
• Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis

  2018cites this paper
• The bacterial lipid II flippase MurJ functions by an alternating-access mechanism

  2018cites this paper
• Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli

  2018influential citation
• The Combined activities of FtsW and MurJ are required for lipid II translocation during cell division in Escherichia coli

  2017cites this paper