Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery

The poor aqueous solubility and low bioavailability of curcumin restrict its clinical application for cancer treatment. In this study, a novel tumor-targeting nanofiber carrier was developed to improve the solubility and tumor-targeting ability of curcumin using a self-assembled Nap-GFFYG-RGD peptide. The morphologies of the peptide nanofiber and the curcumin-encapsulated nanofiber were visualized by transmission electron microscopy. The tumor-targeting activity of the curcumin-encapsulated Nap-GFFYG-RGD peptide nanofiber (f-RGD-Cur) was studied in vitro and in vivo, using Nap-GFFYG-RGE peptide nanofiber (f-RGE-Cur) as the control. Curcumin was encapsulated into the peptide nanofiber, which had a diameter of approximately 10–20 nm. Curcumin showed sustained-release behavior from the nanofibers in vitro. f-RGD-Cur showed much higher cellular uptake in αvβ3 integrin-positive HepG2 liver carcinoma cells than did non-targeted f-RGE-Cur, thereby leading to significantly higher cytotoxicity. Ex vivo studies further demonstrated that curcumin could accumulate markedly in mouse tumors after administration of f-RGD-Cur via the tail vein. These results indicate that Nap-GFFYG-RGD peptide self-assembled nanofibers are a promising hydrophobic drug delivery system for targeted treatment of cancer.

• Publication year

  2013

• Venue

  International Journal of Nanomedicine

• Publication date

  2013-12-24

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.2147/IJN.S55875PMID 24399876PMCID 3875522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A novel polyethylene glycol mediated lipid nanoemulsion as drug delivery carrier for paclitaxel.

  2014cited by this paper
• RGD-conjugated iron oxide magnetic nanoparticles for magnetic resonance imaging contrast enhancement and hyperthermia

  2014cited by this paper
• Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and angiogenesis.

  2013cited by this paper
• A short circulating peptide nanofiber as a carrier for tumoral delivery.

  2013cited by this paper
• Aqueous synthesized near-infrared-emitting quantum dots for RGD-based in vivo active tumour targeting

  2013cited by this paper
• Oral delivery of proteins by biodegradable nanoparticles.

  2013cited by this paper
• The Novel Heterocyclic Trioxirane [(1,3,5-Tris Oxiran-2-yl)Methyl)-1,3,5-Triazinane-2,4,6-Trione (TATT)] Exhibits a Better Anticancer Effect than Platinum-Based Chemotherapy by Induction of Apoptosis and Curcumin Further Enhances its Chemosensitivity

  2013cited by this paper
• Intranuclear drug delivery and effective in vivo cancer therapy via estradiol-PEG-appended multiwalled carbon nanotubes.

  2013cited by this paper
• Oral delivery of therapeutic proteins and peptides: a review on recent developments

  2013cited by this paper
• Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability.

  2013cited by this paper
• Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38.

  2013cited by this paper
• Monitoring glioma growth and tumor necrosis with the U-SPECT-II/CT scanner by targeting integrin αvβ3.

  2013cited by this paper
• Amphiphilic oligomer-based micelles as cisplatin nanocarriers for cancer therapy.

  2013cited by this paper
• Self-assembling peptide nanofibrous scaffolds for tissue engineering: novel approaches and strategies for effective functional regeneration.

  2013cited by this paper
• Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier.

  2013cited by this paper
• Selective tumor cell targeting by the disaccharide moiety of bleomycin.

  2013cited by this paper
• Curcumin nanomedicine: a road to cancer therapeutics.

  2013cited by this paper
• Smart ligand: aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy.

  2013cited by this paper
• Polymer nanocompartments in broad-spectrum medical applications.

  2013cited by this paper
• Polyethyleneimine-mediated synthesis of folic acid-targeted iron oxide nanoparticles for in vivo tumor MR imaging.

  2013cited by this paper
• Self-assembled Tat nanofibers as effective drug carrier and transporter.

  2013influential reference
• PEG-transferrin conjugated TRAIL (TNF-related apoptosis-inducing ligand) for therapeutic tumor targeting.

  2012cited by this paper
• The inhibition of tumor growth and metastasis by self-assembled nanofibers of taxol.

  2012cited by this paper
• Cyclic RGD peptide-modified liposomal drug delivery system: enhanced cellular uptake in vitro and improved pharmacokinetics in rats

  2012cited by this paper
• Ligand conformation dictates membrane and endosomal trafficking of arginine-glycine-aspartate (RGD)-functionalized mesoporous silica nanoparticles.

  2012cited by this paper
• Responsive small molecular hydrogels based on adamantane-peptides for cell culture.

  2012cited by this paper
• Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe

  2012cited by this paper
• Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles.

  2012cited by this paper
• In vivo cancer imaging by poly(ethylene glycol)-b-poly(ɛ-caprolactone) micelles containing a near-infrared probe.

  2012cited by this paper
• Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles.

  2011cited by this paper
• RGD peptide-mediated chitosan-based polymeric micelles targeting delivery for integrin-overexpressing tumor cells

  2011cited by this paper
• Antitumor activity of peptide amphiphile nanofiber-encapsulated camptothecin.

  2011cited by this paper
• RGD‐Modified PEG‐PAMAM‐DOX Conjugate: In Vitro and In Vivo Targeting to Both Tumor Neovascular Endothelial Cells and Tumor Cells

  2011cited by this paper
• Supramolecular hydrogels inspired by collagen for tissue engineering.

  2010cited by this paper
• Integrins and signal transduction.

  2010cited by this paper
• Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage.

  2009cited by this paper
• Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.

  2008cited by this paper
• Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.

  2008cited by this paper
• Shape effects of filaments versus spherical particles in flow and drug delivery.

  2007cited by this paper
• Multiple biological activities of curcumin: a short review.

  2006cited by this paper
• A reevaluation of integrins as regulators of angiogenesis

  2002cited by this paper
• International Journal of Nanomedicine Dovepress Novel Peptide–dendrimer Conjugates as Drug Carriers for Targeting Nonsmall Cell Lung Cancer

  year unknowncited by this paper
• International Journal of Nanomedicine

  year unknowncited by this paper

• Electrospinning: A New Frontier in Peptide Therapeutics

  2025cites this paper
• Advanced Peptide Nanofibers in Delivery of Therapeutic Agents: Recent Trends, Limitations, and Critical Properties

  2025influential citation
• BIO-NANOMATERIALS: PROMISING ANTICANCER PROPERTIES AND TREATMENT STRATEGIES

  2025cites this paper
• Recent Advancements in the Diagnosis and Management of Cancer Using Biomaterials-Fabricated Nanofibers: A Review.

  2024cites this paper
• pH-Responsive Co-Assembled Peptide Hydrogel to Inhibit Drug-Resistant Bacterial Infection and Promote Wound Healing.

  2024cites this paper
• Advances in self-assembled nanotechnology in tumor therapy.

  2024cites this paper
• Recent advances of novel targeted drug delivery systems based on natural medicine monomers against hepatocellular carcinoma

  2024cites this paper
• Recent progress in quantitative analysis of self‐assembled peptides

  2024cites this paper
• Curcumin-based nanofibers: A promising approach for cancer therapy.

  2024cites this paper
• Cancer Treatment Using Nanofibers: A Review

  2024cites this paper
• An enzyme-instructed self-assembly system induces tumor acidosis via sequential-dual effect for cancer selective therapy.

  2023cites this paper
• Supramolecular self-assembled peptide-engineered nanofibers: A propitious proposition for cancer therapy.

  2023cites this paper
• RGD-decorated nanoliposomes for combined delivery of arsenic trioxide and curcumin to prostate cancer cells

  2023cites this paper
• Polymeric Gel Scaffolds and Biomimetic Environments for Wound Healing.

  2023cites this paper
• Pseudomonas aeruginosa targeting cascade photodynamic nanoassemblies for efficient antibacterial and anti-inflammatory therapy

  2023cites this paper
• Peptide Nanofiber System for Sustained Delivery of Anti-VEGF Proteins to the Eye Vitreous

  2023cites this paper
• Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma

  2023cites this paper
• Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

  2023cites this paper
• Glutathione-Triggered Mitochondria-Targeting Reassembly from Polymeric Micelles to Nanofibers for a Synergistic Anticancer Effect.

  2022cites this paper
• Drug Transport via Nanocarrier for Liver Cancer Treatment

  2022cites this paper
• Advancements and Utilizations of Scaffolds in Tissue Engineering and Drug Delivery.

  2022cites this paper
• Gelatin-based nanofiber membranes loaded with curcumin and borneol as a sustainable wound dressing.

  2022cites this paper
• Research Advances of Injectable Functional Hydrogel Materials in the Treatment of Myocardial Infarction

  2022cites this paper
• Targeted regulation of tumor microenvironment through the inhibition of MDSCs by curcumin loaded self-assembled nano-filaments

  2022cites this paper
• Recent Advances in Senotherapeutics Delivery

  2022cites this paper
• Designer Peptides as Versatile Building Blocks for Functional Materials.

  2022cites this paper
• Curcumin nanofibers: A novel approach to enhance the anticancer potential and bioavailability of curcuminoids.

  2022cites this paper
• Antibacterial, cytotoxicity and biodegradability studies of polycaprolactone nanofibers holding green synthesized Ag nanoparticles using atropa belladonna extract

  2022cites this paper
• Natural and Synthetic Biopolymers in Drug Delivery and Tissue Engineering

  2021cites this paper
• Interaction between curcumin and a peptide and their protective effects against hepatic steatosis in mice

  2021cites this paper
• Bio-based nanomaterials for cancer therapy

  2021cites this paper
• Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview.

  2021cites this paper
• Phytoactives-loaded nanocarriers for liver cancer treatment

  2021cites this paper
• Nanoscale dynamic chemical, biological sensor material designs for control monitoring and early detection of advanced diseases

  2020cites this paper
• Nanocarrier-Based Therapeutics and Theranostics Drug Delivery Systems for Next Generation of Liver Cancer Nanodrug Modalities

  2020cites this paper
• Curcumin Based Drug Delivery Systems for Cancer Therapy.

  2020cites this paper
• Superior antitumor effect of self-assembly supramolecular paclitaxel nanoparticles

  2020cites this paper
• Self-assembled hydrophobic Ala-Aib peptide encapsulating curcumin: a convenient system for water insoluble drugs

  2020cites this paper
• Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications

  2020cites this paper
• Myocardial ischemia reperfusion injury is alleviated by curcumin-peptide hydrogel via upregulating autophagy and protecting mitochondrial function

  2020cites this paper
• Nanocarriers-loaded with natural actives as newer therapeutic interventions for treatment of hepatocellular carcinoma

  2020cites this paper
• Curcumin protects thymus against D-galactose-induced senescence in mice

  2020cites this paper
• Harnessing the self-assembly of peptides for the targeted delivery of anti-cancer agents

  2020cites this paper
• Fabrication Strategies of Scaffolds for Delivering Active Ingredients for Tissue Engineering

  2019cites this paper
• Current applications of electrospun polymeric nanofibers in cancer therapy.

  2019cites this paper
• The Role of Curcumin in the Modulation of Ageing

  2019cites this paper
• Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome

  2019cites this paper
• Macrocyclic Amphiphiles for Drug Delivery

  2019cites this paper
• Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery.

  2019cites this paper
• Biomaterials for Sustained and Controlled Delivery of Small Drug Molecules

  2019cites this paper
• Cancer nanomedicine: focus on recent developments and self-assembled peptide nanocarriers.

  2019cites this paper
• Integrin αvβ3 Receptor Overexpressing on Tumor-Targeted Positive MRI Guided Chemotherapy.

  2019cites this paper
• Recent progress in biomedical applications of RGD-Based ligand: From precise cancer theranostics to biomaterial engineering: A systematic review.

  2019cites this paper
• Peptide nanomaterials for drug delivery applications.

  2019cites this paper
• Nanofibers for Medical Diagnosis and Therapy

  2018cites this paper
• Stability and Structural Analysis of A6R Polypeptide Nanosheets: A Theoretical Study Using the Classical Molecular Dynamics Simulation

  2018cites this paper
• Enzyme sensitive smart inulin-dehydropeptide conjugate self-assembles into nanostructures useful for targeted delivery of ornidazole.

  2018cites this paper
• Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy

  2018cites this paper
• PCL nanofibers loaded with beta-carotene: a novel treatment for eczema

  2018cites this paper
• Peptide‐Based Nanocarriers for Cancer Therapy

  2018cites this paper
• Fabrication of cationic nanostructures from short self-assembling amphiphilic mixed α/β-pentapeptide: Potential candidates for drug delivery, gene delivery, and antimicrobial applications.

  2018cites this paper
• Biomedical applications of functional peptides in nano-systems

  2018cites this paper
• Delivery of a TNF‐α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell‐cycle arrest and caspase‐dependent apoptosis

  2018cites this paper
• Cancer-targeted delivery systems based on peptides.

  2018cites this paper
• Chemotherapeutic Delivery from a Self-Assembling Peptide Nanofiber Hydrogel for the Management of Glioblastoma

  2018cites this paper
• EFFECTS OF CURCUMIN-LOADED BACTERIAL CELLULOSE FILMS ON CANCER CELLS Mr. Chayut Subtaweesin A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Engineering Program in Biomedical Engineering

  2018cites this paper
• Construction of ultrasonic nanobubbles carrying CAIX polypeptides to target carcinoma cells derived from various organs

  2017cites this paper
• Noninvasive nanoparticle strategies for brain tumor targeting.

  2017cites this paper
• Overcoming T. gondii infection and intracellular protein nanocapsules as biomaterials for ultrasonically controlled drug release.

  2017cites this paper
• Clinical/preclinical aspects of nanofiber composites

  2017cites this paper
• Superior antitumor effect of extremely high drug loading self-assembled paclitaxel nanofibers.

  2017cites this paper
• Recent advances in self‐assembled peptides: Implications for targeted drug delivery and vaccine engineering

  2017cites this paper
• Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems

  2017cites this paper
• Modulating Drug Release Rate from Partially Silica-Coated Bicellar Nanodisc by Incorporating PEGylated Phospholipid.

  2017cites this paper
• Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects

  2017cites this paper
• Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies

  2017cites this paper
• Advancement in integrin facilitated drug delivery.

  2016cites this paper
• Smart Nanotransformers with Unique Enzyme-Inducible Structural Changes and Drug Release Properties.

  2016cites this paper
• Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art

  2016cites this paper
• Bionanofibers in drug delivery * *Xin Zhao and Lara Yildirimer contributed equally.

  2016cites this paper
• Surface Modification of Electrospun PVDF/PAN Nanofibrous Layers by Low Vacuum Plasma Treatment

  2016cites this paper
• Modulating self-assembly behavior of a salt-free peptide amphiphile (PA) and zwitterionic surfactant mixed system.

  2016cites this paper
• Antioxidant Activities of Raw and Nano Turmeric (Curcuma longa L.) Powders

  2016cites this paper
• Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways

  2016cites this paper
• Building Nanostructures with Drugs.

  2016cites this paper
• Peptide-Induced AIEgen Self-Assembly: A New Strategy to Realize Highly Sensitive Fluorescent Light-Up Probes.

  2016cites this paper
• Multifunctional drug nanocarriers facilitate more specific entry of therapeutic payload into tumors and control multiple drug resistance in cancer

  2016cites this paper
• Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer

  2016cites this paper
• Thioredoxin-Displayed Multipeptide Immunogens.

  2015cites this paper
• Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs

  2015cites this paper
• Nanospheres of doxorubicin as cross-linkers for a supramolecular hydrogelation

  2015cites this paper
• Current Approaches for Improving Intratumoral Accumulation and Distribution of Nanomedicines

  2015cites this paper
• Nanocarriers for the delivery of active ingredients and fractions extracted from natural products used in traditional Chinese medicine (TCM).

  2015cites this paper
• Nano-curcumin prepared via supercritical: Improved anti-bacterial, anti-oxidant and anti-cancer efficacy.

  2015cites this paper
• In vitro and in vivo ocular biocompatibility of electrospun poly(ɛ-caprolactone) nanofibers.

  2015cites this paper
• Dynamic biostability, biodistribution, and toxicity of L/D-peptide-based supramolecular nanofibers.

  2015cites this paper
• Towards protein-based viral mimetics for cancer therapies.

  2015cites this paper
• Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid

  2015cites this paper
• Self‐assembled penetratin‐deferasirox micelles as potential carriers for hydrophobic drug delivery

  2015cites this paper
• Diagnostic imaging and therapeutic application of nanoparticles targeting the liver.

  2015cites this paper