Potassium transport: from clearance to channels and pumps.

Potassium (K) homeostasis depends on the separate and interrelated regulation of K distribution between the intra- and extra-cellular fluid compartments and adequate renal excretion. This brief review focuses on the regulation of internal K distribution and the renal mechanisms of K handling. Based on clearance, micropuncture, and microperfusion studies, a large body of evidence supports the view that normally, renal secretion of K determines excretion and that the principal tubule cells in the initial and cortical collecting tubule secrete K, whereas K reabsorption may occur in intercalated cells. Studies of the electrochemical driving forces, of intracellular ion activities, the characterization of several ATPases, and patch clamp investigations have provided insight into the role of pumps and channels in those tubule cells that regulate K secretion and reabsorption.

• Publication year

  1996

• Venue

  Kidney International

• Publication date

  1996-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/KI.1996.236PMID 8743466
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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