Ubiquitination of Cyclin-Dependent Kinase Inhibitor, Xic1, is Mediated by the Xenopus F-box Protein xSkp2

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cell Cycle

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.5.3.2394PMID 16410731
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The C-terminal Domain of the Xenopus Cyclin-dependent Kinase Inhibitor, p27Xic1, Is Both Necessary and Sufficient for Phosphorylation-independent Proteolysis*

  2005cited by this paper
• Proliferating Cell Nuclear Antigen Recruits Cyclin-dependent Kinase Inhibitor Xic1 to DNA and Couples Its Proteolysis to DNA Polymerase Switching*♦

  2005cited by this paper
• Function and regulation of cullin–RING ubiquitin ligases

  2005cited by this paper
• Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

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• Noncatalytic Requirement for Cyclin A-cdk2 in p27 Turnover

  2004cited by this paper
• Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

  2004cited by this paper
• The SCF ubiquitin ligase: insights into a molecular machine

  2004cited by this paper
• Molecular and Biochemical Characterization of the Skp2-Cks1 Binding Interface*

  2004cited by this paper
• N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).

  2004cited by this paper
• A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin.

  2004cited by this paper
• The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

  2003cited by this paper
• Skp2 regulates Myc protein stability and activity.

  2003cited by this paper
• MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

  2003cited by this paper
• Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase*

  2003cited by this paper
• Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation

  2003cited by this paper
• M Phase-specific Phosphorylation of BRCA2 by Polo-like Kinase 1 Correlates with the Dissociation of the BRCA2-P/CAF Complex*

  2003cited by this paper
• The SCFSkp2 Ubiquitin Ligase Complex Interacts with the Human Replication Licensing Factor Cdt1 and Regulates Cdt1 Degradation*

  2003cited by this paper
• Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

  2003cited by this paper
• A single cdk inhibitor, p27Xic1, functions beyond cell cycle regulation to promote muscle differentiation in Xenopus

  2003cited by this paper
• A Negatively Charged Amino Acid in Skp2 Is Required for Skp2-Cks1 Interaction and Ubiquitination of p27Kip1*

  2003cited by this paper
• Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.

  2003cited by this paper
• UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair.

  2003cited by this paper
• The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus

  2003cited by this paper
• Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication.

  2002cited by this paper
• The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).

  2002cited by this paper
• Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

  2002cited by this paper
• Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

  2002cited by this paper
• A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

  2001cited by this paper
• Regulation of Nuclear Transport and Degradation of the Xenopus Cyclin-dependent Kinase Inhibitor, p27Xic1 *

  2001cited by this paper
• The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

  2001cited by this paper
• A degradation signal located in the C‐terminus of p21WAF1/CIP1 is a binding site for the C8 α‐subunit of the 20S proteasome

  2001cited by this paper
• Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts.

  2001cited by this paper
• The leucine-rich repeat as a protein recognition motif.

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• A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

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• Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

  2001cited by this paper
• Triggering ubiquitination of a CDK inhibitor at origins of DNA replication

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  2001cited by this paper
• Distinct effects of XBF-1 in regulating the cell cycle inhibitor p27(XIC1) and imparting a neural fate.

  2000cited by this paper
• Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex

  2000cited by this paper
• Conjugation of Nedd8 to CUL1 Enhances the Ability of the ROC1-CUL1 Complex to Promote Ubiquitin Polymerization*

  2000cited by this paper
• Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination.

  2000cited by this paper
• Interaction between ubiquitin–protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

  1999cited by this paper
• Cell-Free Degradation of p27kip1, a G1 Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome

  1999cited by this paper
• Identification of novel F-box proteins in Xenopus laevis.

  1999cited by this paper
• Evolving ideas about cyclins.

  1999cited by this paper
• p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina.

  1999cited by this paper
• p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27.

  1999cited by this paper
• Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.

  1999cited by this paper
• SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

  1999cited by this paper
• p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

  1999cited by this paper
• Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen.

  1998cited by this paper
• Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis.

  1998cited by this paper
• Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1.

  1998cited by this paper
• A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.

  1997cited by this paper
• Cyclin E-CDK2 is a regulator of p27Kip1.

  1997cited by this paper
• Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.

  1997cited by this paper
• F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.

  1997cited by this paper
• Phosphorylation‐dependent degradation of the cyclin‐dependent kinase inhibitor p27Kip1

  1997cited by this paper
• Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.

  1996cited by this paper
• Cell cycle control by Xenopus p28Kix1, a developmentally regulated inhibitor of cyclin-dependent kinases.

  1996cited by this paper
• SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

  1996cited by this paper
• Structure of the C-Terminal Region of p21 Complexed with Human PCNA

  1996cited by this paper
• Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

  1996cited by this paper
• p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

  1995cited by this paper
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  1995cited by this paper
• Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.

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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• p21 is a universal inhibitor of cyclin kinases

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• Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins.

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  1987cited by this paper
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• A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription.

  1982cited by this paper

• Ubiquitin-mediated proteolysis in Xenopus extract.

  2016cites this paper
• Ubiquitin-mediated proteolysis in Xenopus extract

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• aPKC Phosphorylates p27Xic1, Providing a Mechanistic Link between Apicobasal Polarity and Cell-Cycle Control

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  2013cites this paper
• The F-box Protein FBXO44 Mediates BRCA1 Ubiquitination and Degradation*

  2012cites this paper
• Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases.

  2011influential citation
• The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis

  2010cites this paper
• The CRL4Cdt2 Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA

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