Identification of Endocannabinoids and Related Compounds in Human Fat Cells

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Obesity

• Publication date

  2007-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/oby.2007.581PMID 17426318
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes

  2009cited by this paper
• Effect of PEA on LPS inflammatory action in human adipocytes.

  2006cited by this paper
• The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Cell Proliferation and Increases Markers of Adipocyte Maturation in Cultured Mouse 3T3 F442A Preadipocytes

  2006cited by this paper
• Cannabinoid receptors regulate Ca2+ signals and insulin secretion in pancreatic β-cell

  2006cited by this paper
• Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol.

  2006cited by this paper
• Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.

  2006cited by this paper
• Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes

  2006cited by this paper
• Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell.

  2006cited by this paper
• Adiponectin Receptors in Human Adipose Tissue: Effects of Obesity, Weight Loss, and Fat Depots

  2006cited by this paper
• The CB1 receptor antagonist rimonabant reverses the diet‐induced obesity phenotype through the regulation of lipolysis and energy balance

  2005cited by this paper
• The anti‐obesity effect of rimonabant is associated with an improved serum lipid profile

  2005cited by this paper
• The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

  2005cited by this paper
• Adipose tissues as an ancestral immune organ: Site‐specific change in obesity

  2005cited by this paper
• Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility.

  2005cited by this paper
• Surface protein expression between human adipose tissue-derived stromal cells and mature adipocytes

  2005cited by this paper
• Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study.

  2005cited by this paper
• The search for the palmitoylethanolamide receptor.

  2005cited by this paper
• Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways.

  2005cited by this paper
• Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.

  2005cited by this paper
• The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide

  2005cited by this paper
• Fat cells: afferent and efferent messages define new approaches to treat obesity.

  2005influential reference
• Activation of the peripheral endocannabinoid system in human obesity.

  2005cited by this paper
• Fatty acid amide hydrolase controls mouse intestinal motility in vivo.

  2005cited by this paper
• The endocannabinoid signalling system: biochemical aspects.

  2005cited by this paper
• Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: review of the available pre-clinical data, and first human studies.

  2005cited by this paper
• Leptin in Immunology1

  2005cited by this paper
• Endocannabinoid control of food intake and energy balance

  2005cited by this paper
• Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha).

  2004cited by this paper
• Oleoylethanolamide Stimulates Lipolysis by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor α (PPAR-α)*

  2004cited by this paper
• CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

  2004cited by this paper
• Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase.

  2003cited by this paper
• Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

  2003cited by this paper
• The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones.

  2003cited by this paper
• Section IV: Lipid Modulators of Islet Function Update on Adipocyte Hormones Regulation of Energy Balance and Carbohydrate/Lipid Metabolism

  2003cited by this paper
• Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice.

  2003cited by this paper
• The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells.

  2003cited by this paper
• The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.

  2003cited by this paper
• Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats

  2003cited by this paper
• Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol

  2002cited by this paper
• Adiponectin--its role in metabolism and beyond.

  2002cited by this paper
• Leptin-regulated endocannabinoids are involved in maintaining food intake

  2001cited by this paper
• Effects of leptin on the differentiation and metabolism of human adipocytes

  2001cited by this paper
• Adipocyte and erythrocyte plasma membrane phospholipid composition and hyperinsulinemia: a study in nondiabetic and diabetic obese women

  2000cited by this paper
• Biosynthesis and turnover of anandamide and other N‐acylethanolamines in peritoneal macrophages

  1999cited by this paper
• Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors

  1999cited by this paper
• Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period

  1999cited by this paper
• Endocannabinoids.

  1998cited by this paper
• Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes*

  1997cited by this paper
• Identification of targets of leptin action in rat hypothalamus.

  1996cited by this paper
• Biosynthesis of an Endogenous Cannabinoid Precursor in Neurons and its Control by Calcium and cAMP

  1996cited by this paper
• Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

  1996influential reference
• Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine.

  1996cited by this paper
• Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells (*)

  1995cited by this paper
• 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.

  1995cited by this paper
• An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).

  1995cited by this paper
• An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (*)

  1995cited by this paper
• Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.

  1995cited by this paper
• Formation and inactivation of endogenous cannabinoid anandamide in central neurons

  1994cited by this paper
• Are dietary saturated, monounsaturated, and polyunsaturated fatty acids deposited to the same extent in adipose tissue of rabbits?

  1993cited by this paper
• Differential mobilization of white adipose tissue fatty acids according to chain length, unsaturation, and positional isomerism.

  1993cited by this paper
• Isolation and structure of a brain constituent that binds to the cannabinoid receptor.

  1992cited by this paper
• Are the n-3 fatty acids from dietary fish oil deposited in the triglyceride stores of adipose tissue?

  1990cited by this paper
• N-acylated glycerophospholipids and their derivatives.

  1990cited by this paper
• Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol.

  1986cited by this paper
• Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes.

  1985cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• The interplay of leptin and the peripheral endocannabinoid system in energy homeostasis and obesity; modulation by linoleic acid and exercise

  2025cites this paper
• Effect of Palmitoylethanolamide Compared to a Placebo on the Gut Microbiome and Biochemistry in an Overweight Adult Population: A Randomised, Placebo Controlled, Double-Blind Study

  2024cites this paper
• The circulating and central endocannabinoid system in obesity and weight loss

  2024cites this paper
• A UHPLC–MS/MS method for determination of N-acylethanolamines in cerebrospinal fluid

  2024cites this paper
• n-3 polyunsaturated fatty acids in phospholipid or triacylglycerol form attenuate nonalcoholic fatty liver disease via mediating cannabinoid receptor 1/adiponectin/ceramide pathway.

  2023cites this paper
• Lipid endocannabinoids in energy metabolism, stress and developmental programming.

  2021cites this paper
• AGMO Inhibitor Reduces 3T3-L1 Adipogenesis

  2021cites this paper
• Endocannabinoids Produced by White Adipose Tissue Modulate Lipolysis in Lean but Not in Obese Rodent and Human

  2021cites this paper
• Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism

  2021cites this paper
• Lipids in the transcriptional regulation of adipocyte differentiation and metabolism

  2020cites this paper
• Endocannabinoids: the lipid effectors of metabolic regulation in health and disease

  2020cites this paper
• Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus

  2019cites this paper
• Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects

  2019cites this paper
• The endocannabinoid system in canine Steroid-Responsive Meningitis-Arteritis and Intraspinal Spirocercosis

  2018cites this paper
• Regulation of Adipose Tissue Metabolism by the Endocannabinoid System.

  2018cites this paper
• Oleic acid-derived oleoylethanolamide: A nutritional science perspective.

  2017cites this paper
• Impact of Dietary Fats on Brain Functions

  2017cites this paper
• Overactivation of the endocannabinoid system alters the anti-lipolytic action of insulin 1 in mouse adipose tissue 2 3

  2017cites this paper
• Overactivation of the endocannabinoid system alters the antilipolytic action of insulin in mouse adipose tissue.

  2017cites this paper
• Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function.

  2017cites this paper
• Central and peripheral control of food intake

  2017cites this paper
• The Fat Side of the Endocannabinoid System: Role of Endocannabinoids in the Adipocyte

  2016cites this paper
• Hydroxytyrosol Inhibits Cannabinoid CB1 Receptor Gene Expression in 3T3‐L1 Preadipocyte Cell Line

  2016cites this paper
• A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women

  2016cites this paper
• Effects of activation of endocannabinoid system on myocardial metabolism.

  2016cites this paper
• The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects.

  2016cites this paper
• An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue.

  2015cites this paper
• Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis

  2015cites this paper
• [Role of endocannabinoid 2-arachidonoylglycerol in the physiology and pathophysiology of the cardiovascular system].

  2014cites this paper
• REVIEW OF LITERATURE OF RIMONABANT HYDROCHLORIDE 1

  2014cites this paper
• Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes

  2014cites this paper
• Hypoxia and adipocyte physiology: implications for adipose tissue dysfunction in obesity.

  2014cites this paper
• The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer's Disease

  2014cites this paper
• Liquid chromatography-tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells.

  2013cites this paper
• Hypoxia and adipose tissue function and dysfunction in obesity.

  2013cites this paper
• Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function.

  2013cites this paper
• Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma.

  2013cites this paper
• Endocannabinoids in obesity: brewing up the perfect metabolic storm?

  2013cites this paper
• Therapeutical potential of CB₂ receptors in immune-related diseases.

  2013cites this paper
• Exogenous Delta9-Tetrahydrocannabinol Influences Circulating Endogenous Cannabinoids in Humans

  2013cites this paper
• Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice

  2012cites this paper
• n-3 Fatty acid derived endocannabinoids: a new link between fish oil and inflammation

  2012cites this paper
• The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke.

  2012cites this paper
• INTRAUTERINE GROWTH RESTRICTION INDUCED ALTERATIONS IN THE ENDOCANNABINOID SYSTEM OF RATS INT RAUTERINE GROWTH RESTRICTION INDUCED AL T ERA TI ONS IN TH E EN DOCANNA BINOID SYSTEM OF RAT S

  2012cites this paper
• Adipose stem cell-based soft tissue regeneration

  2012cites this paper
• New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance

  2012cites this paper
• Investigations of the endocannabinoid system in adipose tissue: effects of obesity/ weight loss and treatment options.

  2011cites this paper
• Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas.

  2011cites this paper
• The Human Serum Metabolome

  2011cites this paper
• STABILITY INDICATING HPLC METHOD FOR DETERMINATION OF RIMONABANT

  2011cites this paper
• A Novel Stability Indicating Liquid Chromatographic Assay for the Estimation of Rimonabant Hydrochloride in Bulk and Pharmaceutical Dosage Forms

  2011cites this paper
• Peripheral effects of the endocannabinoid system in energy homeostasis: Adipose tissue, liver and skeletal muscle

  2011cites this paper
• The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans

  2011cites this paper
• Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation

  2011cites this paper
• A novel validated RP-HPLC method development for the estimation of rimonabant hydrochloride in bulk

  2011cites this paper
• The endocannabinoid system: its roles in energy balance and potential as a target for obesity treatment.

  2010cites this paper
• Palmitoylethanolamide, adipocytes and obesity-related inflammatory states

  2010cites this paper
• Resolvins, protectins and other lipid mediators in obesity-associated inflammatory disorders

  2010cites this paper
• Endocannabinoids and Their Role in Fatty Liver Disease

  2010cites this paper
• Biomarkers of Endocannabinoid System Activation in Severe Obesity

  2010cites this paper
• Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity.

  2010cites this paper
• The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health.

  2010cites this paper
• Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes

  2010cites this paper
• Quantitative estimation of riluzole in human plasma by LC-ESI-MS/MS and its application to a bioequivalence study

  2010cites this paper
• International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

  2010cites this paper
• The endocannabinoid system: critical for the neurotrophic action of psychotropic drugs

  2010cites this paper
• Impact du système endocannabinoïdien sur la physiologie de l'obésité : effets de l'antagonisme des récepteurs CB1 sur le métabolisme glucido-lipidique de la souris obèse

  2010cites this paper
• The role of the endocannabinoid system in lipogenesis and fatty acid metabolism.

  2009cites this paper
• Role of lipid-derived mediators in skeletal muscle insulin resistance.

  2009cites this paper
• The dysregulation of the endocannabinoid system in diabesity—a tricky problem

  2009cites this paper
• Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle

  2009cites this paper
• Anti‐inflammatory Effect of Palmitoylethanolamide on Human Adipocytes

  2009influential citation
• Endocannabinoid system: An overview of its potential in current medical practice.

  2009cites this paper
• RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF RIMONABANT HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

  2009cites this paper
• Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients.

  2009cites this paper
• Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis

  2009cites this paper
• Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation

  2009cites this paper
• The endocannabinoid system: a promising target for the management of type 2 diabetes.

  2009cites this paper
• Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism.

  2009cites this paper
• The endocannabinoid system, Obesity, and insulin resistance

  2008cites this paper
• The endocannabinoid system in obesity and type 2 diabetes

  2008cites this paper
• Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

  2008cites this paper
• Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes

  2008cites this paper
• Novel aspects of adipocyte-induced skeletal muscle insulin resistance

  2008cites this paper
• The EC System and the HPA Axis

  2008cites this paper
• The EC System in the Adipose Tissue and Endocrine Pancreas

  2008cites this paper
• Il sistema endocannabinoide e il controllo del metabolismo energetico: fisiologia e fisiopatologia

  2008cites this paper
• Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through eNOS expression in white adipocytes

  2008cites this paper
• The endocannabinoid system in obesity and type 2 diabetes.

  2008cites this paper
• Inhibitors of cannabinoid receptors and glucose metabolism

  2008cites this paper
• Endocannabinoids: Some Like it Fat (and Sweet Too)

  2008cites this paper
• Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High‐fat Diet

  2008cites this paper
• Peripheral Metabolic Effects of Endocannabinoids and Cannabinoid Receptor Blockade

  2008cites this paper
• The cannabinoid CB1 receptor is expressed in pancreatic delta-cells.

  2008cites this paper
• THE ENDOCANNABINOID SYSTEM IN ADIPOSE TISSUE

  2008cites this paper
• The endocannabinoid system in the regulation of cardiometabolic risk factors.

  2007cites this paper
• Cannabinoid-1 receptor antagonists in type-2 diabetes.

  2007cites this paper
• Role and regulation of acylethanolamides in energy balance: focus on adipocytes and β‐cells

  2007influential citation
• Endocannabinoid system and pathophysiology of adipogenesis: current management of obesity.

  2007cites this paper
• Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players

  2007cites this paper