Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Microbiology and immunology

• Publication date

  2004-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1348-0421.2004.tb03500.xPMID 15031527
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Toll-like receptors.

  2005cited by this paper
• Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.

  2003cited by this paper
• LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

  2003cited by this paper
• Toll-like receptors.

  2003cited by this paper
• TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β*

  2003cited by this paper
• Double-stranded RNA Signaling by Toll-like Receptor 3 Requires Specific Tyrosine Residues in Its Cytoplasmic Domain*

  2003cited by this paper
• Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice*

  2003cited by this paper
• TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

  2003cited by this paper
• Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

  2003cited by this paper
• Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

  2003cited by this paper
• IKKε and TBK1 are essential components of the IRF3 signaling pathway

  2003cited by this paper
• Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.

  2003cited by this paper
• IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

  2003cited by this paper
• Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells 1

  2003cited by this paper
• Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR*

  2003cited by this paper
• Toll-like Receptor Signaling*

  2003cited by this paper
• TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

  2003cited by this paper
• Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

  2003cited by this paper
• Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection

  2003cited by this paper
• Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells

  2003cited by this paper
• Toll-like receptors: key mediators of microbe detection.

  2002cited by this paper
• IRF3 mediates a TLR3/TLR4-specific antiviral gene program.

  2002cited by this paper
• A universal role for MyD88 in TLR/IL-1R-mediated signaling.

  2002cited by this paper
• Of mice and men: species variations of Toll-like receptor expression.

  2002cited by this paper
• Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

  2002cited by this paper
• Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling1

  2002cited by this paper
• Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.

  2002cited by this paper
• The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

  2002cited by this paper
• Viruses and interferon: a fight for supremacy

  2002cited by this paper
• Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

  2001cited by this paper
• Toll-like receptors: critical proteins linking innate and acquired immunity

  2001cited by this paper
• Mycoplasma fermentans Lipoprotein M161Ag-Induced Cell Activation Is Mediated by Toll-Like Receptor 2: Role of N-Terminal Hydrophobic Portion in its Multiple Functions1

  2001cited by this paper
• Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

  2001cited by this paper
• TIRAP: an adapter molecule in the Toll signaling pathway

  2001cited by this paper
• Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells1

  2001cited by this paper
• IRF family of transcription factors as regulators of host defense.

  2001cited by this paper
• Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes1

  2001cited by this paper
• IFNs activate toll-like receptor gene expression in viral infections

  2001cited by this paper
• Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice.

  2001cited by this paper
• Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

  2001cited by this paper
• Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

  2000cited by this paper
• Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

  2000cited by this paper
• The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense.

  2000cited by this paper
• Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.

  2000cited by this paper
• Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

  2000cited by this paper
• Toll-like receptors in the induction of the innate immune response

  2000cited by this paper
• Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells1

  2000cited by this paper
• The smallest known non-avian theropod dinosaur

  2000cited by this paper
• Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA

  1999cited by this paper
• A family of human receptors structurally related to Drosophila Toll.

  1998cited by this paper
• CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species.

  1998cited by this paper
• A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

  1997cited by this paper
• Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.

  1995cited by this paper
• Functional role of type I and type II interferons in antiviral defense.

  1994cited by this paper
• Interferon induction and its dependence on the primary and secondary structure of poly(inosinic acid).poly(cytidylic acid).

  1978cited by this paper
• Structural requirements of the rI n -rC n complex for induction of human interferon.

  1972cited by this paper
• Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.

  1967cited by this paper
• Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum.

  1967cited by this paper
• Studies on the mechanism of action of interferon.

  1961cited by this paper

• Virulence of fowl adenovirus (FAdV) serotype 4 strains impacts cell proliferation and immune response of primary chicken-embryo intestinal epithelial cells

  2025cites this paper
• Network pharmacology and experimental verification in vivo reveal the mechanism of Zhushao Granules against ulcerative colitis

  2025cites this paper
• Mutual regulations between Toxoplasma gondii and type I interferon

  2024cites this paper
• Exploring the Role of Inflammatory Genes and Immune Infiltration in Vestibular Schwannomas Pathogenesis

  2024cites this paper
• Identifying signatures of positive selection in human populations from North Africa

  2023cites this paper
• The emerging role of exosomes in innate immunity, diagnosis and therapy

  2023cites this paper
• Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review.

  2023cites this paper
• Determining the Protective Efficacy of Toll-Like Receptor Ligands to Minimize H9N2 Avian Influenza Virus Transmission in Chickens

  2023cites this paper
• Role of toll‐like receptors in the pathogenesis of COVID‐19: Current and future perspectives

  2023cites this paper
• LncRNA-mRNA integrated profiling analysis in response to white spot syndrome virus in hepatopancreas in Penaeus japonicus.

  2022cites this paper
• Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring

  2022cites this paper
• Sertoli Cell Immune Regulation: A Double-Edged Sword

  2022cites this paper
• Refinement of water-filtered infrared A (wIRA) irradiations of in vitro acute and persistent chlamydial infections.

  2022cites this paper
• TLR3 polymorphisms in HIV infected individuals naïve to ART.

  2022cites this paper
• Development of a Novel Multi-Epitope Vaccine Against Crimean-Congo Hemorrhagic Fever Virus: An Integrated Reverse Vaccinology, Vaccine Informatics and Biophysics Approach

  2021cites this paper
• Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain

  2021cites this paper
• Association of interleukin-18 genotypes (−607C > A) and (−137 G > C) with the hepatitis B virus disease progression to hepatocellular carcinoma

  2021cites this paper
• PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia

  2021cites this paper
• Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico

  2020cites this paper
• Exosomes: Potential Therapies for Disease via Regulating TLRs

  2020cites this paper
• MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by Δ9-tetrahydrocannabinol and cannabidiol in human macrophages.

  2020cites this paper
• Cloning And Analysis Of The Nile Tilapia Toll-Like Receptor Type 5 Mrna Sequence

  2020cites this paper
• Pathological damage, immune-related protein expression, and oxidative stress in lungs of BALB/c mice induced by haze PM2.5 biological components exposure

  2020cites this paper
• Chicken toll-like receptors and their significance in immune response and disease resistance

  2019cites this paper
• Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy

  2019cites this paper
• [Development of drugs on the basis of high-polymeric double-stranded RNA for antiviral and antitumor therapy].

  2019cites this paper
• Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus

  2018cites this paper
• Water Filtered Infrared A and Visible Light (wIRA/VIS) Irradiation Reduces Chlamydia trachomatis Infectivity Independent of Targeted Cytokine Inhibition

  2018cites this paper
• Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

  2017cites this paper
• Identification, characterization and expression analysis of TLR5 in the mucosal tissues of turbot (Scophthalmus maximus L.) following bacterial challenge

  2017cites this paper
• Differential expression of toll-like receptors in the human placenta across early gestation.

  2016cites this paper
• Immunity-Related Protein Expression and Pathological Lung Damage in Mice Poststimulation with Ambient Particulate Matter from Live Bird Markets

  2016cites this paper
• Impact of the Type I Interferon Receptor on the Global Gene Expression Program During the Course of Dendritic Cell Maturation Induced by Polyinosinic Polycytidylic Acid

  2016cites this paper
• Compositions antitumorales et methodes

  2015cites this paper
• Antiviral effects of Jinxin oral liquid against respiratory syncytial virus infection in the BALB/c mice model.

  2015cites this paper
• TLR3 Plays Significant Roles against HBV-Associated HCC

  2015cites this paper
• Specific Oligopeptides in Fermented Soybean Extract Inhibit NF-κB-Dependent iNOS and Cytokine Induction by Toll-Like Receptor Ligands

  2014cites this paper
• Brain Interleukin-1β and the Intrinsic Receptor Antagonist Control Peripheral Toll-Like Receptor 3-Mediated Suppression of Spontaneous Activity in Rats

  2014cites this paper
• Elevated toll-like receptor 3 inhibits pancreatic β-cell proliferation through G1 phase cell cycle arrest.

  2013cites this paper
• cytotoxicity and cytokine production in human NK cells p38 MAPK activation controls the TLR3-mediated up-regulation of

  2013cites this paper
• Polyinosinic:polycytidylic acid loading onto different generations of PAMAM dendrimer-coated magnetic nanoparticles

  2013influential citation
• Integrated stress response-altered pro-inflammatory signals in mucosal immune-related cells

  2013cites this paper
• Comparative expression of Toll-like receptors and inflammatory cytokines in pigs infected with different virulent porcine reproductive and respiratory syndrome virus isolates

  2013cites this paper
• Immunostimulatory properties of Toll-like receptor ligands in chickens.

  2013cites this paper
• IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner

  2013cites this paper
• Increased CXCL10 expression in nasal fibroblasts from patients with refractory chronic rhinosinusitis and asthma.

  2013cites this paper
• An Overview of the Immune Evasion Strategies Adopted by Different Viruses with Special Reference to Classical Swine Fever Virus

  2013cites this paper
• Association between TLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users.

  2013cites this paper
• An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo.

  2013cites this paper
• ZNAĈAJ ODREDJIVANJA INTERLEUKINA-6 I FAKTORA NEKROZE TUMORA KOD OBOLELIH OD SHIZOFRENIJE

  2013cites this paper
• Experimental immunology Cloning and analysis of Nile tilapia Toll-like receptors type-3 mRNA

  2013cites this paper
• Toll-like receptor ligands enhance the protective effects of vaccination against porcine reproductive and respiratory syndrome virus in swine.

  2013cites this paper
• Le virus herpès simplex de type 1 et la réponse immunitaire cérébrale innée

  2013cites this paper
• Prenatal exposure to lipopolysaccharide results in neurodevelopmental damage that is ameliorated by zinc in mice.

  2012cites this paper
• Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines.

  2012cites this paper
• Toll-Like Receptor 3 Expressing Tumor Parenchyma and Infiltrating Natural Killer Cells in Hepatocellular Carcinoma Patients

  2012cites this paper
• Molecular cloning and characterization of toll-like receptor 3, and inductive expression analysis of type I IFN, Mx and pro-inflammatory cytokines in the Indian carp, rohu (Labeo rohita)

  2012cites this paper
• Structural insights of rohu TLR3, its binding site analysis with fish reovirus dsRNA, poly I:C and zebrafish TRIF.

  2012cites this paper
• Contributions of the host immune response to control and protection upon infection with a neurovirulent alphavirus

  2012cites this paper
• Activation of innate immune defense mechanisms contributes to polyomavirus BK-associated nephropathy.

  2012cites this paper
• Poly I:C-Induced Tumor Cell Apoptosis Mediated by Pattern-Recognition Receptors

  2012cites this paper
• Sensing herpes: more than toll

  2012cites this paper
• The Immunogenetics of asthma exacerbations in children

  2011cites this paper
• Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

  2011cites this paper
• Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro.

  2011cites this paper
• The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients

  2011cites this paper
• Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis

  2011cites this paper
• Libération extra-cellulaire de microARN et de complexes nucléo-protéiques par les cellules infectées par EBV : rôle des exosomes et d’autres transporteurs

  2011cites this paper
• CpG oligodeoxynucleotide and double-stranded RNA synergize to enhance nitric oxide production and mRNA expression of inducible nitric oxide synthase, pro-inflammatory cytokines and chemokines in chicken monocytes

  2011cites this paper
• Adjuvants and delivery systems in veterinary vaccinology: current state and future developments

  2011cites this paper
• Interleukin-6 expression was regulated by epigenetic mechanisms in response to influenza virus infection or dsRNA treatment.

  2011cites this paper
• Modulators of Toll-like Receptors -7 and -8

  2011cites this paper
• The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity

  2011cites this paper
• Near Term Prospects for Broad Spectrum Amelioration of Cancer

  2010cites this paper
• Avian toll-like receptors

  2010cites this paper
• Molecular basis for an attenuated cytoplasmic dsRNA response in human embryonic stem cells

  2010cites this paper
• Interferon-α vermittelte Immuntherapie in der Friend Retrovirus Infektion

  2010cites this paper
• Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells

  2010cites this paper
• Recognition of nucleic acids by Toll-like receptors and development of immunomodulatory drugs.

  2010cites this paper
• Synthetic double-stranded RNA oligonucleotides are immunostimulatory for chicken spleen cells

  2010cites this paper
• Poly I:C induced microglial activation impairs motor activity in adult rats.

  2010cites this paper
• Attenuation of the influenza virus sickness behavior in mice deficient in Toll-like receptor 3.

  2010cites this paper
• Pattern recognition receptors of innate immunity and their application to tumor immunotherapy

  2010cites this paper
• Title Poly ( I : C ) induces intense expression of c-IAP 2 and cooperateswith an IAP inhibitor in induction of apoptosis in cancer cells

  2010cites this paper
• The host immunologic response to West Nile encephalitis virus.

  2009cites this paper
• The role of zinc in preventing fetal dysmorphology and brain injury mediated by maternal exposure to infection in pregnancy.

  2009cites this paper
• Toll-Like Receptors: Novel Molecular Targets for Antiviral Immunotherapy

  2009cites this paper
• A review of the fetal brain cytokine imbalance hypothesis of schizophrenia.

  2009cites this paper
• Potential adjuvantic properties of innate immune stimuli

  2009cites this paper
• Maternal dietary zinc supplementation prevents aberrant behaviour in an object recognition task in mice offspring exposed to LPS in early pregnancy.

  2009cites this paper
• Expression of Toll-like receptor mRNA and cytokines in pigs infectedwith porcine reproductive and respiratory syndrome virus

  2009cites this paper
• NUCLEIC ACID AND RECOMBINANT PROTEIN BASED STRATEGIES TO ENHANCE SHRIMP IMMUNE RESPONSE

  2009cites this paper
• Mechanisms of Evasion of the Type I Interferon Antiviral Response by Flaviviruses

  2009cites this paper
• The role of Toll-like receptors in regulating the immune response against respiratory syncytial virus.

  2009cites this paper
• Pattern recognition by Toll-like receptors.

  2009cites this paper
• Toll-Like Receptor 3 Has No Critical Role During Early Immune Response of Human Monocyte-Derived Dendritic Cells After Infection with the Human Cytomegalovirus Strain TB40E

  2009cites this paper
• Expression of Toll-like receptor mRNA and cytokines in pigs infected with porcine reproductive and respiratory syndrome virus.

  2009cites this paper
• Predicting Novel Features of Toll-Like Receptor 3 Signaling in Macrophages

  2009influential citation
• TLR3 gene polymorphisms and liver disease manifestations in chronic hepatitis C

  2009cites this paper
• Role of Toll-like receptor responses for sepsis pathogenesis.

  2008cites this paper