Local hyperthermia in head and neck cancer: mechanism, application and advance

Local hyperthermia (HT), particularly in conjunction with surgery, radiotherapy and chemotherapy was useful for the treatment of human malignant tumors including head and neck cancer. However, at present it suffered from many limitations such as thermal dose control, target treatment regions and discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials to local HT of head and neck cancer that basically take advantage of various targeting approaches. The aim of this paper is to give a brief review of the mechanism, methods and clinical applications of local HT in head and neck cancer, mainly focusing on photothermal therapy (PTT) and nanoparticle-based hyperthermia.

• Publication year

  2016

• Venue

  OncoTarget

• Publication date

  2016-06-30

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.18632/oncotarget.10350PMID 27384678PMCID 5302995
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Status quo and directions in deep head and neck hyperthermia

  2016cited by this paper
• Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles

  2016cited by this paper
• Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications.

  2016cited by this paper
• Quantification of laser local hyperthermia induced by gold plasmonic nanoparticles

  2015cited by this paper
• Quality and comfort in head and neck hyperthermia: A redesign according to clinical experience and simulation studies

  2015cited by this paper
• Ultra-small superparamagnetic iron oxide mediated magnetic hyperthermia in treatment of neck lymph node metastasis in rabbit pyriform sinus VX2 carcinoma

  2015cited by this paper
• Multimodal Image-Guided Surgical and Photodynamic Interventions in Head and Neck Cancer: From Primary Tumor to Metastatic Drainage

  2015cited by this paper
• A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy

  2015cited by this paper
• Thermosensitive, near-infrared-labeled nanoparticles for topotecan delivery to tumors.

  2015cited by this paper
• Near-infrared Light Activatable Multimodal Gold Nanostructures Platform: An Emerging Paradigm for Cancer Therapy.

  2015cited by this paper
• Radiofrequency-triggered tumor-targeting delivery system for theranostics application.

  2015cited by this paper
• Macrophages as nanoparticle delivery vectors for photothermal therapy of brain tumors.

  2015cited by this paper
• Phototheranostic Porphyrin Nanoparticles Enable Visualization and Targeted Treatment of Head and Neck Cancer in Clinically Relevant Models

  2015cited by this paper
• Local tumour hyperthermia as immunotherapy for metastatic cancer

  2014cited by this paper
• Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti‐CTLA‐4 Therapy to Inhibit Cancer Metastasis

  2014cited by this paper
• Microwave hyperthermia in conjunction with radiotherapy in superficial tumours: correlation of thermal parameters with tumour regression.

  2014cited by this paper
• An MRI-Sensitive, Non-Photobleachable Porphysome Photothermal Agent

  2014cited by this paper
• Rose-bengal-conjugated gold nanorods for in vivo photodynamic and photothermal oral cancer therapies.

  2014cited by this paper
• Combined concurrent photodynamic and gold nanoshell loaded macrophage‐mediated photothermal therapies: An in vitro study on squamous cell head and neck carcinoma

  2014cited by this paper
• P(EO-co-LLA) functionalized Fe3O4@mSiO2 nanocomposites for thermo/pH responsive drug controlled release and hyperthermia.

  2014cited by this paper
• An MRI-sensitive, non-photobleachable porphysome photothermal agent.

  2014cited by this paper
• Targeted Iron-Oxide Nanoparticle for Photodynamic Therapy and Imaging of Head and Neck Cancer

  2014influential reference
• A Quixotic journey with a fairy tale ending? A brief history of hyperthermia.

  2014cited by this paper
• Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells

  2014cited by this paper
• [The effect of immunotherapy and hyperthermia for advanced or recurrent head and neck cancer - 74 clinical cases].

  2014cited by this paper
• Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors.

  2014cited by this paper
• Biological impact of superparamagnetic iron oxide nanoparticles for magnetic particle imaging of head and neck cancer cells

  2014cited by this paper
• Radiotherapy in conjunction with superficial and intracavitary hyperthermia for the treatment of solid tumors: survival and thermal parameters

  2013cited by this paper
• Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA

  2013cited by this paper
• Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment.

  2013cited by this paper
• [Conservative thermochemoradiation therapy of locally advanced laryngeal cancer].

  2013cited by this paper
• Gold Nanorods Based Platforms for Light-Mediated Theranostics

  2013cited by this paper
• Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles.

  2013cited by this paper
• Correlation between the expression of Id-1 and hyperthermia-associated molecules in oral squamous cell carcinoma

  2013influential reference
• Long-term efficacy of microwave hyperthermia combined with chemoradiotherapy in treatment of nasopharyngeal carcinoma with cervical lymph node metastases.

  2013cited by this paper
• T-cell receptor repertoires of tumor-infiltrating lymphocytes after hyperthermia using functionalized magnetite nanoparticles.

  2013cited by this paper
• A cell-targeted photodynamic nanomedicine strategy for head and neck cancers.

  2013cited by this paper
• Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells

  2013cited by this paper
• The combination of silencing BAG3 and inhibition of the JNK pathway enhances hyperthermia sensitivity in human oral squamous cell carcinoma cells.

  2013cited by this paper
• Thermochemoradiotherapy using superselective intra-arterial infusion for N3 cervical lymph node metastases of tongue cancer.

  2013cited by this paper
• Magnetic Nanoparticle-Based Hyperthermia for Head & Neck Cancer in Mouse Models

  2012cited by this paper
• Cancer immunotherapy using NKG2D and DNAM-1 systems.

  2012cited by this paper
• Thermochemoradiation therapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases.

  2012cited by this paper
• DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy

  2012cited by this paper
• In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

  2012cited by this paper
• Real-time phase-contrast imaging of photothermal treatment of head and neck squamous cell carcinoma: an in vitro study of macrophages as a vector for the delivery of gold nanoshells

  2012cited by this paper
• Nanoparticles for cancer therapy using magnetic forces.

  2012cited by this paper
• Chemokine-Containing Exosomes Are Released from Heat-Stressed Tumor Cells via Lipid Raft-Dependent Pathway and Act as Efficient Tumor Vaccine

  2011cited by this paper
• Development of microwave antennas for thermal therapy.

  2011cited by this paper
• Gene networks related to the cell death elicited by hyperthermia in human oral squamous cell carcinoma HSC-3 cells.

  2011cited by this paper
• Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents.

  2011cited by this paper
• Chemoradiation with hyperthermia in the treatment of head and neck cancer

  2010cited by this paper
• Hyperthermia-induced apoptosis in Tca8113 cells is inhibited by heat shock protein 27 through blocking phospholipid scramblase 3 phosphorylation

  2010cited by this paper
• Targeted hyperthermia using metal nanoparticles.

  2010cited by this paper
• NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

  2010cited by this paper
• Thermochemotherapy of lower lip squamous cell carcinoma without metastases: an experience of 31 cases.

  2010cited by this paper
• Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of randomized trial.

  2010cited by this paper
• Radio hyperthermia for re-treatment of superficial tumours

  2009cited by this paper
• Nanoshell-enabled photothermal cancer therapy: impending clinical impact.

  2008cited by this paper
• Clinical applications of magnetic nanoparticles for hyperthermia

  2008influential reference
• Plasmonic photothermal therapy (PPTT) using gold nanoparticles

  2008cited by this paper
• Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes

  2008cited by this paper
• Protein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.

  2008cited by this paper
• Hyperthermia: a potent enhancer of radiotherapy.

  2007cited by this paper
• Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2.

  2007cited by this paper
• The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy

  2007cited by this paper
• Cellular level loading and heating of superparamagnetic iron oxide nanoparticles.

  2007cited by this paper
• Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: a novel concept of “heat-controlled necrosis” with heat shock protein expression

  2006cited by this paper
• Monocyte-derived DC Primed With TLR Agonists Secrete IL-12p70 in a CD40-dependent Manner Under Hyperthermic Conditions

  2006cited by this paper
• Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells

  2006cited by this paper
• Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles.

  2006cited by this paper
• A phase I study to study arsenic trioxide with radiation and hyperthermia in advanced head and neck cancer

  2006cited by this paper
• Hyperthermia today: electric energy, a new opportunity in cancer treatment.

  2006cited by this paper
• Immunotargeted nanoshells for integrated cancer imaging and therapy.

  2005cited by this paper
• Randomized trial of hyperthermia and radiation for superficial tumors.

  2005cited by this paper
• More Efficient Induction of HLA-A*0201-Restricted and Carcinoembryonic Antigen (CEA)–Specific CTL Response by Immunization with Exosomes Prepared from Heat-Stressed CEA-Positive Tumor Cells

  2005cited by this paper
• Trends in incidence and prognosis for head and neck cancer in the United States: A site‐specific analysis of the SEER database

  2005cited by this paper
• Hyperthermia Enhances CD95-Ligand Gene Expression in T Lymphocytes1

  2005cited by this paper
• Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells.

  2004cited by this paper
• Evidence for an S-Phase checkpoint regulating DNA replication after heat shock: a review

  2004cited by this paper
• Thermoradiotherapy combined with adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines.

  2003cited by this paper
• The cellular and molecular basis of hyperthermia.

  2002cited by this paper
• Different Efficiency of Heat Shock Proteins (HSP) to Activate Human Monocytes and Dendritic Cells: Superiority of HSP601

  2002cited by this paper
• Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells1

  2002cited by this paper
• [Clinical result of thermochemoradiotherapy for advanced head and neck cancer].

  2001cited by this paper
• Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature.

  2001cited by this paper
• Hyperthermia in oncology.

  2001cited by this paper
• Radiation therapy, cisplatin and hyperthermia in combination in management of patients with recurrent carcinomas of the head and neck with metastatic cervical lymph nodes.

  1999cited by this paper
• First radiotherapy of human metastatic brain tumors delivered by a computerized tomography scanner (CTRx).

  1999cited by this paper
• Can mild hyperthermia improve tumour oxygenation?

  1997cited by this paper
• Thermochemotherapy for cancer of the tongue using magnetic induction hyperthermia (implant heating system: IHS).

  1996cited by this paper
• Preoperative thermochemotherapy of oral cancer using magnetic induction hyperthermia (Implant Heating System: IHS).

  1996cited by this paper
• Response of 145 spontaneous canine head and neck tumours to radiation versus radiation plus microwave hyperthermia: results of a randomized phase III clinical study.

  1995cited by this paper
• Treatment of cancer of the head and neck

  1995cited by this paper
• Simulation of bidirectional ultrasound hyperthermia treatments of neck tumours.

  1994cited by this paper
• IFN-gamma down-regulates Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo.

  1992cited by this paper
• Analysis and testing of a concentric ring applicator for ultrasound hyperthermia with clinical results.

  1991cited by this paper
• Division-associated and division-independent hyperthermic cell death: comparison with other cytotoxic agents.

  1991cited by this paper
• Effects of Hyperthermia, Radiotherapy and Thermoradiotherapy on Tumor Microvascular Permeability

  1990cited by this paper
• Experimental studies of the effects of local hyperthermia on blood flow, oxygen pressure and pH in tumors

  1988cited by this paper

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  2026cites this paper
• Towards a Less Invasive Treatment for Head and Neck Cancer: Initial Evaluation of Gold Nanoparticle-Mediated Photothermal Therapy

  2025cites this paper
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  2025cites this paper
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• The Emerging Role of Nanoparticles Combined with Either Radiotherapy or Hyperthermia in Head and Neck Cancer: A Current Review

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• Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID

  2025cites this paper
• Computational Design of a Thermal Applicator for Brain Hyperthermia Controlled by Capacitor Positioning in Loop Coils

  2025cites this paper
• Temperature-Dependent Effects of Induced Hyperthermia, Including Whole-Body Hyperthermia, on the Hallmarks of Cancer: A Systematic Review

  2025cites this paper
• Advances in screening hyperthermic nanomedicines in 3D tumor models

  2024cites this paper
• Spontaneous regression of head and neck squamous cell carcinoma: a systematic review and meta-analysis of case reports

  2024influential citation
• Polydopamine Coated Nonspherical Magnetic Nanocluster for Synergistic Dual Magneto-Photothermal Cancer Therapy

  2024cites this paper
• Mild hyperthermia upregulates PD-L1 in the tumor microenvironment and enhances antitumor efficacy of PD-L1 blockade in murine squamous cell carcinoma

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• Numerical Study of Optical and Thermal Response of Gold and Silver Coated Copper Nanostructures for Hyperthermia

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• Effect of magnetic anisotropy and interaction on spatial focused hyperthermia for rotating and oscillating fields

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• Neoadjuvant Hyperthermia Combined with Hybrid Nanoarchitectures Enhances Chemoradiotherapy Efficacy in Head and Neck Carcinoma.

  2024cites this paper
• The therapeutic efficacy of different configuration nano-polydopamine drug carrier systems with photothermal synergy against head and neck squamous cell carcinoma

  2024cites this paper
• Use of Cold Atmospheric Plasma in the Treatment of Squamous Cell Carcinoma: in vitro Effects and Clinical Application in Feline Tumors - A Pilot Study.

  2023cites this paper
• Dual-stimuli responsive smart nanoprobe for precise diagnosis and synergistic multi-modalities therapy of superficial squamous cell carcinoma

  2023cites this paper
• Diagnostic potential of serum HSP90 beta for HNSCC and its therapeutic prognosis after local hyperthermia therapy

  2023cites this paper
• Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia

  2023cites this paper
• Hyperthermia maintains death receptor expression and promotes TRAIL-induced apoptosis.

  2023cites this paper
• Pharmacological impact of microRNAs in head and neck squamous cell carcinoma: Prevailing insights on molecular pathways, diagnosis, and nanomedicine treatment

  2023cites this paper
• Polydopamine-Based Material and Their Potential in Head and Neck Cancer Therapy—Current State of Knowledge

  2023influential citation
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  2022cites this paper
• Manganese Single-Atom Nanostructures for Highly Efficient Tumor Therapy

  2022cites this paper
• Insights into Nanomedicine for Head and Neck Cancer Diagnosis and Treatment

  2022influential citation
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  2022cites this paper
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  2022cites this paper
• Local hyperthermia inhibits proliferation of hepatocellular carcinoma cells via regulating the Hippo signaling pathway

  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
• Promising role of hyperthermia concurrent with radiation in the treatment of head-and-neck cancers: A retrospective comparative study

  2019cites this paper
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  2019cites this paper
• Microscale direct measurement of localized photothermal heating in tissue-mimetic hydrogels

  2019cites this paper
• Biomaterials and Nanoparticles for Hyperthermia Therapy

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level

  2018cites this paper
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  2018cites this paper
• Activatable Hybrid Nanotheranostics for Tetramodal Imaging and Synergistic Photothermal/Photodynamic Therapy

  2018cites this paper
• Sapphire capillary interstitial irradiators for laser medicine

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• RADIOFREQUENCY ABLATION TECHNIQUE FOR DEEP SEATED BRAIN TUMORS

  2018cites this paper
• Tissue segmentation of head and neck for hyperthermia treatment planning

  2018influential citation
• Susceptibility of epithelial tumour cell lines to hyperthermia

  2018cites this paper
• Magnetically responsive biopolymeric multilayer films for local hyperthermia.

  2017cites this paper
• PRELIMINARY TESTS OF LOCAL HYPERTHERMIA BASED ON INDUCTIVELY HEATED TUMOR BED IMPLANT

  2017cites this paper
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  2017cites this paper
• Thermal Therapy Modalities for CancerTreatment: A Review and Future Perspectives

  2017cites this paper
• [Mechanism of heat shock protein 90 for regulating 26S proteasome in hyperthermia].

  2016cites this paper