Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biopolymers

• Publication date

  2010-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/bip.21428PMID 20577995
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Two New Solanapyrone Analogues from the Endophytic Fungus Nigrospora sp. YB‐141 of Azadirachta indica

  2009cited by this paper
• Acyltransferase mediated polyketide release from a fungal megasynthase.

  2009cited by this paper
• The biosynthetic logic of polyketide diversity.

  2009cited by this paper
• Fungal type I polyketide synthases.

  2009cited by this paper
• Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan.

  2009cited by this paper
• Introduction to polyketide biosynthesis.

  2009cited by this paper
• Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

  2009cited by this paper
• Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

  2008cited by this paper
• Thioesterase-like role for fungal PKS-NRPS hybrid reductive domains.

  2008cited by this paper
• The chemical versatility of natural-product assembly lines.

  2008cited by this paper
• Synthetic Strategy of Nonreducing Iterative Polyketide Synthases and the Origin of the Classical “Starter‐Unit Effect”

  2008cited by this paper
• Intramolecular cyclizations of polyketide biosynthesis: mining for a "Diels-Alderase"?

  2008cited by this paper
• Identification of the specific sequence recognized by Penicillium citrinum MlcR, a GAL4-type transcriptional activator of ML-236B (compactin) biosynthetic genes.

  2008cited by this paper
• Solanapyrone analogues from a Hawaiian fungicolous fungus.

  2007cited by this paper
• Molecular basis of cytochalasan biosynthesis in fungi: gene cluster analysis and evidence for the involvement of a PKS-NRPS hybrid synthase by RNA silencing.

  2007cited by this paper
• Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis.

  2007cited by this paper
• Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets.

  2007cited by this paper
• Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.

  2006cited by this paper
• 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans.

  2006cited by this paper
• Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase

  2006cited by this paper
• Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes.

  2006cited by this paper
• Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

  2006cited by this paper
• Equisetin biosynthesis in Fusarium heterosporum.

  2005cited by this paper
• Compactin—a review

  2004cited by this paper
• Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization.

  2004cited by this paper
• Chaetoglobosins Q, R, and T, three further new metabolites from Chaetomium globosum.

  2004cited by this paper
• Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

  2003cited by this paper
• Effect of increased dosage of the ML-236B (compactin) biosynthetic gene cluster on ML-236B production in Penicillium citrinum

  2002cited by this paper
• Trichosetin, a Novel Tetramic Acid Antibiotic Produced in Dual Culture of Trichoderma harzianum and Catharanthus roseus Callus

  2002cited by this paper
• Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum

  2002cited by this paper
• Functional analysis of mlcR, a regulatory gene for ML-236B (compactin) biosynthesis in Penicillium citrinum

  2002cited by this paper
• Biosynthetic studies of the tetramic acid antibiotic trichosetin

  2002cited by this paper
• Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus.

  2001cited by this paper
• Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules.

  2001cited by this paper
• Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases

  2000cited by this paper
• Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

  2000cited by this paper
• Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.

  1999cited by this paper
• Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis.

  1999cited by this paper
• Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene.

  1999cited by this paper
• Solanapyrones e-g, antialgal metabolites produced by a marine fungus

  1998cited by this paper
• Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase

  1998cited by this paper
• Biosynthesis of phytotoxins from Alternaria solani

  1997cited by this paper
• Putative Diels-Alder-Catalyzed Cyclization during the Biosynthesis of Lovastatin.

  1996cited by this paper
• Enzymatic activity catalysing exo-selective Diels–Alder reaction in solanapyrone biosynthesis

  1995cited by this paper
• First Direct Evidence in Biological Diels-Alder Reaction of Incorporation of Diene-Dienophile Precursors in the Biosynthesis of Solanapyrones

  1994cited by this paper
• Useful approach to find the plausible biosynthetic precursors of secondary metabolites using P-450 inhibitors: postulated intermediates of chaetoglobosin A

  1992cited by this paper
• Biosynthetic study of chaetoglobosin A: origins of the oxygen and hydrogen atoms, and indirect evidence for biological Diels–Alder reaction

  1992cited by this paper
• New plausible precursors of chaetoglobosin a accumulated by treatment of chaetomium subaffine with cytochrome P-450 inhibitors

  1991cited by this paper
• Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.

  1990cited by this paper
• Chickpea blight: Production of the phytotoxins solanapyrones A and C by Ascochyta rabiei

  1989cited by this paper
• Structure and absolute configuration of solanapyrone D: a new clue to the occurrence of biological Diels–Alder reactions

  1989cited by this paper
• Biosynthesis of solanapyrone A, a phytotoxin of Alternaria solani

  1989cited by this paper
• Synthesis of (±)-solanapyrone A

  1987cited by this paper
• Chaetoglobosins, Cytotoxic 10-(Indol-3-yl)-[13] cytochalasans from Chaetomium spp. IV. 13C-Nuclear Magnetic Resonance Spectra and Their Application to a Biosynthetic Study

  1983cited by this paper
• Microbial hydroxylation of ML-236B (compactin) and monacolin K (MB-530B).

  1983cited by this paper
• Solanapyrones A, B and C, phytotoxic metabolites from the fungus Alternaria solani

  1983cited by this paper
• Synthesis of the cytochalasin D isoindolone unit: solutions to the problem of regiochemistry in N-benzoylpyrrolinone Diels-Alder reactions

  1982cited by this paper
• Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

  1980cited by this paper
• Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase.

  1980cited by this paper
• Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

  1979cited by this paper
• ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium.

  1976cited by this paper
• Antibiotic Produced by Fusarium equiseti NRRL 5537

  1974cited by this paper
• Nomenclature of a class of biologically active mould metabolites: the cytochalasins, phomins, and zygosporins.

  1973cited by this paper
• Methods in Enzymology

  1968cited by this paper
• Isolation and structure of Phomin

  1966cited by this paper
• Studies in relation to Biosynthesis. I. Some possible routes to derivatives of Orcinol and Phloroglucinol

  1953cited by this paper

• A hybrid assembly mechanism employs nonreducing polyketide synthase-like logic for partially reduced polyketide formation

  2026cites this paper
• Metabologenomic profiling of the endemic Australian fungus Aspergillus luteorubrus

  2026cites this paper
• Chemodiversity of Penicillium isolated from alpine and arctic environments, including ten new species.

  2025cites this paper
• Elicitation-Induced Enhancement of Lovastatin and Pigment Production in Monascus purpureus C322

  2025cites this paper
• Komagataella phaffii: a versatile platform for the production of value-added chemicals

  2025cites this paper
• From chaos to tranquillity: a modern approach to the identification, nomenclature and phylogeny of Aspergillus, Penicillium and other Eurotiales, including an updated accepted species list.

  2025cites this paper
• The Role of Enoyl Reductase in the Monacolin K Biosynthesis Pathway in Monascus spp.

  2025cites this paper
• Equisetin protects from atherosclerosis in vivo by binding to STAT3 and inhibiting its activity.

  2024cites this paper
• Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles.

  2024cites this paper
• The chemical ecology and physiological functions of type I polyketide natural products: the emerging picture.

  2024cites this paper
• Discovery, Biosynthesis, Total Synthesis, and Biological Activities of Solanapyrones: [4 + 2] Cycloaddition-Derived Polyketides of Fungal Origin

  2024cites this paper
• Metabolomic insights into Monascus ‐fermented rice products: Implications for monacolin K content and nutritional optimization

  2024cites this paper
• Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle

  2023cites this paper
• Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.

  2023cites this paper
• The biosynthetic logic and enzymatic machinery of approved fungi-derived pharmaceuticals and agricultural biopesticides.

  2023cites this paper
• Genomic Based Analysis of the Biocontrol Species Trichoderma harzianum: A Model Resource of Structurally Diverse Pharmaceuticals and Biopesticides

  2023cites this paper
• Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer

  2023cites this paper
• Identification of the polyketide synthase gene responsible for the synthesis of tanzawaic acids in Penicillium steckii IBWF104-06.

  2022cites this paper
• Characterization of stereospecific enoyl reductase ActVI-ORF2 for pyran ring formation in the actinorhodin biosynthesis of Streptomyces coelicolor A3(2).

  2022cites this paper
• Genus-wide analysis of Fusarium polyketide synthases reveals broad chemical potential.

  2022cites this paper
• Simultaneous detection of monacolins and citrinin of angkak produced by Monascus purpureus strains using Liquid Chromatography-Mass Spectrometry (LC-MS/MS)

  2021cites this paper
• New Trends and Future Opportunities in the Enzymatic Formation of C−C, C−N, and C−O bonds

  2021cites this paper
• Detection of biosynthetic genes of microbially-synthesized secondary metabolites in a contaminated tropical agricultural soil

  2021cites this paper
• Increasing Lovastatin Production by Re-routing the Precursors Flow of Aspergillus terreus via Metabolic Engineering

  2021cites this paper
• Genome mining of secondary metabolites from a marine-derived Aspergillus terreus B12

  2021cites this paper
• Aspergillus terreus Species Complex

  2021cites this paper
• Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products

  2021cites this paper
• Structural basis for the biosynthesis of lovastatin

  2021cites this paper
• Antimicrobial production by strictly anaerobic Clostridium species.

  2020cites this paper
• An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes

  2020cites this paper
• New knowledge about the biosynthesis of lovastatin and its production by fermentation of Aspergillus terreus

  2020cites this paper
• Bacterial-Like Nonribosomal Peptide Synthetases Produce Cyclopeptides in the Zygomycetous Fungus Mortierella alpina

  2020cites this paper
• Construction of Escherichia coli Whole-Cell Biosensors for Statin Efficacy and Production Test

  2020cites this paper
• Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis

  2020cites this paper
• High-Yielding Lovastatin Producer Aspergillus terreus Shows Increased Resistance to Inhibitors of Polyamine Biosynthesis

  2020cites this paper
• Requirement of LaeA for sporulation, pigmentation and secondary metabolism in Chaetomium globosum.

  2020cites this paper
• Current status on the molecular biology of zearalenone: its biosynthesis and molecular detection of zearalenone producing Fusarium species

  2020cites this paper
• Genetic diversity of polyketide synthases and nonribosomal peptide synthetases in fungi

  2020cites this paper
• Divergence of metabolites in three phylogenetically close Monascus species (M. pilosus, M. ruber, and M. purpureus) based on secondary metabolite biosynthetic gene clusters

  2020cites this paper
• Lost in Translation: Challenges with Heterologous Expression of Lichen Polyketide Synthases

  2019cites this paper
• Biotechnological potential and applications of microbial consortia.

  2019cites this paper
• Improved lovastatin production by inhibiting (+)-geodin biosynthesis in Aspergillus terreus.

  2019cites this paper
• Fungal Highly-Reducing Polyketide Synthases and Associated Natural Products

  2019cites this paper
• A polyketide synthase gene cluster associated with the sexual reproductive cycle of the banana pathogen, Pseudocercospora fijiensis

  2019cites this paper
• Improved methanol-derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast

  2018cites this paper
• Overexpression of acetyl-CoA carboxylase in Aspergillus terreus to increase lovastatin production.

  2018cites this paper
• Engineered monoculture and co-culture of methylotrophic yeast for de novo production of monacolin J and lovastatin from methanol.

  2018cites this paper
• The architectures of iterative type I PKS and FAS.

  2018cites this paper
• A comprehensive catalogue of polyketide synthase gene clusters in lichenizing fungi

  2018cites this paper
• Engineering of the Filamentous Fungus Penicillium chrysogenum as Cell Factory for Natural Products

  2018cites this paper
• Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin

  2018cites this paper
• Relationship between lichen species composition, secondary metabolites and soil pH, organic matter, and grain characteristics in Manitoba

  2018cites this paper
• Genetic engineering of Penicillium chrysogenum for the reactivation of biosynthetic pathways with potential pharmaceutical value

  2018cites this paper
• Discovery and Characterization of Fungal Natural Product Biosynthetic Pathways

  2018cites this paper
• Chromosome level assembly and secondary metabolite potential of the parasitic fungus Cordyceps militaris

  2017cites this paper
• Fungal volatiles - a survey from edible mushrooms to moulds.

  2017cites this paper
• The Gα1-cAMP signaling pathway controls conidiation, development and secondary metabolism in the taxol-producing fungus Pestalotiopsis microspora.

  2017cites this paper
• Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases.

  2017cites this paper
• Functional analysis of polyketide synthases in the biocontrol fungus Clonosthachys rosea

  2017cites this paper
• A CRE1- regulated cluster is responsible for light dependent production of dihydrotrichotetronin in Trichoderma reesei

  2017cites this paper
• Production of statins by fungal fermentation

  2017cites this paper
• Synthetic biology tools for metabolic engineering of the filamentous fungus Penicillium chrysogenum

  2017cites this paper
• New and Bioactive Compounds from Penicillium concentricum, an Endophytic Fungus of the Liverwort Trichocolea tomentella

  2017cites this paper
• A genomics-guided study of the biosynthesis of microbial secondary metabolites

  2016cites this paper
• Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

  2016cites this paper
• Polyketides in Aspergillus terreus: biosynthesis pathway discovery and application

  2016cites this paper
• Secondary metabolism by industrially improved Penicillium chrysogenum strains

  2016influential citation
• Secondary metabolite production by Penicillium chrysogenum

  2016influential citation
• Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase

  2016cites this paper
• Comparative genomics to explore phylogenetic relationship, cryptic sexual potential and host specificity of Rhynchosporium species on grasses

  2016cites this paper
• Exploitation of Aspergillus terreus for the Production of Natural Statins

  2016cites this paper
• Heterologous gene expression and functional analysis of a type III polyketide synthase from Aspergillus niger NRRL 328.

  2016cites this paper
• Biogenesis of Triterpene Dimers from Orthoquinones Related to Quinonemethides: Theoretical Study on the Reaction Mechanism

  2016cites this paper
• Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain.

  2016cites this paper
• A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.

  2015cites this paper
• Biochemical and Structural Elucidation of Polyketide Synthase and Non-Ribosomal Peptide Synthetase Enzymes Using Novel Pantetheine Analogues

  2015cites this paper
• Aspergillus nidulans as a platform for discovery and characterization of complex biosynthetic pathways

  2015cites this paper
• Investigation of the biosynthesis of lovastatin and cytochalasin E, two fungal polyketides assembled by iterative PKS-NRPS enzymes

  2015cites this paper
• Six‐Membered Rings, and Their Fused Derivatives

  2015cites this paper
• Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction.

  2015cites this paper
• Involvement of Lipocalin‐like CghA in Decalin‐Forming Stereoselective Intramolecular [4+2] Cycloaddition

  2015cites this paper
• Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin.

  2015cites this paper
• High frequency of homologous gene disruption by single-stranded DNA in the taxol-producing fungus Pestalotiopsis microspora

  2015cites this paper
• Genome analysis of Daldinia eschscholtzii strains UM 1400 and UM 1020, wood-decaying fungi isolated from human hosts

  2015cites this paper
• Heterologous production of fungal secondary metabolites in Aspergilli

  2015cites this paper
• Secondary Metabolites of Cyanobacteria and Drug Development

  2015cites this paper
• Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain

  2014cites this paper
• Steps towards the synthetic biology of polyketide biosynthesis

  2014cites this paper
• Title Comparative genomics of the major fungal agents of human and animal Sporotrichosis : Sporothrix schenckii and Sporothrix brasiliensis Permalink

  2014cites this paper
• Recent advances in genome mining of secondary metabolites in Aspergillus terreus

  2014cites this paper
• Comparative genomics of the major fungal agents of human and animal Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis

  2014cites this paper
• Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites

  2014cites this paper
• Analysis of the Protein Domain and Domain Architecture Content in Fungi and Its Application in the Search of New Antifungal Targets

  2014cites this paper
• Comparative genomics of the major agents of human and animal Sporotrichosis : Sporothrix schenckii and Sporothrix

  2014cites this paper
• Biocatalysts for natural product biosynthesis.

  2014cites this paper
• Isolation of Pyrrolocins A–C: cis- and trans-Decalin Tetramic Acid Antibiotics from an Endophytic Fungal-Derived Pathway

  2014cites this paper
• Lovastatin, Compactin, and Related Anticholesterolemic Agents

  2014cites this paper
• Quorum sensing for improved production of industrially useful products from filamentous fungi

  2014cites this paper
• Explorations of caffeic acid derivatives: total syntheses of rufescenolide, yunnaneic acids C and D, and studies toward yunnaneic acids A and B.

  2014cites this paper
• Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts

  2013cites this paper