Leveraging the cortical cholinergic system to enhance attention.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neuropharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neuropharm.2012.06.060PMID 22796110PMCID PMC3445745
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Efficacy and safety of the novel α4β2 neuronal nicotinic receptor partial agonist ABT-089 in adults with attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled crossover study

  2012cited by this paper
• Cholinergic contributions to the cognitive symptoms of schizophrenia and the viability of cholinergic treatments.

  2012cited by this paper
• Layer-Specific Modulation of the Prefrontal Cortex by Nicotinic Acetylcholine Receptors

  2012cited by this paper
• Cognitive Control in Adolescence: Neural Underpinnings and Relation to Self-Report Behaviors

  2011cited by this paper
• Enhanced Control of Attention by Stimulating Mesolimbic–Corticopetal Cholinergic Circuitry

  2011cited by this paper
• Challenges to attention: A continuous arterial spin labeling (ASL) study of the effects of distraction on sustained attention

  2011cited by this paper
• Prompt but inefficient: nicotine differentially modulates discrete components of attention

  2011cited by this paper
• Nicotinic Acetylcholine Receptor β2 Subunits in the Medial Prefrontal Cortex Control Attention

  2011cited by this paper
• Sustained attention in mice: expanding the translational utility of the SAT by incorporating the Michigan Controlled Access Response Port (MICARP).

  2011cited by this paper
• Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging

  2011cited by this paper
• Safety and efficacy of ABT-089 in pediatric attention-deficit/hyperactivity disorder: results from two randomized placebo-controlled clinical trials.

  2011cited by this paper
• Corticogeniculate feedback and visual processing in the primate

  2011cited by this paper
• Deficits in attentional control: cholinergic mechanisms and circuitry-based treatment approaches.

  2011cited by this paper
• Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition

  2011cited by this paper
• Prefrontal β2 Subunit-Containing and α7 Nicotinic Acetylcholine Receptors Differentially Control Glutamatergic and Cholinergic Signaling

  2010cited by this paper
• ABT-594 improves performance in the 5-choice serial reaction time task under conditions of increased difficulty, sub-chronic dosing, and in poorly-performing subjects.

  2010cited by this paper
• The Nicotinic Acetylcholine Receptor α5 Subunit Plays a Key Role in Attention Circuitry and Accuracy

  2010cited by this paper
• Regulation and function of the tonic component of cortical acetylcholine release.

  2010cited by this paper
• Cholinergic Enhancement Increases the Effects of Voluntary Attention but Does Not Affect Involuntary Attention

  2010cited by this paper
• A Subpopulation of Neuronal M4 Muscarinic Acetylcholine Receptors Plays a Critical Role in Modulating Dopamine-Dependent Behaviors

  2010influential reference
• Enhancement of Attentional Performance by Selective Stimulation of α4β2* nAChRs: Underlying Cholinergic Mechanisms

  2010cited by this paper
• Performance effects of nicotine during selective attention, divided attention, and simple stimulus detection: an fMRI study.

  2009cited by this paper
• Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders.

  2009cited by this paper
• M1 agonists as a potential disease-modifying therapy for Alzheimer's disease.

  2009cited by this paper
• Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity

  2009cited by this paper
• A Selective Allosteric Potentiator of the M1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning

  2009cited by this paper
• Effects of acute nicotine on brain function in healthy smokers and non-smokers: Estimation of inter-individual response heterogeneity

  2009cited by this paper
• Attention – oscillations and neuropharmacology

  2009cited by this paper
• nAChR agonist-induced cognition enhancement: integration of cognitive and neuronal mechanisms.

  2009cited by this paper
• The Nucleus Accumbens: A Switchboard for Goal-Directed Behaviors

  2009cited by this paper
• Cholinergic modulation of visual working memory during aging: a parametric PET study.

  2009cited by this paper
• Midbrain dopamine neurons signal preference for advance information about upcoming rewards.

  2009cited by this paper
• Rats and humans paying attention: cross-species task development for translational research.

  2008cited by this paper
• Prospective memory or prospective attention: physiological and pharmacological support for an attentional model.

  2008cited by this paper
• Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health.

  2008cited by this paper
• Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

  2008cited by this paper
• Galantamine for the treatment of cognitive impairments in people with schizophrenia.

  2008cited by this paper
• Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia.

  2008cited by this paper
• Cholinergic enhancement reduces spatial spread of visual responses in human early visual cortex.

  2008cited by this paper
• Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative.

  2008cited by this paper
• Efficacy and Safety of Donepezil in Patients with Schizophrenia or Schizoaffective Disorder: Significant Placebo/Practice Effects in a 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

  2008cited by this paper
• Cholinergic Mediation of Attention

  2008cited by this paper
• Positive effects of nicotine on cognition: the deployment of attention for prospective memory

  2008cited by this paper
• Glutamatergic Contributions to Nicotinic Acetylcholine Receptor Agonist-Evoked Cholinergic Transients in the Prefrontal Cortex

  2008cited by this paper
• Initial phase 2 trial of a nicotinic agonist in schizophrenia.

  2008cited by this paper
• Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition.

  2007cited by this paper
• Prefrontal acetylcholine release controls cue detection on multiple timescales.

  2007cited by this paper
• Neuromodulation by Glutamate and Acetylcholine can Change Circuit Dynamics by Regulating the Relative Influence of Afferent Input and Excitatory Feedback

  2007cited by this paper
• No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia

  2007cited by this paper
• Treating schizophrenia symptoms with an α7 nicotinic agonist, from mice to men

  2007cited by this paper
• Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiative.

  2007cited by this paper
• Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network

  2007influential reference
• Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men.

  2007cited by this paper
• A default mode of brain function: A brief history of an evolving idea

  2007cited by this paper
• Toward a Neuro-Cognitive Animal Model of the Cognitive Symptoms of Schizophrenia: Disruption of Cortical Cholinergic Neurotransmission Following Repeated Amphetamine Exposure in Attentional Task-Performing, but Not Non-Performing, Rats

  2007cited by this paper
• The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability.

  2006cited by this paper
• Attentional Modulation of Thalamic Reticular Neurons

  2006cited by this paper
• Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)

  2006cited by this paper
• More attention must be paid: the neurobiology of attentional effort.

  2006cited by this paper
• Prefrontal Projections to the Thalamic Reticular Nucleus form a Unique Circuit for Attentional Mechanisms

  2006cited by this paper
• M1 receptors play a central role in modulating AD-like pathology in transgenic mice.

  2006cited by this paper
• ABT-089, a neuronal nicotinic receptor partial agonist, for the treatment of attention-deficit/hyperactivity disorder in adults: results of a pilot study.

  2006cited by this paper
• Preclinical research into cognition enhancers.

  2006cited by this paper
• Nicotine Modulates Reorienting of Visuospatial Attention and Neural Activity in Human Parietal Cortex

  2005cited by this paper
• Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I

  2005cited by this paper
• Nicotine effects on adults with attention-deficit/hyperactivity disorder

  2005influential reference
• Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans.

  2005cited by this paper
• Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part II

  2005cited by this paper
• Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in alzheimer's disease

  2005cited by this paper
• Coordination of Voluntary and Stimulus-Driven Attentional Control in Human Cortex

  2005cited by this paper
• Cerebral Cortex doi:10.1093/cercor/bhi079 Augmented Prefrontal Acetylcholine Release during Challenged Attentional Performance

  2005cited by this paper
• Three-dimensional chemoarchitecture of the basal forebrain: spatially specific association of cholinergic and calcium binding protein-containing neurons.

  2005cited by this paper
• Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection.

  2005cited by this paper
• Prefrontal cortical modulation of acetylcholine release in posterior parietal cortex.

  2005cited by this paper
• Evidence for synergistic modulation of early information processing by nicotinic and muscarinic receptors in humans

  2004cited by this paper
• Identification of separable cognitive factors in schizophrenia.

  2004cited by this paper
• Nicotine Improves Sustained Attention in Mice: Evidence for Involvement of the α7 Nicotinic Acetylcholine Receptor

  2004cited by this paper
• Effects of scopolamine and nicotine on human rapid information processing performance

  2004cited by this paper
• Effects of cholinergic enhancement on visual stimulation, spatial attention, and spatial working memory.

  2004influential reference
• Rapid assessment of in vivo cholinergic transmission by amperometric detection of changes in extracellular choline levels

  2004cited by this paper
• Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release.

  2003cited by this paper
• Electrophysiological evidence for the existence of a posterior cortical-prefrontal-basal forebrain circuitry in modulating sensory responses in visual and somatosensory rat cortical areas.

  2003cited by this paper
• Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands

  2003cited by this paper
• Neuroimaging Studies of Attention: From Modulation of Sensory Processing to Top-Down Control

  2003cited by this paper
• Attentional effects of nicotinic agonists in rats.

  2003cited by this paper
• Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

  2003influential reference
• Attention modulates responses in the human lateral geniculate nucleus

  2002cited by this paper
• Control of goal-directed and stimulus-driven attention in the brain

  2002cited by this paper
• Differential cortical acetylcholine release in rats performing a sustained attention task versus behavioral control tasks that do not explicitly tax attention.

  2002cited by this paper
• Cognitive mechanisms of nicotine on visual attention.

  2002cited by this paper
• The modular organization of brain systems. Basal forebrain: the last frontier.

  2002cited by this paper
• Nicotinic receptor subtypes and cognitive function.

  2002cited by this paper
• Effect of nicotine on brain activation during performance of a working memory task

  2001cited by this paper
• Cholinergic dilation of cerebral blood vessels is abolished in M5 muscarinic acetylcholine receptor knockout mice

  2001cited by this paper
• Nicotinic treatment of Alzheimer's disease.

  2001cited by this paper
• Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M1 Muscarinic Acetylcholine Receptor

  2001cited by this paper
• Distinct Changes in Cortical Acetylcholine and Noradrenaline Efflux during Contingent and Noncontingent Performance of a Visual Attentional Task

  2001influential reference
• The cognitive neuroscience of sustained attention: where top-down meets bottom-up.

  2001cited by this paper
• Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task.

  2000cited by this paper
• Sustained Visual Attention Performance-Associated Prefrontal Neuronal Activity: Evidence for Cholinergic Modulation

  2000cited by this paper

• Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment: Associations With Gene Expression, Neurotransmitter Receptor Distribution, and SVM–SHAP Classification

  2026cites this paper
• Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024

  2025cites this paper
• Depression vulnerability involves brain activity and connectivity changes consistent with cholinergic deviancy

  2025cites this paper
• Cognition and modulation of the cholinergic system.

  2025cites this paper
• Evaluating the Efficacy of Chronic Galantamine on Sustained Attention and Cholinergic Neurotransmission in A Pre-Clinical Model of Traumatic Brain Injury

  2024cites this paper
• A Little “Re-Cognition” Goes a Long Way for Pro-Cognitive Therapeutics in Alcohol Studies

  2024cites this paper
• Scopolamine Induced Non-cognitive Effects in the Radial-arm maze: Alleviation by Physostigmine

  2023cites this paper
• Aroma of the essential oil of peppermint reduces aggressive driving behaviour in healthy adults

  2023cites this paper
• Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

  2023cites this paper
• The functional connectivity and neuropsychology underlying mental planning operations: data from the digital clock drawing test

  2022cites this paper
• Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder

  2022cites this paper
• Cell-based serum anticholinergic activity assay and working memory in cognitively healthy older adults before and after scopolamine: An exploratory study

  2022cites this paper
• Modern Approaches to Augmenting the Brain Functions

  2021cites this paper
• Lower cholinergic basal forebrain volumes link with cognitive difficulties in schizophrenia

  2021cites this paper
• Event-related potential (P300): the effects of levetiracetam in cognitive performance

  2020cites this paper
• Oxytocin pathway gene networks in the human brain

  2019cites this paper
• Spaceflight Pharmacology

  2019cites this paper
• Higher availability of α4β2 nicotinic receptors (nAChRs) in dorsal ACC is linked to more efficient interference control

  2019influential citation
• Cholinergic potentiation of visual perception and vision restoration in rodents and humans

  2019cites this paper
• Cholinergic nervous system and glaucoma: From basic science to clinical applications.

  2019cites this paper
• Pupillometry as an Objective Measure of Sustained Attention in Young and Older Listeners

  2019cites this paper
• Verbal learning deficits associated with increased anticholinergic burden are attenuated with targeted cognitive training in treatment refractory schizophrenia patients.

  2019cites this paper
• Imaging Markers of Progression in Parkinson's Disease

  2018cites this paper
• Role of prefrontal cortex and cholinergic modulation in attentional performance in rats

  2018cites this paper
• Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer's Disease.

  2017cites this paper
• Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis study

  2017cites this paper
• Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking

  2017cites this paper
• Recent theoretical, neural, and clinical advances in sustained attention research

  2017cites this paper
• Nicotine Withdrawal and Attentional Deficit Studies Across Species: Conflation With Attentional Dysfunction in Psychiatric Patients

  2017cites this paper
• Method for testing sustained attention in touchscreen operant chambers in rats.

  2017cites this paper
• Alterations in Phase-Related Prefrontal Activation During Cognitive Tasks and Nicotinic α4β2 Receptor Availability in Alzheimer’s Disease

  2016cites this paper
• Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications

  2016cites this paper
• Orienting of visual attention in aging.

  2016cites this paper
• Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease.

  2016cites this paper
• The distribution of muscarinic M1 receptors in the human hippocampus.

  2016cites this paper
• Commentary: Visual Feedback of Tongue Movement for Novel Speech Sound Learning

  2016cites this paper
• Acetylcholinergic Nicotinic Receptors as Pharmacological Targets for Cognitive Enhancement: Emerging Evidence from Psychosis Populations

  2016cites this paper
• rienting of visual attention in aging

  2016cites this paper
• Neurobiological impact of nicotinic acetylcholine receptor agonists: an activation likelihood estimation meta-analysis of pharmacologic neuroimaging studies.

  2015cites this paper
• Physiological and neurobehavioral effects of cholinesterase inhibition in healthy adults.

  2015cites this paper
• The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory.

  2015cites this paper
• The molecular genetic architecture of attention deficit hyperactivity disorder

  2015cites this paper
• The Influence of Levetiracetam in Cognitive Performance in Healthy Individuals: Neuropsychological, Behavioral and Electrophysiological Approach

  2015cites this paper
• Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to N-desmethylclozapine.

  2015cites this paper
• Clozapine improves the orienting of attention in schizophrenia.

  2015cites this paper
• Dementia praecox redux: A systematic review of the nicotinic receptor as a target for cognitive symptoms of schizophrenia

  2015cites this paper
• Cholinergic enhancement of perceptual learning : behavioral, physiological, and neuro-pharmacological study in the rat primary visual cortex

  2015cites this paper
• Do Cholinesterase Inhibitors Act Primarily on Attention Deficit? A Naturalistic Study in Alzheimer's Disease Patients

  2014cites this paper
• Neuronal effects of nicotine during auditory selective attention

  2014cites this paper
• α5-containing nicotinic acetylcholine receptors in animal models of neuropathic pain and their contribution to nicotine-induced analgesia

  2014cites this paper
• Massed sentence repetition training can augment and speed up recovery of speech production deficits in patients with chronic conduction aphasia receiving donepezil treatment

  2014cites this paper
• Cholinergic modulation of the medial prefrontal cortex

  2014cites this paper
• REVIEW brain rhythms and cognitive processing

  2014cites this paper
• The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague-Dawley rats of different ages.

  2014cites this paper
• Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs

  2014cites this paper
• The neural and genetic basis of executive function: attention, cognitive flexibility, and response inhibition.

  2014cites this paper
• Boosting visual cortex function and plasticity with acetylcholine to enhance visual perception

  2014cites this paper
• Effect of acupuncture-like stimulation on cortical cerebral blood flow in aged rats

  2014cites this paper
• Effects of sustained proNGF blockade on attentional capacities in aged rats with compromised cholinergic system.

  2014cites this paper
• An Update of the Classical and Novel Methods Used for Measuring Fast Neurotransmitters During Normal and Brain Altered Function

  2014cites this paper
• Contributions of β2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice

  2014cites this paper
• Disposed to Distraction: Genetic Variation in the Cholinergic System Influences Distractibility But Not Time-on-Task Effects

  2014cites this paper
• Pharmacological enhancement of memory or cognition in normal subjects

  2014influential citation
• Neurobiological impact of nicotinic acetylcho- line receptor agonists: An ALE meta-analysis of pharmacological neuroimaging studies

  2014cites this paper
• APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures

  2013influential citation
• Nicotinic acetylcholine receptors controlling attention: behavior, circuits and sensitivity to disruption by nicotine.

  2013cites this paper
• Hierarchical prediction errors in midbrain and basal forebrain during sensory learning.

  2013cites this paper
• Hierarchical Prediction Errors in Midbrain and Basal Forebrain during Sensory Learning.

  2013cites this paper
• Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in rats.

  2013cites this paper
• Neurosystems: brain rhythms and cognitive processing

  2013cites this paper
• Phasic nicotinic potentiation of frog retinotectal transmission facilitates eliciting of higher activity level of the tectum column.

  2013cites this paper
• Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.

  2013cites this paper