(p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cell

• Publication date

  2013-08-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cell.2013.07.048PMID 23993101
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic control of persister formation in Escherichia coli.

  2013influential reference
• Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin

  2013cited by this paper
• Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

  2012cited by this paper
• Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking

  2012cited by this paper
• Direct binding targets of the stringent response alarmone (p)ppGpp

  2012cited by this paper
• Relacin, a Novel Antibacterial Agent Targeting the Stringent Response

  2012cited by this paper
• Conditional cooperativity in toxin–antitoxin regulation prevents random toxin activation and promotes fast translational recovery

  2012influential reference
• Single-molecule investigations of the stringent response machinery in living bacterial cells

  2011cited by this paper
• Bacterial persistence by RNA endonucleases

  2011influential reference
• Metabolite-Enabled Eradication of Bacterial Persisters by Aminoglycosides

  2011cited by this paper
• Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

  2011cited by this paper
• The RpoS-mediated general stress response in Escherichia coli.

  2011cited by this paper
• Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

  2010influential reference
• Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

  2010cited by this paper
• Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

  2010cited by this paper
• Persister cells.

  2010cited by this paper
• Functional roles for noise in genetic circuits

  2010cited by this paper
• ppGpp Conjures Bacterial Virulence

  2010cited by this paper
• Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.

  2010cited by this paper
• ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria.

  2010cited by this paper
• Phenotypic heterogeneity in mycobacterial stringent response

  2010cited by this paper
• The role of physiological heterogeneity in microbial population behavior.

  2010cited by this paper
• Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses

  2009cited by this paper
• Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of Candida albicans

  2009cited by this paper
• Rep Provides a Second Motor at the Replisome to Promote Duplication of Protein-Bound DNA

  2009cited by this paper
• Ectopic production of VapCs from Enterobacteria inhibits translation and trans‐activates YoeB mRNA interferase

  2009cited by this paper
• Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity

  2008cited by this paper
• Bistability, epigenetics, and bet-hedging in bacteria.

  2008cited by this paper
• Group II Intron Protein Localization and Insertion Sites Are Affected by Polyphosphate

  2008cited by this paper
• Stochasticity and Cell Fate

  2008cited by this paper
• Positive Feedback and Noise Activate the Stringent Response Regulator Rel in Mycobacteria

  2008cited by this paper
• Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria

  2008cited by this paper
• Persister cells, dormancy and infectious disease

  2007cited by this paper
• Two higBA loci in the Vibrio cholerae superintegron encode mRNA cleaving enzymes and can stabilize plasmids

  2006cited by this paper
• Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

  2006cited by this paper
• Increased Persistence in Escherichia coli Caused by Controlled Expression of Toxins or Other Unrelated Proteins

  2006cited by this paper
• Non-inherited antibiotic resistance

  2006cited by this paper
• Persisters: a distinct physiological state of E. coli

  2006cited by this paper
• Growing and Analyzing Static Biofilms

  2006cited by this paper
• Bistability in bacteria

  2006cited by this paper
• Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research.

  2006cited by this paper
• Phenotypic Diversity, Population Growth, and Information in Fluctuating Environments

  2005cited by this paper
• Persister cells and tolerance to antimicrobials.

  2004influential reference
• Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli

  2004influential reference
• Bacterial Persistence as a Phenotypic Switch

  2004cited by this paper
• Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis

  2003cited by this paper
• The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice

  2003cited by this paper
• Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins

  2002cited by this paper
• The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison–antidote system

  2001cited by this paper
• Mechanism of regulation of transcription initiation by ppGpp. I. Effects of ppGpp on transcription initiation in vivo and in vitro.

  2001cited by this paper
• Role of Inorganic Polyphosphate in Promoting Ribosomal Protein Degradation by the Lon Protease in E. coli

  2001cited by this paper
• One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

  2000influential reference
• The Stringent Response of Mycobacterium tuberculosis Is Required for Long-Term Survival

  2000cited by this paper
• Distribution of Bacterial Growth Activity in Flow-Chamber Biofilms

  1999cited by this paper
• Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli *

  1997influential reference
• Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation

  1996cited by this paper
• Direct correlation between overproduction of guanosine 3',5'-bispyrophosphate (ppGpp) and penicillin tolerance in Escherichia coli

  1995cited by this paper
• Genetically altered levels of inorganic polyphosphate in Escherichia coli.

  1994cited by this paper
• An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon.

  1993cited by this paper
• Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli.

  1993cited by this paper
• The polyphosphate kinase gene of Escherichia coli. Isolation and sequence of the ppk gene and membrane location of the protein.

  1992cited by this paper
• Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis

  1991cited by this paper
• Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.

  1991cited by this paper
• The rate of killing of Escherichia coli by beta-lactam antibiotics is strictly proportional to the rate of bacterial growth.

  1986cited by this paper
• DNA determinants of rRNA synthesis in E. coli: growth rate dependent regulation, feedback inhibition, upstream activation, antitermination.

  1986cited by this paper
• hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis

  1983cited by this paper
• Control of rRNA and tRNA syntheses in Escherichia coli by guanosine tetraphosphate

  1982cited by this paper
• Simple downshift and resulting lack of correlation between ppGpp pool size and ribonucleic acid accumulation

  1975cited by this paper
• Stringent control of protein synthesis in E. coli.

  1974cited by this paper
• Biochemical Bases for the Antimetabolite Action of l-Serine Hydroxamate

  1971cited by this paper
• Formation of ppGpp in a relaxed and stringent strain of Escherichia coli during diauxie lag.

  1971cited by this paper
• TREATMENT OF STAPHYLOCOCCAL INFECTIONS WITH PENICILLIN BY INTERMITTENT STERILISATION

  1944cited by this paper

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• Bacterial Persister Cells and Development of Antibiotic Resistance in Chronic Infections: An Update

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• Recent Advances in Bacterial Persistence Mechanisms

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• Probing transient memory of cellular states using single-cell lineages

  2023cites this paper
• Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation

  2023cites this paper
• Toxin-antitoxin systems in bacterial pathogenesis.

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• A novel toxin–antitoxin system swpAB alters gene expression patterns and reduces virulence expression in enterohemorrhagic Escherichia coli

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• A Shift in Perspective: A Role for the Type I Toxin TisB as Persistence-Stabilizing Factor

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• A fluctuation-based approach to infer kinetics and topology of cell-state switching

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• Pathogenesis of Bacterial Infections and Bacterial Persistence

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• (p)ppGpp and Its Role in Bacterial Persistence: New Challenges

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