Advances in the role of oxytocin receptors in human parturition.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2017-07-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mce.2017.01.034PMID 28119132
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor

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• The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G(αi) signalling.

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• Exogenous oxytocin modulates human myometrial microRNAs.

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• Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues.

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• Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study

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• The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor.

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• microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-kappaB by targeting CARD10 and COPS8 in gastric cancer

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• microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

  2012cited by this paper
• Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells.

  2012cited by this paper
• MicroRNA-146a modulates TGF-β1-induced phenotypic differentiation in human dermal fibroblasts by targeting SMAD4

  2012cited by this paper
• Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes

  2012cited by this paper
• Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization.

  2012cited by this paper
• Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes*

  2011cited by this paper
• Labor and Inflammation Increase the Expression of Oxytocin Receptor in Human Amnion1

  2011cited by this paper
• Integrative Physiology/Experimental Medicine MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function

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• NF-κB regulates a cassette of immune/inflammatory genes in human pregnant myometrium at term

  2010cited by this paper
• miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor

  2010cited by this paper
• Past, present and future of vasopressin and oxytocin receptor oligomers, prototypical GPCR models to study dimerization processes.

  2010cited by this paper
• miR-146a suppresses invasion of pancreatic cancer cells.

  2010cited by this paper
• Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.

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• miR‐200 Regulates PDGF‐D‐Mediated Epithelial–Mesenchymal Transition, Adhesion, and Invasion of Prostate Cancer Cells

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• A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

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• The effect of mechanical stretch on cyclooxygenase type 2 expression and activator protein-1 and nuclear factor-kappaB activity in human amnion cells.

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• MicroRNA regulation of cyclooxygenase-2 during embryo implantation

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• beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

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• Specific PGF2α receptor (FP) antagonism and human uterine contractility in vitro

  2005cited by this paper
• Human Myometrial Gene Expression Before and During Parturition1

  2005cited by this paper
• Specific PGF(2alpha) receptor (FP) antagonism and human uterine contractility in vitro.

  2005cited by this paper
• Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2.

  2004cited by this paper
• Homo‐ and Hetero‐Dimeric Complex Formations of the Human Oxytocin Receptor

  2004influential reference
• Roles of G‐protein‐coupled receptor dimerization

  2004cited by this paper
• Possible role of the protein kinase C/CPI‐17 pathway in the augmented contraction of human myometrium after gestation

  2003cited by this paper
• Extracellular signal-regulated kinase 1/2 activation by myometrial oxytocin receptor involves Galpha(q)Gbetagamma and epidermal growth factor receptor tyrosine kinase activation.

  2003cited by this paper
• The role of prostaglandins in the initiation of parturition.

  2003cited by this paper
• The effects of inhibiting Rho-associated kinase with Y-27632 on force and intracellular calcium in human myometrium

  2001cited by this paper
• Oxytocin and its Receptor in the Process of Parturition

  2001cited by this paper
• Effect of Oxytocin Receptor Blockade on Rat Myometrial Responsiveness to Prostaglandin F2α1

  2000cited by this paper
• Prostaglandin E2-dependent production of latent matrix metalloproteinase-9 in cultures of human fetal membranes

  2000cited by this paper
• Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

  2000cited by this paper
• Effect of oxytocin receptor blockade on rat myometrial responsiveness to prostaglandin f(2)(alpha).

  2000cited by this paper
• Up-regulation of p21- and RhoA-activated protein kinases in human pregnant myometrium.

  2000cited by this paper
• Prostaglandin E(2)-dependent production of latent matrix metalloproteinase-9 in cultures of human fetal membranes.

  2000cited by this paper
• Activation of FP Prostanoid Receptor Isoforms Leads to Rho-mediated Changes in Cell Morphology and in the Cell Cytoskeleton*

  1999cited by this paper
• Up-regulation of oxytocin receptors in non-pregnant rat myometrium by isoproterenol: effects of steroids.

  1999cited by this paper
• Oxytocin activates mitogen-activated protein kinase and up-regulates cyclooxygenase-2 and prostaglandin production in human myometrial cells.

  1999influential reference
• Effect of oxytocin receptor and beta2-adrenoceptor blockade on myometrial oxytocin receptors in parturient rats.

  1999cited by this paper
• Sex, parturition and motherhood without oxytocin?

  1998cited by this paper
• Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy.

  1998cited by this paper
• The role of N-terminal glycosylation in the human oxytocin receptor.

  1997cited by this paper
• Relationships among sex steroids, oxytocin, and their receptors in the rat uterus during late gestation and at parturition.

  1996cited by this paper
• Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.

  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• The effect of the oxytocin antagonist atosiban on preterm uterine activity in the human.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Oxytocin antagonist inhibitory effect on the rat and baboon uterus may be overcome by prostaglandins.

  1994cited by this paper
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  1993cited by this paper
• Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition.

  1993cited by this paper
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  1993cited by this paper
• Role of Oxytocin in the Regulation of Uterine Activity During Pregnancy and in the Initiation of Labor

  1993cited by this paper
• Comparison of Plasma Oxytocin and Catecholamine Concentrations With Uterine Activity in Pregnant Rhesus Monkeys

  1992cited by this paper
• Molecular size characterization of oxytocin receptors in rabbit amnion.

  1992cited by this paper
• Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women.

  1991cited by this paper
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  1991cited by this paper
• Effects of inactivation of oxytocin receptor and inhibition of prostaglandin synthesis on uterine oxytocin receptor and gap junction formation and labor in the rat.

  1991cited by this paper
• Comparison of plasma oxytocin and catecholamine concentrations with uterine activity in pregnant rhesus monkeys.

  1991cited by this paper
• Human myometrium during pregnancy contains and responds to V1 vasopressin receptors as well as oxytocin receptors.

  1990cited by this paper
• Inhibition of spontaneous uterine contractions during the last trimester in pregnant baboons by an oxytocin antagonist.

  1990cited by this paper
• Photoaffinity labelling of the oxytocin receptor in plasma membranes from rat mammary gland

  1989cited by this paper
• Changes in plasma of PGF2α and PGI2 metabolites at and after delivery at term

  1989cited by this paper
• Changes in plasma levels of PGF2 alpha and PGI2 metabolites at and after delivery at term.

  1989cited by this paper
• Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study

  1988cited by this paper
• Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study

  1987cited by this paper
• Changes in the synthesis and metabolism of prostaglandins by human fetal membranes and decidua at labor.

  1985cited by this paper
• Study of oxytocin receptor: II. oxytocin and prostaglandin F2 alpha receptors in human myometria and amnion-decidua complex during pregnancy and labor.

  1984cited by this paper
• Deduced amino acid sequence from the bovine oxytocin–neurophysin I precursor cDNA

  1983cited by this paper
• Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor.

  1982cited by this paper
• Plasma oxytocin concentrations in men, nonpregnant women, and pregnant women before and during spontaneous labor.

  1981cited by this paper
• Induction of labor with low-dose prostaglandin F2 alpha and oxytocin.

  1980cited by this paper
• Induction of labor with low-dose prostaglandin F2α and oxytocin

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• The separate uterotonic and prostaglandin-releasing actions of oxytocin. Evidence and comparison with angiotensin and methacholine in the isolated rat uterus.

  1980cited by this paper
• Oxytocin receptors: triggers for parturition and lactation?

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