IL-1 Enhances T Cell-Dependent Antibody Production Through Induction of CD40 Ligand and OX40 on T Cells1

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Immunology

• Publication date

  2001-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.167.1.90PMID 11418636
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

  2000cited by this paper
• Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells

  2000cited by this paper
• CD134L Engagement Enhances Human B Cell Ig Production: CD154/CD40, CD70/CD27, and CD134/CD134L Interactions Coordinately Regulate T Cell-Dependent B Cell Responses1

  2000cited by this paper
• Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

  2000cited by this paper
• Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions.

  1999cited by this paper
• OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection.

  1999cited by this paper
• The absence of IL-6 does not affect Th2 cell development in vivo, but does lead to impaired proliferation, IL-2 receptor expression, and B cell responses.

  1999cited by this paper
• Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling.

  1999cited by this paper
• Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).

  1999cited by this paper
• CD4+ T cell responses to CD40-deficient APCs: defects in proliferation and negative selection apply only with B cells as APCs.

  1999cited by this paper
• Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.

  1998cited by this paper
• Interleukin 6 Influences Germinal Center Development and Antibody Production via a Contribution of C3 Complement Component

  1998cited by this paper
• Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

  1998cited by this paper
• Arrest of B lymphocyte terminal differentiation by CD40 signaling: mechanism for lack of antibody-secreting cells in germinal centers.

  1998cited by this paper
• Interleukin-1 receptor antagonist: role in biology.

  1998cited by this paper
• OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors.

  1998cited by this paper
• CD40 and CD154 in cell-mediated immunity.

  1998cited by this paper
• Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses.

  1998cited by this paper
• Enhanced Th2‐like responses in IL‐1 type 1 receptor‐deficient mice

  1998cited by this paper
• Lymphotoxin-α (LTα) Supports Development of Splenic Follicular Structure That Is Required for IgG Responses

  1997cited by this paper
• Structure and Function of Interleukin-1β Converting Enzyme

  1997cited by this paper
• B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.

  1997cited by this paper
• Structure and function of interleukin-1 beta converting enzyme.

  1997cited by this paper
• Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

  1997cited by this paper
• Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.

  1997cited by this paper
• Interleukin-1.

  1997cited by this paper
• Copyright © 1997, American Society for Microbiology Lethal Tuberculosis in Interleukin-6-Deficient Mutant Mice

  1997cited by this paper
• CD28/B7 system of T cell costimulation.

  1996cited by this paper
• The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response

  1996influential reference
• Effect of L-Thyroxine Administration on Antithyroid Antibody Levels, Lipid Profile, and Thyroid Volume in Patients with Hashimoto's Thyroiditis

  1996cited by this paper
• Biologic basis for interleukin-1 in disease.

  1996cited by this paper
• Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans

  1996cited by this paper
• Affinity maturation without germinal centres in lymphotoxin-α-deficient mice

  1996cited by this paper
• Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals.

  1996cited by this paper
• Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response

  1996cited by this paper
• Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.

  1996cited by this paper
• Anti-CD40 monoclonal antibody induces the proliferation of murine B cells as a B-cell mitogen through a distinct pathway from receptors for antigens or lipopolysaccharide.

  1995cited by this paper
• The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.

  1994cited by this paper
• Mice deficient for the CD40 ligand.

  1994cited by this paper
• Humoral immune responses in CD40 ligand-deficient mice

  1994cited by this paper
• Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

  1994cited by this paper
• Influence of the antigen delivery system on immunoglobulin isotype selection and cytokine production in response to influenza A nucleoprotein.

  1993cited by this paper
• Cytokines in Health and Disease

  1992cited by this paper
• Interleukin-1 and interleukin-1 antagonism.

  1991cited by this paper
• IL-1 as adjuvant. Role of T cells in the augmentation of specific antibody production by recombinant human IL-1 alpha.

  1989cited by this paper
• Interleukin‐1

  1987cited by this paper
• The adjuvanticity of interleukin 1 in vivo.

  1983cited by this paper
• The use of the enzyme-linked immunosorbent assay (ELISA) for the detection and quantification of specific antibody from cell cultures.

  1979cited by this paper

• Intradermal injection of human sweat enhances production of specific IgG against antigens solved in the sweat

  2025cites this paper
• Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses

  2025cites this paper
• Germinal Center B cells provide essential IL-1β signals to TFH cells via canonical NLRP3 inflammasome activity post influenza infection

  2025cites this paper
• Incorporating immune cell surrogates into a full-thickness tissue equivalent of human skin to characterize dendritic cell activation

  2024cites this paper
• The Role of TNF Receptor-Associated Factor 5 in the Formation of Germinal Centers by B Cells During the Primary Phase of the Immune Response in Mice

  2024cites this paper
• Interleukin-1 regulates follicular T cells during the germinal center reaction

  2024cites this paper
• Persistent transcriptional changes in cardiac adaptive immune cells following myocardial infarction: New evidence from the re-analysis of publicly available single cell and nuclei RNA-sequencing data sets.

  2024cites this paper
• Differential host responses to COVID-19: Unraveling the complexity.

  2024cites this paper
• Elevated CD4+ T Cell Senescence Associates with Impaired Immune Responsiveness in Severe COVID-19

  2024cites this paper
• Review of T cell proliferation regulatory factors in treatment and prognostic prediction for solid tumors

  2023cites this paper
• Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3

  2023cites this paper
• Molecular Pathways in the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.

  2023cites this paper
• A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation

  2023cites this paper
• CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

  2023cites this paper
• Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin

  2021cites this paper
• Interleukin-1 as Innate Mediator of T Cell Immunity

  2021cites this paper
• Atlantic Salmon Pre-smolt Survivors of Renibacterium salmoninarum Infection Show Inhibited Cell-Mediated Adaptive Immune Response and a Higher Risk of Death During the Late Stage of Infection at Lower Water Temperatures

  2020cites this paper
• Polymorphism in the IL-1β promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax.

  2020cites this paper
• Alternatively activated macrophages; a double-edged sword in allergic asthma

  2020cites this paper
• Immunogenicity of biologic agents in juvenile idiopathic arthritis: a systematic review and meta-analysis

  2019cites this paper
• Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses

  2019cites this paper
• Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells

  2019cites this paper
• Effect of 50-Hz Magnetic Fields on Serum IL-1β and IL-23 and Expression of BLIMP-1, XBP-1, and IRF-4

  2019cites this paper
• Exploiting vita-PAMPs in vaccines.

  2018cites this paper
• The Role of Interleukin-1 Beta in Mediating LPS-Induced Reverse Transendothelial Migration of Intimal Dendritic Cells

  2018cites this paper
• Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells.

  2018cites this paper
• Tfr cells lack IL-2Rα but express decoy IL-1R2 and IL-1Ra and suppress the IL-1–dependent activation of Tfh cells

  2017influential citation
• Interleukin-1 receptor antagonist: an early immunomodulatory cytokine induced by porcine reproductive and respiratory syndrome virus.

  2017cites this paper
• Role of CD4 T cell helper subsets in immune response and deviation of CD8 T cells in mice *

  2017cites this paper
• Cytokine Regulation of Metastasis and Tumorigenicity.

  2016cites this paper
• Immune reactivity in rats selected for the enhancement or elimination of aggressiveness towards humans.

  2015cites this paper
• Expression of Interleukin-1 and Interleukin-1 Receptors Type 1 and Type 2 in Hodgkin Lymphoma

  2015cites this paper
• The role of B cells in periodontitis

  2015cites this paper
• IL-1 Receptor Type 2 Suppresses Collagen-Induced Arthritis by Inhibiting IL-1 Signal on Macrophages

  2015cites this paper
• This information is current as Macrophages Arthritis by Inhibiting IL-1 Signal on IL-1 R Type 2 Suppresses Collagen-Induced Kakuta , Toshiki Watanabe and Yoichiro Iwakura

  2015cites this paper
• Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor

  2014cites this paper
• Increased production of pro-inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD 40 ligand

  2014cites this paper
• Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) Polymorphisms and Graves' Disease Risk: A Meta-Analysis of 11 Case-Control Studies

  2014cites this paper
• Interleukin 1 Beta (IL1beta) Gene Polymorphisms (SNP-511 and SNP+3953) in Hashimoto’s Thyroiditis among the Polish Population

  2014cites this paper
• The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4

  2014cites this paper
• Inflammatory Bone Loss in Experimental Periodontitis Induced by Aggregatibacter actinomycetemcomitans in Interleukin-1 Receptor Antagonist Knockout Mice

  2014cites this paper
• IL-1R1 is required for dendritic cell–mediated T cell reactivation within the CNS during West Nile virus encephalitis

  2013cites this paper
• pneumoniae, but Not to a Soluble Isotype Responses to Intact Streptococcus Antipolysaccharide and Antiprotein Ig In Vivo Type 1 and Type 2 Cognate CD4+ T Cell Help for Induction of Endogenous IL-1R1 Signaling Is Critical for

  2013cites this paper
• Role of salivary gland epithelial cells in the differentiation and activation of T lymphocytes in primary Sjögren's syndrome

  2013cites this paper
• [Interluekin-1: from regulation of cell proliferation to chronic inflammatory diseases].

  2013cites this paper
• Déviation de l’auto-immunité chez la souris NOD invalidée pour la voie ICOS/ICOSL

  2012cites this paper
• Functional niche of inflamed synovium for Th17-cell expansion and activation in rheumatoid arthritis: implication to clinical therapeutics.

  2012cites this paper
• RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation

  2012cites this paper
• Interleukin-1 and tumor necrosis factor α blockade treatment of experimental polymyositis in mice.

  2012cites this paper
• Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice

  2011cites this paper
• Immunology of allergic contact dermatitis.

  2011cites this paper
• Innate Immunity and the Pathogenicity of Inhaled Microbial Particles

  2011cites this paper
• LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb.

  2011cites this paper
• Effects of IL-1 molecules on growth patterns of 3-MCA-induced cell lines: An interplay between immunogenicity and invasive potential

  2010cites this paper
• The IL-1 family: regulators of immunity

  2010cites this paper
• Development of IL-17A-associated autoimmunity

  2010cites this paper
• A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment.

  2010cites this paper
• Cancer immunotherapy targeting T cell costimulatory molecules

  2010cites this paper
• IL-1 and Allergy.

  2010cites this paper
• INNATE IMMUNE SENSING OF A BACTERIAL PORE-FORMING TOXIN: THE ROLE OF THE NLRP3 INFLAMMASOME

  2010cites this paper
• IL‐1 signalling determines the fate of skin grafts expressing non‐self protein in keratinocytes

  2009cites this paper
• Association of the −31C/T functional polymorphism in the interleukin‐1β gene with the intractability of Graves' disease and the proportion of T helper type 17 cells

  2009cites this paper
• Adjuvant Effects for Oral Immunization Provided by Recombinant Lactobacillus casei Secreting Biologically Active Murine Interleukin-1β

  2009cites this paper
• Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity1

  2009cites this paper
• Proinflammatory Adjuvants Enhance the Cognate Helper Activity of Aged CD4 T Cells1

  2009cites this paper
• High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?

  2008cites this paper
• Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

  2008cites this paper
• Association of pesticide exposure, vaccination response, and interleukin-1 gene polymorphisms

  2008cites this paper
• Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.

  2008cites this paper
• The roles of IL‐17A in inflammatory immune responses and host defense against pathogens

  2008cites this paper
• Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission.

  2008cites this paper
• Is interleukin‐1 a good or bad ‘guy’ in tumor immunobiology and immunotherapy?

  2008cites this paper
• IL‐1, IL‐18, and IL‐33 families of cytokines

  2008cites this paper
• TNF-α is critical for antitumor but not antiviral T cell immunity in mice

  2007cites this paper
• Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL‐17

  2007cites this paper
• IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.

  2007cites this paper
• The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modifier gene in SLE.

  2007cites this paper
• MyD 88 Is Required for the Formation of Long-Term Humoral Immunity to Virus Infection 1

  2007cites this paper
• This information is current as Infection Long-Term Humoral Immunity to Virus MyD 88 Is Required for the Formation of

  2007cites this paper
• Inflammasomes and rheumatic diseases: evolving concepts

  2007cites this paper
• TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.

  2007cites this paper
• Neuroprotective Effect of Exogenous Microglia in Global Brain Ischemia

  2007cites this paper
• A new murine model to define the critical pathologic and therapeutic mediators of polymyositis.

  2007cites this paper
• MyD88 Is Required for the Formation of Long-Term Humoral Immunity to Virus Infection1

  2007cites this paper
• IL‐33 induces IL‐13 production by mouse mast cells independently of IgE‐FcεRI signals

  2007cites this paper
• IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

  2006cites this paper
• Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions.

  2006cites this paper
• The role of TNFalpha and IL-17 in the development of excess IL-1 signaling-induced inflammatory diseases in IL-1 receptor antagonist-deficient mice.

  2006cites this paper
• Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma

  2006cites this paper
• Induction of murine interleukin-1 beta expression by water-soluble components from Hericium erinaceum

  2006cites this paper
• Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis

  2006cites this paper
• OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease

  2006cites this paper
• This information is current as Molecules and Secreted TNF Importance of Mast Cell Costimulatory Mast Cells Enhance T Cell Activation :

  2006cites this paper
• Is IL-1 a good therapeutic target in the treatment of arthritis?

  2006cites this paper
• Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF1

  2006cites this paper
• Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis.

  2006cites this paper
• The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions

  2006cites this paper
• Endogenous IL-1R1 Signaling Is Critical for Cognate CD4+ T Cell Help for Induction of In Vivo Type 1 and Type 2 Antipolysaccharide and Antiprotein Ig Isotype Responses to Intact Streptococcus pneumoniae, but Not to a Soluble Pneumococcal Conjugate Vaccine12

  2006influential citation
• IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses.

  2006cites this paper
• IL-1 beta-deficient mice are resistant to induction of experimental SLE.

  2006cites this paper