Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

The majority of new HIV‐1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV‐1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV‐1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV‐1, provide an update on microbicides’ clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV‐1 transmission in the female reproductive tract.

• Publication year

  2015

• Venue

  Clinical & Translational Immunology

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/cti.2015.23PMID 26682051PMCID 4673443
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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