Long-Term Episomal Maintenance of Bovine Papillomavirus Type 1 Plasmids Is Determined by Attachment to Host Chromosomes, Which Is Mediated by the Viral E2 Protein and Its Binding Sites

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Virology

• Publication date

  1999-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.73.5.4404-4412.1999PMID 10196338PMCID PMC104221
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation.

  1998influential reference
• Stability without a centromere.

  1998cited by this paper
• Bovine Papillomavirus Type 1 Genomes and the E2 Transactivator Protein Are Closely Associated with Mitotic Chromatin

  1998influential reference
• Cell cycle: the bacterial approach to coordination.

  1998cited by this paper
• Identification and Characterization of a Bacterial Chromosome Partitioning Site

  1998cited by this paper
• The yeast silent information regulator Sir4p anchors and partitions plasmids

  1997cited by this paper
• Epstein-Barr virus and its replication

  1996cited by this paper
• Cis and trans requirements for stable episomal maintenance of the BPV‐1 replicator.

  1996influential reference
• Viewpoint: Putting the Cell Cycle in Order

  1996cited by this paper
• Co‐operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.

  1995cited by this paper
• Transformed mouse cell lines that consist predominantly of cells maintaining bovine papilloma virus at high copy number.

  1995cited by this paper
• Cell-free replication of the human papillomavirus DNA with homologous viral E1 and E2 proteins and human cell extracts.

  1994cited by this paper
• The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator.

  1993cited by this paper
• Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.

  1993cited by this paper
• E1 protein of human papillomavirus is a DNA helicase/ATPase.

  1993cited by this paper
• Binding of bovine papillomavirus E1 to the origin is not sufficient for DNA replication.

  1993cited by this paper
• The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.

  1993cited by this paper
• Random-choice replication of extrachromosomal bovine papillomavirus (BPV) molecules in heterogeneous, clonally derived BPV-infected cell lines

  1992cited by this paper
• Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins.

  1992cited by this paper
• Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1.

  1991cited by this paper
• The papillomavirus E2 protein: a factor with many talents.

  1991cited by this paper
• Transient replication of BPV‐1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

  1991cited by this paper
• The 68-kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitro

  1991cited by this paper
• The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops.

  1991cited by this paper
• Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells

  1991cited by this paper
• The papillomavirus E2 regulatory proteins.

  1991cited by this paper
• Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1.

  1991cited by this paper
• Activation of BPV-1 replication in vitro by the transcription factor E2

  1991cited by this paper
• Cooperative binding of the E2 protein of bovine papillomavirus to adjacent E2-responsive sequences

  1991cited by this paper
• Trans-acting factors in chromosomal instability.

  1990cited by this paper
• Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator.

  1990cited by this paper
• Isolation of human sequences that replicate autonomously in human cells

  1989cited by this paper
• Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: structural and functional analysis of new viral cDNAs

  1989cited by this paper
• Cis-acting negative control of DNA replication in eukaryotic cells.

  1988cited by this paper
• A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator.

  1987cited by this paper
• Bovine papilloma virus plasmids replicate randomly in mouse fibroblasts throughout S phase of the cell cycle.

  1987cited by this paper
• trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1

  1986cited by this paper
• Random association of Epstein-Barr virus genomes with host cell metaphase chromosomes in Burkitt's lymphoma-derived cell lines

  1985cited by this paper
• Two Epstein-Barr viral nuclear neoantigens distinguished by gene transfer, serology, and chromosome binding.

  1983cited by this paper

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  2025cites this paper
• Human Papillomavirus Genomes Associate with Active Host Chromatin during Persistent Viral Infection

  2025cites this paper
• Tracking replicating HPV genomes in proliferating keratinocytes

  2025cites this paper
• Human papillomavirus genomes associate with active host chromatin during persistent viral infection

  2025cites this paper
• The selfish yeast plasmid exploits a SWI/SNF-type chromatin remodeling complex for hitchhiking on chromosomes and ensuring high-fidelity propagation

  2023cites this paper
• BRD4 as a potential target for human papillomaviruses associated cancer

  2023cites this paper
• Topological implications of DNA tumor viral episomes

  2022cites this paper
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  2021cites this paper
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  2020cites this paper
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  2019cites this paper
• Hitchhiking on chromosomes: A persistence strategy shared by diverse selfish DNA elements.

  2019cites this paper
• Mechanisms of persistence by small DNA tumor viruses.

  2018cites this paper
• Extrachromosomal circular DNA-based amplification and transmission of herbicide resistance in crop weed Amaranthus palmeri

  2018cites this paper
• Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication.

  2018cites this paper
• Chapter 5 Bovine Papillomaviruses — Taxonomy and Genetic Features

  2017cites this paper
• Host cell restriction factors that limit transcription and replication of human papillomavirus.

  2017cites this paper
• Combined skin and muscle vaccination differentially impact the quality of effector T cell functions: the CUTHIVAC-001 randomized trial

  2017cites this paper
• Analyse fonctionnelle des polymorphismes du virus du papillome humain de type 33

  2017cites this paper
• Mechanisms and strategies of papillomavirus replication

  2017cites this paper
• Design of Peptide Inhibitors of Human Papillomavirus 16 (HPV16) Transcriptional Regulator E1-E2 Formation

  2017cites this paper
• Playing with fire: consequences of human papillomavirus DNA replication adjacent to genetically unstable regions of host chromatin.

  2017cites this paper
• Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer

  2017cites this paper
• Brd4 Activates Early Viral Transcription upon Human Papillomavirus 18 Infection of Primary Keratinocytes

  2016cites this paper
• Localization of latency-associated nuclear antigen (LANA) on mitotic chromosomes.

  2016cites this paper
• Molecular Studies of HPV-18 Genome Segregation and Stable Replication

  2016cites this paper
• Viral Genome Tethering to Host Cell Chromatin: Cause and Consequences

  2016cites this paper
• The cellular DNA helicase ChlR 1 regulates chromatin and nuclear matrix attachment of the human papillomavirus type 16 E 2 protein and high copy viral genome establishment

  2016cites this paper
• The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment

  2016cites this paper
• Why do children with severe combined immunodeficiency get warts? The role of the common γ-chain in skin immunity

  2016cites this paper
• The role of the Protein Kinase CKII in the life cycle of Human Papillomaviruses

  2016cites this paper
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  2016cites this paper
• Regulation of viral and host genomes by high risk human papillomavirus E2 protein in association with cellular factors

  2015cites this paper
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  2015cites this paper
• The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle

  2015cites this paper
• Human Papillomavirus Type 18 cis-Elements Crucial for Segregation and Latency

  2015cites this paper
• Studies on the Genome Replication of Human Papillomaviruses

  2015cites this paper
• Disordered interactome of human papillomavirus.

  2014cites this paper
• Human Papillomavirus: Pathogenesis and Host Immune Response

  2014cites this paper
• Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes Associated − Assay Development and High-Throughput Screening for Inhibitors of Kaposi ' s Sarcoma

  2014cites this paper
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  2014cites this paper
• Papillomavirus Genomes Associate with BRD4 to Replicate at Fragile Sites in the Host Genome

  2014cites this paper
• Assay Development and High-Throughput Screening for Inhibitors of Kaposi’s Sarcoma–Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes

  2014cites this paper
• Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence

  2014cites this paper
• Phosphorylation of HPV-16 E2 at Serine 243 Enables Binding to Brd4 and Mitotic Chromosomes

  2014cites this paper
• Human Papillomaviruses: Cervical Cancer and Warts

  2014cites this paper
• Molecular mechanisms of HPV induced carcinogenesis in head and neck.

  2014cites this paper
• Brd4 Is Displaced from HPV Replication Factories as They Expand and Amplify Viral DNA

  2013cites this paper
• Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

  2013cites this paper
• Validation and use of a model system to investigate topical treatment of vulval intraepithelial neoplasia

  2013cites this paper
• Enhanced transgene expression in mammalian cells by recombinant baculovirus vector containing bovine papillomavirus type 1 replication elements

  2013cites this paper
• Inactivation of p53 Rescues the Maintenance of High Risk HPV DNA Genomes Deficient in Expression of E6

  2013cites this paper
• The papillomavirus E2 proteins.

  2013cites this paper
• Analysis of the Papillomavirus E2 and Bromodomain Protein Brd4 Interaction Using Bimolecular Fluorescence Complementation

  2013cites this paper
• Comparative mapping of E2-host interactions unravels new roles of E2 in human papillomavirus-induced pathogenesis

  2013cites this paper
• Bovine Papillomaviruses — Taxonomy and Genetic Features

  2013cites this paper
• Vaccine and immunotherapeutic interventions

  2013cites this paper
• Regulation of Growth Factor and Nutrient Sensing Pathways by Human Papillomavirus E6 Proteins

  2013cites this paper
• Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing

  2013cites this paper
• Co-segregation of yeast plasmid sisters under monopolin-directed mitosis suggests association of plasmid sisters with sister chromatids

  2013cites this paper
• Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

  2013cites this paper
• Genital human papillomavirus infections: current and prospective therapies.

  2012cites this paper
• Mechanisms underlying immunomodulation of HIV-1-specific T-cell responses

  2012cites this paper
• Human Papillomaviruses and Cancer

  2012cites this paper
• Functional Interactions between Chromatin-associated Proteins and Epstein-Barr virus Nuclear Antigen 1 (EBNA1)

  2012cites this paper
• Indicators of therapeutic effect in FIT-06, a Phase II trial of a DNA vaccine, GTU(®)-Multi-HIVB, in untreated HIV-1 infected subjects.

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• Characterization of Nucleosome Positioning in Hepadnaviral Covalently Closed Circular DNA Minichromosomes

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• Contributions of Epstein-Barr Nuclear Antigen 1 (EBNA1) and the Family of Repeats (FR) Region to oriP-mediated Replication and Segregation Functions in Nasopharyngeal Carcinoma

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• Hitchhiking on host chromatin: how papillomaviruses persist.

  2012cites this paper
• Control of Bovine Papillomavirus E2 Function By Acetylation and the Novel E2 Interacting Protein RINT1: A Dissertation

  2012influential citation
• Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression.

  2011cites this paper
• Small Molecule Inhibitors of Human Papillomavirus Protein - Protein Interactions

  2011cites this paper
• Investigating the role of human papillomavirus DNA replication in the development of cervical cancer

  2011cites this paper
• Interactions of the human papillomavirus E6 protein and their role in the persistence of viral episomes

  2011cites this paper
• HPV episome levels are potently decreased by pyrrole-imidazole polyamides.

  2011cites this paper
• Identification and Analysis of Papillomavirus E2 Protein Binding Sites in the Human Genome

  2011cites this paper
• Mart Ustav the Human Genome Papillomavirus E 2 Protein Binding Sites in Identification and Analysis of

  2011cites this paper
• Biology of Sexually Transmitted Human Papillomaviruses

  2011cites this paper
• The Role of E2 Proteins in Papillomavirus DNA Replication

  2011cites this paper
• The natural history of human papillomavirus infections of the mucosal epithelia

  2010cites this paper
• Papillomavirus interaction with cellular chromatin.

  2010cites this paper
• Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses.

  2010cites this paper
• NCoR1 Mediates Papillomavirus E8^E2C Transcriptional Repression

  2010cites this paper
• DNA Replication and Genome Maintenance of Human Papillomavirus Type 16 in Mammalian Cells

  2010cites this paper
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• NCoR 1 Mediates Papillomavirus E 8 E 2 C Transcriptional Repression †

  2010cites this paper
• Human papillomavirus E2 protein with single activation domain initiates HPV18 genome replication, but is not sufficient for long-term maintenance of virus genome.

  2010cites this paper
• Effective Formation of the Segregation-Competent Complex Determines Successful Partitioning of the Bovine Papillomavirus Genome during Cell Division

  2010cites this paper
• Transcriptionally Active Cellular Chromatin Brd 4 Protein Associate with Papillomavirus E 2 Proteins and the Host

  2009cites this paper
• Targeting mitotic chromosomes: a conserved mechanism to ensure viral genome persistence

  2009cites this paper
• Interaction of the Betapapillomavirus E2 Tethering Protein with Mitotic Chromosomes

  2009cites this paper
• Papillomavirus DNA replication - from initiation to genomic instability.

  2009cites this paper
• Bovine papillomavirus type 1 E2 protein heterodimer is functional in papillomavirus DNA replication in vivo.

  2009cites this paper
• Functional Interaction of BPV-1 E2 with the Papillomavirus Genome: A Dissertation

  2009influential citation
• Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle.

  2009influential citation
• A novel interaction between the human papillomavirus type 16 E2 and E1--E4 proteins leads to stabilization of E2.

  2009cites this paper
• Persistent immune responses induced by a human immunodeficiency virus DNA vaccine delivered in association with electroporation in the skin of nonhuman primates.

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  2009cites this paper
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  2009cites this paper