Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  American Journal of Respiratory and Critical Care Medicine

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1164/RCCM.200612-1804OCPMID 17916805PMCID PMC7611754
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
• Neutrophil cell death, activation and bacterial infection in cystic fibrosis

  2005cited by this paper
• Engulfment: ingestion and migration with Rac, Rho and TRIO.

  2005cited by this paper
• Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice

  2004cited by this paper
• Direct oxidation of 2',7'-dichlorodihydrofluorescein by pyocyanin and other redox-active compounds independent of reactive oxygen species production.

  2004cited by this paper
• Modulation of phagocyte apoptosis by bacterial pathogens

  2004cited by this paper
• Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection 1

  2003cited by this paper
• Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cells.

  2003cited by this paper
• Engulfment of Apoptotic Cells Is Negatively Regulated by Rho-mediated Signaling*

  2003cited by this paper
• Pseudomonal infection in cystic fibrosis: the battle continues

  2003cited by this paper
• Caspase-1-Deficient Mice Have Delayed Neutrophil Apoptosis and a Prolonged Inflammatory Response to Lipopolysaccharide-Induced Acute Lung Injury1

  2002cited by this paper
• Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

  2002cited by this paper
• Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.

  2002influential reference
• Induction of Neutrophil Apoptosis by the Pseudomonas aeruginosa Exotoxin Pyocyanin: A Potential Mechanism of Persistent Infection1

  2002cited by this paper
• Lung Infections Associated with Cystic Fibrosis

  2002cited by this paper
• Oxidative stress inhibits the phagocytosis of apoptotic cells that have externalized phosphatidylserine

  2002cited by this paper
• Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages.

  2001cited by this paper
• Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex

  2000cited by this paper
• Expression of antioxidant enzymes in human inflammatory cells.

  2000cited by this paper
• Corpse clearance defines the meaning of cell death

  2000cited by this paper
• Decreased apoptosis and increased activation of alveolar neutrophils in bacterial pneumonia.

  2000cited by this paper
• Cell Death of Human Polymorphonuclear Neutrophils Induced by a Pseudomonas aeruginosa Cystic Fibrosis Isolate Requires a Functional Type III Secretion System

  1999cited by this paper
• Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model.

  1999influential reference
• Pseudomonas aeruginosa Induces Type-III-Secretion-Mediated Apoptosis of Macrophages and Epithelial Cells

  1999cited by this paper
• Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients.

  1999cited by this paper
• Oxidative stress during acute respiratory exacerbations in cystic fibrosis

  1999cited by this paper
• Lung infections. 3. Pseudomonas aeruginosa and other related species.

  1998cited by this paper
• Burkholderia cepacia Produces a Hemolysin That Is Capable of Inducing Apoptosis and Degranulation of Mammalian Phagocytes

  1998cited by this paper
• Pseudomonas aeruginosa and other related species

  1998cited by this paper
• Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

  1998cited by this paper
• Pulmonary oxidative stress response in young children with cystic fibrosis.

  1997cited by this paper
• Granulocyte apoptosis and inflammatory disease.

  1997cited by this paper
• Increased DNA levels in bronchoalveolar lavage fluid obtained from infants with cystic fibrosis.

  1996cited by this paper
• Compartmentalized IL-8 and elastase release within the human lung in unilateral pneumonia.

  1996cited by this paper
• Effects of cystic fibrosis airway secretions on rat lung: role of neutrophil elastase.

  1995cited by this paper
• Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.

  1994cited by this paper
• Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

  1992cited by this paper
• Proinflammatory interactions of pyocyanin and 1-hydroxyphenazine with human neutrophils in vitro.

  1990cited by this paper
• A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123.

  1990cited by this paper
• Effects of pyocyanine, a phenazine dye from Pseudomonas aeruginosa, on oxidative burst and bacterial killing in human neutrophils

  1989cited by this paper
• Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism.

  1989influential reference
• Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

  1989influential reference
• Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium

  1988cited by this paper
• A new method of preparation of pyocyanin and demonstration of an unusual bacterial sensitivity.

  1979cited by this paper

• Modulation of pulmonary immune functions by the Pseudomonas aeruginosa secondary metabolite pyocyanin

  2025cites this paper
• Mutations in the Staphylococcus aureus Global Regulator CodY confer tolerance to an interspecies redox-active antimicrobial

  2025cites this paper
• Anti-pyocyanin Antibody Exhibits Cytotoxicity Protective Effects on Macrophages: A Promising Innovative Therapeutic Approach for Pseudomonas aeruginosa Infections.

  2025cites this paper
• Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells.

  2025cites this paper
• Nitric oxide tunes secreted metabolite bioactivity

  2025cites this paper
• Microbial phenazines: biosynthesis, structural diversity, evolution, regulation, and biological significance

  2025cites this paper
• Pseudomonas aeruginosa-derived metabolites and volatile organic compounds: impact on lung epithelial homeostasis and mucosal immune response

  2025cites this paper
• Mutations in the Staphylococcus aureus Global Regulator CodY Confer Tolerance to an Interspecies Redox-Active Antimicrobial

  2024cites this paper
• Effects of Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on intracellular calcium, mitochondrial function, and viability in human nasal epithelial cells

  2024cites this paper
• The Epistemology of Bacterial Virulence Factor Characterization

  2024cites this paper
• Anti-quorum sensing activity of selected cationic amino acids against Chromobacterium violaceum and Pseudomonas aeruginosa

  2023cites this paper
• The two faces of pyocyanin - why and how to steer its production?

  2023cites this paper
• Pyocyanin as a safe aquaculture drug for the control of vibriosis in shrimp recirculating aquaculture system (RAS)

  2022cites this paper
• Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

  2022cites this paper
• LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation

  2021cites this paper
• The Effect of Cigarette Smoke Exposure on Efferocytosis in Chronic Obstructive Pulmonary Disease; Molecular Mechanisms and Treatment Opportunities

  2021cites this paper
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  2021cites this paper
• Brd4 inhibition ameliorates Pyocyanin-mediated macrophage dysfunction via transcriptional repression of reactive oxygen and nitrogen free radical pathways

  2020cites this paper
• Evaluation of Pyocyanin induced systemic pathogenicity of Pseudomonas aeruginosa.

  2020cites this paper
• Microbial biofilms on medical indwelling devices

  2020cites this paper
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  2020cites this paper
• Cell Proliferation, Survival, Necrosis and Apoptosis

  2020cites this paper
• Factors influencing the acquisition and eradication of early Pseudomonas aeruginosa infection in cystic fibrosis.

  2020cites this paper
• Pitfalls Associated with Discriminating Mixed-Species Biofilms by Flow Cytometry

  2020cites this paper
• Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa.

  2020cites this paper
• Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

  2020cites this paper
• The protective effects of antigen-specific IgY on pyocyanin-treated human lymphoma Raji cells

  2019cites this paper
• The deafness gene GSDME: its involvement in cell apoptosis, secondary necrosis, and cancers

  2019cites this paper
• Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are affected by sub-lethal photodynamic inactivation.

  2019cites this paper
• Anti-inflammatory potential of pyocyanin in LPS-stimulated murine macrophages

  2019cites this paper
• Role of Reactive Oxygen Species in the Correlation Between Host and Microbes

  2019cites this paper
• Effect of Andrographolide and Its Analogs on Bacterial Infection: A Review

  2019cites this paper
• New carboxamides bearing benzenesulphonamides: Synthesis, molecular docking and pharmacological properties.

  2019cites this paper
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  2019cites this paper
• The good side of inflammation: Staphylococcus aureus proteins SpA and Sbi contribute to proper abscess formation and wound healing during skin and soft tissue infections.

  2019cites this paper
• Selective Cu(I) complex with phosphine-peptide (SarGly) conjugate contra breast cancer: Synthesis, spectroscopic characterization and insight into cytotoxic action.

  2018cites this paper
• Database on the taxonomical characterisation and potential toxigenic capacities of microorganisms used for the industrial production of food enzymes and feed additives, which do not have a recommendation for Qualified Presumption of Safety

  2017cites this paper
• Mechanisms and Targeted Therapies for Pseudomonas aeruginosa Lung Infection

  2017cites this paper
• Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells

  2017cites this paper
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  2017cites this paper
• Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure

  2017cites this paper
• Macrophage Dysfunction in Respiratory Disease.

  2017cites this paper
• Prognostic factors in cystic fibrosis - the impact of antibody response and platelet activation

  2017cites this paper
• Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids

  2016cites this paper
• Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin

  2016cites this paper
• Potential Use of Dimethyl Sulfoxide in Treatment of Infections Caused by Pseudomonas aeruginosa

  2016cites this paper
• The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

  2016cites this paper
• Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa

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  2015cites this paper
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  2015cites this paper
• Mcl-1 is vital for neutrophil survival

  2015cites this paper
• Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance.

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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Host-pathogen interplay in the respiratory environment of cystic fibrosis.

  2015cites this paper
• Mcl-1 is vital for neutrophil survival

  2015cites this paper
• The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA

  2015cites this paper
• PcrV antibody protects multi-drug resistant Pseudomonas aeruginosa induced acute lung injury.

  2014cites this paper
• Characterization of the Bacterial Metallothionein, PmtA in the Human Pathogen Pseudomonas aeruginosa

  2014cites this paper
• Regulation of Human Neutrophil Apoptosis and Lifespan in Health and Disease

  2014cites this paper
• Evolutionary Conservation of Divergent Pro-Inflammatory and Homeostatic Responses in Lamprey Phagocytes

  2014cites this paper
• Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans

  2013cites this paper
• Pyocyanin from Pseudomonas induces IL-8 production through the PKC and NF-κB pathways in U937 cells.

  2013cites this paper
• The antioxidant resveratrol down-regulates inflammation in an in-vitro model of Pseudomonas aeruginosa infection of lung epithelial cells.

  2013cites this paper
• The role of macrophages in obstructive airways disease: chronic obstructive pulmonary disease and asthma.

  2013cites this paper
• Efficacy of ceftolozane in a murine model of Pseudomonas aeruginosa acute pneumonia: in vivo antimicrobial activity and impact on host inflammatory response.

  2013cites this paper
• Utilization of Raw Glycerol for Pyocyanin Production from Pseudomonas Aeruginosa in Half-Microbial Fuel Cells: Evaluation of Two Electrochemical Approaches

  2013cites this paper
• Pseudomonas aeruginosa: new insights into pathogenesis and host defenses.

  2013cites this paper
• An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity

  2012cites this paper
• Expression and preliminary functional analysis of Siglec-F on mouse macrophages

  2012cites this paper
• Fish and Mammalian Phagocytes Differentially Regulate Pro-Inflammatory and Homeostatic Responses In Vivo

  2012cites this paper
• Defective phagocytosis in airways disease.

  2012cites this paper
• Regulation of the PhoP-PhoQ two-component system in Pseudomonas aeruginosa and its role in virulence

  2012cites this paper
• In Vitro and in Vivo Characterisation of P. Aeruginosa Oxidoreductase Enzymes in Pathogenesis and Therapy

  2012cites this paper
• Cellular microenvironment in Burkitt’s lymphoma : gene expression profiling of tumour-associated macrophages in situ

  2012cites this paper
• The Roles and Regulation of the Redundant Phenazine Biosynthetic Operons in Pseudomonas aeruginosa PA14

  2012cites this paper
• Increase in interleukin-8 production from circulating neutrophils upon antibiotic therapy in cystic fibrosis patients.

  2012cites this paper
• Effect of Innate Immune Collectin Surfactant Protein D and Adaptive Immune Protein IgM on Enhancing Clearance of Late Apoptotic Cells by Alveolar Macrophages

  2011cites this paper
• DIFFERENTIAL EFFECTS ON CASPASE MEDIATED APOPTOSIS OF HELA CELLS INDUCED BY DIFFERENT PSEUDOMONAS AERUGINOSA CULTURE FRACTIONS

  2011cites this paper
• The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective Cell

  2011cites this paper
• Does linezolid modulate lung innate immunity in a murine model of methicillin-resistant Staphylococcus aureus pneumonia?*

  2011cites this paper
• Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

  2011cites this paper
• Redox active secondary metabolites.

  2011cites this paper
• Pseudomonas aeruginosa in cystic fibrosis: pyocyanin negative strains are associated with BPI-ANCA and progressive lung disease.

  2011cites this paper
• The Role of Reactive-Oxygen-Species in Microbial Persistence and Inflammation

  2011cites this paper
• Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells--possible role in SLE.

  2010cites this paper
• AIP56: A Novel Bacterial Apoptogenic Toxin

  2010cites this paper
• Design, synthesis and antibacterial activity of novel andrographolide derivatives.

  2010cites this paper
• What do we mean when we write “senescence,”“apoptosis,”“necrosis,” or “clearance of dying cells”?

  2010cites this paper
• Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils.

  2010influential citation
• Platelet-derived chemokines: pathophysiology and therapeutic aspects

  2010cites this paper
• Secondary necrosis: The natural outcome of the complete apoptotic program

  2010cites this paper
• N-acetylcysteine inhibits RhoA and promotes apoptotic cell clearance during intense lung inflammation.

  2010cites this paper
• Clearance of apoptotic cells: implications in health and disease

  2010cites this paper
• Bacteria‐induced phagocyte secondary necrosis as a pathogenicity mechanism

  2010cites this paper
• Total (bio)synthesis: strategies of nature and of chemists.

  2010cites this paper
• Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases

  2010cites this paper
• Natural IgM and innate immune collectin SP-D bind to late apoptotic cells and enhance their clearance by alveolar macrophages in vivo.

  2010cites this paper