Factor V (Quebec): a bleeding diathesis associated with a qualitative platelet Factor V deficiency.

No abstract is available for this paper.

• Publication year

  1984

• Venue

  Journal of Clinical Investigation

• Publication date

  1984-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1172/JCI111531PMID 6480825PMCID PMC425288
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional prothrombinase complex assembly on isolated monocytes and lymphocytes.

  1983influential reference
• Radioimmunoassay of factor V in human plasma and platelets.

  1982cited by this paper
• The interaction of human coagulation factor Va with platelets.

  1982cited by this paper
• Coordinate binding of factor Va and factor Xa to the unstimulated platelet.

  1981cited by this paper
• Immunochemical studies of factor V of bovine platelets.

  1981cited by this paper
• Isolation of functional human coagulation factor V by using a hybridoma antibody.

  1981cited by this paper
• Factor V.

  1981cited by this paper
• A simplified procedure for purification of human prothrombin, factor IX and factor X.

  1981cited by this paper
• Subcellular Localization and Secretion of Factor V by Human Platelets

  1981cited by this paper
• Biochemical studies of two patients with the gray platelet syndrome. Selective deficiency of platelet alpha granules.

  1980cited by this paper
• Sex differences in bleeding time and blood loss in normal subjects following aspirin ingestion.

  1980cited by this paper
• Release of human platelet factor V activity is induced by both collagen and ADP and is inhibited by aspirin.

  1980cited by this paper
• Isolation and characterization of single chain bovine factor V.

  1979cited by this paper
• The contribution of bovine Factor V and Factor Va to the activity of prothrombinase.

  1979cited by this paper
• Interactions of a fluorescent active-site-directed inhibitor of thrombin: dansylarginine N-(3-ethyl-1,5-pentanediyl)amide.

  1979cited by this paper
• Interaction of coagulation factor V and factor Va with platelets.

  1979cited by this paper
• Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets.

  1978cited by this paper
• Properties of the factor Xa binding site on human platelets.

  1978cited by this paper
• Prothrombin structure, activation, and biosynthesis.

  1977cited by this paper
• Prothrombin.

  1976cited by this paper
• Factor X activating enzyme from Russell's viper venom: isolation and characterization.

  1976cited by this paper
• Basic mechanisms in blood coagulation.

  1975cited by this paper
• Preparation and partial characterization of two forms of bovine thrombin.

  1975cited by this paper
• Human prothrombin activation.

  1975cited by this paper
• Inherited variants of factor-VIII-related protein in von Willebrand's disease.

  1974cited by this paper
• Quantitative assay of a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation. Relationship to factor VIII procoagulant activity and antigen content.

  1973cited by this paper
• Preparation of Suspensions of Washed Platelets from Humans

  1972cited by this paper
• Detection of carriers of classic hemophilia using an immunologic assay for antihemophilic factor (factor 8().

  1971cited by this paper
• Gray platelet syndrome. A variety of qualitative platelet disorder.

  1971cited by this paper
• The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies.

  1961cited by this paper
• The maintenance of a sustained thrombolytic state in man. I. Induction and effects.

  1959cited by this paper
• Parahaemophilia; haemorrhagic diathesis due to absence of a previously unknown clotting factor.

  1947cited by this paper

• Cerebral sinus venous thrombosis in a child with Québec platelet disorder with high-resolution intracellular localization of urokinase in platelets

  2025cites this paper
• Inherited Disorders of the Fibrinolytic Pathway: Pathogenic Phenotypes and Diagnostic Considerations of Extremely Rare Disorders

  2024cites this paper
• Exploratory Investigation of the Plasma Proteome Associated with the Endotheliopathy of Trauma

  2022cites this paper
• Update on platelet procoagulant mechanisms in health and in bleeding disorders

  2022cites this paper
• Cell-Mediated Hemostasis

  2020cites this paper
• Thrombin generation abnormalities in Quebec platelet disorder

  2020cites this paper
• Platelet transfusion as treatment for factor V deficiency in the parturient: a case report

  2019cites this paper
• A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A.

  2019cites this paper
• A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A.

  2019cites this paper
• Molecular analysis of eight severe FV‐deficient patients in Pakistan: A large series of homozygous for frameshift mutations

  2019cites this paper
• Inherited Disorders of Platelet Function

  2019cites this paper
• Laboratory Assessment of Coagulation

  2018cites this paper
• Hemorrhagic disorders of fibrinolysis: a clinical review

  2018cites this paper
• Platelet-Activation Mechanisms and Vascular Remodeling.

  2018cites this paper
• Endocytosed factor V is trafficked to CD42b+ proplatelet extensions during differentiation of human umbilical cord blood‐derived megakaryocytes

  2018cites this paper
• Gray Platelet Syndrome (GPS)

  2018cites this paper
• Alterations of the Platelet Procoagulant or Fibrinolytic Functions

  2017cites this paper
• Factor V Inhibitors: A Diagnostic and Therapeutic Challenge.

  2017cites this paper
• Defining Platelet-Derived Components Regulating The Prothrombinase Enzyme Complex

  2016cites this paper
• RAPID COMMUNICATION Factor V Quebec Revisited

  2016cites this paper
• Novel biomarkers in vascular remodelling and inflammation in pulmonary arterial hypertension

  2016cites this paper
• Endocytosis of exogenous factor V by ex‐vivo differentiated megakaryocytes from patients with severe parahaemophilia

  2016cites this paper
• Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

  2016cites this paper
• Cellular And Molecular Events Regulating Factor V Endocytosis By Megakaryocytes

  2015cites this paper
• Hemophilias and Other Disorders of Hemostasis

  2014cites this paper
• Normal Coagulation and Hemostasis

  2014cites this paper
• Chapter 73 – Hemophilias and Other Disorders of Hemostasis

  2013cites this paper
• Identification of the Regions in Factor V Mediating its Edocytosis by Megakaryocytes to Form the Unique Platelet-Derived Cofactor Molecule

  2013cites this paper
• Protease-Activated Receptor (PAR) 1 and PAR4 Differentially Regulate Factor V Expression from Human Platelets

  2013cites this paper
• and their relationship to hemorrhagic and thrombotic disorders Blood coagulation factors V and VIII: structural and functional similarities

  2013cites this paper
• Less Common Congenital Disorders of Hemostasis

  2013cites this paper
• Improving blood disorder diagnosis: reflections on the challenges

  2013cites this paper
• Proteolysis of plasma‐derived factor V following its endocytosis by megakaryocytes forms the platelet‐derived factor V/Va pool

  2013cites this paper
• Platelet Disorders in Children

  2013cites this paper
• Interactions Between Platelets and the Coagulation System

  2013cites this paper
• Investigation of the interaction of multimerin 1 with components of prothrombinase, in vitro

  2012cites this paper
• Novel Role for Galectin-8 Protein as Mediator of Coagulation Factor V Endocytosis by Megakaryocytes*

  2012cites this paper
• Extraction of four wisdom teeth in a patient with congenital factor V deficiency hemophilia.

  2011cites this paper
• Modulators of bleeding tendency in severe factor V deficiency

  2011cites this paper
• Clotting factor deficiency in early trauma-associated coagulopathy.

  2011cites this paper
• REVIEW Platelet Disorders in Children: A Diagnostic Approach

  2011cites this paper
• Quebec Platelet Disorder: Update on Pathogenesis, Diagnosis, and Treatment

  2011cites this paper
• Quebec platelet disorder: update on pathogenesis, diagnosis, and treatment.

  2011cites this paper
• Quebec platelet disorder

  2011cites this paper
• thrombin proteolysis Factor V is activated and cleaved by platelet calpain: comparison with

  2011cites this paper
• Inherited platelet disorders: a clinical approach to diagnosis and management

  2011cites this paper
• Platelet disorders in children: A diagnostic approach

  2011influential citation
• bleeding in a patient exposed to topical bovine thrombin Development of antibodies to thrombin and factor V with recurrent

  2011cites this paper
• Current Strategies in Diagnosis of Inherited Storage Pool Defects

  2010cites this paper
• Impaired Platelet Procoagulant Mechanisms in Patients with Bleeding Disorders

  2009cites this paper
• Role of Platelet Electron Microscopy in the Diagnosis of Platelet Disorders

  2009cites this paper
• Inherited trombophilic states and pulmonary embolism

  2009cites this paper
• Advances in understanding the bleeding diathesis in factor V deficiency

  2009influential citation
• Identification of four novel mutations in F5 associated with congenital factor V deficiency

  2009cites this paper
• PLATELETS IN HEMATOLOGIC AND CARDIOVASCULAR DISORDERS: A CLINICAL HANDBOOK

  2008cites this paper
• Quebec platelet disorder: features, pathogenesis and treatment

  2008cites this paper
• Congenital Disorders of Platelet Function

  2008cites this paper
• A unique function for LRP‐1: a component of a two‐receptor system mediating specific endocytosis of plasma‐derived factor V by megakaryocytes

  2008cites this paper
• Inherited platelet disorders.

  2008cites this paper
• THROMBIN REGULATION IN NEWBORN INFANTS

  2007cites this paper
• Chapter 5 – Less Common Congenital Disorders of Hemostasis

  2007cites this paper
• Thrombin regulation in newborn infants

  2007cites this paper
• CHAPTER 19 – Interactions Between Platelets and the Coagulation System

  2007cites this paper
• Congenital platelet disorders.

  2007cites this paper
• Prevalence of reduced fibrinogen binding to platelets in a population of Thoroughbreds.

  2007cites this paper
• Pathophysiology of Haemostasis and Thrombosis Preprint Copy The Extent of Platelet Activation under Shear Depends on Platelet Count : Differential Expression of Anionic Phospholipid and Factor Va

  2006cites this paper
• Inherited defects of coagulation factor V: the hemorrhagic side

  2006cites this paper
• Insights into abnormal hemostasis in the Quebec platelet disorder from analyses of clot lysis

  2006cites this paper
• Coagulation for the clinician.

  2006cites this paper
• Platelet factor V supports hemostasis in a patient with an acquired factor V inhibitor, as shown by prothrombinase and tenase assays

  2006cites this paper
• Typ-2-Diabetes: Assoziationsstudie zur Identifizierung erblicher Risikofaktoren und Ermittlung mit Typ-2-Diabetes in Zusammenhang stehender parentaler Krebs-Risiken

  2005cites this paper
• Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet‐derived cofactor

  2005cites this paper
• Positive feedbacks of coagulation: their role in threshold regulation.

  2005cites this paper
• Procoagulant activity of adherent platelets

  2005cites this paper
• Normal clotting.

  2005cites this paper
• Unique in Vivo Modifications of Coagulation Factor V Produce a Physically and Functionally Distinct Platelet-derived Cofactor

  2004cites this paper
• Bleeding risks associated with inheritance of the Quebec platelet disorder.

  2004cites this paper
• Deletion of multimerin-1 in alpha-synuclein-deficient mice.

  2004cites this paper
• Deletion of multimerin-1 in α-synuclein-deficient mice

  2004cites this paper
• The Prothrombinase Complex: Assembly and Function

  2004cites this paper
• Biosynthetic origin and functional significance of murine platelet factor V.

  2003cites this paper
• Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder

  2003cites this paper
• The dynamics of thrombin formation.

  2003cites this paper
• Factor V: a combination of Dr Jekyll and Mr Hyde.

  2003cites this paper
• Anti‐factor V auto‐antibody in the plasma and platelets of a patient with repeated gastrointestinal bleeding

  2003cites this paper
• Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets.

  2003cites this paper
• Inherited platelet‐based bleeding disorders

  2003cites this paper
• The discovery of factor V: a tricky clotting factor

  2003cites this paper
• COAT platelets

  2003cites this paper
• Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment.

  2003cites this paper
• Platelet Activation and Blood Coagulation

  2002cites this paper
• Molecular and Cellular Hemostasis and Fibrinolysis

  2002cites this paper
• Drugs in development.

  2002cites this paper
• Factor V: Dr. Jeckyll and Mr. Hyde.

  2001cites this paper
• Acquired hemophilia.

  2001cites this paper
• Contribution of Platelet-derived Factor Va to Thrombin Generation on Immobilized Collagen- and Fibrinogen-adherent Platelets

  2001cites this paper
• Platelets and Phospholipids in Tissue Factor-initiated Thrombin Generation

  2001cites this paper
• Platelet factor V New York: A defect in factor V distinct from that in factor V Quebec resulting in impaired prothrombinase generation

  2001cites this paper
• Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator.

  2001cites this paper
• Hemorragia intraventricular neonatal por déficit de factor V

  2000cites this paper