A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cell

• Publication date

  2018-02-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cell.2018.01.032PMID 29474905PMCID PMC6052445
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

  2016influential reference
• An interactive environment for agile analysis and visualization of ChIP-sequencing data

  2016influential reference
• Analyzing CRISPR genome-editing experiments with CRISPResso

  2016influential reference
• Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.

  2016influential reference
• Structural and Functional Analysis of the Cdk13/Cyclin K Complex.

  2016cited by this paper
• The Fanconi anaemia pathway: new players and new functions

  2016influential reference
• MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.

  2016cited by this paper
• NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

  2016influential reference
• Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

  2015cited by this paper
• MXS-Chaining: A Highly Efficient Cloning Platform for Imaging and Flow Cytometry Approaches in Mammalian Systems

  2015influential reference
• Hijacked in cancer: the KMT2 (MLL) family of methyltransferases

  2015cited by this paper
• The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential.

  2015cited by this paper
• Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

  2015cited by this paper
• Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

  2014cited by this paper
• DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

  2014influential reference
• MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

  2014influential reference
• Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

  2014cited by this paper
• The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis

  2014influential reference
• The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation

  2014cited by this paper
• Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.

  2014influential reference
• Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant

  2014cited by this paper
• An optimized microRNA backbone for effective single-copy RNAi.

  2013influential reference
• Genetic Screens in Human Cells Using the CRISPR-Cas9 System

  2013cited by this paper
• Mutational landscape and significance across 12 major cancer types

  2013cited by this paper
• Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.

  2012cited by this paper
• Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.

  2012cited by this paper
• The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

  2011cited by this paper
• RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

  2011cited by this paper
• MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

  2010cited by this paper
• Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.

  2010cited by this paper
• Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.

  2009cited by this paper
• Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.

  2008cited by this paper
• Visualizing spatiotemporal dynamics of multicellular cell-cycle progression.

  2008cited by this paper
• Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

  2007cited by this paper
• MLL translocations, histone modifications and leukaemia stem-cell development

  2007cited by this paper
• High-resolution profiling of histone methylations in the human genome.

  2007cited by this paper
• Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression.

  2005cited by this paper
• Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression

  2004cited by this paper
• Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

  2004cited by this paper
• Definitive hematopoiesis requires the mixed-lineage leukemia gene.

  2004cited by this paper
• Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.

  2003cited by this paper
• Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex.

  2003cited by this paper
• Lentivirus-delivered stable gene silencing by RNAi in primary cells.

  2003cited by this paper
• CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles.

  2001influential reference
• Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.

  2001cited by this paper
• Human Cyclin K, a Novel RNA Polymerase II-Associated Cyclin Possessing Both Carboxy-Terminal Domain Kinase and Cdk-Activating Kinase Activity

  1998cited by this paper
• The protein encoded by the Drosophila position‐effect variegation suppressor gene Su(var)3‐9 combines domains of antagonistic regulators of homeotic gene complexes.

  1994cited by this paper
• The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax

  1993cited by this paper
• The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.

  1992cited by this paper

• The BOD1L subunit of the SETD1A complex sustains the expression of DNA damage repair genes despite restraining H3K4 trimethylation

  2026influential citation
• A Further Case Supporting CCNK as a Neurodevelopmental Disease Gene

  2025cites this paper
• Dual Modes of Gene Regulation by CDK12

  2025cites this paper
• Functional dissection of H3K4 methyltransferases reveals distinct catalytic and non-catalytic roles in C. elegans development

  2025cites this paper
• SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia

  2025cites this paper
• Canonical and Non‐Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer

  2025cites this paper
• Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4–TAF6 axis in the cell cycle

  2025cites this paper
• Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K

  2025influential citation
• Investigate the Effect of ZFP64 on mRNA Expression of HBG Based on Bioinformatics and Experimental Validation

  2025cites this paper
• Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12

  2025cites this paper
• Single amino acid mutations in histone H3.3 illuminate the functional significance of H3K4 methylation in plants

  2025cites this paper
• Regulation of H3K4me3 breadth and MYC expression by the SETD1B catalytic domain in MLL-rearranged leukemia

  2025cites this paper
• A busy BOD1-y: the diverse functions of an intracellular signaling regulatory protein family

  2025cites this paper
• Anlotinib suppresses the DNA damage response by disrupting SETD1A and inducing p53-dependent apoptosis in Transformed Follicular Lymphoma

  2024cites this paper
• Unraveling MLL1-fusion leukemia: Epigenetic revelations from an iPS cell point mutation

  2024cites this paper
• Histone methyltransferases MLL2 and SETD1A/B play distinct roles in H3K4me3 deposition during the transition from totipotency to pluripotency

  2024cites this paper
• Histone lysine methylation modifiers controlled by protein stability

  2024cites this paper
• Fluorescent sensing platform based on two-dimensional layered double hydroxides and exonuclease I for DNA and microRNA detection

  2024cites this paper
• Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons

  2024cites this paper
• Insights into the mechanisms driven by H3K4 KMTs in pancreatic cancer.

  2024cites this paper
• BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A

  2024influential citation
• Epigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a

  2024cites this paper
• KMT2 family of H3K4 methyltransferases: enzymatic activity-dependent and -independent functions.

  2024cites this paper
• MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres

  2023cites this paper
• In Vivo and In Vitro Characterization of the RNA Binding Capacity of SETD1A (KMT2F)

  2023cites this paper
• An essential signaling function of cytoplasmic NELFB is independent of RNA polymerase II pausing

  2023cites this paper
• SETD1A drives stemness by reprogramming the epigenetic landscape in hepatocellular carcinoma stem cells

  2023cites this paper
• Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression.

  2023cites this paper
• SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3

  2023influential citation
• Investigating the tissue specificity and prognostic impact of cis-regulatory cancer risk variants

  2023cites this paper
• Setd1A-mediated methylation of h3k4me3 inhibits ferroptosis in non-small cell lung cancer by regulating the WTAPP1/WTAP axis.

  2023cites this paper
• Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription

  2023cites this paper
• Deep thermal profiling for detection of functional proteoform groups

  2023cites this paper
• A CpG island-encoded mechanism protects genes from premature transcription termination

  2022cites this paper
• The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication

  2022cites this paper
• SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

  2022cites this paper
• Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation.

  2022cites this paper
• Histone-lysine N-methyltransferase 2 (KMT2) Complexes - A New Perspective.

  2022cites this paper
• Targeting the Heterogeneous Genomic Landscape in Triple-Negative Breast Cancer through Inhibitors of the Transcriptional Machinery

  2022cites this paper
• SETD1A-SOX2 axis is involved in tamoxifen resistance in estrogen receptor α-positive breast cancer cells

  2022cites this paper
• Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

  2022cites this paper
• MLL family members regulate H3K4 methylation to ensure CENP-A assembly at human centromeres

  2022cites this paper
• Deep thermal proteome profiling for detection of proteoforms and drug sensitivity biomarkers

  2022cites this paper
• Somatic Hypermutation Spectra Are Independent of the Local Transcriptional and Epigenetic Landscape

  2022cites this paper
• A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells

  2022cites this paper
• H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

  2022cites this paper
• Downregulation of lncRNA FOXD2-AS1 Confers Radiosensitivity to Gastric Cancer Cells via miR-1913/SETD1A Axis

  2022cites this paper
• Using nutrigenomics to evaluate microdiet performance in pike silverside larvae

  2021cites this paper
• Therapeutic Opportunities of Targeting Canonical and Noncanonical PcG/TrxG Functions in Acute Myeloid Leukemia.

  2021cites this paper
• Setd1a Plays Pivotal Roles for the Survival and Proliferation of Retinal Progenitors via Histone Modifications of Uhrf1

  2021cites this paper
• The H3K4 methyltransferase SETD1A is required for proliferation of non-small cell lung cancer cells by promoting S-phase progression.

  2021cites this paper
• Construction of a prognostic model with histone modification-related genes and identification of potential drugs in pancreatic cancer

  2021cites this paper
• Histone H3K4 Methyltransferases as Targets for Drug-Resistant Cancers

  2021cites this paper
• Drug Repurposing for Targeting Acute Leukemia With KMT2A (MLL)—Gene Rearrangements

  2021cites this paper
• An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC development

  2021cites this paper
• Targeting transcription cycles in cancer

  2021cites this paper
• Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour

  2021cites this paper
• Anlotinib suppresses MLL-rearranged acute myeloid leukemia cell growth by inhibiting SETD1A/AKT-mediated DNA damage response.

  2020influential citation
• Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster

  2020cites this paper
• H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress

  2020cites this paper
• COMPASS and SWI/SNF complexes in development and disease

  2020cites this paper
• Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer

  2020cites this paper
• SETD1A augments sorafenib primary resistance via activating YAP in hepatocellular carcinoma.

  2020cites this paper
• SET1/MLL family of proteins: functions beyond histone methylation

  2020influential citation
• Cyclin-dependent kinases and rare developmental disorders

  2020cites this paper
• SETD1A Promotes Proliferation of Castration-Resistant Prostate Cancer Cells via FOXM1 Transcription

  2020cites this paper
• Coordinated regulation of cellular identity–associated H3K4me3 breadth by the COMPASS family

  2020cites this paper
• Resolving DNA Damage: Epigenetic Regulation of DNA Repair

  2020cites this paper
• MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

  2020cites this paper
• The role of SETD1A and SETD1B in development and disease.

  2020cites this paper
• The MLL/SET family and haematopoiesis☆

  2020cites this paper
• Learning from mouse models of MLL fusion gene-driven acute leukemia.

  2020cites this paper
• Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster

  2020cites this paper
• A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells

  2020cites this paper
• CDK12: cellular functions and therapeutic potential of versatile player in cancer

  2020cites this paper
• The complex activities of the SET1/MLL complex core subunits in development and disease.

  2020cites this paper
• Transcriptional regulation by the KMT2 histone H3K4 methyltransferases.

  2020cites this paper
• Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells

  2020cites this paper
• Decrypting chromatin states: DNA barcoding technologies to study chromatin interactions

  2019cites this paper
• Functional consequences of Setd1a haploinsufficiency : from gestation to behaviour

  2019cites this paper
• Molecular mechanisms for stemness maintenance of acute myeloid leukemia stem cells

  2019cites this paper
• Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3

  2019cites this paper
• Lysine demethylase 7a regulates the anterior-posterior development in mouse by modulating the transcription of Hox gene cluster

  2019cites this paper
• Transcriptomic Analysis Identifies RNA Binding Proteins as Putative Regulators of Myelopoiesis and Leukemia

  2019cites this paper
• CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes

  2019cites this paper
• The Unexpected Noncatalytic Roles of Histone Modifiers in Development and Disease.

  2019cites this paper
• Global Reduction of H 3 K 4 me 3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas 1

  2019cites this paper
• SETD1A protects from senescence through regulation of the mitotic gene expression program

  2019cites this paper
• Why are so many MLL lysine methyltransferases required for normal mammalian development?

  2019cites this paper
• SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18*

  2019cites this paper
• Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

  2019cites this paper
• Transcriptional Changes following Cellular Knockdown of the Schizophrenia Risk Gene SETD1A Are Enriched for Common Variant Association with the Disorder

  2019cites this paper
• Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity

  2019cites this paper
• Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice

  2019cites this paper
• De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens

  2019cites this paper
• Histone methyl transferases: A class of epigenetic opportunities to counter uncontrolled cell proliferation.

  2019cites this paper
• Targeting mitosis exit: A brake for cancer cell proliferation.

  2019cites this paper
• Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation and Enhancement of Replicative Intermediate Processing in Saccharomyces cerevisiae

  2019cites this paper
• Targeted therapy for fusion-driven high-risk acute leukemia.

  2018cites this paper
• The histone methyltransferase SETD1A regulates thrombomodulin transcription in vascular endothelial cells.

  2018cites this paper