HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Neurovirology

• Publication date

  2016-05-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s13365-016-0447-2PMID 27178324PMCID PMC5107352
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
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  2014cited by this paper
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  2013influential reference
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