Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Inflammation Research

• Publication date

  2005-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00011-005-1355-8PMID 16134056
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Immunosuppressive Effect of Methotrexate in Active Rheumatoid Arthritis Patients vs. its Stimulatory Effect in Nonactive Patients, as Indicated by Cytometric Measurements of CD4 + T Cell Subpopulations

  2004cited by this paper
• Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation

  2004cited by this paper
• Oxidative stress-induced apoptosis is associated with alterations in mitochondrial caspase activity and Bcl-2-dependent alterations in mitochondrial pH (pHm).

  2004cited by this paper
• Oxidative stress in kidney transplant patients1

  2003cited by this paper
• The anti‐inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species

  2003influential reference
• Tetrahydrofolate and 5‐methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore

  2003cited by this paper
• The induction of apoptosis by methotrexate in activated lymphocytes as indicated by fluorescence hyperpolarization: a possible model for predicting methotrexate therapy for rheumatoid arthritis patients.

  2003influential reference
• Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine.

  2003cited by this paper
• Protein Kinases in the Regulation of Apoptosis in B-cell Chronic Lymphocytic Leukemia

  2003cited by this paper
• The role of free radicals in the pathogenesis of rheumatoid arthritis.

  2003cited by this paper
• [Low dose methotrexate combined with GM-CSF induced differentiation of U937 cells].

  2003cited by this paper
• Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors

  2002cited by this paper
• A synthetic analog of prostaglandin E(1) prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats.

  2002cited by this paper
• Mitochondrial reactive oxygen species in cell death signaling.

  2002cited by this paper
• Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs

  2002cited by this paper
• [p73 gene expression in apoptotic process of acute myeloid leukemia cell line U937 induced by methotrexate].

  2002cited by this paper
• Fluorescence Polarization as a Functional Parameter in Monitoring Living Cells: Theory and Practice

  2002cited by this paper
• Induction of mitochondrial changes in myeloma cells by imexon.

  2001cited by this paper
• Influence of longterm therapy with methotrexate and low dose corticosteroids on type 1 and type 2 cytokine production in CD4+ and CD8+ T lymphocytes of patients with rheumatoid arthritis.

  2001cited by this paper
• Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells.

  2001cited by this paper
• Cell surface CD28 levels define four CD4+ T cell subsets: abnormal expression in rheumatoid arthritis.

  2001cited by this paper
• Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis

  2000cited by this paper
• Fluorescein fluorescence hyperpolarization as an early kinetic measure of the apoptotic process.

  2000cited by this paper
• The biochemistry of apoptosis

  2000cited by this paper
• Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cell derived tumour necrosis factor alpha, increase of interleukin 10, and predicted by the initial concentration of interleukin 4.

  2000cited by this paper
• Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis.

  2000cited by this paper
• Nuclear factor-κB regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells

  1999cited by this paper
• Nuclear factor-kappa B regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells.

  1999cited by this paper
• Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL*

  1999cited by this paper
• Reactive oxygen intermediates as mediators of programmed cell death in plants and animals.

  1999cited by this paper
• More than one way to die: apoptosis, necrosis and reactive oxygen damage

  1999cited by this paper
• A tale of two diseases: atherosclerosis and rheumatoid arthritis.

  1999cited by this paper
• Nitric Oxide Suppresses Apoptosis via Interrupting Caspase Activation and Mitochondrial Dysfunction in Cultured Hepatocytes*

  1999cited by this paper
• Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?

  1999cited by this paper
• T-cell responses in rheumatoid arthritis: systemic abnormalities-local disease.

  1999cited by this paper
• Methotrexate: pentose cycle and oxidative stress

  1998cited by this paper
• Bayesian calculation of methotrexate clearance after low dose intramuscular administration in patients with rheumatoid arthritis.

  1998cited by this paper
• OXIDATIVE STRESS-INDUCED APOPTOSIS: AN OVERVIEW

  1998cited by this paper
• Longterm prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy.

  1998cited by this paper
• APOPTOSIS, REDIFFERENTIATION AND ARRESTING PROLIFERATION SIMULTANEOUSLY TRIGGERED BY OXIDATIVE STRESS IN HUMAN HEPATOMA CELLS

  1998cited by this paper
• Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.

  1998cited by this paper
• Apoptosis in rheumatoid arthritis: a novel pathway in the regulation of synovial tissue.

  1998cited by this paper
• Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.

  1998influential reference
• Fluorescence polarization as an early measure of T-lymphocyte stimulation.

  1997cited by this paper
• Safety, efficacy, and mortality in a long-term cohort of patients with rheumatoid arthritis taking methotrexate: followup after a mean of 13.3 years.

  1997cited by this paper
• Fluorescence depolarization as an early measure of T lymphocyte stimulation.

  1997cited by this paper
• Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings.

  1996cited by this paper
• Reactive oxygen species and programmed cell death.

  1996cited by this paper
• CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

  1996cited by this paper
• Folic acid and methotrexate in rheumatoid arthritis.

  1996cited by this paper
• Superoxide and hydrogen peroxide in relation to mammalian cell proliferation.

  1995cited by this paper
• Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid.

  1995cited by this paper
• Pro-oxidant properties of methotrexate: evaluation and prevention by an anti-oxidant drug.

  1994cited by this paper
• Oxidative stress as a mediator of apoptosis.

  1994cited by this paper
• Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.

  1994cited by this paper
• Divergent signalling via APO‐1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

  1994cited by this paper
• The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

  1993cited by this paper
• Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

  1993cited by this paper
• Induction of apoptosis in human leukemic cells by the ether lipid 1‐octadecyl‐2‐methyl‐RAC‐glycero‐3‐ phosphocholine. A possible basis for its selective action

  1993cited by this paper
• Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.

  1993cited by this paper
• Cell killing and induction of manganous superoxide dismutase by tumor necrosis factor-alpha is mediated by lipoxygenase metabolites of arachidonic acid.

  1992cited by this paper
• Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay

  1991cited by this paper
• Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells.

  1991cited by this paper
• Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective evaluation of 1017 consecutive starts.

  1990cited by this paper
• Mechanism of antigen-driven selection in germinal centres

  1989cited by this paper
• Polyglutamation of methotrexate. Is methotrexate a prodrug?

  1985cited by this paper
• Comparison of low-dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A controlled clinical trial.

  1985cited by this paper
• Efficacy of low-dose methotrexate in rheumatoid arthritis.

  1985cited by this paper
• Application of the phenomenon of changes in the structuredness of cytoplasmic matrix (SCM) in the diagnosis of malignant disorders: a review.

  1977cited by this paper

• Multiple aspects of the chemotherapy effect on immune response

  2025cites this paper
• Effects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment

  2025cites this paper
• Methotrexate-induced disruption of the serum-glucocorticoid inducible protein kinase 3 signaling pathway and its effects on brain development.

  2025cites this paper
• New frontiers in rheumatoid arthritis therapy: From classic DMARDs to biologics and beyond.

  2025cites this paper
• Antioxidant activity and chemoprotective effect of Moringa oleifera Lam. leaf infusion against methotrexate-induced damage in mice

  2025cites this paper
• Chronic proximal tibial aseptic osteitis diagnosed as SAPHO syndrome ameliorated with oral methotrexate: A case report

  2024cites this paper
• Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress

  2024cites this paper
• The interaction of methotrexate with the human C5a and its potential therapeutic implications

  2024cites this paper
• Serum malondialdehyde as a marker of oxidative stress in rheumatoid arthritis

  2024cites this paper
• Combination chemotherapy via poloxamer 188 surface-modified PLGA nanoparticles that traverse the blood–brain–barrier in a glioblastoma model

  2024cites this paper
• Effects of low-dose methotrexate with MMI in patients with Graves' disease: results of a randomized clinical trial.

  2024cites this paper
• Potential Hepatoprotective Effects of Chamaecyparis lawsoniana against Methotrexate-Induced Liver Injury: Integrated Phytochemical Profiling, Target Network Analysis, and Experimental Validation

  2023cites this paper
• A Review on Formulation Development using Chaulmoogra Oil

  2023cites this paper
• L-methionine protects against nephrotoxicity induced by methotrexate through modulation of redox status and inflammation

  2023cites this paper
• Latent Tuberculosis in Psoriasis Patients on Biologic Therapies: Real-World Data from a Care Center in Romania

  2023cites this paper
• Spirulina and Thymoquinone Protect Against Methotrexate-Induced Hepatic Injury in Rats

  2023cites this paper
• Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation

  2023cites this paper
• Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic.

  2023cites this paper
• Manjari Medika Grape Seed Extract Protects Methotrexate-Induced Hepatic Inflammation: Involvement of NF-κB/NLRP3 and Nrf2/HO-1 Signaling System

  2023cites this paper
• Effect of DMARDs on the immunogenicity of vaccines

  2023cites this paper
• Long Term Treatment of Corticostreroids May Cause Hepatotoxicity and Oxidative Damage: A Case Controlled Study

  2023cites this paper
• Antiapoptotic and anticoagulant effects of camel milk and camel urine in methotrexate-induced hepatotoxicity

  2023cites this paper
• TITLE OF THE ARTICLE: EXOINTERACTIVE AMELIORATION AGAINST METHOTREXATE INTOXICATION IN MOUSE SPERMATOZOA

  2023cites this paper
• Therapeutic drug monitoring of disease-modifying antirheumatic drugs in circulating leukocytes in immune-mediated inflammatory diseases

  2023cites this paper
• DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action

  2023cites this paper
• A Meta-Analysis Evaluating the Effectiveness and Safety of Upadacitinib in Treating Rheumatoid Arthritis in Patients With Inadequate Response to Disease-Modifying Anti-Rheumatic Drugs

  2023cites this paper
• Evaluation of thiol/disulfide hemostasis and serum Ischemia modified albumin as oxidative stress biomarkers in systemic lupus erythematosus patients: Relationship with major organ involvement and disease activity

  2022cites this paper
• Polydatin combats methotrexate‐induced pulmonary fibrosis in rats: Involvement of biochemical and histopathological assessment

  2022cites this paper
• A Randomized Open-Labeled Trial of Methotrexate as a Steroid-Sparing Agent for Patients With Generalized Myasthenia Gravis

  2022cites this paper
• ADSC-Exosomes Alleviate MTX-induced Rat Neuronal Damage by Activating Nrf2-ARE Pathway

  2022cites this paper
• Lymphocyte activation gene-3 (LAG-3) regulatory T cells: An evolving biomarker for treatment response in autoimmune diseases.

  2022cites this paper
• Quillaja saponaria bark saponin attenuates methotrexate induced hepatic oxidative stress, inflammation and associated liver injury in rats

  2022cites this paper
• Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values - implications and way forward.

  2022cites this paper
• The Protective Effects of Nutraceutical Components in Methotrexate-Induced Toxicity Models—An Overview

  2022cites this paper
• Mitochondrial Dysfunction in Rheumatoid Arthritis

  2022cites this paper
• Anti-rheumatoid drugs advancements: New insights into the molecular treatment of rheumatoid arthritis.

  2022cites this paper
• Ferroptosis in inflammatory arthritis: A promising future

  2022cites this paper
• Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats

  2022influential citation
• Diallyl Disulfide Attenuates Methotrexate-Induced Hepatic Oxidative Injury, Inflammation and Apoptosis and Enhances its Anti-tumor Activity.

  2021cites this paper
• Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis.

  2021cites this paper
• Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis

  2021cites this paper
• Impact of Different JAK Inhibitors and Methotrexate on Lymphocyte Proliferation and DNA Damage

  2021cites this paper
• Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease

  2021cites this paper
• NIR and glutathione trigger the surface release of methotrexate linked by Diels-Alder adducts to anisotropic gold nanoparticles.

  2021cites this paper
• Incomptine A Induces Apoptosis, ROS Production and a Differential Protein Expression on Non-Hodgkin’s Lymphoma Cells

  2021cites this paper
• Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses

  2021cites this paper
• Methotrexate and theaflavin-3, 3′-digallate synergistically restore the balance between apoptosis and autophagy in synovial fibroblast of RA: an ex vivo approach with cultured human RA FLS

  2021cites this paper
• Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence

  2021cites this paper
• Normas

  2020cites this paper
• Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

  2020cites this paper
• The Selfish Immune System when the Immune System Overrides the ‘Selfish’ Brain

  2020cites this paper
• Protective Effects of Origanum onites Essential Oil in the Methotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity

  2020cites this paper
• Methotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis

  2020cites this paper
• Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat.

  2020cites this paper
• Using pharmacogenetics to predict methotrexate response in rheumatoid arthritis patients

  2020cites this paper
• Part II. high-dose methotrexate with leucovorin rescue for severe COVID-19: An immune stabilization strategy for SARS-CoV-2 induced ‘PANIC’1 attack

  2020influential citation
• Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling

  2020cites this paper
• Comparative efficacy and safety of 15 and 30 mg upadacitinib administered to patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials

  2019cites this paper
• Methotrexate Affects Cerebrospinal Fluid Folate and Tau Levels and Induces Late Cognitive Deficits in Mice.

  2019cites this paper
• Chaulmoogra oil based methotrexate loaded topical nanoemulsion for the treatment of psoriasis

  2019cites this paper
• Unexpected mechanism of colitis amelioration by artesunate, a natural product from Artemisia annua L.

  2019cites this paper
• Auxiliary in vitro and in vivo biological evaluation of hydrogen peroxide sensitive prodrugs of methotrexate and aminopterin for the treatment of rheumatoid arthritis.

  2019cites this paper
• Methotrexate an Old Drug with New Tricks

  2019influential citation
• Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats

  2019cites this paper
• Effects of Hesperidin on Memory Impairments Induced by Methotrexate in Adult Rats

  2019cites this paper
• Blocking osteopontin‐fibronectin interactions reduce extracellular fibronectin deployment and arthritic immunopathology

  2018cites this paper
• Comparative efficacy and safety of baricitinib 2 mg and 4 mg in patients with active rheumatoid arthritis

  2018cites this paper
• Mechanism-based pharmacodynamic interactions of glucocorticoids and disease-modifying antirheumatic drugs: A review

  2018cites this paper
• Comparative efficacy and safety of biosimilar adalimumab and originator adalimumab in combination with methotrexate in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials

  2018cites this paper
• Rapid Response Fluorescence Probe Enabled In Vivo Diagnosis and Assessing Treatment Response of Hypochlorous Acid‐Mediated Rheumatoid Arthritis

  2018cites this paper
• What's new about the mechanism of methotrexate action in psoriasis?

  2018cites this paper
• Problems hidden in plain sight

  2018cites this paper
• Targeted Graphene Oxide Networks: Cytotoxicity and Synergy with Anticancer Agents.

  2018cites this paper
• Comparative efficacy and safety of biosimilar‐infliximab and originator‐infliximab in combination with methotrexate in patients with active rheumatoid arthritis: a meta‐analysis of randomized controlled trials

  2018cites this paper
• Methotrexate-induced apoptosis in human ovarian adenocarcinoma SKOV-3 cells via ROS-mediated bax/bcl-2-cyt-c release cascading

  2018cites this paper
• Predicting methotrexate resistance in rheumatoid arthritis patients

  2018cites this paper
• Spirulina ameliorates methotrexate hepatotoxicity via antioxidant, immune stimulation, and proinflammatory cytokines and apoptotic proteins modulation

  2018cites this paper
• Oral Agents for Psoriasis

  2018cites this paper
• Level of serum soluble endothelial leukocyte adhesion molecule-1 in psoriatic patients after narrow-band ultraviolet-B and relation to disease activity: a case–control study

  2017cites this paper
• Lutein Induces Autophagy via Beclin-1 Upregulation in IEC-6 Rat Intestinal Epithelial Cells.

  2017cites this paper
• Expression of Th1 and Th2 Cytokine and Associated Transcription Factors in Peripheral Blood Mononuclear Cells and Correlation with Disease Severity.

  2017cites this paper
• Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach.

  2017cites this paper
• Antifungal activity of the cationic antimicrobial polymer-polyhexamethylene guanidine hydrochloride and its mode of action.

  2017cites this paper
• Endoplasmic reticulum stress plays an important role in methotrexate-related cognitive impairment in adult rats.

  2017cites this paper
• Much more than you expected: The non-DHFR-mediated effects of methotrexate.

  2017cites this paper
• Methotrexate, blood pressure and markers of arterial function in patients with rheumatoid arthritis: a repeated cross-sectional study

  2017cites this paper
• Methotrexate treatment provokes apoptosis of proliferating keratinocyte in psoriasis patients

  2017cites this paper
• Evaluation of psoriasis severity and inflammatory responses under concomitant treatment with methotrexate plus micronutrients for psoriasis vulgaris: a randomized double blind trial.

  2017cites this paper
• Oxidative stress and inhibition of nitric oxide generation underlie methotrexate-induced senescence in human colon cancer cells.

  2017cites this paper
• Increased baseline RUNX2, caspase 3 and p21 gene expressions in the peripheral blood of disease‐modifying anti‐rheumatic drug‐naïve rheumatoid arthritis patients are associated with improved clinical response to methotrexate therapy

  2017cites this paper
• Insights on methotrexate in psoriatic disease.

  2016cites this paper
• Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers

  2016cites this paper
• Efficacy and safety of methotrexate plus certolizumab pegol or placebo in active rheumatoid arthritis

  2016cites this paper
• Effect of methotrexate exposure at middle gestation on the inner plate of the ocular cup and lens in the rat fetus

  2016cites this paper
• Protective effect of propolis on methotrexate-induced kidney injury in the rat

  2016cites this paper
• Conserved molecular mechanisms underlying the effects of small molecule xenobiotic chemotherapeutics on cells.

  2016cites this paper
• Methotrexate regulates Th-1 response by suppressing caspase-1 and cytokines in psoriasis patients.

  2016cites this paper
• STUDY OF MDA AND SGPT LEVELS IN PATIENTS WITH PSORIASIS

  2016cites this paper
• Methotrexate normalized keratinocyte activation cycle by overturning abnormal keratins as well as deregulated inflammatory mediators in psoriatic patients.

  2015cites this paper
• Effect of methotrexate on cerebellar development in infant rats

  2015cites this paper