Compounded medications for ocular surface disease

Purpose: Citation analysis represents one of the best currently available methods for quantifying the impact of articles. Bibliometric studies list the ‘‘best sellers’’ in a single field of interest. The purpose of the present study was to identify and analyze the most frequently cited papers in dry eye research that may be of high interest for researchers and clinicians. Methods: We reviewed the database of the Institute for Scientific Information to identify articles published from 1900 to September 2016. All dry eye articles published in 59 ophthalmology journals were identified. The top 100 articles were selected for further analysis of authorship, source journal, number of citations, citation rate, geographic origin, article type, and level of evidence. Results: The 100 most-cited articles were published between 1983 and 2011, with most of them in the 2000s. The number of citations per article ranged from 96 to 610, and was greatest for articles published in the 2000s. Each of these articles was published in one of 15 journals. Most articles represented LevelIII evidence, followed by Levels II and I. Conclusions: The present study focusing on dry eye research revealed that 55% of the most-cited articles came from the U.S. and 18% from Japan. Diagnostics and therapy were the areas of focus of most of the clinical articles; 13% of the most cited papers were review articles. This analysis provides researchers and clinicians with a detailed overview on the most cited dry eye papers over the past decades. © 2017 Elsevier Inc. All rights reserved.

• Publication year

  2021

• Venue

  The ocular surface

• Publication date

  2021-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jtos.2021.09.004PMID 34555526PMCID 9760211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Importing oncology trials from China: a bridge over troubled waters?

  2022cited by this paper
• Medicaid Spending on Drugs Marketed Without US Food and Drug Administration Approval in 2020.

  2022cited by this paper
• Aducanumab and Accelerated Approval: Where Do We Go From Here?

  2022cited by this paper
• FDA Facilitating Innovation of Ophthalmic Devices While Balancing the Need for Safety and Effectiveness.

  2022cited by this paper
• How a site peddles author slots in reputable publishers’ journals

  2022cited by this paper
• Mixed Response to the CMS Decision on Coverage for Aducanumab

  2022cited by this paper
• Performing Cost-Effectiveness Analyses to Support Policy Making

  2022cited by this paper
• Revisiting FDA Approval of Aducanumab.

  2021cited by this paper
• AMWA-EMWA-ISMPP joint position statement on medical publications, preprints, and peer review

  2021cited by this paper
• Approval of Aducanumab for Alzheimer Disease-the FDA's Perspective.

  2021cited by this paper
• Medicare and the Shocking US Food and Drug Administration Approval of Aducanumab: Crisis or Opportunity?

  2021cited by this paper
• A Perspective on the Current Role of Teprotumumab in Treatment of Thyroid Eye Disease.

  2021cited by this paper
• Why Is Aducanumab Priced at $56,000 per Patient? Lessons for Drug-Pricing Reform.

  2021cited by this paper
• Medicare Coverage of Aducanumab - Implications for State Budgets.

  2021cited by this paper
• European law could boost clinical trials reporting.

  2021cited by this paper
• Challenges in confirming drug effectiveness after early approval

  2021cited by this paper
• Challenges of cost-effectiveness analyses of novel therapeutics for Inherited Retinal Diseases: Cost-effectiveness analysis in Inherited Retinal Diseases.

  2021cited by this paper
• Prescribing Aducanumab in the Face of Meager Efficacy and Real Risks

  2021cited by this paper
• Aducanumab, Amyloid Lowering, and Slowing of Alzheimer Disease

  2021cited by this paper
• Clinical Efficacy, Drug Safety, and Surrogate Endpoints

  2021cited by this paper
• The Accelerated Approval of Aducanumab for Treatment of Patients With Alzheimer Disease.

  2021cited by this paper
• An Appropriate Use of Accelerated Approval - Aducanumab for Alzheimer's Disease.

  2021cited by this paper
• Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study.

  2021cited by this paper
• Unapproved drugs - A fix to an unintended consequence of an FDA policy.

  2021cited by this paper
• What Do We Know About Remdesivir Drug Interactions?

  2020cited by this paper
• Regulatory and Developmental Aspects of Biomarkers in the Treatment of Ocular Surface Disease.

  2020cited by this paper
• Clinical Pharmacology Considerations for Developing Small‐Molecule Treatments for COVID‐19

  2020cited by this paper
• Local Investigators Significantly Overestimate Overall Response Rates Compared to Blinded Independent Central Reviews in Phase 2 Oncology Trials

  2020cited by this paper
• FDA review times for new drugs in ophthalmology

  2020cited by this paper
• Five Unapproved Drugs Found in Cognitive Enhancement Supplements

  2020cited by this paper
• Repurposing medications

  2020cited by this paper
• Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology.

  2019cited by this paper
• A Systematic Review and Meta-analysis of Bevacizumab in First-line Metastatic Breast Cancer: Lessons for the Research and Regulatory Enterprises.

  2019cited by this paper
• TFOS DEWS II Iatrogenic Dry Eye Report

  2018influential reference
• TFOS DEWS II Diagnostic Methodology report.

  2017influential reference
• Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease.

  2017cited by this paper
• Dysfunctional tear syndrome: dry eye disease and associated tear film disorders – new strategies for diagnosis and treatment

  2017cited by this paper
• A Randomized Multicenter Study Comparing 0.1%, 0.15%, and 0.3% Sodium Hyaluronate with 0.05% Cyclosporine in the Treatment of Dry Eye

  2017cited by this paper
• TFOS DEWS II pain and sensation report.

  2017influential reference
• Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation.

  2017cited by this paper
• Randomised masked trial of the clinical safety and tolerability of MGO Manuka Honey eye cream for the management of blepharitis

  2017cited by this paper
• TFOS DEWS II Tear Film Report.

  2017influential reference
• TFOS DEWS II Sex, Gender, and Hormones Report.

  2017influential reference
• Compliance and Subjective Patient Responses to Eyelid Hygiene

  2017cited by this paper
• TFOS DEWS II Definition and Classification Report.

  2017cited by this paper
• TFOS DEWS II pathophysiology report.

  2017influential reference
• Punctal occlusion for dry eye syndrome.

  2017influential reference
• TFOS DEWS II Epidemiology Report.

  2017influential reference
• A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease.

  2017influential reference
• TFOS DEWS II Management and Therapy Report.

  2017cited by this paper
• Commercial lid cleanser outperforms baby shampoo for management of blepharitis in randomized, double-masked clinical trial

  2017influential reference
• Intranasal Tear Neurostimulation: An Emerging Concept in the Treatment of Dry Eye

  2017cited by this paper
• Omega‐3 supplementation is neuroprotective to corneal nerves in dry eye disease: a pilot study

  2017cited by this paper
• Efficacy and Safety of 0.2% Hyaluronic Acid in the Management of Dry Eye Disease

  2017cited by this paper
• A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease.

  2017cited by this paper
• Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease.

  2016cited by this paper
• Effect of Moisture Chamber Spectacles on Tear Functions in Dry Eye Disease

  2016cited by this paper
• Neuroactive steroids, nociception and neuropathic pain: A flashback to go forward.

  2016cited by this paper
• Safety and Efficacy Clinical Trials for SYL1001, a Novel Short Interfering RNA for the Treatment of Dry Eye Disease.

  2016cited by this paper
• Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study

  2016cited by this paper
• Assessment of the effect of cyclosporine-A 0.05% emulsion on the ocular surface and corneal sensation following cataract surgery.

  2016cited by this paper
• Combination Therapy of Intense Pulsed Light Therapy and Meibomian Gland Expression (IPL/MGX) Can Improve Dry Eye Symptoms and Meibomian Gland Function in Patients With Refractory Dry Eye: A Retrospective Analysis

  2016cited by this paper
• Influence of Omega 3 and 6 Fatty Acids on Human Meibomian Gland Epithelial Cells

  2016cited by this paper
• Comparison of Topical Application of TSG-6, Cyclosporine, and Prednisolone for Treating Dry Eye

  2016influential reference
• ω-3 Tear Film Lipids Correlate With Clinical Measures of Dry Eye

  2016cited by this paper
• PRGF exerts more potent proliferative and anti-inflammatory effects than autologous serum on a cell culture inflammatory model.

  2016cited by this paper
• Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro

  2016cited by this paper
• Trends and topics in eye disease research in PubMed from 2010 to 2014

  2016cited by this paper
• Demodex treatment in external ocular disease: the outcomes of a Tasmanian case series

  2016cited by this paper
• Diquafosol promotes corneal epithelial healing via intracellular calcium-mediated ERK activation.

  2016cited by this paper
• The relief of dry eye signs and symptoms using a combination of lubricants, lid hygiene and ocular nutraceuticals

  2016cited by this paper
• Trends in ophthalmology journals: a five-year bibliometric analysis (2009-2013).

  2016cited by this paper
• Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction

  2016cited by this paper
• Effects of Punctal Occlusion on Clinical Signs and Symptoms and on Tear Cytokine Levels in Patients with Dry Eye.

  2016influential reference
• In-vivo heat retention comparison of eyelid warming masks.

  2016cited by this paper
• Understanding Neuropathic Corneal Pain—Gaps and Current Therapeutic Approaches

  2016cited by this paper
• The sustained effect (12 months) of a single-dose vectored thermal pulsation procedure for meibomian gland dysfunction and evaporative dry eye

  2016cited by this paper
• Long-term tolerance of preservative-free eye drops containing macrogol hydroxystearate as an excipient.

  2016cited by this paper
• Accelerated Restoration of Ocular Surface Health in Dry Eye Disease by Self-Retained Cryopreserved Amniotic Membrane.

  2016influential reference
• Publication trends in corneal transplantation: a bibliometric analysis

  2016cited by this paper
• Efficacy and Safety of 0.1% Cyclosporine a Cationic Emulsion in the Treatment of Severe Dry Eye Disease: A Multicenter Randomized Trial

  2016influential reference
• Bibliometrics: tracking research impact by selecting the appropriate metrics

  2016cited by this paper
• Over the counter (OTC) artificial tear drops for dry eye syndrome.

  2016influential reference
• Long-term Natural History of Dry Eye Disease from the Patient's Perspective.

  2016cited by this paper
• Impact of the Topical Ophthalmic Corticosteroid Loteprednol Etabonate on Intraocular Pressure

  2016cited by this paper
• Long-Term (3 Year) Effects of a Single Thermal Pulsation System Treatment on Meibomian Gland Function and Dry Eye Symptoms

  2016cited by this paper
• Autologous Serum Eye Drops Accelerate Epithelial Healing After LASEK*

  2016cited by this paper
• Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study.

  2016cited by this paper
• The Effect of Autologous Platelet Lysate Eye Drops: An In Vivo Confocal Microscopy Study

  2016cited by this paper
• Five-year results of Small Incision Lenticule Extraction (ReLEx SMILE)

  2016cited by this paper
• Oral Antibiotics for Meibomian Gland-Related Ocular Surface Disease: A Report by the American Academy of Ophthalmology.

  2016cited by this paper
• Effect of Oral Re-esterified Omega-3 Nutritional Supplementation on Dry Eyes

  2016cited by this paper
• Report of the Inaugural Meeting of the TFOS i(2) = initiating innovation Series: Targeting the Unmet Need for Dry Eye Treatment.

  2016influential reference
• Short-Term Omega 3 Fatty Acids Treatment for Dry Eye in Young and Middle-Aged Visual Display Terminal Users

  2016cited by this paper
• A Single-Center Pilot Prospective Study of Topical Application of Platelet-Derived Eye Drops for Patients with Ocular Chronic Graft-versus-Host Disease.

  2016cited by this paper
• Effects of Autologous Serum Eye Drops on Conjunctival Expression of MUC5AC in Patients With Ocular Surface Disorders

  2016cited by this paper
• Product Exclusivity Granted by the U.S. Food and Drug Administration.

  2016cited by this paper
• Temperature profiles of patient-applied eyelid warming therapies.

  2015cited by this paper
• Matrix metalloproteinase 9 and transglutaminase 2 expression at the ocular surface in patients with different forms of dry eye disease.

  2015cited by this paper
• Comparison of Self-applied Heat Therapy for Meibomian Gland Dysfunction

  2015cited by this paper

• Photocontrolled Bionic Micro‐Nano Hydrogel System used Novel Functional Strategy for Cell Delivery and Large‐Scale Corneal Repair

  2025cites this paper
• Adverse eye effects of smoke exposure at prescribed burns in wildland firefighters

  2025influential citation
• Pipeline: Pharmacotherapy of Dry Eye Disease in Vertebrates.

  2025cites this paper
• IFITM1/OVOL1 Axis Is a Novel Regulator of the Expansion of the Limbal Epithelial Stem/Early Transient Amplifying Cell Population

  2025cites this paper
• Limbal stem cell deficiency approaches and limbal niche restoration

  2025influential citation
• Enhanced Tear Film Concentrations of Cefazolin and Chloramphenicol Using Cross‐Linked Hyaluronic Acid in Canine Eyes

  2025cites this paper
• Lotilaner for Demodex Blepharitis: The Journey from Veterinary Use to Human Medicine

  2025influential citation
• A highly selective inhibitor of discoidin domain receptor‐1 (DDR1‐IN‐1) protects corneal epithelial cells from YAP/ACSL4‐mediated ferroptosis in dry eye

  2024cites this paper
• Compounded 0.01% Atropine—What's in the Bottle?

  2023cites this paper
• Tenon excision with fibrin glue-assisted reattachment of conjunctiva flap (T.E.F.A.R.C) for the treatment of conjunctivochalasis

  2023cites this paper
• Ocular surface disease: a known yet overlooked side effect of topical glaucoma therapy

  2023cites this paper
• Amniotic Membrane Transplant: About A Case in Mali

  2023cites this paper
• The evaluation of the effect of tafluprost on the intraocular pressure of healthy male guinea pigs under different light‐and‐darkness regimes

  2023cites this paper
• Compounding of Low-Concentration Atropine for Myopia Control

  2022cites this paper
• Comparison of tear function among newly diagnosed polycystic ovary syndrome (PCOS) and PCOS under treatment

  2022cites this paper
• Reflections on the Ocular Surface: Summary of the Presentations at the 4th Coronis Foundation Ophthalmic Symposium Debate: "A Multifactorial Approach to Ocular Surface Disorders" (August 31 2021).

  2022cites this paper
• Blast Eye Injury After Mobile Phone Battery Explosion: How to Manage it?

  2022cites this paper
• All trans retinoic acid as a host-directed immunotherapy for tuberculosis

  2022cites this paper
• Topical Pirfenidone-Loaded Liposomes Ophthalmic Formulation Reduces Haze Development after Corneal Alkali Burn in Mice

  2022cites this paper
• The effect of tamarind seed polysaccharidecontaining eye drop in dry eye syndrome: Results of an interventional, comparative, clinical study

  2021cites this paper
• Proton Sensing on the Ocular Surface: Implications in Eye Pain

  2021cites this paper
• Involvement of ocular surface in graft‐versus‐host disease: An update from immunopathogenesis to treatment

  2021cites this paper
• Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries

  2021cites this paper
• Understanding cornea epithelial stem cells and stem cell deficiency: Lessons learned using vertebrate model systems

  2021cites this paper
• Single-Anastomosis Duodenal Jejunal Bypass Improve Glucose Metabolism by Regulating Gut Microbiota and Short-Chain Fatty Acids in Goto-Kakisaki Rats

  2020cites this paper
• Material, Immunological, and Practical Perspectives on Eye Drop Formulation

  2020cites this paper
• The impact of the dry eye syndrome on the quality of life in elderly patients-minireview

  2020cites this paper
• There is a Role in Detection of SARS-CoV-2 in Conjunctiva and Tears: a comprehensive review.

  2020cites this paper
• Commensals Modulate Innate Immune Response Through L-Plastin to Bacterial Keratitis

  2019cites this paper
• Evaluation of IL8 pathway on the ocular surface: new insights in patients with ocular mucous membrane pemphigoid

  2019cites this paper
• Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea

  2019cites this paper
• The prevalence of dry eye syndrome among patients at the eye clinic in Nelson Mandela Academic Hospital

  2019cites this paper
• The global prevalence of dry eye disease and its association with economy: a systematic review

  2019cites this paper
• IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea

  2018cites this paper
• Surface Immobilization of Natural Wetting and Lubricating Agents for the Development of Novel Biomimetic Contact Lenses

  2018cites this paper
• Management of Alkali Eye Injury

  2018cites this paper
• Estimating the prevalence of dry eye among patients attending a tertiary ophthalmology clinic in Eastern India

  2018cites this paper
• Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents

  2018cites this paper
• Management of a neurotrophic deep corneal ulcer with amniotic membrane transplantation in a patient with functional monocular vision

  2017cites this paper
• Expression patterns of conjunctival mucin 5AC and aquaporin 5 in response to acute dry eye stress

  2017cites this paper
• Additive effects and safety of fixed combination therapy with 1% brinzolamide and 0.5% timolol versus 1% dorzolamide and 0.5% timolol in prostaglandin‐treated glaucoma patients

  2017cites this paper
• Antimicrobial susceptibility of bacteria isolated from children infected eyes in Benha University hospital

  2016cites this paper
• Corneal recovery in a rabbit limbal stem cell deficiency model by autologous grafts of tertiary outgrowths from cultivated limbal biopsy explants

  2016cites this paper
• Management of allergic conjunctivitis and dry eye

  2014cites this paper
• Central corneal thickness in patients with meibomian gland dysfunction a

  2011cites this paper
• Paradigm Shift in Therapeutic Modalities for Devastating Ocular Surface Disorders

  2009cites this paper
• Contact Lens Wear Affects Tear Film Evaporation

  2008cites this paper
• Automatic Detection of Pre-ocular Tear Film Break-Up Sequence in Dry Eyes

  2008cites this paper
• Scanning electron microscopy study of the tarsal and orbital conjunctival surfaces compared to peripheral corneal epithelium in pigmented rabbits

  2007cites this paper
• [Comparative study of treatment of the dry eye syndrome due to disturbances of the tear film lipid layer with lipid-containing tear substitutes].

  2006cites this paper
• Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells

  2005cites this paper
• The Promises and Challenges of Regenerative Medicine

  2005cites this paper
• Autologe Serum-Augentropfen zur Therapie der Augenoberfläche

  2002cites this paper
• In vitro and in vivo effects of a lubricant in a contact lens solution

  2002cites this paper