Polylactides in additive biomanufacturing.

New advanced manufacturing technologies under the alias of additive biomanufacturing allow the design and fabrication of a range of products from pre-operative models, cutting guides and medical devices to scaffolds. The process of printing in 3 dimensions of cells, extracellular matrix (ECM) and biomaterials (bioinks, powders, etc.) to generate in vitro and/or in vivo tissue analogue structures has been termed bioprinting. To further advance in additive biomanufacturing, there are many aspects that we can learn from the wider additive manufacturing (AM) industry, which have progressed tremendously since its introduction into the manufacturing sector. First, this review gives an overview of additive manufacturing and both industry and academia efforts in addressing specific challenges in the AM technologies to drive toward AM-enabled industrial revolution. After which, considerations of poly(lactides) as a biomaterial in additive biomanufacturing are discussed. Challenges in wider additive biomanufacturing field are discussed in terms of (a) biomaterials; (b) computer-aided design, engineering and manufacturing; (c) AM and additive biomanufacturing printers hardware; and (d) system integration. Finally, the outlook for additive biomanufacturing was discussed.

• Publication year

  2016

• Venue

  Advanced Drug Delivery Reviews

• Publication date

  2016-12-15

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1016/j.addr.2016.07.006PMID 27492211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Key challenges in additive biomanufacturing are organized around biomaterials, computer-aided design/engineering/manufacturing, printer hardware, and system integration, with polylactides discussed as an important biomaterial class in that context.

  Confidence 0.94

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• Bioprinting is presented as the 3D printing of cells, extracellular matrix, and biomaterials to create in vitro or in vivo tissue-analogue structures.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• Additive biomanufacturing is framed as a way to design and fabricate products ranging from pre-operative models and cutting guides to medical devices and scaffolds.

  Confidence 0.95

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review

• additive biomanufacturing

  fields

  An application of additive manufacturing to produce biological or medical products such as models, devices, and scaffolds.

  Aliases: AM-enabled biomanufacturing

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• additive manufacturing

  fields

  The broader layer-by-layer manufacturing sector from which the review draws technical lessons and challenge framing.

  Aliases: AM

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• bioprinting

  processes

  The 3D printing of cells, extracellular matrix, and biomaterials to build tissue-analogue structures.

  Aliases: 3D bioprinting

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• polylactides

  materials

  A family of lactide-based polymers considered here as biomaterial candidates for additive biomanufacturing.

  Aliases: PLA, polylactide

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• printer hardware

  equipment

  The physical printing systems and machine components used to carry out additive biomanufacturing.

  Aliases: printers hardware, hardware

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review
• system integration

  processes

  The coordination of materials, design, engineering, and hardware into a functioning additive biomanufacturing workflow.

  Aliases: integration

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) reviewAK (4715169a40) review

• Residual Stress

  2018cited by this paper
• Evaluation of polycaprolactone − poly‐D,L‐lactide copolymer as biomaterial for breast tissue engineering

  2017cited by this paper
• Transformation of Breast Reconstruction via Additive Biomanufacturing

  2016cited by this paper
• Computer Aided Manufacturing

  2016influential reference
• Ozone Gas as a Benign Sterilization Treatment for PLGA Nanofiber Scaffolds

  2016cited by this paper
• Ozone Gas as a Benign Sterilization Treatment for PLGA Nanofibre Scaffolds

  2016cited by this paper
• Online Monitoring of Additive Manufacturing Processes Using Ultrasound

  2016cited by this paper
• 3D Printing Surgical Implants at the clinic: A Experimental Study on Anterior Cruciate Ligament Reconstruction

  2016cited by this paper
• Characterization and preparation of bioinspired resorbable conduits for vascular reconstruction

  2016cited by this paper
• PLA composites: From production to properties.

  2016cited by this paper
• Polylactides-Methods of synthesis and characterization.

  2016cited by this paper
• Biofabrication: reappraising the definition of an evolving field

  2016cited by this paper
• Three-dimensional printing in cardiac surgery and interventional cardiology: a single-centre experience.

  2015cited by this paper
• Additive manufacturing techniques for the production of tissue engineering constructs

  2015cited by this paper
• 3D-Printed ABS and PLA Scaffolds for Cartilage and Nucleus Pulposus Tissue Regeneration

  2015cited by this paper
• Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing.

  2015influential reference
• Continuous liquid interface production of 3D objects

  2015cited by this paper
• Hydrogels for Engineering of Perfusable Vascular Networks

  2015cited by this paper
• Streamlining the additive manufacturing digital spectrum: A systems approach

  2015cited by this paper
• Development of a surgical navigation system based on augmented reality using an optical see-through head-mounted display

  2015cited by this paper
• Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA

  2015cited by this paper
• Additive manufacturing in biomedical sciences and the need for definitions and norms

  2015cited by this paper
• Additively Manufactured Device for Dynamic Culture of Large Arrays of 3D Tissue Engineered Constructs

  2015cited by this paper
• Chapter 1:PLA Synthesis. From the Monomer to the Polymer

  2014cited by this paper
• Toward an integrated computational system for describing the additive manufacturing process for metallic materials

  2014cited by this paper
• Materials perspective of polymers for additive manufacturing with selective laser sintering

  2014cited by this paper
• Implementation of a thermomechanical model for the simulation of selective laser melting

  2014cited by this paper
• Development and characterisation of a new bioink for additive tissue manufacturing.

  2014cited by this paper
• Real-time advanced spinal surgery via visible patient model and augmented reality system

  2014cited by this paper
• Bioactive nanoparticles stimulate bone tissue formation in bioprinted three-dimensional scaffold and human mesenchymal stem cells.

  2014cited by this paper
• Oxidative degradation of polylactide (PLA) and its effects on physical and mechanical properties

  2014cited by this paper
• 3D printing of MRI compatible components: why every MRI research group should have a low-budget 3D printer.

  2014cited by this paper
• Biofabrication of customized bone grafts by combination of additive manufacturing and bioreactor knowhow

  2014cited by this paper
• Is the Poly (L- Lactide- Co– Caprolactone) Nanofibrous Membrane Suitable for Urinary Bladder Regeneration?

  2014cited by this paper
• Micro-Computed Tomography Based Computational Fluid Dynamics for the Determination of Shear Stresses in Scaffolds Within a Perfusion Bioreactor

  2014cited by this paper
• 3D bioprinting of tissues and organs

  2014influential reference
• An Experimental Investigation into Additive Manufacturing-Induced Residual Stresses in 316L Stainless Steel

  2014cited by this paper
• Customised titanium implant fabricated in additive manufacturing for craniomaxillofacial surgery

  2014cited by this paper
• A Review on Process Monitoring and Control in Metal-Based Additive Manufacturing

  2014cited by this paper
• Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds

  2014cited by this paper
• Multitool and Multi-Axis Computer Numerically Controlled Accumulation for Fabricating Conformal Features on Curved Surfaces

  2014cited by this paper
• Development of a novel low-temperature deposition machine using screw extrusion to fabricate poly(l-lactide-co-glycolide) acid scaffolds

  2014cited by this paper
• Simulation in Manufacturing: Review and Challenges

  2014cited by this paper
• Electron Beam Additive Manufacturing of Titanium Components: Properties and Performance

  2013cited by this paper
• Biodegradable vascular scaffold ABSORB BVS™ – scientific evidence and methods of implantation

  2013cited by this paper
• Compound fabrication: A multi-functional robotic platform for digital design and fabrication

  2013cited by this paper
• Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma?

  2013cited by this paper
• Fabrication and in vitro characterization of bioactive glass composite scaffolds for bone regeneration

  2013cited by this paper
• High-resolution PLA-based composite scaffolds via 3-D printing technology.

  2013cited by this paper
• Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

  2013cited by this paper
• Augmented reality intravenous injection simulator based 3D medical imaging for veterinary medicine.

  2013cited by this paper
• Fully 3‐dimensional digitally planned reconstruction of a mandible with a free vascularized fibula and immediate placement of an implant‐supported prosthetic construction

  2013cited by this paper
• Evaluation of the effective diffusivity of a freeform fabricated scaffold using computational simulation.

  2013cited by this paper
• Large Scale Production

  2013cited by this paper
• Bone tissue engineering using 3D printing

  2013cited by this paper
• PLA-HA Scaffolds: Preparation and Bioactivity☆

  2013cited by this paper
• Effects of copolymer microstructure on the properties of electrospun poly(l‐lactide‐co‐ε‐caprolactone) absorbable nerve guide tubes

  2013cited by this paper
• Antimicrobial activity of poly(l-lactide acid)/silver nanocomposite fibers

  2013cited by this paper
• Integration of a thermal imaging feedback control system in electron beam melting

  2012cited by this paper
• Computer-aided manufacturing in medicine.

  2012cited by this paper
• Additive Manufacturing: Status and Opportunities

  2012cited by this paper
• The future of dental devices is digital.

  2012cited by this paper
• Remanufacture of turbine blades by laser cladding, machining and in-process scanning in a single machine

  2012cited by this paper
• Control of melt pool temperature and deposition height during direct metal deposition process

  2012cited by this paper
• Augmented reality applications in design and manufacturing

  2012cited by this paper
• Detection of Process Failures in Layerwise Laser Melting with Optical Process Monitoring

  2012cited by this paper
• Additive Manufacturing Solutions for Improved Medical Implants

  2012cited by this paper
• Additive manufacturing of tissues and organs

  2012cited by this paper
• A Tissue Engineering Solution for Segmental Defect Regeneration in Load-Bearing Long Bones

  2012cited by this paper
• Numerical Modeling of the Additive Manufacturing (AM) Processes of Titanium Alloy

  2012cited by this paper
• Biofabrication of Osteochondral Tissue Equivalents by Printing Topologically Defined, Cell-Laden Hydrogel Scaffolds

  2011cited by this paper
• A layerless additive manufacturing process based on CNC accumulation

  2011cited by this paper
• Design of an Optical system for the In Situ Process Monitoring of Selective Laser Melting (SLM)

  2011cited by this paper
• The use of BoneWelding® technology in spinal surgery: an experimental study in sheep

  2011cited by this paper
• Microstructure design of biodegradable scaffold and its effect on tissue regeneration.

  2011cited by this paper
• Additive manufacturing by direct metal deposition

  2011cited by this paper
• The Influence of Pore Structure on Internal Flow Field Shear Stress within Scaffold

  2011cited by this paper
• The influence of the scaffold design on the distribution of adhering cells after perfusion cell seeding.

  2011cited by this paper
• Determination of geometrical factors in Layerwise Laser Melting using optical process monitoring

  2011cited by this paper
• Bioprinting of hybrid tissue constructs with tailorable mechanical properties

  2011cited by this paper
• Nanoparticle carriers based on copolymers of poly(l-aspartic acid co-l-lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine for drug delivery

  2011cited by this paper
• Thinking ahead the Future of Additive Manufacturing – Analysis of Promising Industries

  2011influential reference
• Load-Adaptive Scaffold Architecturing: A Bioinspired Approach to the Design of Porous Additively Manufactured Scaffolds with Optimized Mechanical Properties

  2011cited by this paper
• Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering.

  2010cited by this paper
• Virtual topological optimisation of scaffolds for rapid prototyping.

  2010cited by this paper
• Photo-Cross-Linked Poly(DL-lactide)-Based Networks. Structural Characterization by HR-MAS NMR Spectroscopy and Hydrolytic Degradation Behavior

  2010cited by this paper
• Low cost integration of additive and subtractive processes for hybrid layered manufacturing

  2010cited by this paper
• Melt Pool Temperature Control for Laser Metal Deposition Processes—Part I: Online Temperature Control

  2010cited by this paper
• Topology optimization of three dimensional tissue engineering scaffold architectures for prescribed bulk modulus and diffusivity

  2010cited by this paper
• Melt Pool Temperature Control for Laser Metal Deposition Processes—Part II: Layer-to-Layer Temperature Control

  2010cited by this paper
• Experimental and computational characterization of designed and fabricated 50:50 PLGA porous scaffolds for human trabecular bone applications

  2010cited by this paper
• Composite nanofiber of bioactive glass nanofiller incorporated poly(lactic acid) for bone regeneration

  2010cited by this paper
• Mathematically defined tissue engineering scaffold architectures prepared by stereolithography.

  2010influential reference
• Fabricating a pearl/PLGA composite scaffold by the low-temperature deposition manufacturing technique for bone tissue engineering

  2010cited by this paper
• Poly-Lactic Acid: Production, Applications, Nanocomposites, and Release Studies.

  2010cited by this paper
• Three-dimensional nanocomposite scaffolds fabricated via selective laser sintering for bone tissue engineering.

  2010cited by this paper
• Scaffold-free vascular tissue engineering using bioprinting.

  2009cited by this paper
• Development of biomaterial scaffold for nerve tissue engineering: Biomaterial mediated neural regeneration

  2009cited by this paper
• A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography.

  2009cited by this paper
• Fumaric acid monoethyl ester-functionalized poly(D,L-lactide)/N-vinyl-2-pyrrolidone resins for the preparation of tissue engineering scaffolds by stereolithography.

  2009cited by this paper

• Enzymatic routes to initiator-based functional biodegradable polyesters

  2026cites this paper
• Role of 3D printing in healthcare: A comprehensive review on treatment and training

  2025cites this paper
• Additive Manufacturing in Biomedical: Applications, Challenges, and Prospects

  2025cites this paper
• Advancements of prosthetic running blades: An in-depth literature review

  2025cites this paper
• Robocast Zn- and Co-doped bioactive glass/tricalcium phosphate scaffolds for bone regeneration

  2025cites this paper
• Bioprinting of self-healing materials and nanostructures for biomedical applications: Recent advances and progresses on fabrication and characterization techniques

  2024cites this paper
• Materials for 3D printing in healthcare sector: A review

  2024cites this paper
• Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications

  2024cites this paper
• Geometry-modulated all organic 3D printed smart PLA fibers for flextension amplified giant mechanical energy harvesting and Machine learning assisted pressure mapping

  2024cites this paper
• Melt-Extrusion Additive Manufacturing for Tissue Engineering: Applications and Limitations

  2024cites this paper
• A Review of Additive Manufacturing in Tissue Engineering and Regenerative Medicine

  2024cites this paper
• Challenges and Future Perspectives for Additively Manufactured Polylactic Acid Using Fused Filament Fabrication in Dentistry

  2023cites this paper
• Recent Advances in Additive Manufacturing, Applications and Challenges for Dentistry: A Review.

  2023cites this paper
• Additive Manufacturing of α-Amino Acid Based Poly(ester amide)s for Biomedical Applications

  2022cites this paper
• Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming

  2022cites this paper
• In vitro Evaluation of a 20% Bioglass-Containing 3D printable PLA Composite for Bone Tissue Engineering

  2022cites this paper
• Additive manufacturing technologies: industrial and medical applications

  2022cites this paper
• 3D printable biomaterials for dental restoration: A systematic review

  2022cites this paper
• Cholecalciferol as Bioactive Plasticizer of High Molecular Weight Poly(D,L-Lactic Acid) Scaffolds for Bone Regeneration

  2022cites this paper
• On the development of meta-structure-based conformal sensors for biomedical applications

  2022cites this paper
• Manufacturing of scaffolds with interconnected internal open porosity and surface roughness.

  2022cites this paper
• Simulation of radiative transfer in gas-liquid foams

  2022cites this paper
• Scaffold Geometry Modulation of Mechanotransduction and its influence on Epigenetics.

  2022cites this paper
• Osteoblast on Porous HA-TCP Scaffold Derived from Blood Cockle Shells Synthesis : In Vivo Study

  2021cites this paper
• A parameter study on optimal scaffolds in a simple model for bone regeneration

  2021cites this paper
• Materials Based on Chitosan and Polylactide: From Biodegradable Plastics to Tissue Engineering Constructions

  2021cites this paper
• Effect of the Chemical Structure of Chitosan Copolymers with Oligolactides on the Morphology and Properties of Macroporous Hydrogels Based on Them

  2021cites this paper
• Additive Manufacturing Using Melt Extruded Thermoplastics for Tissue Engineering.

  2021cites this paper
• Computer-Aided Tissue Engineering: Methods and Protocols

  2021cites this paper
• Additive Manufacturing Processes in Medical Applications

  2021cites this paper
• In Vitro Characterization of Poly(Lactic Acid)/ Poly(Hydroxybutyrate)/ Thermoplastic Starch Blends for Tissue Engineering Application

  2021cites this paper
• State of the art in additive manufacturing and its possible chemical and particle hazards—review

  2021cites this paper
• 4D printing of shape memory polylactic acid (PLA)

  2021cites this paper
• Selection of additive manufacturing technologies in productive systems: a decision support model

  2020cites this paper
• Nondegradative additive manufacturing of medical grade copolyesters of high molecular weight and with varied elastic response

  2020cites this paper
• Development of new biocompatible 3D printed graphene oxide-based scaffolds.

  2020cites this paper
• Processing of poly-l-lactide and poly(l-lactide-co-trimethylene carbonate) blends by fused filament fabrication and fused granulate fabrication using RepRap 3D printer

  2020cites this paper
• The use of three-dimensional model construction of virtual technology in orthopedic treatment

  2020cites this paper
• Printed soft optical waveguides of PLA copolymers for guiding light into tissue.

  2020cites this paper
• Bioprinting: From Tissue and Organ Development to in Vitro Models

  2020cites this paper
• Supramolecular Interactions in Hybrid Polylactide Blends—The Structures, Mechanisms and Properties

  2020cites this paper
• Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds

  2020cites this paper
• Functional Polylactide Blend Films for Controlling Mesenchymal Stem Cell Behaviour

  2020cites this paper
• Polylactide Used as Filment in 3D Printing – Part 1: FTIR, DRIFT and TG-DTG Studies

  2020cites this paper
• Crack initiation and growth in additively printed ABS: Effect of print architecture studied using DIC

  2020cites this paper
• Minimise thermo-mechanical batch variations when processing medical grade lactide based copolymers in additive manufacturing

  2020cites this paper
• Biodegradable cellular polylactic acid ferroelectrets with strong longitudinal and transverse piezoelectricity

  2020cites this paper
• Mechanical and hydrolytic properties of thin polylactic acid films by fused filament fabrication.

  2020cites this paper
• Fracture behavior of additively printed ABS: Effects of print architecture and loading rate

  2020cites this paper
• The Evolution of Surface-Selective Laser Sintering: Modifying and Forming 3D Structures for Tissue Engineering

  2020cites this paper
• Hybrid Polylactide Blends | Encyclopedia

  2020cites this paper
• The effect of geometry on mechanical properties of biodegradable polylactic-acid tensile-test specimens by material extrusion

  2019cites this paper
• Optimization of Bone Scaffold Porosity Distributions

  2019cites this paper
• Morphology, molecular interactions and H2O diffusion in a poly(lactic-acid)/graphene composite: A vibrational spectroscopy study.

  2019cites this paper
• Biocompatibility of Resorbable Polymers: A Historical Perspective and Framework for the Future.

  2019cites this paper
• Customised Interventions Utilising Additive Manufacturing

  2019cites this paper
• Printability and critical insight into polymer properties during direct- extrusion based 3D printing of medical grade polylactide and copolyesters.

  2019cites this paper
• Process-Driven Microstructure Control in Melt-Extrusion-Based 3D Printing for Tailorable Mechanical Properties in a Polycaprolactone Filament

  2018cites this paper
• Effect of the pore size in a 3D bioprinted gelatin scaffold on fibroblast proliferation

  2018cites this paper
• Applications of additive manufacturing in dentistry: A review.

  2018cites this paper
• Current state of fabrication technologies and materials for bone tissue engineering.

  2018cites this paper
• Simultaneous elastic shape optimization for a domain splitting in bone tissue engineering

  2018cites this paper
• Optimizing Bone Scaffold Porosity Distributions

  2018cites this paper
• Organ Bioprinting: Are We There Yet?

  2018cites this paper
• Design, fabrication and evaluation of a hybrid biomanufacturing system for tissue engineering

  2018cites this paper
• Medical grade polylactide, copolyesters and polydioxanone: Rheological properties and melt stability

  2018cites this paper
• Review of the main factors controlling the fracture toughness and impact strength properties of natural composites

  2018cites this paper
• Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications.

  2017cites this paper
• Melt electrowriting with additive manufacturing principles

  2017cites this paper
• Current developments in multifunctional smart materials for 3D/4D bioprinting

  2017cites this paper
• Dielectric Properties of 3D Printed Polylactic Acid

  2017cites this paper
• Social aspects in additive manufacturing of pharmaceutical products

  2017cites this paper