Preclinical and Clinical Development of Dexketoprofen

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Drugs

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2165/00003495-199600525-00005PMID 8922555
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Spinal Actions of Nonsteroidal Anti-Inflammatory Drugs and the Dissociation between their Anti-Inflammatory and Analgesic Effects

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• A New Strategy for the Treatment of Inflammatory Pain

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• Spinal Cord Effects of Antipyretic Analgesics

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• Differential Analgesic Effects of Aspirin-Like Drugs

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• Pharmacokinetics of enantiomers of chiral non-steroidal anti-inflammatory drugs

  2010cited by this paper
• New insights into the mode of action of anti-inflammatory drugs

  2005cited by this paper
• Endoscopic evaluation of the effect of ketoprofen, ibuprofen and aspirin on the gastroduodenal mucosa

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• Pharmacokinetics of ketoprofen enantiomers in cholecystectomy patients: influence of probenecid

  2004cited by this paper
• Diffusion of intramuscular ketoprofen into the cerebrospinal fluid

  2004cited by this paper
• Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs

  2004cited by this paper
• Stereoselective metabolic pathways of ketoprofen in the rat: incorporation into triacylglycerols and enantiomeric inversion.

  1996cited by this paper
• Analgesic Efficacy of Low Doses of Dexketoprofen in the Dental Pain Model

  1996cited by this paper
• Bioinversion of R(−)-Ketoprofen After Oral Administration in Healthy Volunteers

  1996cited by this paper
• Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs

  1996cited by this paper
• Pharmacokinetics of ketoprofen enantiomers after different doses of the racemate.

  1995cited by this paper
• Correlation between Nonsteroidal Anti-Inflammatory Drug Efficacy in a Clinical Pain Model and the Dissociation of their Anti-Inflammatory and Analgesic Properties in Animal Models

  1995cited by this paper
• Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use.

  1995cited by this paper
• Stereoselective esterase activity of human serum albumin toward ketoprofen glucuronide.

  1995cited by this paper
• In vitro fenoprofenyl-coenzyme A thioester formation: interspecies variations.

  1995cited by this paper
• Non-steroidal anti-inflammatory drugs and spinal nociceptive processing

  1995cited by this paper
• Inversion of (R)- to (S)-ketoprofen in eight animal species.

  1995cited by this paper
• (-)-R-fenoprofen: formation of fenoprofenyl-coenzyme A by rat liver microsomes.

  1995cited by this paper
• Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects.

  1995cited by this paper
• Enantioselective disposition of ibuprofen in elderly persons with and without renal impairment.

  1995cited by this paper
• [Intestinal complications induced by non-steroidal anti-steroidal anti-inflammatory agents].

  1995cited by this paper
• Disposition and covalent binding of ibuprofen and its acyl glucuronide in the elderly

  1995cited by this paper
• Mucosal erosions in longterm non-steroidal anti-inflammatory drug users: predisposition to ulceration and relation to Helicobacter pylori.

  1995cited by this paper
• Activity of nimesulide on constitutive and inducible cyclooxygenases.

  1995cited by this paper
• Stereoselective disposition of ibuprofen enantiomers in human cerebrospinal fluid.

  1995cited by this paper
• Gastrointestinal blood loss induced by three different non-steroidal anti-inflammatory drugs.

  1995cited by this paper
• Inflammatory mediators of pain.

  1995cited by this paper
• Effects of nabumetone on prostanoid biosynthesis in humans

  1995cited by this paper
• Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats

  1995cited by this paper
• Pharmacokinetics and relative bioavailability after single dose administration of 25 mg ketoprofen solution as compared to tablets.

  1995cited by this paper
• Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation.

  1995cited by this paper
• Comparison of parenteral diclofenac and ketoprofen for postoperative pain relief after maxillofacial surgery

  1995cited by this paper
• Effects of the novel anti‐inflammatory compounds, N‐[2‐(cyclohexyloxy)‐4‐nitrophenyl] methanesulphonamide (NS‐398) and 5‐methanesulphonamido‐6‐(2, 4‐difluorothiophenyl)‐1‐indanone (L‐745, 337), on the cyclo‐oxygenase activity of human blood prostaglandin endoperoxide synthases

  1995cited by this paper
• Stereoselective disposition of ibuprofen in patients with compromised renal haemodynamics.

  1995cited by this paper
• 2-Arylpropionyl-CoA epimerase: partial peptide sequences and tissue localization.

  1995cited by this paper
• Moment analysis of stereoselective biliary excretion and chiral inversion of ketoprofen enantiomers in perfused rat liver.

  1995cited by this paper
• Enantioselective effects of experimental diabetes mellitus on the metabolism of ibuprofen.

  1995cited by this paper
• New molecules in analgesia.

  1995cited by this paper
• Death attributed to antirheumatic medication in a nationwide series of 1666 patients with rheumatoid arthritis who have died.

  1995cited by this paper
• Covalent binding of suprofen to renal tissue of rat correlates with excretion of its acyl glucuronide.

  1995cited by this paper
• Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin.

  1995cited by this paper
• Peptic ulcer and gastrointestinal hemorrhage associated with nonsteroidal anti-inflammatory drug use in patients younger than 65 years. A large health maintenance organization cohort study.

  1995cited by this paper
• Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1.

  1995cited by this paper
• Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

  1994cited by this paper
• Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs.

  1994cited by this paper
• Nonsteroidal anti-inflammatory drugs and peptic ulcers: mechanisms, risk factors and treatment.

  1994cited by this paper
• Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test.

  1994cited by this paper
• Bidirectional chiral inversion of the enantiomers of the nonsteroidal antiinflammatory drug oxindanac in dogs.

  1994cited by this paper
• Interactions of anti-inflammatory 2-arylpropionates (profens) with the metabolism of fatty acids: in vitro studies.

  1994cited by this paper
• Rationale for the development of stereochemically pure enantiomers: are the R enantiomers of chiral nonsteroidal anti-inflammatory drugs inactive?

  1994cited by this paper
• Non-steroidal anti-inflammatory drugs associated with gastroduodenal injury and Helicobacter pylori.

  1994cited by this paper
• Non-steroidal anti-inflammatory drugs: how do they damage the gut?

  1994cited by this paper
• Pharmacokinetics of ketoprofen enantiomers in monkeys following single and multiple oral administration.

  1994cited by this paper
• Intestinal toxicity of non-steroidal anti-inflammatory drugs.

  1994cited by this paper
• Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs.

  1994cited by this paper
• Is the inversion from R- to S-ketoprofen concentration dependent? Investigations in rats in vivo and in vitro.

  1994cited by this paper
• Drug Chirality: On the Mechanism of R‐Aryl Propionic Acid Class NSAIDs. Epimerization in Humans and the Clinical Implications for the Use of Racemates

  1994cited by this paper
• Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

  1994cited by this paper
• NSAIDs: time to re-evaluate gut toxicity.

  1994cited by this paper
• Rac-flurbiprofen is more ulcerogenic than its (S)-enantiomer.

  1993cited by this paper
• Stereoselective cyclooxygenase inhibition in cellular models by the enantiomers of ketoprofen.

  1993cited by this paper
• [Stereoselective protein binding of non-steroidal anti-inflammatory agents. Pharmacological implications].

  1993cited by this paper
• Variation in the risk of peptic ulcer complications with nonsteroidal antiinflammatory drug therapy.

  1993cited by this paper
• Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans.

  1993cited by this paper
• Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

  1993cited by this paper
• Stereoselective protein binding of ketoprofen: effect of albumin concentration and of the biological system.

  1993cited by this paper
• In vitro irreversible binding of ketoprofen glucuronide to plasma proteins.

  1993cited by this paper
• Ketorolac penetration into the cerebrospinal fluid of humans.

  1993cited by this paper
• Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

  1993cited by this paper
• Stereoselectivity of biliary excretion of 2-arylpropionates in rats.

  1993cited by this paper
• The influence of renal function on the enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in patients with rheumatoid arthritis.

  1993cited by this paper
• Central analgesic activity of nonsteroidal antiinflammatory drugs in animal and human pain models.

  1993cited by this paper
• Equipotent inhibition by R(-)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro.

  1993cited by this paper
• Disposition of Ibuprofen in Patients with Liver Cirrhosis

  1993cited by this paper
• Spinal actions of NSAIDS in blocking spinally mediated hyperalgesia: the role of cyclooxygenase products.

  1993cited by this paper
• Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

  1993cited by this paper
• Inhibition of rat peroxisomal palmitoyl-CoA ligase by xenobiotic carboxylic acids.

  1992cited by this paper
• Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin.

  1992cited by this paper
• Formation of glycine conjugate and (-)-(R)-enantiomer from (+)-(S)-2-phenylpropionic acid suggesting the formation of the CoA thioester intermediate of (+)-(S)-enantiomer in dogs.

  1992cited by this paper
• Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs

  1992cited by this paper
• The effect of the enantiomers of ibuprofen and flurbiprofen on the beta-oxidation of palmitate in the rat.

  1992cited by this paper
• Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.

  1992cited by this paper
• Enantioselective pharmacodynamics of the nonsteroidal antiinflammatory drug ketoprofen: in vitro inhibition of human platelet cyclooxygenase activity.

  1992cited by this paper
• The effects of ibuprofen enantiomers on hepatocyte intermediary metabolism and mitochondrial respiration.

  1992cited by this paper
• Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

  1992cited by this paper
• Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism.

  1992cited by this paper
• 20 years' experience with ketoprofen.

  1991cited by this paper
• Plasma protein binding of ketoprofen enantiomers in man: method development and its application.

  1991cited by this paper
• Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo.

  1991cited by this paper
• The efficacy and safety of ketoprofen in postsurgical dental pain.

  1991cited by this paper
• Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen.

  1991cited by this paper
• Non-steroidal anti-inflammatory drugs: Major questions remain unanswered

  1991cited by this paper
• The efficacy and safety of ketoprofen in postsurgical dental pain.

  1991cited by this paper
• Stereoselective disposition of ketoprofen in rats.

  1991cited by this paper
• Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

  1991cited by this paper

• Diclofenac sodium vs. dexketoprofen trometamol: selecting NSAIDs for managing postoperative inflammatory complications after third molar surgery—a randomized clinical trial

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• Analgesic efficiency of dexketoprofen trometamol in third molar surgery: a systematic review and meta-analysis

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• A Physiologically Based Pharmacokinetic Model for Studying the Biowaiver Risk of Biopharmaceutics Classification System Class I Drugs With Rapid Elimination: Dexketoprofen Trometamol Case Study

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• Discovery of Carboxylesterases via Metagenomics: Putative Enzymes that Contribute to Chemical Kinetic Resolution

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• Experimental and computational studies of enantioseparation of three profen enantiomers with a focus on quantification of the enantiomeric impurities present in the corresponding enantiopure S-profen drugs.

  2022cites this paper
• Choice of optimal non-steroidal anti-inflammatory drug from position of cardiologist

  2021cites this paper
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• Pain syndrome in oncology. Possibilities of dexketoprofen administration

  2020cites this paper
• Relationships between Anhydrous and Solvated Species of Dexketoprofen Trometamol: A Solid-State Point of View

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• Real-world experience with tramadol plus dexketoprofen fixed-dose combination in postoperative pain management: A series of case studies from Asia

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• The Analgesic Effect of Dexketoprofen Trometamol When Added to Lidocaine for Intravenous Regional Anesthesia

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• A Randomized Double-Blind Study: Evulation of Comparing Intravenous Fentanyl with Intravenous Tramadol Administered to Patients with Pain Control Due to Urinary Stone Disease

  2019cites this paper
• Expert Consensus on Clinical Use of an Orally Administered Dexketoprofen Plus Tramadol Fixed-Dose Combination in Moderate-To-Severe Acute Pain: A Delphi Study

  2019cites this paper
• Практические рекомендации по лечению анемии при злокачественных новообразованиях

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  2019cites this paper
• Combined site-specific release retardant mini-matrix tablets (C-SSRRMT) for extended oral delivery of dexketoprofen trometamol: in vitro evaluation and single versus multiple doses pharmacokinetic study in human volunteers

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• Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study

  2019cites this paper
• An in vitro investigation of genotoxic effects of dexketoprofen trometamol on healthy human lymphocytes

  2018cites this paper
• Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta‐analysis

  2018cites this paper
• Effects of the Preoperative Administration of Dexketoprofen Trometamol on Pain and Swelling After Implant Surgery: A Randomized, Double-Blind Controlled Trial.

  2018cites this paper
• Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect

  2018cites this paper
• Determination of profens in pharmaceuticals by heart-cut achiral-chiral two-dimensional HPLC

  2018cites this paper
• Evaluation and comparison of postoperative analgesic effects of dexketoprofen and methadone in dogs.

  2018cites this paper
• Multimodal analgesia in moderate-to-severe pain: a role for a new fixed combination of dexketoprofen and tramadol

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  2017influential citation
• Comparison of the analgesic efficacy of preoperative/postoperative oral dexketoprofen trometamol in third molar surgery: A randomized clinical trial.

  2016cites this paper
• [Dexketoprofen trometamol in dorsalgia treatment].

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• Crystal structure and characterization of esterase Est25 mutants reveal improved enantioselectivity toward (S)-ketoprofen ethyl ester

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• Comparison of the isoflurane concentration of using dexketoprofen or methadone at premedication during orthopedic surgery in dogs.

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• The determination of histopathological and biochemical effects of the rabbit knee joint injected dexketoprofen trometamol

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• Cloning and characterization of a novel thermostable esterase from Bacillus gelatini KACC 12197.

  2015cites this paper
• Enantioselective pharmacokinetics of ketoprofen in calves after intramuscular administration of a racemic mixture.

  2015cites this paper
• Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures

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• Effect of pre-emptive dexketoprofen trometamol on acute cortisol, inflammatory response and oxidative stress to hot-iron disbudding in calves.

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• Immunomodulatory properties of gamithromycin, dexamethasone and ketoprofen in lipopolysaccharide-induced inflammation in calves

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• İntravenöz rejyonel anestezi tekniğinde prilokain, prilokaine eklenen deksketoprofen ve deksametazonun etkinliklerinin karşilaştirilmasi Comparison the effects of prilocaine and the addition of dexketoprofen and dexamethasone to prilocaine for intravenous regional anesthesia

  2014cites this paper
• The effect of intravenously given dexketoprofen trometamol on postoperative pain in ovariohysterectomized dogs

  2014cites this paper
• Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol and Meperidine HCl in the Relief of Renal Colic

  2014cites this paper
• Majör ortopedik cerrahi sonrasi ağri tedavisinde deksketoprofen veya lornoksikam kullanimi: Randomize ve kontrollü bir çalişma

  2014cites this paper
• Effects of dexketoprofen trometamol on stress and oxidative stress in cattle undergoing claw trimming.

  2014cites this paper
• [Effect of intravenous dexketoprofen use on postoperative analgesic consumption in patients with lumbar disc surgery].

  2014cites this paper
• [Comparison the effects of prilocaine and the addition of dexketoprofen and dexamethasone to prilocaine for intravenous regional anesthesia].

  2014cites this paper
• Effect of low-dose dexketoprofen trometamol and paracetamol on postoperative complications after impacted third molar surgery on healthy volunteers: A pilot study

  2014cites this paper
• Perioperative dexketoprofen or lornoxicam administration for pain management after major orthopedic surgery: a randomized, controlled study.

  2014cites this paper
• Intra-articular injection of dexketoprofen in rat knee joint : Histopathologic assessment of cartilage & synovium

  2014cites this paper
• Dexketoprofen trometamol in the acute treatment of migraine attack: a phase II, randomized, double-blind, crossover, placebo-controlled, dose optimization study.

  2013cites this paper
• Postoperative analgesic effects of dexketoprofen, buprenorphine and tramadol in dogs undergoing ovariohysterectomy.

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
• Evaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II

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• The efficacy of adding dexketoprofen trometamol to tramadol with patient controlled analgesia technique in post-laparoscopic cholecystectomy pain treatment Laparoskopik kolesistektomi sonrasi ağri tedavisinde hasta kontrollü analjezi yönteminde tramadole deksketoprofen trometamol eklenmesinin etkinl

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  2011influential citation
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• The Analgesic Effect of Dexketoprofen When Added to Lidocaine for Intravenous Regional Anaesthesia: A Prospective, Randomized, Placebo-Controlled Study

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• Systematic review of dexketoprofen in acute and chronic pain

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  2003cites this paper