Human X‐Box binding protein‐1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines

No abstract is available for this paper.

• Publication year

  2007

• Venue

  The FASEB Journal

• Publication date

  2007-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.06-7990comPMID 17660348
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress.

  2006cited by this paper
• The unfolded protein response

  2006cited by this paper
• Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers.

  2006cited by this paper
• Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays.

  2006cited by this paper
• MDA‐7/IL‐24 regulates proliferation, invasion and tumor cell radiosensitivity: A new cancer therapy?

  2005cited by this paper
• The nuclear factor κB inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)–induced apoptosis in antiestrogen-resistant breast cancer cells

  2005cited by this paper
• The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells.

  2005cited by this paper
• Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers

  2005cited by this paper
• Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.

  2005cited by this paper
• Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer.

  2005cited by this paper
• Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice

  2005cited by this paper
• MatInspector and beyond: promoter analysis based on transcription factor binding sites

  2005cited by this paper
• Tissue transglutaminase-induced alterations in extracellular matrix inhibit tumor invasion

  2005cited by this paper
• The 'miss rate' for the analysis of gene expression data.

  2005cited by this paper
• twilight; a Bioconductor package for estimating the local false discovery rate

  2005cited by this paper
• [Machinery of programmed cell death].

  2005cited by this paper
• Array Comparative Genomic Hybridization Analysis of Genomic Alterations in Breast Cancer Subtypes

  2004cited by this paper
• RNA Integrity Number ( RIN ) – Standardization of RNA Quality Control Application

  2004cited by this paper
• Of Mice and Myc: c-Myc and Mammary Tumorigenesis

  2004cited by this paper
• Interferon Regulatory Factor-1 Mediates the Proapoptotic but Not Cell Cycle Arrest Effects of the Steroidal Antiestrogen ICI 182,780 (Faslodex, Fulvestrant)

  2004cited by this paper
• XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

  2004cited by this paper
• Breast Cancer Cells Can Evade Apoptosis-Mediated Selective Killing by a Novel Small Molecule Inhibitor of Bcl-2

  2004cited by this paper
• Discriminatory Mining of Gene Expression Microarray Data

  2003cited by this paper
• Exploration, normalization, and summaries of high density oligonucleotide array probe level data.

  2003cited by this paper
• Upregulation and overexpression of human x-box binding protein 1 (hXBP-1) gene in primary breast cancers

  2003cited by this paper
• Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens.

  2003cited by this paper
• Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24

  2003cited by this paper
• Chipping away at the chip bias: RNA degradation in microarray analysis

  2003cited by this paper
• Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling

  2003cited by this paper
• Ligand-independent activation of estrogen receptor alpha by XBP-1.

  2003influential reference
• Estrogen Withdrawal-Induced NF-κB Activity and Bcl-3 Expression in Breast Cancer Cells: Roles in Growth and Hormone Independence

  2003cited by this paper
• Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.

  2003cited by this paper
• Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro

  2003cited by this paper
• Estimation of False Discovery Rates in Multiple Testing: Application to Gene Microarray Data

  2003cited by this paper
• The Bcl-2-regulated apoptotic pathway

  2003cited by this paper
• Comprehensive Identification of Human bZIP Interactions with Coiled-Coil Arrays

  2003influential reference
• Ligand‐independent activation of estrogen receptor α by XBP‐1

  2003influential reference
• Placental overgrowth in mice lacking the imprinted gene Ipl

  2002cited by this paper
• Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).

  2002cited by this paper
• C‐myc gene expression alone is sufficient to confer resistance to antiestrogen in human breast cancer cells

  2002cited by this paper
• Gene expression profiles of poor-prognosis primary breast cancer correlate with survival.

  2002cited by this paper
• Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment.

  2002cited by this paper
• Novel Therapeutic Approach: Ligands for PPARγ and Retinoid Receptors Induce Apoptosis in bcl-2-positive Human Breast Cancer Cells

  2002cited by this paper
• IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.

  2002cited by this paper
• mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK

  2002cited by this paper
• Analysis of gene expression profiles associated with cisplatin resistance in human ovarian cancer cell lines and tissues using cDNA microarray.

  2001cited by this paper
• Cellular and molecular pharmacology of antiestrogen action and resistance.

  2001cited by this paper
• Predicting the clinical status of human breast cancer by using gene expression profiles

  2001cited by this paper
• The machinery of programmed cell death.

  2001cited by this paper
• Plasma cell differentiation requires the transcription factor XBP-1

  2001cited by this paper
• XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

  2001cited by this paper
• Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer.

  2001cited by this paper
• Molecular portraits of human breast tumours

  2000cited by this paper
• Insulin-like Growth Factor-binding Protein-3 Modulates Expression of Bax and Bcl-2 and Potentiates p53-independent Radiation-induced Apoptosis in Human Breast Cancer Cells*

  2000cited by this paper
• Gene expression profiling of primary breast carcinomas using arrays of candidate genes.

  2000cited by this paper
• An essential role in liver development for transcription factor XBP-1.

  2000cited by this paper
• Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73*

  2000cited by this paper
• C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance

  2000cited by this paper
• Two Distinct Pathways Leading to Nuclear Apoptosis

  2000cited by this paper
• 17β-Estradiol Inhibits Apoptosis in MCF-7 Cells, Inducing bcl-2 Expression via Two Estrogen-Responsive Elements Present in the Coding Sequence

  2000cited by this paper
• Polychemotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

  1998cited by this paper
• Tamoxifen for early breast cancer: an overview of the randomised trials

  1998cited by this paper
• The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

  1998cited by this paper
• The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice.

  1998cited by this paper
• Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

  1998cited by this paper
• Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.

  1998cited by this paper
• Genomic imprinting of a human apoptosis gene homologue, TSSC3.

  1998cited by this paper
• The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

  1997cited by this paper
• The end-joining reaction in V(D)J recombination.

  1997cited by this paper
• The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core.

  1996cited by this paper
• Expression pattern of S100 calcium‐binding proteins in human tumors

  1996cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer.

  1995cited by this paper
• In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesis

  1993cited by this paper
• A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.

  1990cited by this paper
• Evidence that the time of entry into S is determined by events occurring in early G1.

  1988cited by this paper
• A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis.

  1983cited by this paper
• Effects of tamoxifen on cell cycle progression of synchronous MCF-7 human mammary carcinoma cells.

  1983influential reference
• Exploration, Normalization, and Summaries of High Density Oligonucleotide Array Probe Level Data

  year unknowncited by this paper

• Wild‐Type and rtA181T/sW172* Mutant Strains of Hepatitis B Virus Drive Hepatocarcinogenesis via Distinct GRP78‐Mediated ER Stress Pathways

  2025cites this paper
• XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer

  2025cites this paper
• Development and evaluation of a self-assembled nanoparticle-based prodrug for sustained delivery of 4-phenylbutyric acid

  2025cites this paper
• Immunohistochemical Expression of IRE1 and PERK in Breast Cancer: Associations With Clinicopathological Characteristics and Survival Outcomes

  2025cites this paper
• A miR-770-5p/XBP1-driven pathway controls ESR1 expression and tamoxifen response in luminal breast cancer

  2025cites this paper
• Hypoxia-driven perturbations of proteostasis and therapeutic vulnerabilities in cancer.

  2025cites this paper
• An approach based on clustering for detecting differentially expressed genes in microarray data analysis

  2024cites this paper
• Mechanisms of endocrine resistance in hormone receptor-positive breast cancer

  2024cites this paper
• TMBIM6/BI-1 is an intracellular environmental regulator that induces paraptosis in cancer via ROS and Calcium-activated ERAD II pathways

  2024cites this paper
• RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity

  2023cites this paper
• Endoplasmic Reticulum Stress and Cancer: Could Unfolded Protein Response Be a Druggable Target for Cancer Therapy?

  2023cites this paper
• miRNA-378 Is Downregulated by XBP1 and Inhibits Growth and Migration of Luminal Breast Cancer Cells

  2023cites this paper
• Activation of kappa opioid receptor (KOR) inhibits estrogen receptor (ER)-positive breast cancer through the KOR-ER-XBP1 pathway.

  2023cites this paper
• Autophagy and Breast Cancer: Connected in Growth, Progression, and Therapy

  2023cites this paper
• The NF-κB Transcriptional Network Is a High-Dose Vitamin C-Targetable Vulnerability in Breast Cancer

  2023cites this paper
• The unfolded protein response and the biology of uveal melanoma.

  2022cites this paper
• Endoplasmic reticulum stress targeted therapy for breast cancer

  2022cites this paper
• Spliced or Unspliced, That Is the Question: The Biological Roles of XBP1 Isoforms in Pathophysiology

  2022cites this paper
• UPR'NİN IRE1α/XBP-1 DALININ GSK2850163 ARACILI İNHİBİSYONU MEME KANSERİ HÜCRELERİNDE TAMOKSİFENE DUYARLILIĞI ARTIRIR

  2022cites this paper
• Age alters the oncogenic trajectory toward luminal mammary tumors that activate unfolded proteins responses

  2022cites this paper
• Ligand-mediated nanomedicines against breast cancer: a review.

  2022cites this paper
• Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance

  2021influential citation
• Potential roles of natural products in the targeting of proteinopathic neurodegenerative diseases.

  2021cites this paper
• A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells

  2021cites this paper
• A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response

  2021cites this paper
• Decidua Parietalis Mesenchymal Stem/Stromal Cells and Their Secretome Diminish the Oncogenic Properties of MDA231 Cells In Vitro

  2021cites this paper
• TXNIP links anticipatory unfolded protein response to estrogen reprogramming glucose metabolism in breast cancer cells.

  2021cites this paper
• ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance.

  2021cites this paper
• Nuclear Mechanisms Involved in Endocrine Resistance

  2021cites this paper
• A novel XBP1 variant is highly enriched in cancer tissues and is specifically required for cancer cell survival.

  2021cites this paper
• Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges.

  2020cites this paper
• SOX2OT Long Noncoding RNA Is Regulated by the UPR in Oestrogen Receptor-Positive Breast Cancer

  2020cites this paper
• The emerging role of XBP1 in cancer.

  2020cites this paper
• Development of targeted therapy therapeutics to sensitize triple-negative breast cancer chemosensitivity utilizing bacteriophage phi29 derived packaging RNA

  2020cites this paper
• X‐box binding protein 1 (XBP1) function in diseases

  2020cites this paper
• Endoplasmic reticulum stress signals in the tumour and its microenvironment

  2020cites this paper
• XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation

  2020cites this paper
• Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma

  2020cites this paper
• Targeting the Unfolded Protein Response in Hormone-Regulated Cancers.

  2020cites this paper
• Systemic Delivery of Aptamer Conjugated XBP1 siRNA Nanoparticle for Efficient Suppression of HER2+ Breast Cancer.

  2020cites this paper
• Roles of Spliced and Unspliced XBP1 in Breast Cancer

  2019cites this paper
• Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance

  2019cites this paper
• Downregulation of XBP1 decreases serous ovarian cancer cell viability and enhances sensitivity to oxidative stress by increasing intracellular ROS levels

  2019cites this paper
• Gm40600 suppressed SP 2/0 isograft tumor by reducing Blimp1 and Xbp1 proteins

  2019cites this paper
• Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells

  2019cites this paper
• Role of estrogen and its receptors mediated-autophagy in cell fate and human diseases.

  2019cites this paper
• The NF-KB pathway and endocrine therapy resistance in breast cancer

  2019cites this paper
• Role of Protein Translation in Unfolded Protein Response

  2019cites this paper
• Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling

  2019cites this paper
• The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer

  2019cites this paper
• The Unfolded Protein Response in Triple-Negative Breast Cancer

  2019cites this paper
• Regulation of Nrf2 by X Box-Binding Protein 1 in Retinal Pigment Epithelium

  2018cites this paper
• The three branches of the unfolded protein response exhibit differential significance in breast cancer growth and stemness

  2018cites this paper
• Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities.

  2018cites this paper
• Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.

  2018cites this paper
• The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer

  2018cites this paper
• High N-Acetyltransferase 1 Expression is Associated with Estrogen Receptor Expression in Breast Tumors, but is not Under Direct Regulation by Estradiol, 5α-androstane-3β, 17β-Diol, or Dihydrotestosterone in Breast Cancer Cells

  2018cites this paper
• The Unfolded Protein Response in Breast Cancer

  2018cites this paper
• IDENTIFYING REGULATION OF CANT 1 DURING ENDOPLASMIC RETICULUM STRESS-INDUCED CELL DEATH by ÖZNUR AKTAY

  2018cites this paper
• Estrogen Receptor β and Breast Cancer

  2018cites this paper
• Endoplasmic Reticulum Stress and Autophagy

  2018cites this paper
• Nuclear factor‐kappa B‐dependent X‐box binding protein 1 signalling promotes the proliferation of nucleus pulposus cells under tumour necrosis factor alpha stimulation

  2018cites this paper
• Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response

  2018influential citation
• Coordinating Organismal Physiology Through the Unfolded Protein Response

  2018cites this paper
• Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling.

  2018cites this paper
• Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

  2017cites this paper
• Targeting protein quality control pathways in breast cancer

  2017cites this paper
• Knockdown of IRE1α inhibits colonic tumorigenesis through decreasing β-catenin and IRE1α targeting suppresses colon cancer cells

  2017cites this paper
• Introduction: Cancer Gene Networks.

  2017cites this paper
• Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer

  2017cites this paper
• BASP1 interacts with oestrogen receptor α and modifies the tamoxifen response

  2017cites this paper
• Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness

  2017cites this paper
• Knockdown of XBP1 by RNAi in Mouse Granulosa Cells Promotes Apoptosis, Inhibits Cell Cycle, and Decreases Estradiol Synthesis

  2017cites this paper
• Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells

  2017cites this paper
• Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

  2017cites this paper
• Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer.

  2016cites this paper
• Critical role of XBP1 in cancer signalling is regulated by PIN1.

  2016cites this paper
• Targeting the angio-proteostasis network: Combining the forces against cancer.

  2016cites this paper
• Estrogen signaling and unfolded protein response in breast cancer.

  2016cites this paper
• Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment

  2016cites this paper
• Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy

  2016cites this paper
• XBP1 Regulates the Biosynthetic Capacity of the Mammary Gland During Lactation by Controlling Epithelial Expansion and Endoplasmic Reticulum Formation.

  2016cites this paper
• Anticipatory UPR Activation: A Protective Pathway and Target in Cancer.

  2016cites this paper
• Anticipatory activation of the unfolded protein response by epidermal growth factor is required for immediate early gene expression and cell proliferation.

  2016cites this paper
• NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK–eIF2α–ATF4 signalling in breast cancer

  2016cites this paper
• Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

  2016cites this paper
• Apoptotic action of botulinum toxin on masseter muscle in rats: early and late changes in the expression of molecular markers

  2016cites this paper
• Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis.

  2015cites this paper
• Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers

  2015cites this paper
• ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.

  2015cites this paper
• Interplay between unfolded protein response and autophagy promotes tumor drug resistance

  2015influential citation
• Endocrine resistance in breast cancer--An overview and update.

  2015cites this paper
• Molecular mechanisms of tamoxifen-associated endometrial cancer (Review)

  2015cites this paper
• Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors

  2015cites this paper
• TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling

  2015cites this paper
• Application of Metabolomics in Drug Resistant Breast Cancer Research

  2015cites this paper
• Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

  2015cites this paper
• A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1

  2015cites this paper
• Stress Response Pathways in Cancer

  2015cites this paper
• Impact on angiogenesis and ER stress and its effect on chemoresistance through PlGF inhibition in a mouse model of hepatocellular carcinoma

  2015cites this paper