Different dosage regimens of rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotype status

M. Sugimoto,T. Furuta,N. Shirai,M. Kajimura,A. Hishida,M. Sakurai,K. Ohashi,T. Ishizaki

Published 2004 in Clinical pharmacology and therapy

ABSTRACT

For the treatment of gastroesophageal reflux disease, intragastric pH should be lower than 4.0 for no more than 4 hours a day (<16.7%). We aimed to develop optimal dosage regimens for rabeprazole to control nocturnal acidity in relation to cytochrome P450 (CYP) 2C19 genotypes.

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