Sequential phosphorylation of SLP‐76 at tyrosine 173 is required for activation of T and mast cells

No abstract is available for this paper.

• Publication year

  2011

• Venue

  EMBO Journal

• Publication date

  2011-08-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2011.213PMID 21725281PMCID PMC3160187
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Absence of Tec Family Kinases Interleukin-2 Inducible T cell Kinase (Itk) and Bruton's Tyrosine Kinase (Btk) Severely Impairs FcϵRI-dependent Mast Cell Responses*

  2011cited by this paper
• Independent and Cooperative Roles of Adaptor Molecules in Proximal Signaling during FcεRI-Mediated Mast Cell Activation

  2010influential reference
• Understanding signal integration through targeted mutations of an adapter protein

  2010influential reference
• In Vivo Significance of ITK-SLP-76 Interaction in Cytokine Production

  2010cited by this paper
• Cooperative interactions at the SLP‐76 complex are critical for actin polymerization

  2010cited by this paper
• The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.

  2009cited by this paper
• Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.

  2009cited by this paper
• Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation

  2009cited by this paper
• Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell Differentiation*S⃞

  2009cited by this paper
• Adapters in the organization of mast cell signaling

  2009cited by this paper
• Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation

  2009cited by this paper
• Digital signaling and hysteresis characterize ras activation in lymphoid cells.

  2009cited by this paper
• SLP-65 Phosphorylation Dynamics Reveals a Functional Basis for Signal Integration by Receptor-proximal Adaptor Proteins*

  2009cited by this paper
• Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCγ1

  2009cited by this paper
• A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation.

  2008cited by this paper
• Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.

  2008influential reference
• Defining the Specificity Space of the Human Src Homology 2 Domain*S

  2008cited by this paper
• Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.

  2007cited by this paper
• Dual Role of SLP-76 in Mediating T Cell Receptor-induced Activation of Phospholipase C-γ1*

  2007cited by this paper
• A remote substrate docking mechanism for the tec family tyrosine kinases.

  2007influential reference
• Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses

  2007cited by this paper
• SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK

  2007influential reference
• Clustal W and Clustal X version 2.0

  2007cited by this paper
• A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76

  2007cited by this paper
• SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

  2006cited by this paper
• Functional Hierarchy of the N-Terminal Tyrosines of SLP-761

  2006influential reference
• Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.

  2006cited by this paper
• Recruitment and activation of PLCγ1 in T cells: a new insight into old domains

  2006cited by this paper
• A New Tyrosine Phosphorylation Site in PLCγ1: The Role of Tyrosine 775 in Immune Receptor Signaling

  2005cited by this paper
• Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases

  2005cited by this paper
• Isozyme-specific Stimulation of Phospholipase C-γ2 by Rac GTPases*♦

  2005cited by this paper
• Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1.

  2005cited by this paper
• Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases.

  2005cited by this paper
• T Cell Receptor-induced Activation of Phospholipase C-γ1 Depends on a Sequence-independent Function of the P-I Region of SLP-76*

  2005cited by this paper
• A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.

  2005cited by this paper
• Early Phosphorylation Kinetics of Proteins Involved in Proximal TCR-Mediated Signaling Pathways

  2005cited by this paper
• Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton1

  2005influential reference
• Selective Itk inhibitors block T-cell activation and murine lung inflammation.

  2004cited by this paper
• Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function*[boxs]

  2004cited by this paper
• SH 2 Domains Recognize Specific Phosphopeptide Sequences

  2004influential reference
• Structural Requirements of SLP-76 in Signaling via the High-Affinity Immunoglobulin E Receptor (FcεRI) in Mast Cells

  2003cited by this paper
• Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells.

  2003cited by this paper
• A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes.

  2003cited by this paper
• A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.

  2002cited by this paper
• Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

  2002influential reference
• Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes*

  2001cited by this paper
• Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT

  2001influential reference
• Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT.

  2001cited by this paper
• Differential requirement for SLP-76 domains in T cell development and function.

  2001cited by this paper
• Membrane Raft-Dependent Regulation of Phospholipase Cγ-1 Activation in T Lymphocytes

  2001cited by this paper
• Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane

  2000cited by this paper
• Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

  2000cited by this paper
• Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells*

  2000cited by this paper
• Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade*

  2000influential reference
• SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity*

  1999cited by this paper
• Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling.

  1999cited by this paper
• Regulation of phospholipase C isozymes: activation of phospholipase C-gamma in the absence of tyrosine-phosphorylation.

  1999cited by this paper
• Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.

  1999cited by this paper
• Interaction of SLP adaptors with the SH2 domain of Tec family kinases

  1999cited by this paper
• The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.

  1999influential reference
• Phospholipase C-gamma as a signal-transducing element.

  1999cited by this paper
• SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.

  1999cited by this paper
• Association of Nck with tyrosine‐phosphorylated SLP‐76 in activated T lymphocytes

  1999cited by this paper
• SLP-76 binding to p56lck: a role for SLP-76 in CD4-induced desensitization of the TCR/CD3 signaling complex.

  1999influential reference
• Reconstitution of Btk Signaling by the Atypical Tec Family Tyrosine Kinases Bmx and Txk*

  1999cited by this paper
• AHNAK, a Protein That Binds and Activates Phospholipase C-γ1 in the Presence of Arachidonic Acid*

  1999cited by this paper
• Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

  1998cited by this paper
• Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76.

  1998cited by this paper
• Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

  1998influential reference
• BLNK: a central linker protein in B cell activation.

  1998cited by this paper
• SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

  1998cited by this paper
• Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.

  1998influential reference
• T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

  1998cited by this paper
• The Amino-Terminal Src Homology 2 Domain of Phospholipase Cγ1 Is Essential for TCR-Induced Tyrosine Phosphorylation of Phospholipase Cγ1

  1998influential reference
• The amino-terminal Src homology 2 domain of phospholipase C gamma 1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1.

  1998influential reference
• Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.

  1998cited by this paper
• Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

  1998cited by this paper
• Three domains of SLP-76 are required for its optimal function in a T cell line.

  1997cited by this paper
• Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.

  1997cited by this paper
• Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

  1997cited by this paper
• Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

  1997influential reference
• Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function*

  1996influential reference
• Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.

  1996cited by this paper
• p95vav associates with tyrosine-phosphorylated SLP-76 in antigen- stimulated T cells

  1996cited by this paper
• Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

  1996influential reference
• SH2 domains recognize specific phosphopeptide sequences.

  1993cited by this paper
• Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line

  1984cited by this paper

• Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy

  2025cites this paper
• Weak SLP-76-PLC-γ1 interaction in the LAT-nucleated multi-protein complex fine-tunes TCR signal strength to optimize T cell responsiveness

  2025cites this paper
• Survival and Developmental Progression of Unselected Thymocytes in the Absence of the T‐Cell Adaptor Gads

  2024cites this paper
• Full T-cell activation and function in teleosts require collaboration of first and co-stimulatory signals

  2024cites this paper
• Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway

  2023cites this paper
• Conformational switches that control the TEC kinase – PLCγ signaling axis

  2022cites this paper
• Development of immunomodulatory RNA therapeutics for immune disorders

  2022cites this paper
• Interleukin-2 inducible T cell kinase (ITK) may participate in the anti-bacterial immune response of Nile tilapia via regulating T-cell activation.

  2022cites this paper
• T cell receptor (TCR) signaling in health and disease

  2021influential citation
• Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects

  2020cites this paper
• Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads

  2020influential citation
• Three-dimensional localization microscopy in live flowing cells

  2020cites this paper
• Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses

  2019influential citation
• ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation

  2019cites this paper
• TCR Signal Strength Controls Dynamic NFAT Activation Threshold and Graded IRF4 Expression in CD8+ T Cells

  2019influential citation
• Mg2+ regulation of kinase signaling and immune function

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• Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.

  2018cites this paper
• Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT

  2017cites this paper
• Quantitative phosphoproteomics for studying B-cell receptor signaling in Burkitt's lymphoma.

  2017influential citation
• Molecular mechanisms underlying the evolution of the slp76 signalosome

  2017cites this paper
• Upregulation of GLE1 and LCP2 Genes in H5N1 Influenza Virus Infected Patients

  2016cites this paper
• Adapter Molecules in Immune Receptor Signaling

  2016cites this paper
• Upregulation of GLE 1 and LCP 2 Genes in H 5 N 1 Influenza Virus Infected Patients

  2016cites this paper
• GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.

  2015cites this paper
• The role of the GRB2 family of adaptor proteins in T cell receptor-mediated signaling

  2015cites this paper
• Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.

  2015cites this paper
• Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.

  2015cites this paper
• Mechanistic insight into the regulation of Tec family kinase activity - substrate selection and conformational preferences

  2014cites this paper
• The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux.

  2014cites this paper
• Substrate recognition of PLCγ1 via a specific docking surface on Itk.

  2013cites this paper
• The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation

  2013cites this paper
• SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation*

  2013cites this paper
• Cutting Edge: Feed-Forward Activation of Phospholipase Cγ2 via C2 Domain–Mediated Binding to SLP65

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• Studies on ITK-SYK signaling pathways

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