Structural Requirements of SLP-76 in Signaling via the High-Affinity Immunoglobulin E Receptor (FcεRI) in Mast Cells

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular and Cellular Biology

• Publication date

  2003-04-01

• Fields of study

  Biology

• Identifiers
  DOI 10.1128/MCB.23.7.2395-2406.2003PMCID PMC150723
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

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  2001influential reference
• Recruitment of Slp-76 to the Membrane and Glycolipid-Enriched Membrane Microdomains Replaces the Requirement for Linker for Activation of T Cells in T Cell Receptor Signaling

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• SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.

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• SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity*

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• Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway.

  1999cited by this paper
• Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.

  1999influential reference
• Interaction of SLP adaptors with the SH2 domain of Tec family kinases

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• The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.

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• Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

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  1998influential reference
• SLP-76 Is a Substrate of the High Affinity IgE Receptor-stimulated Protein Tyrosine Kinases in Rat Basophilic Leukemia Cells*

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• Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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• Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases*

  1997influential reference
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• Three domains of SLP-76 are required for its optimal function in a T cell line.

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• Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

  1997influential reference
• The role of Grb2-associated proteins in T-cell activation.

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• Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.

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• Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

  1996cited by this paper
• Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase*

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• Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex.

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• HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.

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• Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells (*)

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• Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

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