JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Brain : a journal of neurology

• Publication date

  2011-03-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/brain/awr025PMID 21371995PMCID PMC4571138
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Microglia and neuropathic pain.

  2013cited by this paper
• SOCS3-Mediated Blockade of JAK/STAT3 Signaling Pathway Reveals Its Major Contribution to Spinal Cord Neuroinflammation and Mechanical Allodynia after Peripheral Nerve Injury

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• Disruption of Astrocyte STAT3 Signaling Decreases Mitochondrial Function and Increases Oxidative Stress In Vitro

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• Microglia and neuropathic pain

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• Src-dependent STAT-3-mediated Expression of Monocyte Chemoattractant Protein-1 Is Required for 15(S)-Hydroxyeicosatetraenoic Acid-induced Vascular Smooth Muscle Cell Migration*

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• Neuropathic pain: a maladaptive response of the nervous system to damage.

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• Current challenges in glia-pain biology.

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• JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

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  2008influential reference
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  2008cited by this paper
• JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat

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• Sciatic Nerve Ligation-Induced Proliferation of Spinal Cord Astrocytes Is Mediated by κ Opioid Activation of p38 Mitogen-Activated Protein Kinase

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• The neuropathic pain triad: neurons, immune cells and glia

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• A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

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• Mechanisms of Disease: neuropathic pain—a clinical perspective

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• Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway.

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• Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia.

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  2005cited by this paper
• ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

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• Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury.

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• Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

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• Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration

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• Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain.

  2004cited by this paper
• Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis

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• Cell-cycle targeted therapies.

  2004cited by this paper
• Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia

  2003cited by this paper
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  2003cited by this paper
• What does Stat3 do?

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• Can we conquer pain?

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• Glial activation: a driving force for pathological pain.

  2001cited by this paper
• Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT)

  2000cited by this paper
• Neuronal plasticity: increasing the gain in pain.

  2000cited by this paper
• Neurochemical and Cellular Reorganization of the Spinal Cord in a Murine Model of Bone Cancer Pain

  1999cited by this paper
• Neuropathic pain: aetiology, symptoms, mechanisms, and management.

  1999cited by this paper
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  1999cited by this paper
• Endogenous interleukin‐6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice

  1999cited by this paper
• Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior

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• Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.

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• Microglial Turnover in the Injured CNS: Activated Microglia Undergo Delayed DNA Fragmentation Following Peripheral Nerve Injury

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• “Model”

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