SB-649915-B, a Novel 5-HT1A/B Autoreceptor Antagonist and Serotonin Reuptake Inhibitor, is Anxiolytic and Displays Fast Onset Activity in the Rat High Light Social Interaction Test

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Neuropsychopharmacology

• Publication date

  2007-10-01

• Fields of study

  Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.1038/sj.npp.1301341PMID 17356576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B

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  2007influential reference
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  2005influential reference
• The 5-HT1A receptor antagonist (S)-UH-301 decreases dopamine release in the rat nucleus accumbens and striatum

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  2004influential reference
• Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats.

  2004cited by this paper
• Depression: a case of neuronal life and death?

  2004cited by this paper
• Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor

  2004cited by this paper
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  2004influential reference
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  2002cited by this paper
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  1996influential reference
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  1996influential reference
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  1994influential reference
• Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors.

  1994cited by this paper
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• Modulation of 5‐HT release in the guinea‐pig brain following long‐term administration of antidepressant drugs

  1994influential reference
• 5-HT and antidepressants: new views from microdialysis studies.

  1993cited by this paper
• A quantitative autoradiographic study of serotonin1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments.

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• Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists.

  1989cited by this paper
• Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain.

  1989cited by this paper
• Zacopride: anxiolytic profile in rodent and primate models of anxiety

  1988influential reference
• Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment.

  1988cited by this paper
• Modifications of the Serotonin System by Antidepressant Treatments: Implications for the Therapeutic Response in Major Depression

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• Distress vocalization in rat pups. A simple screening method for anxiolytic drugs.

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• The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs.

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• A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants.

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• CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?

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• Applied Regression Analysis

  1968influential reference

• Structural basis of vilazodone dual binding mode to the serotonin transporter

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  2016cites this paper
• Multi-target therapeutics for neuropsychiatric and neurodegenerative disorders.

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  2015cites this paper
• The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory

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  2010cites this paper
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