Zacopride: anxiolytic profile in rodent and primate models of anxiety

No abstract is available for this paper.

• Publication year

  1988

• Venue

  The Journal of pharmacy and pharmacology

• Publication date

  1988-04-01

• Fields of study

  Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.1111/j.2042-7158.1988.tb05254.xPMID 2900320
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Zacopride, a potent 5‐HT3 antagonist

  1988cited by this paper
• Actions of sulpiride and tiapride in a simple model of anxiety in mice.

  1987cited by this paper
• The effect of GR38032F, novel 5‐HT3‐receptor antagonist on gastric emptying in the guinea‐pig

  1987cited by this paper
• Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

  1987cited by this paper
• 5-Hydroxytryptamine M-receptor antagonism in the hypothalamus facilitates gastric emptying in the guinea-pig.

  1986cited by this paper
• Serotonergic mechanisms in the behavioral effects of buspirone and gepirone.

  1986cited by this paper
• Inhibition of cisplatin‐induced vomiting by selective 5‐hydroxytryptamine M‐receptor antagonism

  1986cited by this paper
• Recent developments in 5HT-related pharmacology of animal models of anxiety.

  1986cited by this paper
• Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine.

  1986cited by this paper
• Pustative anxiolytics 8-OH-DPAT, buspirone and TVX Q 7821 are agonists at 5-HT1A autoreceptors in the raphé nuclei

  1986cited by this paper
• Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs

  1985cited by this paper
• 5‐Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205–930 in the guinea‐pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in‐vivo

  1985cited by this paper
• Neuronal 5-HT receptors in the periphery.

  1984cited by this paper
• The biological basis of benzodiazepine actions.

  1983cited by this paper
• Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines.

  1981cited by this paper
• The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs.

  1980cited by this paper
• An ethogram of the common marmoset (Calithrix jacchus jacchus): general behavioural repertoire.

  1976cited by this paper

• Comparative Study on the Neuroprotective Effects of Perindopril and Benazepril in Experimentally-induced Chronic Mild Stress in Rats

  2025cites this paper
• A Drug-Screening Platform for Podocytopathies in Drosophila Nephrocytes.

  2025cites this paper
• Interplay of Endoplasmic Reticulum Stress, Inflammation, Apoptosis, and Oxidative Stress in Corticosteroid-Induced Anxiety and Depression: Exploring Therapeutic Potential of Hydrogen Sulfide and Sertraline.

  2025cites this paper
• The potential neuroprotective effect of empagliflozin against depressive-like behavior induced by chronic unpredictable mild stress in rats: Involvement of NLRP3 inflammasome.

  2025cites this paper
• Jiannao pills mitigate chronic restraint stress-induced anxiety in mice through the regulation of intestinal microflora.

  2024cites this paper
• Neurobenifical Effect of Anised In Rats Exposed to Mercury

  2022cites this paper
• Tachykinin NK2 antagonist for treatments of various disease states.

  2021cites this paper
• Saxagliptin ameliorated the depressive-like behavior induced by chronic unpredictable mild stress in rats: Impact on incretins and AKT/PI3K pathway.

  2021cites this paper
• Neuroprotective effects of Wharton’s jelly-derived mesenchymal stem cells on motor deficits due to Parkinson’s disease

  2021cites this paper
• A standardized polyherbal preparation POL-6 diminishes alcohol withdrawal anxiety by regulating Gabra1, Gabra2, Gabra3, Gabra4, Gabra5 gene expression of GABAA receptor signaling pathway in rats

  2021cites this paper
• Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence

  2021cites this paper
• Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence.

  2021cites this paper
• Antidepressant and Anxiolytic profiles of Cymbopogon Flexuosus Ethanolic extract in Chronic Unpredictable Mild Stress induced in rats

  2021cites this paper
• Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress

  2021cites this paper
• Therapeutic potential of serotonin 4 receptor for chronic depression and its associated comorbidity in the gut.

  2020cites this paper
• Comparative Perspectives on Temperament and Personality in Human and Nonhuman Animals

  2020cites this paper
• COMBINED EFFECT OF SELECTIVE BIOACTIVE COMPOUNDS FROM PLANT ORIGIN IN AN ANIMAL MODEL OF ANXIETY

  2020cites this paper
• Behavioural responses of anxiety in aversive and non-aversive conditions between young and aged Sprague-Dawley rats.

  2020cites this paper
• Synthesis and Anxiolytic Activity of some novel benzotriazole derivatives

  2019cites this paper
• Identification of Three Antimicrobials Activating Serotonin Receptor 4 in Colon Cells

  2019cites this paper
• Bacopa monnieri abrogates alcohol abstinence-induced anxiety-like behavior by regulating biochemical and Gabra1, Gabra4, Gabra5 gene expression of GABAA receptor signaling pathway in rats.

  2019cites this paper
• EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF OCIMUM SANCTUM (TULSI) LEAF IN WISTAR ALBINO RATS AFTER SUB-ACUTE ADMINISTRATION

  2018cites this paper
• Methanolic extract of Jasminum humile L. leaves possess anxiolytic activity mediated via the gabaergic system in the central nervous system of mice

  2018cites this paper
• Differential contributions of subregions of the dorsal anterior cingulate cortex to negative emotion in the common marmoset

  2018cites this paper
• Distinguishing Between Goosebumps, Tingling, Coldness, and Shivers According to Affective Composition

  2018influential citation
• Synthesis and Anxiolytic Activity of 2-(Substituted)-5-[(N-Benzotriazolomethyl)-1,3, 4-Thiadiazolyl]-4-Thiazolidinone

  2018cites this paper
• ANTIANXIETY EFFECT OF ETHYL PYRUVATE IN TYPE 2 DIABETIC RATS

  2017cites this paper
• Evaluation of antianxiety activity of ethanolic extract of leaves of Ocimum sanctum (tulsi) in albino mice

  2017cites this paper
• Anxiolytic activity of aqueous extract of Camellia sinensis in rats

  2016cites this paper
• Comparative Study on the Activity of Agomelatine and/or Curcumin against Development of Depression in Rats

  2016cites this paper
• BEHAVIOR AND GLUTAMATE TRANSAMINASE CHANGES IN RAT EXPOSED TO LEAD AND TREATED BY WORMWOOD EXTRACT

  2016cites this paper
• Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract from Camellia euphlebia Merr. ex Sealy in Mice

  2015cites this paper
• Anxiogenic effect on acute administration of gemifloxacin in rats

  2015cites this paper
• Tests for Anxiolytic Activity

  2015cites this paper
• GEMIFLOXACIN: ANXIOGENIC ACTIVITY IN WISTAR ALBINO RATS

  2015cites this paper
• Phytochemicals from Morinda citrifolia Linn. (Noni) and their bioactivities: A review Weiping Yin and Mian-Ying Wang Some observations on Noni as a Rasayan in the perspective of Ayurveda

  2015influential citation
• Pharmacological evaluation of novel 5-HT3 receptor antagonist, QCM-13 (N-cyclohexyl-3-methoxyquinoxalin-2-carboxamide) as anti-anxiety agent in behavioral test battery

  2015cites this paper
• Assessing anxiety in nonhuman primates.

  2014influential citation
• GSK356278, a Potent, Selective, Brain-Penetrant Phosphodiesterase 4 Inhibitor That Demonstrates Anxiolytic and Cognition-Enhancing Effects without Inducing Side Effects in Preclinical Species

  2014cites this paper
• On the risk concerns of zacopride, a moderate IK1 channel agonist with cardiac protective action.

  2014cites this paper
• Mouse models for the investigation of MAPT and its role in neurodegenerative disease

  2013cites this paper
• Lack of interaction of endocannabinoids and 5-HT(3) neurotransmission in associative fear circuits of the amygdala: evidence from electrophysiological and behavioural experiments.

  2013cites this paper
• The protective effect of St. Thomas cardioplegia enriched with zacopride on the isolated rat heart.

  2013cites this paper
• A Novel Discovery of IK1 Channel Agonist: Zacopride Selectively Enhances IK1 Current and Suppresses Triggered Arrhythmias in the Rat

  2012cites this paper
• EVALUATION AND COMPARISON OF ANXIOLYTIC EFFEC T OF FLAXSEED OIL AND PERILLA OIL IN MICE

  2011cites this paper
• Study of the Anxiolytic Activity of Captopril Against the Anxiogenic Potential of Ciprofloxacin in Different Models of Anxiety in Rats

  2011cites this paper
• Anxiolytic Effect of Chronic Administration of Gallic acid in Rats

  2011cites this paper
• Arylalkylamine-, β-carboline-, quinolizine- and azecine-derived compounds and their in vitro interaction with the ionotropic 5-HT3 receptor: search for new lead structures

  2010cites this paper
• Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats

  2010cites this paper
• Research Article Available online through www.ditonline.info

  2010cites this paper
• Antianxiety effect of aqueous extract of fruits of Emblica officinalis (EO) on acute and chronic administration in rats.

  2010cites this paper
• Animal models of anxiety and anxiolytic drug action.

  2010cites this paper
• ATIAXIETY EFFECTS OF LEAVES OFELUMBOUCIFERA GAERT. IMICE

  2009cites this paper
• A TI-A XIETY EFFECTS OF LEAVES OF ELUMBO UCIFERA GAERT . I MICE

  2009cites this paper
• Effect of roots of Tylophora indica (Burm.f.) on stress and anxiety in animal models

  2009cites this paper
• LOSARTAN AND PROPRANOLOL POTENTIATE ANTIDEPRESSANT AND ANXIOLYTIC ACTIVITY OF VENLAFAXINE IN EXPERIMENTAL ANIMALS WITHOUT ALTERING THE SYSTOLIC BLOOD PRESSURE.

  2009cites this paper
• PSYCHOTROPIC INTERACTIONS OF SOME ANTI-HYPERTENSIVES IN MALE ALBINO RATS AND MICE

  2008cites this paper
• Antidepressant activity of fosinopril, ramipril and losartan, but not of lisinopril in depressive paradigms of albino rats and mice.

  2008cites this paper
• SB-649915-B, a Novel 5-HT1A/B Autoreceptor Antagonist and Serotonin Reuptake Inhibitor, is Anxiolytic and Displays Fast Onset Activity in the Rat High Light Social Interaction Test

  2007influential citation
• Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy.

  2007cites this paper
• Effect of a polyherbal formulation on anxiety and behaviour mediated via monoamine neurotransmitters

  2007cites this paper
• Ion channel diseases of the central nervous system.

  2006cites this paper
• Antianxiety activity of NR-ANX-C, a polyherbal preparation in rats

  2006cites this paper
• Observer Effects on the Behavior of Non-habituated Wild Living Marmosets (Callithrix jacchus)

  2006cites this paper
• Behavioral effects of modafinil in marmoset monkeys

  2006influential citation
• Tachyphylaxis to 5-HT3-receptor-mediated activation of vagal afferents is prevented by co-activation of 5-HT2 receptors.

  2006cites this paper
• 5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model

  2005cites this paper
• Effects of 8-OH-DPAT, buspirone and ICS 205-930 on feeding in a novel environment: comparisons with chlordiazepoxide and FG 7142

  2005cites this paper
• 5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions

  2005cites this paper
• Are there changes in sensitivity to 5-HT3 receptor ligands following chronic diazepam treatment?

  2005cites this paper
• Chronic administration of the 5-HT3 receptor antagonist BRL 43694; effects on reflex epilepsy and social behaviour of the Mongolian gerbil

  2005cites this paper
• Anxiolytic effects of nitrous oxide in mice in the light-dark and holeboard exploratory tests

  2005cites this paper
• Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

  2004cites this paper
• Anxiolytic-like profile in Wistar, but not Sprague–Dawley rats in the social interaction test

  2004influential citation
• SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats.

  2004cites this paper
• Drugs of the Future: Review Cellular and molecular action of the putative GABA- mimetic, gabapentin

  2003cites this paper
• Cellular and molecular action of the putative GABA-mimetic, gabapentin

  2003cites this paper
• A review of 25 years of the social interaction test.

  2003cites this paper
• The Effects of Diazepam on Pharmacologically induced Anxiety in the Common Marmoset ( Callithrix jacchus ) with FG 7142 A Senior

  2002cites this paper
• Anxiolytic-like effects of kava-kava in the elevated plus maze test--a comparison with diazepam.

  2002cites this paper
• Non-human primate models for investigating fear and anxiety.

  2002cites this paper
• Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice

  2001cites this paper
• Anxiolytic-like effects of DAIZAC, a selective high-affinity 5-HT(3) receptor antagonist, in the mouse elevated plus-maze.

  2001cites this paper
• Different effects of diazepam in Fischer rats and two stocks of Wistar rats in tests of anxiety.

  2001cites this paper
• 5-HT(3) receptor antagonists and anxiety; a preclinical and clinical review.

  2000cites this paper
• Anxiolytic profile of ropinirole in the rat, mouse and common marmoset

  2000cites this paper
• Synthesis and preliminary pharmacological results on new naphthalene derivatives as 5-HT(4) receptor ligands.

  2000cites this paper
• Animal Models of Integrated Serotoninergic Functions: Their Predictive Value for the Clinical Applicability of Drugs Interfering with Serotoninergic Transmission

  2000cites this paper
• Acute and Chronic Role of 5-HT3 Neuronal System on Behavioral and Neuroendocrine Changes Induced by Intravenous Cholecystokinin Tetrapeptide Administration in Humans

  1999cites this paper
• Inhibition of NMDA‐receptor mediated response in the rat medial prefrontal cortical pyramidal cells by the 5‐HT3 receptor agonist SR 57227A and 5‐HT: Intracellular studies

  1998cites this paper
• An anxiolytic-like effect of ondansetron disappears in oxazepam-tolerant rats.

  1998cites this paper
• Psychotropic and neurotropic activity

  1997cites this paper
• [11C]S21007, a putative partial agonist for 5-HT3 receptors PET studies. Rat and primate in vivo biological evaluation.

  1997cites this paper
• 5-HT3 receptors

  1997cites this paper
• Receptor binding profile and anxiolytic‐type activity of deramciclane (EGIS‐3886) in animal models

  1997cites this paper
• Behavioural effects in mice of subchronic buspirone, ondansetron and tianeptine. I. Social interactions.

  1997cites this paper
• Marmoset conspecific confrontation: an ethologically-based model of anxiety.

  1997cites this paper
• "Anxiolytic" action of diazepam and abecarnil in a modified open field test.

  1996cites this paper
• The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed byd-serine

  1996cites this paper
• An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors.

  1996cites this paper