Influence of Formulation Factors on the Aerosol Performance and Stability of Lysozyme Powders: a Systematic Approach

No abstract is available for this paper.

• Publication year

  2018

• Venue

  AAPS PharmSciTech

• Publication date

  2018-02-27

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1208/s12249-018-0980-9PMID 29488193
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Influence of Formulation Factors on the Aerosol Performance and Stability of Lysozyme Powders: a Systematic Approach

  2018cited by this paper
• How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions

  2017cited by this paper
• Investigation of factors affecting the stability of lysozyme spray dried from ethanol-water solutions.

  2017cited by this paper
• Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes

  2017cited by this paper
• Role of Buffers in Protein Formulations.

  2017cited by this paper
• Inhaled Biologics: From Preclinical to Product Approval.

  2016cited by this paper
• Formulation of proteins and monoclonal antibodies (mAbs)

  2015cited by this paper
• Physical Characterization of Tobramycin Inhalation Powder: I. Rational Design of a Stable Engineered-Particle Formulation for Delivery to the Lungs.

  2015cited by this paper
• Mapping the solid-state properties of crystalline lysozyme during pharmaceutical unit-operations.

  2015cited by this paper
• Emerging inhalation aerosol devices and strategies: where are we headed?

  2014cited by this paper
• Physical and immunogenic stability of spray freeze-dried influenza vaccine powder for pulmonary delivery: comparison of inulin, dextran, or a mixture of dextran and trehalose as protectants.

  2013cited by this paper
• Sucrose Conformational Polymorphism: A Jigsaw Puzzle with Multiple Routes to a Unique Solution

  2009cited by this paper
• Spray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary delivery

  2008cited by this paper
• Inhaling medicines: delivering drugs to the body through the lungs

  2007cited by this paper
• Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice.

  2007cited by this paper
• Particle engineering techniques for inhaled biopharmaceuticals.

  2006cited by this paper
• Spray freezing into liquid versus spray-freeze drying: influence of atomization on protein aggregation and biological activity.

  2006cited by this paper
• Physical characterisation of formulations for the development of two stable freeze-dried proteins during both dried and liquid storage.

  2005cited by this paper
• Liquid-spray or dry-powder systems for inhaled delivery of peptide and proteins?

  2005cited by this paper
• Protein Powders for Encapsulation: A Comparison of Spray-Freeze Drying and Spray Drying of Darbepoetin Alfa

  2004cited by this paper
• The role of particle engineering in relation to formulation and de-agglomeration principle in the development of a dry powder formulation for inhalation of cetrorelix.

  2004cited by this paper
• Spray freezing into liquid nitrogen for highly stable protein nanostructured microparticles.

  2004cited by this paper
• Protein spray freeze drying. 2. Effect of formulation variables on particle size and stability.

  2002cited by this paper
• Rational design of stable lyophilized protein formulations: theory and practice.

  2002cited by this paper
• Spray-freeze-drying for protein powder preparation: particle characterization and a case study with trypsinogen stability.

  2002cited by this paper
• Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations.

  2002cited by this paper
• Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein.

  2001cited by this paper
• Lyophilization and development of solid protein pharmaceuticals.

  2000cited by this paper
• Protein Spray-Freeze Drying. Effect of Atomization Conditions on Particle Size and Stability

  2000cited by this paper
• Protein Inhalation Powders: Spray Drying vs Spray Freeze Drying

  1999cited by this paper
• Stability and surface activity of lactate dehydrogenase in spray-dried trehalose.

  1999cited by this paper
• Rational Design of Stable Lyophilized Protein Formulations: Some Practical Advice

  1997cited by this paper
• The Stabilization and Encapsulation of Human Growth Hormone into Biodegradable Microspheres

  1997cited by this paper
• Prediction of drug residence times in regions of the human respiratory tract following aerosol inhalation.

  1986cited by this paper

• Effect of formulation composition on stability and aerosol performance of respirable high load monoclonal antibody powders.

  2026cites this paper
• Aerosol Particle Design to Promote Targeting in the Respiratory Tract

  2025cites this paper
• Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs

  2024cites this paper
• Screening of sugars and cyclodextrins as carriers in montelukast dry powder inhalers processed by spray freeze drying

  2023cites this paper
• Understanding the impact of mannitol on physical stability and aerosolization of spray-dried protein powders for inhalation.

  2023cites this paper
• Advancements in Particle Engineering for Inhalation Delivery of Small Molecules and Biotherapeutics

  2022cites this paper
• Bioanalytical Workflow for Qualitative and Quantitative Assessment of Hot-Melt Extruded Lysozyme Formulations

  2022cites this paper
• Stabilizing Vaccines via Drying: Quality by Design Considerations.

  2022cites this paper
• Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug‐resistant Gram‐negatives

  2022cites this paper
• Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery

  2022cites this paper
• Effect of Buffer Salts on Physical Stability of Lyophilized and Spray-Dried Protein Formulations Containing Bovine Serum Albumin and Trehalose

  2022cites this paper
• Advances in the development of antimicrobial peptides and proteins for inhaled therapy.

  2021cites this paper
• Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae

  2021cites this paper
• Pharmaceutical Quality, Team Science, and Education Themes: Observations and Commentary on a Remarkable AAPS PharmSciTech Theme Issue

  2021cites this paper
• Dry Powder Pharmaceutical Biologics for Inhalation Therapy.

  2021cites this paper
• Particle Size Reduction Techniques of Pharmaceutical Compounds for the Enhancement of Their Dissolution Rate and Bioavailability

  2021cites this paper
• Understanding the Impact of Protein-Excipient Interactions on Physical Stability of Spray-Dried Protein Solids.

  2021cites this paper
• Identification of Stability Constraints in the Particle Engineering of an Inhaled Monoclonal Antibody Dried Powder.

  2021cites this paper
• Spray Freeze-Drying as a Solution to Continuous Manufacturing of Pharmaceutical Products in Bulk

  2020cites this paper
• Broad-Spectrum, Patient-Adaptable Inhaled Niclosamide-Lysozyme Particles are Efficacious Against Coronaviruses in Lethal Murine Infection Models

  2020cites this paper
• Physical stability of dry powder inhaler formulations

  2019cites this paper
• Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders.

  2019cites this paper
• Influence of Formulation Factors on the Aerosol Performance and Stability of Lysozyme Powders: a Systematic Approach

  2018cites this paper
• Modern frontiers and applications of spray‐freeze‐drying in design of food and biological supplements

  2018cites this paper