Regenerating the central nervous system: how easy for planarians!

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Development, Genes and Evolution

• Publication date

  2007-11-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00427-007-0188-6PMID 17999079
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Experimental studies of the regeneration of Planaria maculata

  2015cited by this paper
• Regeneration in Planarians

  2015cited by this paper
• Observations and experiments on regeneration in Planarians

  2015cited by this paper
• Identification of a platyhelminth neuropeptide receptor.

  2007cited by this paper
• Observations on Some Interesting Phenomena in Animal Physiology, Exhibited by Several Species of Planariae

  2007cited by this paper
• Clathrin-mediated endocytic signals are required for the regeneration of, as well as homeostasis in, the planarian CNS

  2007influential reference
• Morphogenesis defects are associated with abnormal nervous system regeneration following roboA RNAi in planarians

  2007influential reference
• The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system.

  2007cited by this paper
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  2007cited by this paper
• Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates

  2007cited by this paper
• Regeneration and maintenance of the planarian midline is regulated by a slit orthologue.

  2007influential reference
• The role of extracellular matrix in CNS regeneration.

  2007cited by this paper
• Wnt signaling is required for antero-posterior patterning of the planarian brain.

  2007influential reference
• Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica.

  2007cited by this paper
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  2006influential reference
• Chemorepellent Axon Guidance Molecules in Spinal Cord Injury

  2006cited by this paper
• Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: a lesson from studies on planarian

  2006influential reference
• The power of regeneration and the stem-cell kingdom: freshwater planarians (Platyhelminthes).

  2006cited by this paper
• Regulation of commissural axon pathfinding by slit and its Robo receptors.

  2006cited by this paper
• The nervous system of Tricladida. II. Neuroanatomy ofDugesia tigrina (Paludicola, Dugesiidae): An immunocytochemical study

  2006influential reference
• Molecular mechanisms of axon guidance.

  2006cited by this paper
• Classical transmitters and their receptors in flatworms

  2005cited by this paper
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  2005influential reference
• Molecular mechanisms of optic axon guidance

  2005cited by this paper
• The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain.

  2005influential reference
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  2005influential reference
• Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea.

  2005influential reference
• Neural Projections in Planarian Brain Revealed by Fluorescent Dye Tracing

  2005influential reference
• Neuropeptide signalling systems in flatworms

  2005influential reference
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004influential reference
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  2003cited by this paper
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  2003cited by this paper
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  2003influential reference
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  2003influential reference
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  2003cited by this paper
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  2003cited by this paper
• Promotion of axonal regeneration in the injured CNS.

  2003cited by this paper
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  2003influential reference
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002influential reference
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  2002cited by this paper
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  2002cited by this paper
• Pathfinding and error correction by retinal axons: the role of astray/robo2.

  2002cited by this paper
• Planarian fibroblast growth factor receptor homologs expressed in stem cells and cephalic ganglions

  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
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  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
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  2002influential reference
• Induction of a noggin-like gene by ectopic DV interaction during planarian regeneration.

  2002cited by this paper
• Regeneration in the metazoans: why does it happen?

  2000influential reference
• Regeneration in the metazoans: why does it happen?

  2000cited by this paper
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  2000cited by this paper
• Bromodeoxyuridine specifically labels the regenerative stem cells of planarians.

  2000cited by this paper
• Molecular and cellular aspects of planarian regeneration.

  1999cited by this paper
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  1999influential reference
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  1999influential reference
• Cellular and Molecular Basis of Regeneration: From Invertebrates to Humans

  1998cited by this paper
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  1998influential reference
• A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain

  1997influential reference
• Myocyte differentiation and body wall muscle regeneration in the planarian Girardia tigrina

  1997cited by this paper
• Neuronal signal substances in asexual multiplication and development in flatworms

  1996cited by this paper
• The nervous system of Tricladida. III. Neuroanatomy ofDendrocoelum lacteum andPolycelis tenuis (Plathelminthes, Paludicola): an immunocytochemical study

  1996cited by this paper
• Development of the nervous system in Dugesia tigrina during regeneration after fission and decapitation

  1996influential reference
• GYIRFamide: a novel FMRFamide-related peptide (FaRP) from the triclad turbellarian, Dugesia tigrina.

  1995cited by this paper
• The flatworm nervous system: pattern and phylogeny.

  1995influential reference
• Gamma‐aminobutyric acid in the nervous system of a planarian

  1994cited by this paper
• Neuropeptide F (Moniezia expansa): localization and characterization using specific antisera

  1992cited by this paper
• The serotoninergic, cholinergic and peptidergic components of the nervous system in the monogenean parasite,Diclidophora merlangi: a cytochemical study

  1990cited by this paper
• Development and differentiation of neuronal subsets in asexually reproducing Microstomum lineare

  1989cited by this paper
• "Neuroendocrine cells" in flatworms--progenitors to metazoan neurons?

  1989cited by this paper
• Photoperiodic modulation of cephalic melatonin in planarians.

  1987cited by this paper
• Somatostatin-like peptide and regeneration capacities in planarians.

  1986cited by this paper
• Neuropeptides in a microturbellarian--whole mount immunocytochemistry.

  1985cited by this paper
• Radioimmunological and immunocytochemical demonstration of Met-enkephalin in planaria.

  1983cited by this paper
• [The role of serotonin and catecholamines in the regeneration of the Planaria Polycelis tenvis].

  1979cited by this paper
• Rôle de la sérotonine et des catécholamines dans la régénération de la planaire Polycelis tenuis

  1979cited by this paper
• The nervous system in planarians: Peripheral and gastrodermal plexuses, pharynx innervation, and the relationship between central nervous system structure and the acoelomate organization

  1978influential reference
• The Role of the Nervous System in the Planarian Regeneration : I.Regeneration of Body Fragments Deprived of Ventral Nerve Cords

  1978cited by this paper
• Ultrastructure of nerve plexus in flatworms

  1977cited by this paper
• Ultrastructure of nerve plexus in flatworms. II. Sites of synaptic interactions.

  1975cited by this paper
• Ultrastructure of the nerve plexus in flatworms

  1974cited by this paper
• Inductive role of the nerve cord in regeneration of isolated postpharyngeal body sections of Dugesia dorotocephala.

  1973cited by this paper
• Die Evolution des Orthogons der Spiralier und das Archicölomatenproblem

  1972cited by this paper

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• Neuropeptide-mediated temporal sensory filtering in a primordial nervous system

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  2024cites this paper
• Radical pairs and superoxide amplification can explain magnetic field effects on planarian regeneration

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  2021influential citation
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  2021cites this paper
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  2021cites this paper
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  2021influential citation
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  2021cites this paper
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  2021cites this paper
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  2020influential citation
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  2020cites this paper
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  2020cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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