Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  American Journal of Respiratory and Critical Care Medicine

• Publication date

  2009-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1164/rccm.200812-1837OCPMID 19590023
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury.

  2009cited by this paper
• PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages.

  2008cited by this paper
• Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

  2008cited by this paper
• The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.

  2007cited by this paper
• Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule IκB Kinase Inhibitors

  2007cited by this paper
• Key developmental regulators change during hyperoxia‐induced injury and recovery in adult mouse lung

  2007cited by this paper
• GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.

  2007cited by this paper
• Endotoxin induced peritonitis elicits monocyte immigration into the lung: implications on alveolar space inflammatory responsiveness

  2006cited by this paper
• Resolution of in flammation: state of the art, definitions and terms

  2006cited by this paper
• Alveolar Epithelial Cells Direct Monocyte Transepithelial Migration upon Influenza Virus Infection: Impact of Chemokines and Adhesion Molecules1

  2006cited by this paper
• Is it time for implementation of tight glycaemia control by intensive insulin therapy in every ICU?

  2006cited by this paper
• The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival

  2006cited by this paper
• GM-CSF receptor expression and signaling is decreased in lungs of ethanol-fed rats.

  2006cited by this paper
• Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa.

  2006cited by this paper
• Tumor necrosis factor-alpha stimulates gastric epithelial cell proliferation.

  2005cited by this paper
• Moraxella catarrhalis--infected alveolar epithelium induced monocyte recruitment and oxidative burst.

  2005cited by this paper
• Protection of epithelial cells by keratinocyte growth factor signaling.

  2005cited by this paper
• Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter.

  2005cited by this paper
• Resolution of inflammation: the beginning programs the end

  2005cited by this paper
• Tumor necrosis factor- (cid:1) stimulates gastric epithelial cell proliferation

  2004cited by this paper
• Synergy between IL-8 and GM-CSF in reproductive tract epithelial cell secretions promotes enhanced neutrophil chemotaxis.

  2004cited by this paper
• The inflammatory macrophage

  2003cited by this paper
• Alternative activation of macrophages

  2003cited by this paper
• GM-CSF Induction in Human Lung Fibroblasts by IL-1β, TNF-α, and Macrophage Contact

  2003cited by this paper
• Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury.

  2003cited by this paper
• Processes involved in the repair of injured airway epithelia.

  2003cited by this paper
• CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury.

  2003cited by this paper
• GM-CSF induction in human lung fibroblasts by IL-1beta, TNF-alpha, and macrophage contact.

  2003cited by this paper
• The inflammatory macrophage: a story of Jekyll and Hyde.

  2003cited by this paper
• Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense.

  2002cited by this paper
• Anti-inflammatory lipid mediators and insights into the resolution of inflammation

  2002cited by this paper
• Maintenance of the mouse type II cell phenotype in vitro.

  2002cited by this paper
• Possible new role for NF-kappaB in the resolution of inflammation.

  2001cited by this paper
• Alveolar epithelial type II cell: defender of the alveolus revisited

  2001cited by this paper
• Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice.

  2001cited by this paper
• Transforming growth factor-beta(1) modifies fibroblast growth factor-2 production in type II cells.

  2001cited by this paper
• Possible new role for NF-κB in the resolution of inflammation

  2001cited by this paper
• Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.

  2001cited by this paper
• Transforming Growth Factor-β1 Modifies Fibroblast Growth Factor-2 Production in Type II Cells

  2001cited by this paper
• Interleukin-1beta augments in vitro alveolar epithelial repair.

  2000cited by this paper
• Granulocyte-Macrophage Colony-Stimulating Factor in the Innate Immune Response to Pneumocystis carinii Pneumonia in Mice1

  2000cited by this paper
• Toll-like receptors in the induction of the innate immune response

  2000cited by this paper
• The acute respiratory distress syndrome.

  2000cited by this paper
• Interleukin-1β augments in vitro alveolar epithelial repair

  2000cited by this paper
• GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection.

  1999cited by this paper
• Treatment of adult respiratory distress syndrome: plea for rescue therapy of the alveolar epithelium

  1999cited by this paper
• Mechanism of Activation of the GM‐CSF, IL‐3, and IL‐5 Family of Receptors

  1998cited by this paper
• Heparin-binding EGF-like growth factor is a mitogen for rat alveolar type II cells.

  1997cited by this paper
• Cell cycle kinetics in the alveolar epithelium.

  1997cited by this paper
• GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice.

  1997cited by this paper
• Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice.

  1996cited by this paper
• T1 alpha protein is developmentally regulated and expressed by alveolar type I cells, choroid plexus, and ciliary epithelia of adult rats.

  1996cited by this paper
• Effect of exposure to silica on human alveolar macrophages in supporting growth activity in type II epithelial cells.

  1996cited by this paper
• Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis.

  1994cited by this paper
• Localization, synthesis, and processing of surfactant protein SP-C in rat lung analyzed by epitope-specific antipeptide antibodies.

  1994cited by this paper
• Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.

  1993cited by this paper
• Pulmonary epithelial cell urokinase-type plasminogen activator. Induction by interleukin-1 beta and tumor necrosis factor-alpha.

  1992cited by this paper
• Reactivity of alveolar epithelial cells in primary culture with type I cell monoclonal antibodies.

  1992cited by this paper
• Pulmonary epithelial cell urokinase-type plasminogen activator : induction by interleukin-1β and tumor necrosis factor-α

  1992cited by this paper
• Molecular physiology of granulocyte-macrophage colony-stimulating factor.

  1991cited by this paper

• Transcriptional coordination in multicellular lineage differentiation during lung organogenesis: deciphering the role of epithelial cells as a microenvironmental regulatory hub.

  2026cites this paper
• Therapeutic potential of targeting novel signaling pathways in regulating chronic inflammation in obstructive lung disorders.

  2026cites this paper
• Kaempferol alleviates sepsis related acute lung injury by inhibiting the activation of alveolar macrophages mediated by extracellular vesicles from alveolar epithelial cells.

  2025cites this paper
• Mechanisms of alveolar type II epithelial cells’ mitochondrial quality control during acute lung injury/acute respiratory distress syndrome: bridging the gap between oxidative stress, inflammation, and fibrosis

  2025cites this paper
• Siglec-F+ neutrophils promote the resolution of acute lung injury through ALOX15 induction.

  2025cites this paper
• Mechanistic Insights into Carbon Black-Activated AKT/TMEM175 Cascade Impairing Macrophage-Epithelial Cross-Talk and Airway Epithelial Proliferation.

  2025cites this paper
• Evaluating the evidence for GM-CSF as a host-directed therapy in respiratory infections.

  2025cites this paper
• Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology.

  2025cites this paper
• Cell-cell crosstalk in the pathogenesis of acute lung injury and acute respiratory distress syndrome

  2025cites this paper
• ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury

  2025cites this paper
• Cell Cross-Talk in Alveolar Microenvironment: From Lung Injury to Fibrosis

  2024cites this paper
• Repair and regeneration of the alveolar epithelium in lung injury

  2024cites this paper
• Yip1 interacting factor homolog B mediates the unconventional secretion of ORF8 during SARS-CoV-2 infection

  2024cites this paper
• Severity and prognosis of COVID-19 complicated by autoimmune pulmonary alveolar proteinosis.

  2024cites this paper
• Immune-Epithelial Cell Interactions in Lung Development, Homeostasis and Disease.

  2024cites this paper
• TNF signaling mediates lipopolysaccharide-induced lung epithelial progenitor cell responses in mouse lung organoids.

  2024cites this paper
• The role of alveolar macrophages in viral respiratory infections and their therapeutic implications

  2024cites this paper
• Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury

  2024cites this paper
• Regulation of macrophage activation by lactylation in lung disease

  2024cites this paper
• Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS.

  2024cites this paper
• The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis

  2024cites this paper
• Apoptotic cell death in disease—Current understanding of the NCCD 2023

  2023cites this paper
• Protection of Chickens from Mycoplasma gallisepticum through the MAPK/ERK/JNK Pathway by a Compound of Ten Chinese Medicine Formulas1

  2023cites this paper
• OPTIMA: An Open-Label, Non-comparative Pilot Trial of Inhaled Molgramostim in Pulmonary Nontuberculous Mycobacterial Infection.

  2023cites this paper
• Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

  2023cites this paper
• Repairing Mechanisms for Distal Airway Injuries and Related Targeted Therapeutics for Chronic Lung Diseases

  2023cites this paper
• Ethanol-exposed lung fibroblasts cause airway epithelial barrier dysfunction

  2023cites this paper
• Role of GM-CSF in lung balance and disease

  2023cites this paper
• Therapeutic agents for ARDS

  2022cites this paper
• Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice

  2022cites this paper
• After the Storm: Regeneration, Repair, and Reestablishment of Homeostasis Between the Alveolar Epithelium and Innate Immune System Following Viral Lung Injury

  2022cites this paper
• The Role of Macrophages and Alveolar Epithelial Cells in the Development of ARDS

  2022cites this paper
• New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.

  2022cites this paper
• Host-directed immunotherapy of viral and bacterial infections: past, present and future

  2022cites this paper
• GM-CSF: Orchestrating the Pulmonary Response to Infection

  2022influential citation
• Immunopathological Changes in SARS-CoV-2 Critical and Non-critical Pneumonia Patients: A Systematic Review to Determine the Cause of Co-infection

  2021cites this paper
• Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

  2021cites this paper
• The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review

  2021cites this paper
• Diversity of Macrophages in Lung Homeostasis and Diseases

  2021cites this paper
• The Role of Macrophages During Mammalian Tissue Remodeling and Regeneration Under Infectious and Non-Infectious Conditions

  2021cites this paper
• Characterization of a flexible AAV-DTR/DT mouse model of acute epithelial lung injury

  2021cites this paper
• Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

  2021cites this paper
• Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD

  2021cites this paper
• Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy

  2021cites this paper
• Stromal–immune cell crosstalk fundamentally alters the lung microenvironment following tissue insult

  2021cites this paper
• ИММУНОБИОЛОГИЧЕСКИЕ СВОЙСТВА ГРАНУЛОЦИТАРНО-МАКРОФАГАЛЬНОГО ФАКТОРА

  2021cites this paper
• IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice

  2021cites this paper
• Aging impairs alveolar epithelial type II cell function in acute lung injury.

  2020cites this paper
• Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury

  2020cites this paper
• GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

  2020cites this paper
• Clean bioprinting - Fabrication of 3D organ models devoid of animal components.

  2020cites this paper
• GM-CSF: A Promising Target in Inflammation and Autoimmunity

  2020cites this paper
• Recombinant human granulocyte macrophage-colony stimulating factor expressed in yeast (sargramostim): A potential ally to combat serious infections.

  2020cites this paper
• Mechanisms of ATII-to-ATI Cell Differentiation during Lung Regeneration

  2020cites this paper
• Inflammatory responses of urban air PM modulated by chemical composition and different air quality situations in Nanjing, China.

  2020cites this paper
• Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection: let the virus be its own demise

  2020cites this paper
• Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19

  2020cites this paper
• Macrophage responses associated with COVID-19: A pharmacological perspective

  2020cites this paper
• Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

  2020cites this paper
• Peptidoglykan-erkennende Proteine in der Streptococcus pneumoniae Pneumonie: Einfluss auf den Verlauf und Interaktion mit dem Mikrobiom

  2019cites this paper
• Respiratory Epithelial Cells as Master Communicators during Viral Infections

  2019cites this paper
• Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection

  2019cites this paper
• Airway macrophages as the guardians of tissue repair in the lung

  2019cites this paper
• Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets.

  2019cites this paper
• Tissue kallikrein regulates alveolar macrophage apoptosis early in influenza virus infection.

  2019cites this paper
• Single cell RNA sequencing identifies TGFβ as a key regenerative cue following LPS-induced lung injury.

  2019cites this paper
• A Novel TNF-α-Targeting Aptamer for TNF-α-Mediated Acute Lung Injury and Acute Liver Failure

  2019cites this paper
• Single-cell RNA sequencing identifies TGF-b as a key regenerative cue following LPS-induced lung injury

  2019cites this paper
• Pharmacological therapies for acute respiratory distress syndrome

  2019cites this paper
• Peptidoglycan Recognition Protein 4 Limits Bacterial Clearance and Inflammation in Lungs by Control of the Gut Microbiota

  2019cites this paper
• Early antiviral action of KLK1

  2019cites this paper
• CD103-mediated regulation of airway hypersensitivity responses to bioaerosol-associated antigens

  2018cites this paper
• Lipocalin-2 abrogates epithelial cell cycle arrest by PPARγ inhibition

  2018cites this paper
• Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke.

  2018cites this paper
• The role of respiratory epithelium in host defence against influenza virus infection

  2018cites this paper
• Alveolar Epithelial Cell-Derived Mediators: Potential Direct Regulators of Large Airway and Vascular Responses.

  2017cites this paper
• Chapter 10 – Acute Respiratory Distress Syndrome

  2017cites this paper
• A novel in vitro macrophage senescence model to study macrophaging

  2017cites this paper
• KRASG12D expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment.

  2017cites this paper
• miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.

  2017cites this paper
• Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury

  2017cites this paper
• Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.

  2017cites this paper
• Tyk2 as a target for immune regulation in human viral/bacterial pneumonia

  2017cites this paper
• Barrier-tissue macrophages: functional adaptation to environmental challenges

  2017cites this paper
• Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury

  2017cites this paper
• Advanced Age Alters Monocyte and Macrophage Responses

  2016cites this paper
• 15 – Injury and Repair

  2016cites this paper
• Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia—a new therapeutic strategy?

  2016cites this paper
• Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

  2016cites this paper
• University of Groningen Macrophages: the overlooked target for pulmonary fibrosis and COPD Boorsma, Carian Eline

  2016cites this paper
• Correction: Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

  2016cites this paper
• Human Influenza Virus Infections

  2016cites this paper
• Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair

  2016cites this paper
• Caractérisation des propriétés anti-infectieuses de la flagelline, agoniste du Toll-like receptor 5

  2015cites this paper
• Epithelial biology in idiopathic pulmonary fibrosis

  2015cites this paper
• Immunomodulatory regulation of lung regeneration and repair

  2015cites this paper
• The Role of Alveolar Macrophages in Pulmonary Inflammation After Intoxication and Burn Injury

  2015cites this paper
• Erratum to: Recruitment of Gr1+CD11b+F4/80+Population in the Bone Marrow and Spleen by Irradiation-Induced Pulmonary Damage

  2015cites this paper
• Influenza virus-induced lung injury: pathogenesis and implications for treatment

  2015cites this paper
• Intraalveolar TNF-&agr; in Combined Burn and Inhalation Injury Compared With Intraalveolar Interleukin-6

  2015cites this paper