Subcellular myocardial effects of verapamil and D600: comparison with propranolol.

The effects of verapamil and D 600 , organic calcium antagonists, were compared with those of propranolol on several subcellular components of guinea-pig hearts. The organic calcium antagonists blocked Ca ++ -dependent action potentials and contractions induced in K + -depolarized hearts by either catecholamines or high external Ca ++ . Propranolol blocked only catecholamine-induced Ca ++ -dependent contractions. Organic Ca ++ antagonists alone did not prevent catecholamine-induced increases in tissue levels of cyclic adenosine monophosphafe, nor did they alter the ability of epinephrine to activate myocardial adenylate cyclase in vitro. At concentrations which were effective in whole hearts, neither organic Ca ++ antagonists nor propranolol affected Ca ++ binding or release by isolated sarcoplasmic reticulum fragments. D 600 at a concentration of 10 -5 M and propranolol at a concentration of 10 -4 M minimally reduced Ca ++ accumulation by isolated sarcoplasmic reticulum fragments. Organic Ca ++ antagonists appear to block sarcolemmal Ca ++ influx channels and by this mechanism these drugs may antagonize some of the effects of catecholamines without interacting with beta adrenergic receptors.

• Publication year

  1974

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1974-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)29985-2PMID 4153724
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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