What should animal models of depression model?

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Neuroscience and Biobehavioral Reviews

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/J.NEUBIOREV.2005.03.006PMID 15893377
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Onset and Early Behavioral Effects of Pharmacologically Different Antidepressants and Placebo in Depression

  2004cited by this paper
• Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain: putative implications for psychiatry and psychopharmacology

  2004cited by this paper
• Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders.

  2004cited by this paper
• Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment.

  2003cited by this paper
• Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain.

  2003cited by this paper
• Bi-phasic change in BDNF gene expression following antidepressant drug treatment.

  2003cited by this paper
• Prevalence, etiology, and treatment of depression in Parkinson's disease.

  2003cited by this paper
• Clinical and health services relationships between major depression, depressive symptoms, and general medical illness.

  2003cited by this paper
• Early improvement under mirtazapine and paroxetine predicts later stable response and remission with high sensitivity in patients with major depression.

  2003cited by this paper
• Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

  2002cited by this paper
• Effects of reboxetine on Hamilton Depression Rating Scale factors from randomized, placebo-controlled trials in major depression

  2002cited by this paper
• Comorbid psychiatric disorders in late life depression.

  2002cited by this paper
• Stress reactivity of the brain noradrenergic system in three rat strains differing in their neuroendocrine and behavioral responses to stress: implications for susceptibility to stress-related neuropsychiatric disorders.

  2002cited by this paper
• Comorbidity of mood and anxiety disorders: the rule, not the exception?

  2002cited by this paper
• Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress.

  2002cited by this paper
• Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress.

  2002cited by this paper
• Effects of Reboxetine on Anxiety, Agitation, and Insomnia: Results of a Pooled Evaluation of Randomized Clinical Trials

  2002cited by this paper
• Neuropsychopharmacology : The Fifth Generation of Progress

  2002cited by this paper
• Depression and epilepsy: How closely related are they?

  2002cited by this paper
• Pharmacologic treatment of generalized anxiety disorder.

  2001cited by this paper
• Limitations to enhancing the speed of onset of antidepressants — are rapid action antidepressants possible?

  2001cited by this paper
• Clinical importance of long-term antidepressant treatment

  2001cited by this paper
• Panic disorder: the place of benzodiazepines and selective serotonin reuptake inhibitors.

  2001cited by this paper
• Irritable bowel syndrome, anxiety, and depression: what are the links?

  2001cited by this paper
• Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?

  2001cited by this paper
• Comorbidity of depression and anxiety disorders in later life

  2001cited by this paper
• A Review of the Epidemiology and Approaches to the Treatment of Social Anxiety Disorder

  2000cited by this paper
• How fast are antidepressants?

  2000cited by this paper
• Locus coeruleus and regulation of behavioral flexibility and attention.

  2000cited by this paper
• Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial.

  2000cited by this paper
• How Long does it Take for Antidepressant Therapies to Act?

  2000cited by this paper
• From arousal to cognition: the integrative position of the prefrontal cortex.

  2000cited by this paper
• Role of norepinephrine in depression.

  2000cited by this paper
• A review of the efficacy of serotonergic and noradrenergic reuptake inhibitors for treatment of major depression.

  1999cited by this paper
• Natural history and preventative treatment of recurrent mood disorders.

  1999cited by this paper
• Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action.

  1999cited by this paper
• The structure of common mental disorders.

  1999cited by this paper
• Fluoxetine Versus Moclobemide: Cross-Comparison Between the Time Courses of Improvement

  1999cited by this paper
• A randomized, placebo-controlled, dose-response trial of venlafaxine hydrochloride in the treatment of major depression.

  1998cited by this paper
• Structural relationships among dimensions of the DSM-IV anxiety and mood disorders and dimensions of negative affect, positive affect, and autonomic arousal.

  1998cited by this paper
• Comorbidity of anxiety and unipolar mood disorders.

  1998cited by this paper
• Dimensional assessment of onset of action of antidepressants: a comparative study of moclobemide vs. clomipramine in depressed patients with blunted affect and psychomotor retardation.

  1998cited by this paper
• A meta-analysis of eight randomized, double-blind, controlled clinical trials of mirtazapine for the treatment of patients with major depression and symptoms of anxiety.

  1998cited by this paper
• A double-blind study comparing paroxetine and maprotiline in depressed outpatients.

  1997cited by this paper
• Antidepressant-like effect of brain-derived neurotrophic factor (BDNF).

  1997cited by this paper
• Delayed onset of action of antidepressant drugs? Survey of recent results

  1997cited by this paper
• Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

  1997cited by this paper
• A molecular and cellular theory of depression.

  1997cited by this paper
• The forced swimming test as a model for core and component behavioral effects of antidepressant drugs.

  1997cited by this paper
• Comorbid depression and anxiety spectrum disorders

  1996cited by this paper
• Onset of antidepressant activity: Reexamining the structure of depression and multiple actions of drugs

  1996cited by this paper
• Delayed onset of action of antidepressant drugs? Survey of results of Zurich meta-analyses.

  1996cited by this paper
• Relationships Among Negative, Positive, and Depressive Symptoms in Schizophrenia and Psychotic Depression

  1996cited by this paper
• Major Depression and Generalised Anxiety Disorder

  1996cited by this paper
• Chronological milestones to guide drug change. When should clinicians switch antidepressants?

  1996cited by this paper
• Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

  1995cited by this paper
• The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism.

  1995cited by this paper
• Characterizing onset in psychopharmacological clinical trials.

  1995cited by this paper
• Psychopharmacology: The Fourth Generation of Progress

  1995cited by this paper
• Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

  1995cited by this paper
• Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples.

  1995cited by this paper
• Early nonresponse to fluoxetine as a predictor of poor 8-week outcome.

  1995cited by this paper
• How long to onset of antidepressant action: a meta‐analysis of patients treated with fluoxetine or placebo

  1994cited by this paper
• Antidepressant drug selection: criteria and options.

  1994cited by this paper
• Time course of improvement under antidepressant treatment: a survival-analytical approach.

  1993cited by this paper
• Modulatory role of serotonin in neural information processing: implications for human psychopathology.

  1992cited by this paper
• Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications.

  1991cited by this paper
• Prediction of efficacy of antidepressant by 1-week test therapy in depression.

  1991cited by this paper
• Single-unit and physiological analyses of brain norepinephrine function in behaving animals.

  1991cited by this paper
• Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance.

  1991cited by this paper
• Sleep deprivation therapy.

  1991cited by this paper
• Three-year outcomes for maintenance therapies in recurrent depression.

  1990cited by this paper
• Five-year outcome for maintenance therapies in recurrent depression.

  1990cited by this paper
• Onset of response in relation to outcome in depressed outpatients with placebo and imipramine.

  1989cited by this paper
• Use of pattern analysis to identify true drug response. A replication.

  1987cited by this paper
• The timing, specificity and clinical prediction of tricyclic drug effects in depression

  1987cited by this paper
• Reconciling the role of central serotonin neurons in human and animal behavior

  1986cited by this paper
• Animal models of depression: parallels and correlates to severe depression in humans.

  1985cited by this paper
• Double‐blind comparison between a serotonin and a noradrenaline reuptake blocker in the treatment of depressed outpatients

  1985cited by this paper
• Noradrenergic modulation of sensorimotor processes in intact rats: the masseteric reflex as a model system

  1985cited by this paper
• A Multi-Vantaged Approach to Measurement of Behavioral and Affect States for Clinical and Psychobiological Research

  1984cited by this paper
• Identification of true drug response to antidepressants. Use of pattern analysis.

  1984cited by this paper
• Early improvement as a predictor of response to amitriptyline and nortriptyline: a comparison of 2 patient samples

  1982cited by this paper
• Comparative Onset of Improvement in Depressive Symptomatology with Drug Treatment, Electroconvulsive Therapy, and Placebo

  1981cited by this paper
• A double-blind comparative study of desipramine hydrochloride and diazepam in the control of mixed anxiety/depression symptomatology.

  1979cited by this paper
• A double-blind comparative study of desipramine hydrochloride and diazepam in the control of mixed anxiety/depression symptomatology.

  1979cited by this paper
• Behavioural despair in rats: a new model sensitive to antidepressant treatments.

  1978cited by this paper
• Animal model of depression. I. Review of evidence: implications for research.

  1969cited by this paper
• Selective block of rat mouse-killing by antidepressants.

  1965cited by this paper
• The treatment of depressive states with G 22355 (imipramine hydrochloride).

  1958cited by this paper
• Nonparametric Estimation from Incomplete Observations

  1958cited by this paper

• Effects of chronic stress and angiotensin II type 1 receptor blockade on rats' performance in the five-choice serial reaction time task (5-CSRTT).

  2025cites this paper
• Licit use of illicit drugs for treating depression: the pill and the process

  2024cites this paper
• Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis

  2024cites this paper
• Awakening the dormant: Role of axonal guidance cues in stress-induced reorganization of the adult prefrontal cortex leading to depression-like behavior

  2023cites this paper
• Antidepressant effects of novel positive allosteric modulators of Trk-receptor mediated signaling – a potential therapeutic concept?

  2023cites this paper
• Resilience to the effects of social stress on vulnerability to developing drug addiction

  2022cites this paper
• New Horizons for Phenotyping Behavior in Rodents: The Example of Depressive-Like Behavior

  2022cites this paper
• Translational Strategies for Developing Biomarkers for Major Depression: Lessons Learned from Animal Models

  2022cites this paper
• Stress Markers for Mental States and Biotypes of Depression and Anxiety: A Scoping Review and Preliminary Illustrative Analysis

  2021cites this paper
• Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis

  2021cites this paper
• Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment

  2020cites this paper
• Rare Functional Variants Associated with Antidepressant Remission in Mexican-Americans: Short title: Antidepressant remission and pharmacogenetics in Mexican-Americans.

  2020cites this paper
• GPCR and RTK Regulation in Neurons: The Impact of Stress on GPCR and RTK signalling and Crosstalk

  2020cites this paper
• An Overview of Antidepression Model

  2020cites this paper
• Estudio de la actividad antidepresiva de los extractos etanólico, flavonoídico y fracciones mayoritarias flavonoídicas de Viola tricolor L. “pensamiento”, usando la prueba de nado forzado modificado

  2019cites this paper
• Sick and grumpy: Changes in social behaviour after a controlled immune stimulation in group-housed gilts.

  2019cites this paper
• Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner

  2019cites this paper
• Towards a comparative science of emotion: Affect and consciousness in humans and animals

  2019cites this paper
• Assessment of emotional predisposition in dogs using PANAS (Positive and Negative Activation Scale) and associated relationships in a sample of dogs from Brazil

  2019cites this paper
• Antidepressant‐like effect induced by Cannabidiol is dependent on brain serotonin levels

  2018cites this paper
• Δ3,2-Hydroxybakuchiol Attenuates Depression in Multiple Rodent Models Possibly by Inhibition of Monoamine Transporters in Brain

  2018cites this paper
• The effect of lipopolysaccharide (LPS) on inflammatory markers in blood and brain and on behavior in individually-housed pigs.

  2018cites this paper
• ect of lipopolysaccharide ( LPS ) on in fl ammatory markers in blood and brain and on behavior in individually-housed pigs

  2018cites this paper
• Rodent models of mental illness in polycystic ovary syndrome: the potential role of hypothalamic-pituitary-adrenal dysregulation and lessons for behavioral researchers.

  2018cites this paper
• A possible link between food and mood Jørgensen

  2018cites this paper
• Effects of the chronic restraint stress induced depression on reward‐related learning in rats

  2017cites this paper
• Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior.

  2017cites this paper
• Common Marmosets: A Potential Translational Animal Model of Juvenile Depression

  2017cites this paper
• Feeling Fishy: Trait Differences in Zebrafish (Danio Rerio)

  2017cites this paper
• Modelling depression in animals: at the interface of reward and stress pathways

  2017cites this paper
• Medial prefrontal cortical NMDA receptors regulate depression-like behavior and dictate limbic thalamus innervation

  2017cites this paper
• Animal models of major depression and their clinical implications.

  2016cites this paper
• Stress-based animal models of depression: Do we actually know what we are doing?

  2016influential citation
• Mouse Models for Drug Discovery

  2016cites this paper
• Mouse Models for Studying Depression-Like States and Antidepressant Drugs.

  2016cites this paper
• Pharmacological Inhibition of the G9a/GLP Histone Methyltransferase and Anxiety-related Behaviour in the Mouse

  2016cites this paper
• Pathogenesis of depression: Insights from human and rodent studies.

  2016cites this paper
• Ethological concepts enhance the translational value of animal models.

  2015cites this paper
• Deep Brain Stimulation for Obesity

  2015cites this paper
• Antidepressant-like effects induced by NMDA receptor blockade and NO synthesis inhibition in the ventral medial prefrontal cortex of rats exposed to the forced swim test

  2015cites this paper
• In vitro and in vivo characterization of PA01, a novel promising triple reuptake inhibitor.

  2015cites this paper
• Sex-dependent role of interleukin-1 signaling in emotional and cognitive behaviors in mice: Phenotyping male and female 1L1-R1 null mutant mice

  2015cites this paper
• The contribution of proteomic studies in humans, animal models, and after antidepressant treatments to investigate the molecular neurobiology of major depression

  2015cites this paper
• Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers

  2014cites this paper
• A Possible Link between Food and Mood: Dietary Impact on Gut Microbiota and Behavior in BALB/c Mice

  2014cites this paper
• The ups and downs of modelling mood disorders in rodents.

  2014cites this paper
• Alterations of Amino Acid Level in Depressed Rat Brain

  2014cites this paper
• Brain-derived neurotrophic factor response in vulnerable and resilient genetic lines in the chick anxiety-depression model.

  2013cites this paper
• Strain vulnerability and resiliency in the chick anxiety-depression model.

  2013cites this paper
• The Effects of Ketamine on Cognitive Bias in a Stress Vulnerable Chick Strain

  2013cites this paper
• N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence.

  2013cites this paper
• Stress, monoamines, and cognitive flexibility

  2013cites this paper
• Gender differences in genetic mouse models evaluated for depressive-like and antidepressant behavior

  2013cites this paper
• Long-term antidepressant treatment inhibits neuropathic pain-induced CREB and PLCγ-1 phosphorylation in the mouse spinal cord dorsal horn.

  2013cites this paper
• Oral S-adenosyl methionine (SAM) mediates disruptions in methyl group metabolism due to retinoic acid therapy and alters neurotransmitter metabolism: Implications for major depressive disorder

  2013cites this paper
• Animal models of depression vulnerability.

  2013cites this paper
• Effects of social housing on hippocampal dendrites and behavior in ovariectomized rats.

  2013cites this paper
• The Role of Molecular Chaperones in the Etiology and Treatment of Psychiatric Diseases in the Elderly

  2013cites this paper
• Pharmacological reversal of cognitive bias in the chick anxiety-depression model.

  2012cites this paper
• Investigating the psychopharmacology of cognitive affective bias in rats using an affective tone discrimination task

  2012cites this paper
• Molecular adaptation to chronic antidepressant treatment: evidence for a more rapid response to the novel α₂-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, compared to the SNRI, venlafaxine.

  2012cites this paper
• Progress in Neuro-Psychopharmacology & Biological Psychiatry

  2012influential citation
• Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.

  2012cites this paper
• The Utility of Animal Models in Understanding Links between Psychosocial Processes and Cardiovascular Health.

  2011cites this paper
• The effect of ketamine on stereotypic behavior in pregnant crated sows

  2011cites this paper
• The effects of environmental enrichment in the chick anxiety-depression model.

  2011cites this paper
• Long-lasting cognitive deficit induced by stress is alleviated by acute administration of antidepressants.

  2011cites this paper
• Animal models for depression and the mismatch hypothesis of disease.

  2011cites this paper
• Beyond the glutamate N-methyl D-aspartate receptor in major depressive disorder: the mTOR signaling pathway / Majör depresif bozuklukta glutamat N-metil-D-aspartat reseptörlerinin ötesi: mTOR sinyal yolağı

  2011cites this paper
• Evaluation of a novel translational task for assessing emotional biases in different species

  2011cites this paper
• Dissection of Forebrain Corticotropin-Releasing Hormone Receptor 1 Signaling in Stress-Induced Cognitive Deficits –– The Role of Synaptic Cell Adhesion Molecules

  2011cites this paper
• A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

  2011cites this paper
• New views on antidepressant action.

  2011cites this paper
• Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management

  2011cites this paper
• Early life stress paradigms in rodents: potential animal models of depression?

  2011cites this paper
• N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment

  2010cites this paper
• Qui non proficit, deficit: experimental models for 'integrative' research of affective disorders.

  2010cites this paper
• Effects of chronic stress: a comparison between tethered and loose sows.

  2010cites this paper
• Neural substrates of psychostimulant withdrawal-induced anhedonia.

  2010cites this paper
• Chronic, constant-rate, gastric drug infusion in nontethered rhesus macaques (Macaca mulatta).

  2010cites this paper
• Mouse models for studying depression-like states and antidepressant drugs.

  2010cites this paper
• Development of an ethologically relevant chronic stress model of depression

  2010cites this paper
• Genetic Animal Models of Depression

  2010cites this paper
• Animal Models of Depression – Where Are We Going?

  2010cites this paper
• Antidepressant-like effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

  2010cites this paper
• Ketamine induces rapid onset of antidepressant action: neurophysiological biomarkers as predictors of effect.

  2009cites this paper
• Violence against women: impacts on psychological health and stress hormones

  2009cites this paper
• Behavioral and Brain Functions

  2009influential citation
• Stress, depression and cardiovascular dysregulation: A review of neurobiological mechanisms and the integration of research from preclinical disease models

  2009cites this paper
• A novel acute anemia model for pharmacological research in mice by compelled acute exercise

  2009cites this paper
• A Bayesian formulation of behavioral control.

  2009cites this paper
• Antidepressant efficacy screening of novel targets in the chick anxiety-depression model

  2009cites this paper
• Modelling the anxiety-depression continuum in chicks

  2009cites this paper
• 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay.

  2009cites this paper
• The effects of inhaled bergamot and geranium essential oils on rat behaviour

  2009cites this paper
• Repeated social defeat in female pigs does not induce neuroendocrine symptoms of depression, but behavioral adaptation.

  2008cites this paper
• Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress

  2008influential citation
• Developing Therapeutics for Bipolar Disorder (BPD): From Animal Models to the Clinic

  2008cites this paper
• Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice

  2008cites this paper
• From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes.

  2008cites this paper