Oxidized LDL Levels Are Increased in HIV Infection and May Drive Monocyte Activation

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Acquired Immune Deficiency Syndromes

• Publication date

  2015-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/QAI.0000000000000566PMID 25647528PMCID PMC4446174
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
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  1998cited by this paper
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