Peptides bound to major histocompatibility complex molecules.

Peptides are the means by which immune effector T cells recognize and defend against the foreign proteins of pathogens. T cell recognition of these molecules, however, is strictly dependent on peptide binding to the receptor-like molecules of the major histocompatibility complex (MHC) locus. The basic unit of recognition is a trimolecular complex consisting of the T cell antigen receptor, the MHC molecule, and the MHC-bound peptide ligand. The multistep process that culminates in MHC presentation of peptides to T cells begins in the last phases of protein catabolism. While the individual roles of many key molecules involved in peptide presentation have recently been defined, there still remain many questions regarding processing of proteins into MHC-bound peptides. This review summarizes the recent developments in peptide antigen processing for MHC molecules, with focus on how proteins are believed to be sampled and selected for degradation into peptides.

• Publication year

  1998

• Venue

  Peptides

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0196-9781(97)00277-5PMID 9437752
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Heat shock proteins transfer peptides during antigen processing and CTL priming

  2004cited by this paper
• MHC ligands and peptide motifs: first listing

  2004cited by this paper
• MHC Ligands and Peptide Motifs

  1998cited by this paper
• The proteasome‐specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

  1997cited by this paper
• Nomenclature for factors of the HLA System, 1996.

  1997cited by this paper
• Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

  1997cited by this paper
• Nomenclature for factors of the HLA system, 1996.

  1997cited by this paper
• Localization of class I histocompatibility molecule assembly by subfractionation of the early secretory pathway.

  1997cited by this paper
• How selective is the transporter associated with antigen processing?

  1996cited by this paper
• Translocation of long peptides by transporters associated with antigen processing (TAP)

  1996cited by this paper
• The cDNA for the ubiquitin-52-amino-acid fusion protein from rat encodes a previously unidentified 60 S ribosomal subunit protein.

  1996cited by this paper
• Peptide antigen production by the proteasome: complexity provides efficiency.

  1996cited by this paper
• Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.

  1996cited by this paper
• Presentation of a cytosolic antigen by major histocompatibility complex class II molecules requires a long-lived form of the antigen.

  1996cited by this paper
• Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway.

  1996cited by this paper
• Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma

  1996cited by this paper
• The requirement for proteasome activity class I major histocompatibility complex antigen presentation is dictated by the length of preprocessed antigen

  1996cited by this paper
• A third interferon‐γ‐induced subunit exchange in the 20S proteasome

  1996cited by this paper
• A role for the proteasome regulator PA28alpha in antigen presentation.

  1996cited by this paper
• A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity

  1996cited by this paper
• Tissue-Specific Self-Peptides Bound by Major Histocompatibility Complex Class I Molecules of a Human Pancreatic β-cell Line

  1996cited by this paper
• The molecular chaperone calnexin facilitates folding and assembly of class I histocompatibility molecules.

  1996cited by this paper
• The protease inhibitor, N-acetyl-L-leucyl-L-leucyl-leucyl-L- norleucinal, decreases the pool of major histocompatibility complex class I-binding peptides and inhibits peptide trimming in the endoplasmic reticulum

  1996cited by this paper
• A new foreign policy: MHC class I molecules monitor the outside world.

  1996cited by this paper
• A role for the proteasome regulator PA28α in antigen presentation

  1996cited by this paper
• Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands.

  1996cited by this paper
• Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression.

  1996cited by this paper
• Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.

  1996cited by this paper
• Molecular chaperones in antigen presentation.

  1995cited by this paper
• Characterization of TAP‐Independent and Brefeldin A‐Resistant Presentation of Sendai Virus Antigen to CD8+ Cytotoxic T Lymphocytes

  1995cited by this paper
• Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment

  1995cited by this paper
• The peptide-binding motif for the human transporter associated with antigen processing

  1995cited by this paper
• MHC class I expression and transport in a calnexin-deficient cell line.

  1995cited by this paper
• Proteolysis: The proteasome: a protein-degrading organelle?

  1995cited by this paper
• Ubiquitin in homeostasis, development and disease

  1995cited by this paper
• Regulation of the DNA binding activity of NF-kappa B.

  1995cited by this paper
• Regulation of the DNA binding activity of NF-κB

  1995cited by this paper
• Generation, translocation, and presentation of MHC class I-restricted peptides.

  1995cited by this paper
• Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses.

  1995cited by this paper
• Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments.

  1995cited by this paper
• Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway.

  1995cited by this paper
• Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype.

  1995cited by this paper
• Dependence of Peptide Binding by MHC Class I Molecules on Their Interaction with TAP

  1995cited by this paper
• Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC class I-restricted cytotoxic T lymphocytes in vivo.

  1995cited by this paper
• Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum

  1995cited by this paper
• Association of the Invariant Chain with Major Histocompatibility Complex Class I Molecules Directs Trafficking to Endocytic Compartments (*)

  1995cited by this paper
• Hepatitis B virus small surface antigen particles are processed in a novel endosomal pathway for major histocompatibility complex class I‐restricted epitope presentation

  1995cited by this paper
• HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading.

  1995cited by this paper
• Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis

  1995cited by this paper
• Quality control in the secretory pathway.

  1995cited by this paper
• TAP polymorphism does not influence transport of peptide variants in mice and humans

  1995cited by this paper
• A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules

  1995cited by this paper
• Unique Expression of Major Histocompatibility Complex Class I Proteins in the Absence of Glucose Trimming and Calnexin Association *

  1995cited by this paper
• The levels of ubiquitinated histone H2A are highly upregulated in transformed human cells: partial colocalization of uH2A clusters and PCNA/cyclin foci in a fraction of cells in S-phase.

  1995cited by this paper
• Peptide binding to MHC class I molecules: Implications for antigenic peptide prediction

  1995cited by this paper
• The three-dimensional structure of peptide-MHC complexes.

  1995cited by this paper
• Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages.

  1995cited by this paper
• Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.

  1994cited by this paper
• From lysosomes into the cytosol: the intracellular pathway of Trypanosoma cruzi.

  1994cited by this paper
• Selectivity of MHC-encoded peptide transporters from human, mouse and rat

  1994cited by this paper
• Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

  1994cited by this paper
• Isolation and characterization of the intracellular MHC class II compartment

  1994cited by this paper
• The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules

  1994cited by this paper
• Endogenous antigen presentation by MHC class II molecules

  1994cited by this paper
• Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

  1994cited by this paper
• A role for calnexin (IP90) in the assembly of class II MHC molecules.

  1994cited by this paper
• Importance of peptide amino and carboxyl termini to the stability of MHC class I molecules.

  1994cited by this paper
• TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide.

  1994cited by this paper
• Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu.

  1994cited by this paper
• Interaction of MHC class I molecules with the transporter associated with antigen processing.

  1994cited by this paper
• MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding.

  1994cited by this paper
• Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum.

  1994cited by this paper
• Accessory cell requirements for saponin adjuvant-induced class I MHC antigen-restricted cytotoxic T-lymphocytes.

  1994cited by this paper
• Peptide transporter‐independent, stress protein‐mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation

  1994cited by this paper
• Calnexin: a membrane-bound chaperone of the endoplasmic reticulum.

  1994cited by this paper
• Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.

  1994cited by this paper
• Three-dimensional structure of a peptide extending from one end of a class I MHC binding site

  1994cited by this paper
• The smaller protein formed as a ubiquitin fusion in Drosophila is processed from ubiquitin and found on the 60S ribosomal subunit.

  1994cited by this paper
• HLA class I self peptides isolated from a T-cell leukemia reveal the allele-specific motif of HLA-B38.

  1994cited by this paper
• Definition of specific peptide motifs for four major HLA-A alleles.

  1994cited by this paper
• Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator

  1994cited by this paper
• Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

  1994cited by this paper
• Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling

  1994cited by this paper
• Trimming of antigenic peptides in an early secretory compartment

  1994cited by this paper
• Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

  1994cited by this paper
• MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding

  1994cited by this paper
• HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

  1994cited by this paper
• Leishmania major infection in mice primes for specific major histocompatibility complex class I‐restricted CD8+ cytotoxic T cell responses

  1994cited by this paper
• Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.

  1994cited by this paper
• Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

  1993cited by this paper
• Major histocompatibility complex class I‐binding peptides are recycled to the cell surface after internalization

  1993cited by this paper
• The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86

  1993cited by this paper
• HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs.

  1993cited by this paper
• Sequence of a prominent 16-residue self-peptide bound to HLA-B27 in a lymphoblastoid cell line.

  1993cited by this paper
• Consensus motifs and peptide ligands of MHC class I molecules.

  1993cited by this paper
• Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter.

  1993cited by this paper
• The biochemistry and cell biology of antigen processing and presentation.

  1993cited by this paper
• Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine

  1993cited by this paper
• Rapid degradation of an unassembled immunoglobulin light chain is mediated by a serine protease and occurs in a pre-Golgi compartment.

  1993cited by this paper
• Naturally processed cytokine-derived peptide bound to HLA-class II molecules.

  1993cited by this paper

• Evolutionary Perspective of Nonclassical MHC Class I and Innate-like T Cells Relevance in Immune Surveillance

  2025cites this paper
• HLA‐A promoter, coding, and 3′UTR sequences in a Brazilian cohort, and their evolutionary aspects

  2019cites this paper
• Physiopathologie

  2019cites this paper
• Green Tea Catechin-Inactivated Viral Vaccine Platform

  2017cites this paper
• Intérêt du séquençage dans les typages HLA et la greffe de cellules souches hématopoïétiques

  2015influential citation
• Peptide Antibodies: Past, Present, and Future.

  2015cites this paper
• Peptide Antibodies

  2015cites this paper
• Prediction of HLA-DRB1*0401 binding peptides using support vector machine

  2014cites this paper
• Diagnostic and Protective Aspects of Humoral Immune Responses to Epstein-Barr Virus Encoded Proteins in Nasopharyngeal Carcinoma

  2010cites this paper
• pulmonary T cell responses to IC 31 R ©-adjuvanted model protective antigens

  2009cites this paper
• Biomaterials Immune Response

  2008cites this paper
• Modulation of phenotype and function of dendritic cells by a therapeutic synthetic killer peptide

  2006cites this paper
• Gallium arsenide exposure impairs splenic B cell accessory function.

  2003cites this paper
• Impact of in vitro gallium arsenide exposure on macrophages.

  2003cites this paper
• Hidden Markov model-based approach as the first screening of binding peptides that interact with MHC class II molecules

  2003influential citation
• Synthesis, conformation and T-helper cell stimulation of an O-linked glycopeptide epitope containing extended carbohydrate side-chains.

  2002cites this paper
• Cognate T Cell Help Is Sufficient to Trigger Anti-Nuclear Autoantibodies in Naive Mice1

  2001cites this paper
• Immunosuppression by arsenic: a comparison of cathepsin L inhibition and apoptosis.

  2001cites this paper
• Anti-Nuclear Autoantibodies in Naive Mice Cognate T Cell Help Is Sufficient to Trigger

  2001cites this paper
• Mucosal immune response to aeroallergens

  2001cites this paper
• Immune cell functions in pancreatic cancer.

  2000cites this paper
• Delta(9)-tetrahydrocannabinol selectively increases aspartyl cathepsin D proteolytic activity and impairs lysozyme processing by macrophages.

  2000cites this paper
• In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG)

  2000cites this paper
• Epitope mimics and determinant spreading: pathways to autoimmunity

  2000cites this paper
• La réponse immunitaire locale dans la rhinite allergique

  1998cites this paper