The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Gastroenterology

• Publication date

  2011-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1053/j.gastro.2011.05.005PMID 21684281PMCID PMC4905727
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evolving Concepts of the Pathogenesis of Irritable Bowel Syndrome: To Treat the Brain or the Gut?

  2012cited by this paper
• Costs of irritable bowel syndrome in the UK and US

  2012cited by this paper
• Irritable bowel syndrome: Epidemiology, diagnosis and treatment: An update for health‐care practitioners

  2010cited by this paper
• Enteric serotonergic neurones … finally!

  2009cited by this paper
• Postinfectious irritable bowel syndrome.

  2009cited by this paper
• Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice.

  2009cited by this paper
• Strain‐specific genetics, anatomy and function of enteric neural serotonergic pathways in inbred mice

  2009cited by this paper
• Irritable Bowel Syndrome Subtypes Defined by Rome II and Rome III Criteria are Similar

  2009cited by this paper
• Evolving Concepts of the Pathogenesis of Irritable Bowel Syndrome: To Treat the Brain or the Gut?

  2009cited by this paper
• Infection, inflammation, and the irritable bowel syndrome.

  2009cited by this paper
• The burden of IBS: Looking at metrics

  2009cited by this paper
• International Survey of Patients With IBS: Symptom Features and Their Severity, Health Status, Treatments, and Risk Taking to Achieve Clinical Benefit

  2009cited by this paper
• Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients

  2008cited by this paper
• First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.

  2008cited by this paper
• Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice

  2008cited by this paper
• Postinfectious irritable bowel syndrome.

  2008cited by this paper
• Serotonin and GI clinical disorders.

  2008cited by this paper
• Serotonin (5-HT) release and uptake measured by real-time electrochemical techniques in the rat ileum.

  2008cited by this paper
• Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

  2008cited by this paper
• The FDA's Decision-Making Process: Isn't It Time to Temper the Principle of Protective Paternalism?

  2008cited by this paper
• Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials.

  2008cited by this paper
• Tegaserod for Female Patients Suffering From IBS With Mixed Bowel Habits or Constipation: A Randomized Controlled Trial

  2008cited by this paper
• Mapping 5-HT inputs to enteric neurons of the guinea-pig small intestine.

  2007cited by this paper
• FUNCTIONAL BOWEL DISORDERS

  2007cited by this paper
• Maternal serotonin is crucial for murine embryonic development

  2007cited by this paper
• Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome.

  2007cited by this paper
• High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression.

  2007cited by this paper
• Recent advances in understanding the role of serotonin in gastrointestinal motility and functional bowel disorders

  2007cited by this paper
• REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders

  2007cited by this paper
• ROME III: The Functional Gastrointestinal Disorders

  2007cited by this paper
• In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffin cells of the guinea pig ileum.

  2007cited by this paper
• Introduction. The Rome Foundation and Rome III

  2007cited by this paper
• Tegaserod for Constipation‐Predominant Irritable Bowel Syndrome

  2007cited by this paper
• Serotonin, Inflammation, and IBS: Fitting the Jigsaw Together?

  2007cited by this paper
• Rome III: The Functional Gastrointestinal Disorders

  2006cited by this paper
• Quality of life of patients with irritable bowel syndrome is low compared to others with chronic diseases

  2006cited by this paper
• Activation of peripheral 5‐HT4 receptors attenuates colonic sensitivity to intraluminal distension

  2006cited by this paper
• Review article: intestinal serotonin signalling in irritable bowel syndrome

  2006cited by this paper
• The effects of tegaserod, a 5-HT receptor agonist, on gastric emptying in a murine model of diabetes mellitus.

  2005cited by this paper
• Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome.

  2005cited by this paper
• Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction

  2005cited by this paper
• Cilansetron: a new serotonergic agent for the irritable bowel syndrome with diarrhoea

  2005cited by this paper
• Real‐time detection of serotonin release from enterochromaffin cells of the guinea‐pig ileum

  2004cited by this paper
• Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome.

  2004cited by this paper
• Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function

  2003cited by this paper
• Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

  2003cited by this paper
• Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome

  2001cited by this paper
• Activation of Intrinsic Afferent Pathways in Submucosal Ganglia of the Guinea Pig Small Intestine

  2000cited by this paper
• The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors.

  2000cited by this paper
• Noxious stimulation of emesis.

  1999cited by this paper
• Direct and indirect actions of 5‐hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum

  1998cited by this paper
• Sensitivity to 5‐hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum

  1998cited by this paper
• Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity

  1994cited by this paper
• Effects of 5-hydroxytryptamine on discharge of vagal mucosal afferent fibres from the upper gastrointestinal tract of the ferret.

  1993cited by this paper
• Intracellular metabolism of biogenic amines in paraneurons.

  1989cited by this paper
• p-Chlorophenylalanine: a specific depletor of brain serotonin.

  1966cited by this paper
• Histology of the enterochromaffin cell system

  1966cited by this paper
• Occurrence of indolealkylamines in nature

  1966cited by this paper
• The action of 5‐hydroxytryptamine, 5‐hydroxytryptophan and reserpine on intestinal peristalsis in anaesthetized guinea‐pigs

  1959cited by this paper
• The release of 5‐hydroxytryptamine in relation to pressure exerted on the intestinal mucosa

  1959cited by this paper
• The effect of intraluminal application of 5‐hydroxytryptamine and 5‐hydroxytryptophan on peristalsis; the local production of 5‐HT and its release in relation to intraluminal pressure and propulsive activity

  1958cited by this paper
• An investigation of the peristaltic reflex in relation to anatomical observations.

  1958cited by this paper

• Glucocorticoid signaling mitigates colitis-associated visceral hypersensitivity by suppressing 5-HT release in enterochromaffin cells via a GR-PI3K-SGK1 axis.

  2026cites this paper
• Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

  2025cites this paper
• Tryptophan Metabolism in Health and Disease- Implications for non-communicable diseases.

  2025cites this paper
• Early-Life Stress Induced by Neonatal Maternal Separation Leads to Intestinal 5-HT Accumulation and Causes Intestinal Dysfunction

  2024cites this paper
• Progress in Signaling Pathways Associated to Irritable Bowel Syndrome

  2024cites this paper
• Multiomics Analysis Revealed Colorectal Cancer Pathogenesis.

  2024cites this paper
• Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.

  2023cites this paper
• Efficient Synthesis of Chiral Aryl Alcohol with a Novel Kosakonia radicincitans Isolate in Tween 20/L-carnitine: Lysine-Containing Synergistic Reaction System

  2023cites this paper
• Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.

  2023cites this paper
• Effect of Shugan Jianpi Recipe Combined with Cross Moxibustion on Biochemical Examination Indexes and Total Score of TCM Symptoms in Patients with Spleen-Stomach Damp-Heat Diarrhea Irritable Bowel Syndrome

  2022cites this paper
• Saudi Arabia Running title : Prevalence and correlates of irritable bowel syndrome among medical students Type :

  2022cites this paper
• Corrigendum to "Dopamine and serotonin regulate tumor behavior by affecting angiogenesis

  2022cites this paper
• Role of Ion Channels in the Chemotransduction and Mechanotransduction in Digestive Function and Feeding Behavior

  2022influential citation
• Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.

  2022cites this paper
• Prevalence and correlates of irritable bowel syndrome among medical students at Jeddah, Saudi Arabia

  2022cites this paper
• 5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome

  2022cites this paper
• Herpes Simplex Virus-1 Induced Serotonin-Associated Metabolic Pathways Correlate With Severity of Virus- and Inflammation-Associated Ocular Disease

  2022cites this paper
• Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

  2021cites this paper
• Serotonin in the Pathogenesis of Lymphocytic Colitis

  2021cites this paper
• Unraveling Autocrine Signaling Pathways through Metabolic Fingerprinting in Serous Ovarian Cancer Cells

  2021cites this paper
• Tryptophan‐derived serotonin‐kynurenine balance in immune activation and intestinal inflammation

  2021cites this paper
• The role of serotonin and its pathways in gastrointestinal disorders

  2021cites this paper
• Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism

  2021cites this paper
• The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis.

  2021cites this paper
• Irritable bowel syndrome: Current therapies and future perspectives

  2020cites this paper
• Tryptophan hydroxylase and serotonin synthesis regulation

  2020cites this paper
• An update on efficacy and safety considerations for the latest drugs used to treat irritable bowel syndrome

  2020cites this paper
• Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns

  2019cites this paper
• Inhibition of serotonin synthesis: A novel therapeutic paradigm.

  2019cites this paper
• Abnormalities of mucosal serotonin metabolism and 5‐HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron

  2019cites this paper
• Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands.

  2019cites this paper
• Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions

  2019cites this paper
• The TPH1 rs211105 gene polymorphism affects abdominal symptoms and quality of life of diarrhea-predominant irritable bowel syndrome

  2018cites this paper
• Advancements in drug development for diarrhea-predominant irritable bowel syndrome

  2018cites this paper
• New treatments and therapeutic targets for IBS and other functional bowel disorders

  2018cites this paper
• IMMUNO-ENDOCRINE INTERACTIONS IN INTESTINAL INFLAMMATION

  2018cites this paper
• Peripheral Serotonin Synthesis as a New Drug Target.

  2018cites this paper
• A systematic review of the association between urinary biomarkers and pain

  2017cites this paper
• Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome. The SEPD perspective.

  2017cites this paper
• New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond

  2017cites this paper
• Heterogeneity of enterochromaffin cells within the gastrointestinal tract

  2017cites this paper
• Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease

  2017cites this paper
• Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis.

  2017influential citation
• Fatigue and Co-occurring Symptoms in Women with Irritable Bowel Syndrome

  2017cites this paper
• Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases

  2017cites this paper
• Fatigue and Co-occurring Symptoms in Women with Irritable Bowel Syndrome Jungyoun (Claire) Han A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Washington 2016 Reading Committee: Monica E. Jarrett, Chair

  2016cites this paper
• Inflammation in irritable bowel syndrome: Myth or new treatment target?

  2016cites this paper
• Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.

  2016influential citation
• Pharmacological, Pharmacokinetic, and Pharmacogenomic Aspects of Functional Gastrointestinal Disorders.

  2016cites this paper
• Inhibition of Peripheral Synthesis of Serotonin as a New Target in Neuroendocrine Tumors.

  2016cites this paper
• Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation

  2016cites this paper
• Eluxadoline for the treatment of diarrhoea-predominant irritable bowel syndrome

  2016cites this paper
• Oridonin Alleviates Visceral Hyperalgesia in a Rat Model of Postinflammatory Irritable Bowel Syndrome: Role of Colonic Enterochromaffin Cell and Serotonin Availability

  2016cites this paper
• High risk of drug‐induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors

  2016cites this paper
• Expression of serotonin, chromogranin-A, serotonin receptor-2B, tryptophan hydroxylase-1, and serotonin reuptake transporter in the intestine of dogs with chronic enteropathy

  2016cites this paper
• IBS and IBD — separate entities or on a spectrum?

  2016cites this paper
• Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation

  2016cites this paper
• Systematic review: instruments to assess abdominal pain in irritable bowel syndrome

  2015cites this paper
• Secretory diarrhoea: mechanisms and emerging therapies

  2015cites this paper
• Rebuttal from Terence K. Smith and Michael D. Gershon

  2015cites this paper
• Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness.

  2015cites this paper
• Pilot study of Biomarkers for predicting effectiveness of ramosetron in diarrhea‐predominant irritable bowel syndrome: expression of S100A10 and polymorphisms of TPH1

  2015cites this paper
• Emerging drug for diarrhea predominant irritable bowel syndrome

  2015cites this paper
• New and Investigational Agents for Irritable Bowel Syndrome

  2015cites this paper
• Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism – a preliminary study

  2015cites this paper
• High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes

  2014cites this paper
• TOPIC HIGHLIGHT

  2014cites this paper
• Treatment of abdominal pain in irritable bowel syndrome

  2014cites this paper
• Recent advances in pharmacological treatment of irritable bowel syndrome.

  2014cites this paper
• Dopamine and serotonin regulate tumor behavior by affecting angiogenesis.

  2014cites this paper
• 5‐HT modulators and other antidiarrheal agents and cathartics

  2014cites this paper
• Brain–Gut Axis and Neural Control

  2014cites this paper
• Measurement of Plasma, Serum, and Platelet Serotonin in Individuals With High Bone Mass and Mutations in LRP5

  2014cites this paper
• Editorial: abnormal permeability and altered mucosal serotonin metabolism in the irritable bowel syndrome – is there a link?

  2014cites this paper
• Editorial: patients' preferences and health utility assessment in those with HCV treated with sofosbuvir – stating the obvious? Authors' reply

  2014cites this paper
• TPH Gene Polymorphisms Are Associated With Disease Perception and Quality of Life in Women With Irritable Bowel Syndrome

  2014cites this paper
• Intestinal permeability – a new target for disease prevention and therapy

  2014influential citation
• Metabolic Kinetics of 5-Hydroxytryptamine and the Research Targets of Functional Gastrointestinal Disorders

  2014cites this paper
• 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract

  2013cites this paper
• Identification of a Functional TPH1 Polymorphism Associated With Irritable Bowel Syndrome Bowel Habit Subtypes

  2013cites this paper
• Current and future pharmacological treatments for diarrhea-predominant irritable bowel syndrome

  2013cites this paper
• Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

  2013cites this paper
• Prevention of catheter-related blood stream infections in children with intestinal failure

  2013cites this paper
• Probiotics VSL#3 Protect against Development of Visceral Pain in Murine Model of Irritable Bowel Syndrome

  2013cites this paper
• Clinical trials in irritable bowel syndrome: a review.

  2013cites this paper
• Gut-derived Serotonin and Bone Formation

  2013cites this paper
• Biomarqueur associé avec le syndrome du côlon irritable et la maladie de crohn

  2013cites this paper
• How understanding gut serotonin secretion could potentially lead to new treatments for osteoporosis

  2013cites this paper
• Pharmacological agents currently in clinical trials for disorders in neurogastroenterology.

  2013cites this paper
• Motility disorders of the colon and rectum

  2013cites this paper
• A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea

  2013cites this paper
• Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome

  2013cites this paper
• Identification of unique release kinetics of serotonin from guinea‐pig and human enterochromaffin cells

  2013cites this paper
• Selective inhibition of mucosal serotonin as treatment for IBD?

  2013cites this paper
• Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

  2013cites this paper
• Treatment of irritable bowel syndrome: sex and gender specific aspects.

  2012cites this paper
• Serotonin and GI Disorders: An Update on Clinical and Experimental Studies

  2012cites this paper
• Revisiting concepts of visceral nociception in irritable bowel syndrome

  2012cites this paper
• An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome

  2012cites this paper
• Role of serotonin in gastrointestinal physiology and pathology.

  2011cites this paper