Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Trends in immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.it.2013.09.001PMID 24269668PMCID PMC3947349
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neutrophil Homeostasis and Periodontal Health in Children and Adults

  2014cited by this paper
• 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution

  2013cited by this paper
• Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions

  2013cited by this paper
• Exploring the genetic basis of chronic periodontitis: a genome-wide association study

  2013cited by this paper
• Disruption of immune regulation by microbial pathogens and resulting chronic inflammation

  2013cited by this paper
• Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms.

  2013cited by this paper
• Role of TLR2‐dependent IL‐10 production in the inhibition of the initial IFN‐γ T cell response to Porphyromonas gingivalis

  2013cited by this paper
• Role of complement in host-microbe homeostasis of the periodontium.

  2013cited by this paper
• Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.

  2013cited by this paper
• Compartmentalized and systemic control of tissue immunity by commensals

  2013cited by this paper
• The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation

  2013cited by this paper
• The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin.

  2013cited by this paper
• Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-κB Ligand

  2013cited by this paper
• Epigenetic biomarkers: a step forward for understanding periodontitis

  2013cited by this paper
• A Comparison of Aggregatibacter actinomycetemcomitans (Aa) Virulence Traits in a Rat Model for Periodontal Disease

  2013cited by this paper
• Mobile Microbiome

  2013cited by this paper
• Suppression of T-Cell Chemokines by Porphyromonas gingivalis

  2013cited by this paper
• RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury.

  2013cited by this paper
• Neutrophil recruitment and function in health and inflammation

  2013cited by this paper
• The keystone-pathogen hypothesis

  2012cited by this paper
• Prevalence of Periodontitis in Adults in the United States: 2009 and 2010

  2012cited by this paper
• IL‐17‐producing γδ T cells and innate lymphoid cells

  2012cited by this paper
• Neutrophils come of age in chronic inflammation.

  2012cited by this paper
• Fusobacterium nucleatum and Tannerella forsythia Induce Synergistic Alveolar Bone Loss in a Mouse Periodontitis Model

  2012cited by this paper
• The Presence of IL-17+/FOXP3+ Double-positive Cells in Periodontitis

  2012cited by this paper
• Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis.

  2012cited by this paper
• Paradigm shift in the pharmacological management of periodontal diseases.

  2012cited by this paper
• Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist

  2012cited by this paper
• The RANKL-OPG system in clinical periodontology.

  2012cited by this paper
• The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

  2012cited by this paper
• Targeting IL-17 and TH17 cells in chronic inflammation

  2012cited by this paper
• Genetic susceptibility to periodontitis.

  2012cited by this paper
• Porphyromonas gingivalis as a Potential Community Activist for Disease

  2012cited by this paper
• Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.

  2012cited by this paper
• Has the use of molecular methods for the characterization of the human oral microbiome changed our understanding of the role of bacteria in the pathogenesis of periodontal disease?

  2011cited by this paper
• Review of osteoimmunology and the host response in endodontic and periodontal lesions

  2011cited by this paper
• Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement.

  2011cited by this paper
• Th17 cells can provide B cell help in autoantibody induced arthritis.

  2011cited by this paper
• Microbial manipulation of receptor crosstalk in innate immunity

  2011cited by this paper
• Functional specialization of interleukin-17 family members.

  2011cited by this paper
• Induction of IL-10-producing CD4+ T-cells in Chronic Periodontitis

  2011cited by this paper
• Diabetes mellitus and periodontitis: a tale of two common interrelated diseases

  2011cited by this paper
• Filifactor alocis Has Virulence Attributes That Can Enhance Its Persistence under Oxidative Stress Conditions and Mediate Invasion of Epithelial Cells by Porphyromonas gingivalis

  2011cited by this paper
• Biological approaches to the development of novel periodontal therapies--consensus of the Seventh European Workshop on Periodontology.

  2011cited by this paper
• Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity

  2011cited by this paper
• Molecular Signaling Mechanisms of the Periopathogen, Treponema denticola

  2011cited by this paper
• Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing

  2011cited by this paper
• Synergistic virulence of Porphyromonas gingivalis and Treponema denticola in a murine periodontitis model.

  2011cited by this paper
• How has neutrophil research improved our understanding of periodontal pathogenesis?

  2011cited by this paper
• Neutrophils in the activation and regulation of innate and adaptive immunity

  2011cited by this paper
• Metabolite Cross-Feeding Enhances Virulence in a Model Polymicrobial Infection

  2011cited by this paper
• IL-23-producing CD68(+) macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions.

  2011cited by this paper
• Filifactor alocis interactions with gingival epithelial cells.

  2011cited by this paper
• Comparison of neutrophil functions in aggressive and chronic periodontitis.

  2010cited by this paper
• Virulence mechanisms of Tannerella forsythia.

  2010cited by this paper
• Periodontitis: a polymicrobial disruption of host homeostasis

  2010cited by this paper
• γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.

  2010cited by this paper
• Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease

  2010cited by this paper
• Prevention: Reducing the risk of CVD in patients with periodontitis

  2010cited by this paper
• Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis.

  2010cited by this paper
• Proinflammatory T helper type 17 cells are effective B-cell helpers

  2010cited by this paper
• Too old to fight? Aging and its toll on innate immunity.

  2010cited by this paper
• Periodontitis in RA—the citrullinated enolase connection

  2010cited by this paper
• Evidence for a cross-talk between human neutrophils and Th17 cells.

  2010cited by this paper
• Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints

  2010cited by this paper
• “Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

  2010cited by this paper
• Innate IL-17-producing cells: the sentinels of the immune system

  2010cited by this paper
• Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

  2009cited by this paper
• Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption.

  2009cited by this paper
• IL-17 and Th17 Cells.

  2009cited by this paper
• The gut microbiota shapes intestinal immune responses during health and disease

  2009cited by this paper
• The Involvement of IL-23 and the Th17 Pathway in Periodontitis

  2009cited by this paper
• Oral administration of type-II collagen suppresses IL-17-associated RANKL expression of CD4+ T cells in collagen-induced arthritis.

  2008cited by this paper
• Cytokines that promote periodontal tissue destruction.

  2008cited by this paper
• Homeostatic Regulation of Blood Neutrophil Counts

  2008cited by this paper
• Analysis of the activity to induce toll-like receptor (TLR)2- and TLR4-mediated stimulation of supragingival plaque.

  2008cited by this paper
• Cytokines in the pathogenesis of rheumatoid arthritis

  2007cited by this paper
• The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

  2007cited by this paper
• B cells in periodontitis: friends or enemies?

  2007cited by this paper
• The role of T cells in periodontal disease: homeostasis and autoimmunity.

  2007cited by this paper
• Are dental diseases examples of ecological catastrophes?

  2003cited by this paper
• of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln The Human Oral Microbiome The Human Oral Microbiome

  year unknowncited by this paper

• Association between single point aMMP8 levels and previous periodontal disease progression - a long-term follow-up after 10 years in patients with stage III/IV periodontitis.

  2026cites this paper
• Diabète et maladies parodontales : une relation bidirectionnelle

  2026cites this paper
• The Impact of Periodontal Treatment on Rheumatoid Arthritis Outcomes: The Microbial Link

  2026cites this paper
• Periodontal Status and Disease Activity in Psoriatic Arthritis and Psoriasis: A Cross-Sectional Study

  2026cites this paper
• GENETIC POLYMORPHISMS IN TOLL-LIKE RECEPTOR 2, TOLL-LIKE RECEPTOR 4, NUCLEAR FACTOR-KAPPA B, AND INTERLEUKIN-4 GENES AND THEIR ASSOCIATION WITH CHRONIC PERIODONTITIS

  2026cites this paper
• Dental plaque biofilm-targeting composite nanomaterials: advances and outlook.

  2026cites this paper
• Transcription-based comparison of Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis-induced experimental periodontitis

  2026cites this paper
• Microbial dysbiosis and immune dysregulation in periodontitis and peri-implantitis

  2026cites this paper
• Salivary Proteome Role in Infection and Immunity.

  2026cites this paper
• Diet type and the oral microbiome

  2026cites this paper
• Cascade Therapy of Periodontitis via Sequential Release of Ribosome-Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF-Based System.

  2026cites this paper
• Research Hotspots and Development Trends in the Field of Periodontal Disease and Coronary Atherosclerotic Heart Disease

  2026cites this paper
• Nitrogen Species Modulate Macrophage ER Stress to Preserve Alveolar Bone: A Translational Adjunct for Periodontal Care

  2026cites this paper
• Periodontitis and diabetes: a bidirectional link.

  2026cites this paper
• Adjunctive Therapies in Periodontitis: Current Concepts and the Future.

  2026cites this paper
• Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review and Meta-Analysis

  2026cites this paper
• Association Between Periodontal Health Knowledge and Oral Hygiene Practices in a National Cohort of Thai Adults

  2026cites this paper
• Self-Assembled Charge-Complementary Hydrogel with Sustained Release of Antimicrobial Peptides for Periodontitis Treatment.

  2026cites this paper
• Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies

  2026cites this paper
• The Oral Microbiome, Oral Hyperpermeability, and Periodontitis in Metabolic Syndrome.

  2026cites this paper
• From Oxidised LDL to Potential Novel Applications in Gingival Crevicular Fluid Analysis

  2025cites this paper
• Electrochemical and optical biosensors for periodontitis detection

  2025cites this paper
• Immunological pathways triggered by Porphyromonas gingivalis in periodontitis: New insights into molecular mechanisms.

  2025cites this paper
• Tetramethoxyluteolin, an active constituent in mulberry leaves, promotes osteogenesis of jaw bone marrow mesenchymal stem cells in periodontitis microenvironment via NF-κB inhibition.

  2025cites this paper
• Felodipine Allays High Cholesterol-Aggravated Periodontitis via Attenuating 27-Hydroxycholesterol.

  2025cites this paper
• Multi-dimensional role of AGEs in periodontitis: from matrix remodeling to neuro-immune crosstalk

  2025cites this paper
• A review on the role of polyphenols against periodontitis

  2025cites this paper
• Microbial-triggered integrated stress response in sulcular and junctional keratinocytes exacerbates immunopathology in periodontitis.

  2025cites this paper
• A Comparison of Periodontal Health in Elderly Individuals with and Without Metabolic Syndrome: A Retrospective Study

  2025cites this paper
• Unveiling the Impact of Porphyromonas gingivalis‐Associated Periodontitis on Stroke Outcome in Mice

  2025cites this paper
• The Role of Porphyromonas gingivalis in Oral Carcinogenesis and Progression by Remodelling the Tumour Microenvironment: A Narrative Review

  2025cites this paper
• Inflammatory and Immunological Basis of Periodontal Diseases.

  2025cites this paper
• Measuring the Invisible: Microbial Diagnostics for Periodontitis—A Narrative Review

  2025cites this paper
• Using the Immune System for Effective Periodontal and Caries Management

  2025cites this paper
• C-C Chemokine Ligand (CCL5), C-C Chemokine Receptor Type 5 (CCR5) and Tumor Necrosis Factor (TNF)-α Polymorphisms Detection in Patients with Periodontitis

  2025cites this paper
• GCN2-Mediated Integrated Stress Response Attenuates Periodontitis

  2025cites this paper
• Four-Week Evaluation of the Interaction Pattern Among Saccharibacteria, Nitrate-Reducing Bacteria, and Periodontopathogens in Orthodontic Miniscrew Implants

  2025cites this paper
• Sensitive, Low-Cost, Early Detection of Periodontal Disease Using Surface-Enhanced Raman Spectroscopy with Easy-to-Use Silver Nanomesh-Coated Periopaper.

  2025cites this paper
• Microbiota–Host Interactions: Exploring Their Dynamics and Contributions to Human Diseases

  2025cites this paper
• Recent Advances in Injectable Hydrogel Biotherapeutics for Regenerative Dental Medicine

  2025cites this paper
• Mendelian randomization reveals a causal link between age at menarche and reduced risk of periodontitis

  2025cites this paper
• Microbial Markers for Diagnosis and Risk Assessment for Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis

  2025cites this paper
• INFECTIVE ENDOCARDITIS AND ORAL INFECTIONS: PREVENTION AND THERAPEUTIC APPROACHES

  2025cites this paper
• Lys-specific gingipain (Kgp) of P. gingivalis promotes viral infection by disabling the interferon pathway

  2025cites this paper
• Some South African medicinal plants associated with oral health care: Their phytochemical constituents and involvement in biological activities

  2025cites this paper
• Rapamycin's Role in Periodontal Health and Therapeutics: A Scoping Review.

  2025cites this paper
• Porphyromonas gingivalis Lysate Induces TLR-2/4-Dependent NF-κB Activation and Inflammatory Damage in the Human Placental Barrier

  2025cites this paper
• Mesenchymal stem cell-derived apoptotic vesicles: emerging cell-free strategy for periodontitis treatment

  2025cites this paper
• Novel small molecule targeting PgQC reduces Porphyromonas gingivalis virulence

  2025cites this paper
• Identification of Key Periodontitis Genes and Their Mechanisms of Action Using Comprehensive Multiple Microarray Analysis and Mendelian Randomization Methods

  2025cites this paper
• Dual-drug carboxymethyl chitosan hydrogel: Development, characterization, and in vitro evaluation for periodontal therapy.

  2025cites this paper
• NASH exacerbates inflammatory bone destruction and macrophage NLRP3 inflammasome activation in ligature-induced periodontitis.

  2025cites this paper
• A Novel Postbiotic Reduces Canine Halitosis

  2025cites this paper
• Beyond antibiotics: advances in photothermal strategies for oral infections

  2025cites this paper
• Osteocyte dysregulation in periodontitis: Pathological mechanisms and therapeutic potential.

  2025cites this paper
• Unveiling the dental cellular landscape: A comprehensive review of single-cell RNA sequencing in human dental tissues

  2025cites this paper
• Diminished osteoprotegerin production by gingival fibroblasts from periodontitis patients is associated with their reduced ability to suppress osteoclastogenesis

  2025cites this paper
• Cytokine Changes in Gingival Crevicular Fluid and Serum After Non-Surgical Periodontal Therapy in Patients with Periodontitis: A Systematic Review and Narrative Synthesis

  2025cites this paper
• Beyond the oral niche: Lacticaseibacillus paracasei LPC-37 unlocks oral-gastric-intestinal crosstalk for butyric acid-dependent oral inflammation alleviation.

  2025cites this paper
• Dimethyl Citraconate Alleviates Periodontitis via Activating the NRF2 Cascade

  2025cites this paper
• FOXP3+ T Cells—An Emerging Evidence in Periodontitis Therapeutics

  2025cites this paper
• Alternative Polyadenylation Drives Runaway Pro-Inflammatory Macrophages in Periodontitis by Enabling Escape From miRNA Repression.

  2025cites this paper
• Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation

  2025cites this paper
• Toxin-antitoxin Systems in Periodontal Disease is a Gap in Research: A Proof of Concept Study

  2025cites this paper
• Fibroblast-derived versican exacerbates periodontitis progression by regulating macrophage migration and inflammatory cytokine secretion.

  2025cites this paper
• Association of Oral Health Determinants With Oral Squamous Cell Carcinoma in Never‐Smoking Adults

  2025cites this paper
• New considerations in selecting donors for dental pulp stem cells: a pilot study

  2025cites this paper
• Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases

  2025cites this paper
• The Role of Senescence in Experimental Periodontitis at the Causal Level: An in Vivo Study

  2025cites this paper
• Porphyromonas gingivalis affects neutrophil pro-inflammatory activities

  2025cites this paper
• Regulation of tryptophan-indole metabolic pathway in Porphyromonas gingivalis virulence and microbiota dysbiosis in periodontitis

  2025cites this paper
• Microbiological and Metabolomic Analysis of Biomarkers for Grades A and B in Stage II Periodontitis

  2025cites this paper
• Association between osteoporosis and periodontitis.

  2025cites this paper
• Osteodestructive Peripheral Giant Cell Granulomas in Mandibular Premolar Area Diagnosis and Treatment: A Case Report

  2025cites this paper
• Recent advances in nanomaterials for integrated phototherapy and immunotherapy

  2025cites this paper
• The mouse experimental periodontitis by silk-ligature placement triggers systemic inflammation potentially exacerbating pulmonary inflammation.

  2025cites this paper
• Natural and induced immune responses in oral cavity and saliva

  2025influential citation
• Relationship Between the Mandibular Cortical Index and Periodontitis Stage/Grade: A Retrospective Radiographic Study

  2025cites this paper
• Bacterial translocation signatures and subgingival microbiome in individuals with periodontitis

  2025cites this paper
• Annexin A2 Contributes to Release of Extracellular Vimentin in Response to Inflammation

  2025cites this paper
• Longitudinal host-microbiome dynamics of metatranscription identify hallmarks of progression in periodontitis

  2025cites this paper
• Hybrid-designed metal-phenolic nanoparticles for synergistic nano-gene periodontal therapy.

  2025cites this paper
• Untargeted Salivary Metabolomics and Proteomics: Paving the Way for Early Detection of Periodontitis

  2025cites this paper
• Antibacterial potential of essential oils against oral pathogenic bacteria: A literature and clinical review.

  2025cites this paper
• Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation

  2025cites this paper
• Glycosylation orchestrates virulence and pathogenicity of periodontal keystone pathogens

  2025cites this paper
• Long noncoding RNA MIR100HG regulates inflammatory response by interacting with RNA-binding protein Quaking in periodontitis.

  2025cites this paper
• Integrating Biotechnology into Prosthodontic Care for Older Adults: A Scoping Review

  2025cites this paper
• Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study

  2025cites this paper
• Diagnosis of Periodontitis via Neutrophil Degranulation Signatures Identified by Integrated scRNA-Seq and Deep Learning

  2025cites this paper
• Selective bacterial proteolysis in periodontal disease: Molecular mechanisms and therapeutic implications, a narrative review.

  2025cites this paper
• Association between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data

  2025cites this paper
• Potential of Sambucus williamsii var. coreana Extract as a Safe and Effective Antimicrobial Agent for Periodontal Applications

  2025cites this paper
• Evaluating diagnostic accuracy and consistency in applying the 2017 periodontal classification among dental professionals.

  2025cites this paper
• Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic

  2025cites this paper
• Étiopathogénie des maladies parodontales

  2025cites this paper
• Periodontitis and Atrial Fibrillation.

  2025cites this paper
• Exploring the Therapeutic Potential of Diverse Bacterial Strains for Management of Periodontal Diseases.

  2025cites this paper
• Empiric or individually targeted antimicrobial therapy. Historical perspective and current state.

  2025cites this paper
• Relationship Between the Salivary Microbiome and Oral Malodor Metabolites in Older Thai Individuals with Periodontitis and the Cytotoxic Effects of Malodor Compounds on Human Oral Squamous Carcinoma (HSC-4) Cells

  2025cites this paper