Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Pharmacology and Therapeutics

• Publication date

  2007-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.PHARMTHERA.2006.12.004PMID 17328956
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vascular Endothelial Growth Factor

  2009cited by this paper
• Pluripotency of mesenchymal stem cells derived from adult marrow

  2007cited by this paper
• Transforming growth factor-beta induces development of the T(H)17 lineage.

  2006cited by this paper
• TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

  2006cited by this paper
• A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

  2006cited by this paper
• Bone marrow transplantation ameliorates pathology in interleukin‐10 knockout colitic mice

  2006cited by this paper
• T helper cell effector fates--who, how and where?

  2006cited by this paper
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  2005cited by this paper
• A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.

  2005cited by this paper
• Interleukin-17 augments tumor necrosis factor-α-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts

  2005cited by this paper
• Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.

  2005cited by this paper
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

  2005cited by this paper
• Interleukin (IL)-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts via NF-kappaB, AP-1 and MAP-kinase dependent pathways

  2005cited by this paper
• Autologous hematopoietic stem cell transplantation for Crohn's disease: high risk for a high reward.

  2005cited by this paper
• Colitis and colony-stimulating factors (CSFs): is stimulation of innate immunity through CSFs really effective for the treatment of chronic colitis?

  2005cited by this paper
• Leukocytapheresis in Ulcerative Colitis: Results of a Multicenter Double-Blind Prospective Case-Control Study with Sham Apheresis as Placebo Treatment

  2005cited by this paper
• Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response

  2005cited by this paper
• Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

  2005cited by this paper
• TH-17: a giant step from TH1 and TH2

  2005cited by this paper
• T(H)-17: a giant step from T(H)1 and T(H)2.

  2005cited by this paper
• Interleukin-1beta and tumor necrosis factor-alpha upregulate interleukin-23 subunit p19 gene expression in human colonic subepithelial myofibroblasts.

  2005cited by this paper
• Interleukin‐17 and lipopolysaccharides synergistically induce cyclooxygenase‐2 expression in human intestinal myofibroblasts

  2005cited by this paper
• Novel pathophysiological concepts of inflammatory bowel disease

  2005cited by this paper
• IL-22 increases the innate immunity of tissues.

  2004cited by this paper
• The gastrointestinal stem cell

  2004cited by this paper
• Innate immunity and mucosal bacterial interactions in the intestine

  2004cited by this paper
• Interleukin-17 family members and inflammation.

  2004cited by this paper
• Epithelial tissue chimerism after human hematopoietic cell transplantation is a real phenomenon.

  2004cited by this paper
• Suppression of interleukin-1β- and tumor necrosis factor-·-induced inflammatory responses by leukocytapheresis therapy in patients with ulcerative colitis

  2004cited by this paper
• Functional Expression of the Interleukin-11 Receptor α-Chain and Evidence of Antiapoptotic Effects in Human Colonic Epithelial Cells*

  2004cited by this paper
• Suppression of interleukin-1beta- and tumor necrosis factor-alpha-induced inflammatory responses by leukocytapheresis therapy in patients with ulcerative colitis.

  2004cited by this paper
• IL‐12 and IL‐23: master regulators of innate and adaptive immunity

  2004cited by this paper
• Role of Fibroblast Growth Factor-2 in the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Intestinal Myofibroblasts

  2004cited by this paper
• Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease.

  2003cited by this paper
• Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17

  2003cited by this paper
• Regulation of IL-11 expression in intestinal myofibroblasts: role of c-Jun AP-1- and MAPK-dependent pathways.

  2003cited by this paper
• Increased expression of interleukin 17 in inflammatory bowel disease

  2003cited by this paper
• Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

  2003cited by this paper
• An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells

  2003cited by this paper
• Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.

  2003cited by this paper
• Intestinal myofibroblasts in innate immune responses of the intestine.

  2003cited by this paper
• High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease.

  2003cited by this paper
• The interleukin-10 family of cytokines.

  2002cited by this paper
• IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts.

  2002cited by this paper
• Intestinal subepithelial myofibroblasts in inflammatory bowel diseases

  2002cited by this paper
• Interleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts.

  2002cited by this paper
• Methylation reveals a niche: stem cell succession in human colon crypts

  2002cited by this paper
• Inflammatory bowel disease.

  2002cited by this paper
• Interleukin-1β and Tumor Necrosis Factor-α Induce Chemokine and Matrix Metalloproteinase Gene Expression in Human Colonic Subepithelial Myofibroblasts

  2002cited by this paper
• Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract

  2002cited by this paper
• Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts.

  2002cited by this paper
• IL-17 Selectively Down-Regulates TNF-α-Induced RANTES Gene Expression in Human Colonic Subepithelial Myofibroblasts1

  2002cited by this paper
• Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon

  2002cited by this paper
• Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal.

  2002cited by this paper
• IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells1

  2002cited by this paper
• IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts.

  2002cited by this paper
• Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts.

  2002cited by this paper
• Gastrointestinal stem cells

  2002cited by this paper
• A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1

  2002cited by this paper
• Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells.

  2002cited by this paper
• The stem-cell niche theory: lessons from flies

  2002cited by this paper
• Dominant role of the niche in melanocyte stem-cell fate determination

  2002cited by this paper
• Pluripotency of mesenchymal stem cells derived from adult marrow

  2002cited by this paper
• Bone marrow contributes to renal parenchymal turnover and regeneration

  2001cited by this paper
• Stem cells find their niche

  2001cited by this paper
• Bone marrow cells regenerate infarcted myocardium

  2001cited by this paper
• Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.

  2001cited by this paper
• Morphogenesis and renewal of hair follicles from adult multipotent stem cells.

  2001cited by this paper
• VEGF, basic-FGF, and TGF-β in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation

  2001cited by this paper
• Differential activation of cytokine secretion in primary human colonic fibroblast/myofibroblast cultures.

  2001cited by this paper
• VEGF, basic-FGF, and TGF-β in Crohn’s disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation

  2001cited by this paper
• Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease

  2000cited by this paper
• Radiation induced cytochrome c release causes loss of rat colonic fluid absorption by damage to crypts and pericryptal myofibroblasts

  2000cited by this paper
• Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

  2000cited by this paper
• Chronic Colitis in IL-10-/- Mice: Insufficient Counter Regulation of a Th1 Response

  2000cited by this paper
• Cell differentiation: Hepatocytes from non-hepatic adult stem cells

  2000cited by this paper
• Myofibroblasts: paracrine cells important in health and disease.

  2000cited by this paper
• Use of concurrent G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells in children with malignant disease

  2000cited by this paper
• Stem cell factor (SCF) can regulate the activation and expansion of murine intraepithelial lymphocytes.

  2000cited by this paper
• IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease.

  2000cited by this paper
• Matrix metalloproteinases: biologic activity and clinical implications.

  2000cited by this paper
• Increased production of matrix metalloproteinase‐3 and tissue inhibitor of metalloproteinase‐1 by inflamed mucosa in inflammatory bowel disease

  2000cited by this paper
• From marrow to brain: expression of neuronal phenotypes in adult mice.

  2000cited by this paper
• Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

  2000cited by this paper
• Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma

  2000cited by this paper
• Liver from bone marrow in humans

  2000cited by this paper
• Matrix Metalloproteinases*

  1999cited by this paper
• Bone marrow as a potential source of hepatic oval cells.

  1999cited by this paper
• Myofibroblasts. II. Intestinal subepithelial myofibroblasts.

  1999cited by this paper
• Increased production of vascular endothelial growth factor by intestinal mucosa of patients with inflammatory bowel disease.

  1999cited by this paper
• Water transport revisited

  1999cited by this paper
• Hematopoietic, immunomodulatory and epithelial effects of interleukin-11

  1999cited by this paper
• Myofibroblasts. II. Intestinal subepithelial myofibroblasts.

  1999cited by this paper
• Dystrophin expression in the mdx mouse restored by stem cell transplantation

  1999cited by this paper
• Powell, D. W. et al. Myofibroblasts. I. Paracrine cells important in health and disease. Am. J. Physiol. 277, C1-C9

  1999cited by this paper
• Increased serum levels of vascular endothelial growth factor in patients with inflammatory bowel disease.

  1998cited by this paper
• Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease.

  1998cited by this paper
• Course of Crohn's disease after allogeneic marrow transplantation.

  1998cited by this paper
• Muscle regeneration by bone marrow-derived myogenic progenitors.

  1998cited by this paper
• Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation.

  1998cited by this paper

• In vivo transcriptomic profiling of colonic mucosa during Brachyspira hyodysenteriae infection in pigs.

  2026cites this paper
• Cellular and molecular mechanisms in the pathogenesis of pouchitis: more than just the microbiota

  2025cites this paper
• Biomolecular Aspects of Reelin in Neurodegenerative Disorders: An Old Candidate for a New Linkage of the Gut–Brain–Eye Axis

  2025cites this paper
• Molecular Basis of Chronic Intestinal Wall Fibrosis in Inflammatory Bowel Diseases

  2025cites this paper
• Human intestinal stromal cells promote homeostasis in normal mucosa but inflammation in Crohn’s disease in a retinoic acid–deficient manner

  2024cites this paper
• The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis

  2024cites this paper
• Towards Full Thickness Small Intestinal Models: Incorporation of Stromal Cells

  2023cites this paper
• Reelin through the years: From brain development to inflammation.

  2023cites this paper
• A novel tetra-PEG based hydrogel for prevention of esophageal stricture after ESD in a porcine model.

  2023cites this paper
• An Analysis of the Content of Metalloproteinases in the Intestinal Wall of Patients with Crohn’s Disease

  2023cites this paper
• Effects of Glycyrrhiza Polysaccharides on Chickens' Intestinal Health and Homeostasis

  2022cites this paper
• Molecular Basis of Intestinal Fibrosis in Inflammatory Bowel Disease

  2022cites this paper
• Stem Cell-Based Therapies for Inflammatory Bowel Disease

  2022cites this paper
• Advances in stem cell therapy for intestinal diseases: mechanisms, perspectives regarding clinical applications, and challenges.

  2022cites this paper
• Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology

  2022cites this paper
• Cells and Mediators of Inflammation as Effectors of Epithelial Repair in the Inflamed Intestine.

  2021cites this paper
• Characterization of a bovine intestinal myofibroblast cell line and stimulation using phytoglycogen-based nanoparticles bound to inosine monophosphate

  2021cites this paper
• Caffeic Acid Modulates Processes Associated with Intestinal Inflammation

  2021cites this paper
• The Role of Extracellular Matrix Components in Inflammatory Bowel Diseases

  2021cites this paper
• Organ- and Site-Specific HOX Gene Expression in Stromal Cells

  2021cites this paper
• Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation

  2020cites this paper
• Mechanisms of Immunosuppression in Colorectal Cancer

  2020cites this paper
• Protective Effect of Thalidomide on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis in Rats via the Inhibition of T Helper 17 Cells

  2020cites this paper
• Fibroblast Reprogramming in Gastrointestinal Cancer

  2020cites this paper
• Application of Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids as a Model of Epithelial Damage and Fibrosis in Inflammatory Bowel Disease.

  2020cites this paper
• Matrix Metalloproteinase 3 Predicts Therapeutic Response in Inflammatory Bowel Disease Patients Treated With Infliximab.

  2020cites this paper
• Development and characterization of a stable bovine intestinal sub-epithelial myofibroblast cell line from ileum of a young calf

  2019influential citation
• Intestinal fibrosis.

  2019cites this paper
• Resveratrol decreases TNFα-induced ICAM-1 expression and release by Sirt-1-independent mechanism in intestinal myofibroblasts.

  2019cites this paper
• Role of Bovine Ileal Sub-epithelial Myofibroblasts and Epithelial Cells in Innate Immunity

  2018influential citation
• Extracellular matrix remodeling and TGF‐β1/Smad signaling in diabetic colon mucosa

  2018influential citation
• Cellular Interactions in the Intestinal Stem Cell Niche

  2018cites this paper
• Myofibroblastic lesions in the oral cavity: Immunohistochemical and ultrastructural analysis.

  2018cites this paper
• Expression of human cathelicidin peptide LL‐37 in inflammatory bowel disease

  2018cites this paper
• Reelin expression is up-regulated in mice colon in response to acute colitis and provides resistance against colitis.

  2017cites this paper
• Reelin‐Dab1 signaling system in human colorectal cancer

  2017cites this paper
• Mesenchymal Cells in Colon Cancer.

  2017cites this paper
• Buckwheat bioactive compounds, their derived phenolic metabolites and their health benefits

  2017cites this paper
• Tissue engineering for the treatment of short bowel syndrome in children

  2017cites this paper
• Expression of Interleukin-26 is upregulated in inflammatory bowel disease

  2017cites this paper
• Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue

  2016cites this paper
• Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish

  2016cites this paper
• Loss of mesenchymal bone morphogenetic protein signaling leads to development of reactive stroma and initiation of the gastric neoplastic cascade

  2016cites this paper
• The contribution of T cell-derived cytokines and proteases to chronic inflammation in the human intestine

  2016cites this paper
• Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment

  2016cites this paper
• Aryl hydrocarbon receptor‐driven signals inhibit collagen synthesis in the gut

  2016cites this paper
• Stem Cell Transplantation for Crohn’s Disease

  2015cites this paper
• IL-33 activates tumor stroma to promote intestinal polyposis

  2015cites this paper
• Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease

  2015cites this paper
• Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary cultures

  2015cites this paper
• IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

  2015cites this paper
• Effects of inflammation on stem cells: together they strive?

  2015cites this paper
• TAK1 is a key modulator of the profibrogenic phenotype of human ileal myofibroblasts in Crohn's disease.

  2015cites this paper
• Vitamin D Prevents the Intestinal Fibrosis Via Induction of Vitamin D Receptor and Inhibition of Transforming Growth Factor-Beta1/Smad3 Pathway

  2015cites this paper
• Enriched Intestinal Stem Cell Seeding Improves the Architecture of Tissue-Engineered Intestine

  2015cites this paper
• Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update

  2015cites this paper
• Using Helium-Generated Cold Plasma to Control Infection and Healing

  2015cites this paper
• In vitro evaluation of the cytotoxicity and modulation of mechanisms associated with inflammation induced by perfluorooctanesulfonate and perfluorooctanoic acid in human colon myofibroblasts CCD-18Co.

  2015cites this paper
• Inflammatory and Immune Activation in Intestinal Myofibroblasts Is Developmentally Regulated

  2015cites this paper
• Effect of interleukin-17 on gene expression profile of fibroblasts from Crohn's disease patients.

  2014cites this paper
• Dab1 and reelin participate in a common signal pathway that controls intestinal crypt/villus unit dynamics

  2014cites this paper
• Intestinal stem cells and the colorectal cancer microenvironment.

  2014cites this paper
• An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration.

  2014cites this paper
• Helium Generated Cold Plasma Finely Regulates Activation of Human Fibroblast-Like Primary Cells

  2014cites this paper
• Tissue communication in regenerative inflammatory signaling: lessons from the fly gut

  2014cites this paper
• Use of Zebrafish As a Model for Understanding the Interplay Between Inflammation and Stem Cells

  2014cites this paper
• Chemopreventive drugs: mechanisms via inhibition of cancer stem cells in colorectal cancer.

  2014cites this paper
• Chemopreventive drugs : Mechanisms via inhibition of cancer stem cells in colorectal cancer

  2014cites this paper
• The role of interleukin 17 in Crohn’s disease-associated intestinal fibrosis

  2013cites this paper
• Roles of substance P and ATP in the subepithelial fibroblasts of rat intestinal villi.

  2013cites this paper
• A bioabsorbable polymer patch for the treatment of esophageal defect in a porcine model

  2013cites this paper
• Allogeneic Hematopoietic Stem Cell Transplantation May Restore Gluten Tolerance in Patients With Celiac Disease

  2013cites this paper
• Regulation of intestinal cancer stem cells.

  2013cites this paper
• Self-renewal of the gastric epithelium from stem and progenitor cells.

  2013cites this paper
• Obesity, Inflammation and Cancer

  2013cites this paper
• A novel population of subepithelial platelet-derived growth factor receptor α-positive cells in the mouse and human colon.

  2013cites this paper
• Inflammation, Obesity, and Colon Cancer

  2013cites this paper
• Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.

  2012cites this paper
• Reelin Is Involved in the Crypt-Villus Unit Homeostasis

  2012cites this paper
• IL-1β stimulation of CCD-18co myofibroblasts enhances repair of epithelial monolayers through Wnt-5a.

  2012cites this paper
• A comprehensive study of adult stromal cells derived from mesenchymal tissues and their application in tendon regeneration

  2012cites this paper
• Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts.

  2012cites this paper
• Role of N-acetylcysteine and GSH redox system on total and active MMP-2 in intestinal myofibroblasts of Crohn's disease patients

  2012cites this paper
• Human foetal intestinal fibroblasts are hyper-responsive to lipopolysaccharide stimulation.

  2012cites this paper
• IL-1 (cid:1) stimulation of CCD-18co myofibroblasts enhances repair of epithelial monolayers through Wnt-5a of

  2012cites this paper
• Intestinal stromal cells in mucosal immunity and homeostasis

  2012cites this paper
• Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: ‘brothers in arms’

  2011cites this paper
• Stem cells and their implications for colorectal cancer

  2011cites this paper
• ATP induces contraction mediated by the P2Y(2) receptor in rat intestinal subepithelial myofibroblasts.

  2011cites this paper
• Ultrastructural and Immunohistochemical Analysis of Intestinal Myofibroblasts During the Early Organogenesis of the Human Small Intestine

  2011cites this paper
• Inflammasomes in intestinal inflammation and cancer.

  2011cites this paper
• Etude des interactions entre Helicobacter pylori et les cellules épithéliales gastriques

  2011cites this paper
• A Multicellular Approach Forms a Significant Amount of Tissue-Engineered Small Intestine in the Mouse

  2011cites this paper
• Tissue-Engineered Intestine

  2011cites this paper
• Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.

  2011cites this paper
• Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.

  2011cites this paper
• Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis.

  2011cites this paper
• Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

  2011cites this paper
• Interleukin-32α expression in human colonic subepithelial myofibroblasts.

  2011cites this paper
• Intestinal myofibroblasts: targets for stem cell therapy.

  2011cites this paper